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Protein

Probable UTP--glucose-1-phosphate uridylyltransferase

Gene

fyu1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.1 Publication

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi129 – 1291MagnesiumBy similarity
Metal bindingi252 – 2521MagnesiumBy similarity
Active sitei394 – 3941By similarity

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • UTP:glucose-1-phosphate uridylyltransferase activity Source: PomBase

GO - Biological processi

  • UDP-glucose metabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_283534. Glycogen synthesis.
REACT_289634. Formation of the active cofactor, UDP-glucuronate.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Name:fyu1
ORF Names:SPCC1322.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1322.04.
PomBaseiSPCC1322.04. fyu1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Probable UTP--glucose-1-phosphate uridylyltransferasePRO_0000185763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151Phosphoserine1 Publication
Modified residuei17 – 171Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP78811.
PaxDbiP78811.

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

BioGridi275456. 2 interactions.
MINTiMINT-4691308.
STRINGi4896.SPCC1322.04.1.

Structurei

3D structure databases

ProteinModelPortaliP78811.
SMRiP78811. Positions 28-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni455 – 50652OligomerizationBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

eggNOGiCOG4284.
HOGENOMiHOG000113618.
InParanoidiP78811.
KOiK00963.
OMAiIAKDVSY.
OrthoDBiEOG7KDFKX.
PhylomeDBiP78811.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

P78811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLAPRPLGR QHSKSQSAFA FDNTATSIAA STMKNELNHL ASTVKDPLAK
60 70 80 90 100
KAFQKEMDNF FSLFSRYLQE DARGSEINWD LVESPKPEQV VEYDTITEAG
110 120 130 140 150
GLSRDYLNKL AVLKLNGGLG TTMGCVGPKS IIEVRDGNSF LDLSVRQIEH
160 170 180 190 200
LNRKYNVNVP FVLMNSFNTD EATAKVIKKY EAHKIDILTF NQSRYPRVHK
210 220 230 240 250
ETLLPVPHTA DSAIDEWYPP GHGDVFEALT NSGIIDTLIA QGKEYLFVSN
260 270 280 290 300
IDNLGAVVDL NILNHMVETN AEYLMELTNK TKADVKGGTL IDYDGNVRLL
310 320 330 340 350
EIAQVPPQHV EEFKSIKKFK YFNTNNLWFH LPSVKRVVNN HELSMEIIPN
360 370 380 390 400
KKTIKHKGEN INIIQLETAA GAAIRHFKNA HGVNVPRRRF LPVKTCSDLL
410 420 430 440 450
LVKSDLYSIN HGQVEMNPRR FGGTAPLVKL GAHFKKVADF SAHIPSIPKI
460 470 480 490 500
LELDHLTITG DVNIGRNVTL KGTVIIVASD ANRIDIPNGS VLENCVITGN

LNILEH
Length:506
Mass (Da):56,430
Last modified:January 11, 2001 - v2
Checksum:iCC4B7EF856D25630
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA22857.1.
D89160 mRNA. Translation: BAA13822.1.
PIRiT40935.
T42521.
RefSeqiNP_588132.1. NM_001023122.2.

Genome annotation databases

EnsemblFungiiSPCC1322.04.1; SPCC1322.04.1:pep; SPCC1322.04.
GeneIDi2538877.
KEGGispo:SPCC1322.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA22857.1.
D89160 mRNA. Translation: BAA13822.1.
PIRiT40935.
T42521.
RefSeqiNP_588132.1. NM_001023122.2.

3D structure databases

ProteinModelPortaliP78811.
SMRiP78811. Positions 28-506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275456. 2 interactions.
MINTiMINT-4691308.
STRINGi4896.SPCC1322.04.1.

Proteomic databases

MaxQBiP78811.
PaxDbiP78811.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1322.04.1; SPCC1322.04.1:pep; SPCC1322.04.
GeneIDi2538877.
KEGGispo:SPCC1322.04.

Organism-specific databases

EuPathDBiFungiDB:SPCC1322.04.
PomBaseiSPCC1322.04. fyu1.

Phylogenomic databases

eggNOGiCOG4284.
HOGENOMiHOG000113618.
InParanoidiP78811.
KOiK00963.
OMAiIAKDVSY.
OrthoDBiEOG7KDFKX.
PhylomeDBiP78811.

Enzyme and pathway databases

ReactomeiREACT_283534. Glycogen synthesis.
REACT_289634. Formation of the active cofactor, UDP-glucuronate.

Miscellaneous databases

NextBioi20800057.
PROiP78811.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 203-506.
    Strain: PR745.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-17, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "Production of ibuprofen acyl glucosides by human UGT2B7."
    Buchheit D., Dragan C.A., Schmitt E.I., Bureik M.
    Drug Metab. Dispos. 39:2174-2181(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY, FUNCTION.

Entry informationi

Entry nameiUGPA1_SCHPO
AccessioniPrimary (citable) accession number: P78811
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2001
Last modified: June 24, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.