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Protein

Probable UTP--glucose-1-phosphate uridylyltransferase

Gene

fyu1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.1 Publication

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi129MagnesiumBy similarity1
Binding sitei129UTPBy similarity1
Binding sitei192UTPBy similarity1
Binding sitei221UTP; via amide nitrogenBy similarity1
Binding sitei222SubstrateBy similarity1
Metal bindingi252MagnesiumBy similarity1
Binding sitei252UTPBy similarity1
Active sitei394By similarity1
Binding sitei394UTPBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • UTP:glucose-1-phosphate uridylyltransferase activity Source: PomBase

GO - Biological processi

  • glycogen metabolic process Source: GO_Central
  • UDP-glucose metabolic process Source: PomBase

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-173599 Formation of the active cofactor, UDP-glucuronate
R-SPO-3322077 Glycogen synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Name:fyu1
ORF Names:SPCC1322.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1322.04
PomBaseiSPCC1322.04 fyu1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857631 – 506Probable UTP--glucose-1-phosphate uridylyltransferaseAdd BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15Phosphoserine1 Publication1
Modified residuei17Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP78811
PaxDbiP78811
PRIDEiP78811

PTM databases

iPTMnetiP78811

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

BioGridi275456, 3 interactors
STRINGi4896.SPCC1322.04.1

Structurei

3D structure databases

ProteinModelPortaliP78811
SMRiP78811
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 118UTP bindingBy similarity4
Regioni117 – 118Substrate bindingBy similarity2
Regioni250 – 252Substrate bindingBy similarity3
Regioni455 – 506OligomerizationBy similarityAdd BLAST52

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

HOGENOMiHOG000113618
InParanoidiP78811
KOiK00963
OMAiMEIIPNG
OrthoDBiEOG092C1XSD
PhylomeDBiP78811

Family and domain databases

CDDicd00897 UGPase_euk, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR029044 Nucleotide-diphossugar_trans
IPR002618 UDPGP_fam
IPR016267 UDPGP_trans
PfamiView protein in Pfam
PF01704 UDPGP, 1 hit
PIRSFiPIRSF000806 UDPGP, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

P78811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLAPRPLGR QHSKSQSAFA FDNTATSIAA STMKNELNHL ASTVKDPLAK
60 70 80 90 100
KAFQKEMDNF FSLFSRYLQE DARGSEINWD LVESPKPEQV VEYDTITEAG
110 120 130 140 150
GLSRDYLNKL AVLKLNGGLG TTMGCVGPKS IIEVRDGNSF LDLSVRQIEH
160 170 180 190 200
LNRKYNVNVP FVLMNSFNTD EATAKVIKKY EAHKIDILTF NQSRYPRVHK
210 220 230 240 250
ETLLPVPHTA DSAIDEWYPP GHGDVFEALT NSGIIDTLIA QGKEYLFVSN
260 270 280 290 300
IDNLGAVVDL NILNHMVETN AEYLMELTNK TKADVKGGTL IDYDGNVRLL
310 320 330 340 350
EIAQVPPQHV EEFKSIKKFK YFNTNNLWFH LPSVKRVVNN HELSMEIIPN
360 370 380 390 400
KKTIKHKGEN INIIQLETAA GAAIRHFKNA HGVNVPRRRF LPVKTCSDLL
410 420 430 440 450
LVKSDLYSIN HGQVEMNPRR FGGTAPLVKL GAHFKKVADF SAHIPSIPKI
460 470 480 490 500
LELDHLTITG DVNIGRNVTL KGTVIIVASD ANRIDIPNGS VLENCVITGN

LNILEH
Length:506
Mass (Da):56,430
Last modified:January 11, 2001 - v2
Checksum:iCC4B7EF856D25630
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA22857.1
D89160 mRNA Translation: BAA13822.1
PIRiT40935
T42521
RefSeqiNP_588132.1, NM_001023122.2

Genome annotation databases

EnsemblFungiiSPCC1322.04.1; SPCC1322.04.1:pep; SPCC1322.04
GeneIDi2538877
KEGGispo:SPCC1322.04

Similar proteinsi

Entry informationi

Entry nameiUGPA1_SCHPO
AccessioniPrimary (citable) accession number: P78811
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2001
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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