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Reviewed, UniProtKB/Swiss-Prot P78812 (6PGD_SCHPO)

Last modified November 25, 2008. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44
Gene names
ORF Names: SPBC660.16
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

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Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

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Ontologies

Keywords

   Biological processPentose shunt
   LigandNADP
   Molecular functionOxidoreductase
   PTMPhosphoprotein
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processcellular response to stress

Inferred from expression pattern. Source: GeneDB_SPombe

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

pentose-phosphate shunt, oxidative branch

Inferred from direct assay. Source: GeneDB_SPombe

   Cellular componentcytosol

Inferred from direct assay. Source: GeneDB_SPombe

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

phosphogluconate dehydrogenase (decarboxylating) activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4924926-phosphogluconate dehydrogenase, decarboxylating
PRO_0000090074

Amino acid modifications

Modified residue1071Phosphoserine
Modified residue2151Phosphoserine

Experimental info

Sequence conflict219 – 2202IA → ST in BAA13823. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P78812-1 [UniParc].

Last modified January 11, 2001. Version 2.
Checksum: F55F342957A9D3E1

FASTA49253,680
        10         20         30         40         50         60 
MSQKEVADFG LIGLAVMGQN LILNGADKGF TVCCYNRTTS RVDEFLANEA KGKSIVGAHS 

        70         80         90        100        110        120 
LEEFVSKLKK PRVCILLVKA GKPVDYLIEG LAPLLEKGDI IVDGGNSHYP DTTRRCEELA 

       130        140        150        160        170        180 
KKGILFVGSG VSGGEEGARY GPSLMPGGNP AAWPRIKPIF QTLAAKAGNN EPCCDWVGEQ 

       190        200        210        220        230        240 
GAGHYVKMVH NGIEYGDMQL ICETYDIMKR GLGMSCDEIA DVFEKWNTGK LDSFLIEITR 

       250        260        270        280        290        300 
DVLRYKADDG KPLVEKILDA AGQKGTGKWT AQNALEMGTP VSLITEAVFA RCLSSLKSER 

       310        320        330        340        350        360 
VRASKKLTGP NTKFTGDKKQ LIDDLEDALY ASKIISYAQG FMLMREAAKE YGWKLNNAGI 

       370        380        390        400        410        420 
ALMWRGGCII RSVFLKDITE AFREDPNLES ILFHPFFTNG VEKAQAGWRR VVAQAAMLGI 

       430        440        450        460        470        480 
PVPATSTGLS FYDGYRSAVL PANLLQAQRD YFGAHTFRVL PEAADKSLPA DKDIHINWTG 

       490 
HGGNISATTY DA

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References

[1]"Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
DNA Res. 4:363-369(1997) [PubMed: 9501991] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: PR745.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.
[3]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107 AND SER-215, MASS SPECTROMETRY.

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Cross-references

Sequence databases

D89161 mRNA. Translation: BAA13823.1. Different initiation.
CU329671 Genomic DNA. Translation: CAA22536.1.
PIRT40628.
T42523.
RefSeqNP_595095.1.

3D structure databases

HSSPHSSP built from PDB template 2PGD based on UniProtKB P00349.
ModBaseSearch...

Genome annotation databases

GeneID2541146.
KEGGspo:SPBC660.16.
NMPDRfig|4896.1.peg.961.

Organism-specific databases

GeneDB_SpombeSPBC660.16.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-003196-MON.

Gene expression databases

ArrayExpressP78812.

Family and domain databases

InterProIPR006183. 6-phosphogluconate_DHase.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NAD-bd.
IPR006184. 6PGdom_BS.
IPR013328. DHase_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PRINTSPR00076. 6PGDHDRGNASE.
TIGRFAMsTIGR00873. gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry name6PGD_SCHPO
AccessionPrimary (citable) accession number: P78812
Secondary accession number(s): Q9UQW5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 11, 2001
Last modified: November 25, 2008
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents