P78811 (UGPA1_SCHPO) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 75.
History...
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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Probable UTP--glucose-1-phosphate uridylyltransferase EC=2.7.7.9 Alternative name(s): UDP-glucose pyrophosphorylase Short name=UDPGP Short name=UGPase | ||
| Gene names |
| ||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | ||
| Taxonomic identifier | 284812 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 506 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Plays a central role as a glucosyl donor in cellular metabolic pathways By similarity. |
| Catalytic activity | UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose. |
| Subunit structure | Homooctamer By similarity. |
| Sequence similarities | Belongs to the UDPGP type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Magnesium Metal-binding |
| Molecular function | Nucleotidyltransferase Transferase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | UDP-glucose metabolic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe cellular response to stressInferred from expression pattern. Source: GeneDB_Spombe |
| Cellular component | cytosol Inferred from direct assay. Source: GeneDB_Spombe nucleusInferred from direct assay. Source: GeneDB_Spombe |
| Molecular function | UTP:glucose-1-phosphate uridylyltransferase activity Inferred from sequence or structural similarity. Source: GeneDB_Spombe metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 506 | 506 | Probable UTP--glucose-1-phosphate uridylyltransferase | PRO_0000185763 | |||||
Regions | |||||||||
| Region | 455 – 506 | 52 | Oligomerization By similarity | ||||||
Sites | |||||||||
| Active site | 394 | 1 | By similarity | ||||||
| Metal binding | 129 | 1 | Magnesium By similarity | ||||||
| Metal binding | 252 | 1 | Magnesium By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 15 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 17 | 1 | Phosphoserine Ref.3 | ||||||
Sequences
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References
| [1] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.  Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843. |
| [2] | "Identification of open reading frames in Schizosaccharomyces pombe cDNAs." Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H. DNA Res. 4:363-369(1997) [PubMed: 9501991] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 203-506. Strain: PR745. |
| [3] | "Phosphoproteome analysis of fission yeast." Wilson-Grady J.T., Villen J., Gygi S.P. J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-17, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CU329672 Genomic DNA. Translation: CAA22857.1. D89160 mRNA. Translation: BAA13822.1. |
| PIR | T40935. T42521. |
| RefSeq | NP_588132.1. NM_001023122.1. |
3D structure databases | |
| ProteinModelPortal | P78811. |
| SMR | P78811. Positions 28-506. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P78811. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | SPCC1322.04.1; SPCC1322.04.1:pep; SPCC1322.04. |
| GeneID | 2538877. |
| KEGG | spo:SPCC1322.04. |
| NMPDR | fig|4896.1.peg.470. |
Organism-specific databases | |
| GeneDB_Spombe | SPCC1322.04. |
Phylogenomic databases | |
| eggNOG | fuNOG05246. |
| GeneTree | EFGT00050000004058. |
| HOGENOM | HBG316482. |
| OMA | NDLTFLD. |
| OrthoDB | EOG4KSST8. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-000074-MONOMER. |
Gene expression databases | |
| ArrayExpress | P78811. |
Family and domain databases | |
| InterPro | IPR002618. UDPGP_trans. IPR016267. UDPGP_trans_subgr. [Graphical view] |
| KO | K00963. |
| PANTHER | PTHR11952:SF1. PTHR11952:SF1. 1 hit. PTHR11952. UDPGP_trans. 1 hit. |
| Pfam | PF01704. UDPGP. 1 hit. [Graphical view] |
| PIRSF | PIRSF000806. UDPGP. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | UGPA1_SCHPO | ||||||||
| Accession | Primary (citable) accession number: P78811 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |