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P78811 (UGPA1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable UTP--glucose-1-phosphate uridylyltransferase

EC=2.7.7.9
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name=UDPGP
Short name=UGPase
Gene names
Name:fuy1
ORF Names:SPCC1322.04
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a central role as a glucosyl donor in cellular metabolic pathways. Ref.5

Catalytic activity

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose. Ref.5

Subunit structure

Homooctamer By similarity.

Subcellular location

Cytoplasm. Nucleus Ref.3.

Sequence similarities

Belongs to the UDPGP type 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 506506Probable UTP--glucose-1-phosphate uridylyltransferase
PRO_0000185763

Regions

Region455 – 50652Oligomerization By similarity

Sites

Active site3941 By similarity
Metal binding1291Magnesium By similarity
Metal binding2521Magnesium By similarity

Amino acid modifications

Modified residue151Phosphoserine Ref.4
Modified residue171Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
P78811 [UniParc].

Last modified January 11, 2001. Version 2.
Checksum: CC4B7EF856D25630

FASTA50656,430
        10         20         30         40         50         60 
MDLAPRPLGR QHSKSQSAFA FDNTATSIAA STMKNELNHL ASTVKDPLAK KAFQKEMDNF 

        70         80         90        100        110        120 
FSLFSRYLQE DARGSEINWD LVESPKPEQV VEYDTITEAG GLSRDYLNKL AVLKLNGGLG 

       130        140        150        160        170        180 
TTMGCVGPKS IIEVRDGNSF LDLSVRQIEH LNRKYNVNVP FVLMNSFNTD EATAKVIKKY 

       190        200        210        220        230        240 
EAHKIDILTF NQSRYPRVHK ETLLPVPHTA DSAIDEWYPP GHGDVFEALT NSGIIDTLIA 

       250        260        270        280        290        300 
QGKEYLFVSN IDNLGAVVDL NILNHMVETN AEYLMELTNK TKADVKGGTL IDYDGNVRLL 

       310        320        330        340        350        360 
EIAQVPPQHV EEFKSIKKFK YFNTNNLWFH LPSVKRVVNN HELSMEIIPN KKTIKHKGEN 

       370        380        390        400        410        420 
INIIQLETAA GAAIRHFKNA HGVNVPRRRF LPVKTCSDLL LVKSDLYSIN HGQVEMNPRR 

       430        440        450        460        470        480 
FGGTAPLVKL GAHFKKVADF SAHIPSIPKI LELDHLTITG DVNIGRNVTL KGTVIIVASD 

       490        500 
ANRIDIPNGS VLENCVITGN LNILEH 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 203-506.
Strain: PR745.
[3]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-17, IDENTIFICATION BY MASS SPECTROMETRY.
[5]"Production of ibuprofen acyl glucosides by human UGT2B7."
Buchheit D., Dragan C.A., Schmitt E.I., Bureik M.
Drug Metab. Dispos. 39:2174-2181(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: CATALYTIC ACTIVITY, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329672 Genomic DNA. Translation: CAA22857.1.
D89160 mRNA. Translation: BAA13822.1.
PIRT40935.
T42521.
RefSeqNP_588132.1. NM_001023122.2.

3D structure databases

ProteinModelPortalP78811.
SMRP78811. Positions 28-506.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275456. 4 interactions.
MINTMINT-4691308.
STRING4896.SPCC1322.04-1.

Proteomic databases

MaxQBP78811.
PaxDbP78811.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC1322.04.1; SPCC1322.04.1:pep; SPCC1322.04.
GeneID2538877.
KEGGspo:SPCC1322.04.

Organism-specific databases

PomBaseSPCC1322.04.

Phylogenomic databases

eggNOGCOG4284.
HOGENOMHOG000113618.
KOK00963.
OMAPPNGKRC.
OrthoDBEOG7KDFKX.
PhylomeDBP78811.

Family and domain databases

Gene3D3.90.550.10. 1 hit.
InterProIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_trans.
IPR016267. UDPGP_trans_subgr.
[Graphical view]
PANTHERPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFPIRSF000806. UDPGP. 1 hit.
SUPFAMSSF53448. SSF53448. 1 hit.
ProtoNetSearch...

Other

NextBio20800057.
PROP78811.

Entry information

Entry nameUGPA1_SCHPO
AccessionPrimary (citable) accession number: P78811
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2001
Last modified: June 11, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names