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Protein

Probable aspartate-semialdehyde dehydrogenase

Gene

SPCC1827.06c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.By similarity

Catalytic activityi

L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Probable aspartokinase (SPBC19F5.04)
  2. Probable aspartate-semialdehyde dehydrogenase (SPCC1827.06c)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes L-homoserine from L-aspartate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Probable aspartokinase (SPBC19F5.04)
  2. Probable aspartate-semialdehyde dehydrogenase (SPCC1827.06c)
  3. Probable homoserine dehydrogenase (SPBC776.03)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Probable aspartokinase (SPBC19F5.04)
  2. Probable aspartate-semialdehyde dehydrogenase (SPCC1827.06c)
  3. Probable homoserine dehydrogenase (SPBC776.03)
  4. Probable homoserine kinase (SPBC4C3.03)
  5. Threonine synthase (thrc)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei111PhosphateBy similarity1
Active sitei151Acyl-thioester intermediateBy similarity1
Binding sitei179SubstrateBy similarity1
Binding sitei205SubstrateBy similarity1
Binding sitei208PhosphateBy similarity1
Binding sitei240SubstrateBy similarity1
Active sitei247Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADPBy similarity4
Nucleotide bindingi39 – 40NADPBy similarity2
Nucleotide bindingi182 – 183NADPBy similarity2
Nucleotide bindingi335 – 336NADPBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis, Methionine biosynthesis, Threonine biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00034; UER00016
UPA00050; UER00463
UPA00051; UER00464

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aspartate-semialdehyde dehydrogenase (EC:1.2.1.11)
Short name:
ASA dehydrogenase
Short name:
ASADH
Alternative name(s):
Aspartate-beta-semialdehyde dehydrogenase
Gene namesi
ORF Names:SPCC1827.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1827.06c
PomBaseiSPCC1827.06c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001413991 – 357Probable aspartate-semialdehyde dehydrogenaseAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei323Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP78780
PaxDbiP78780
PRIDEiP78780

PTM databases

iPTMnetiP78780

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi275837, 2 interactors
IntActiP78780, 1 interactor
STRINGi4896.SPCC1827.06c.1

Structurei

3D structure databases

ProteinModelPortaliP78780
SMRiP78780
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000013358
InParanoidiP78780
KOiK00133
OMAiCEEEMKM
OrthoDBiEOG092C309U
PhylomeDBiP78780

Family and domain databases

HAMAPiMF_02121 ASADH, 1 hit
InterProiView protein in InterPro
IPR005676 Asp_semi-ald_DH_pep-lack
IPR012080 Asp_semialdehyde_DH
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
IPR012280 Semialdhyde_DH_dimer_dom
PfamiView protein in Pfam
PF01118 Semialdhyde_dh, 1 hit
PF02774 Semialdhyde_dhC, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00978 asd_EA, 1 hit

Sequencei

Sequence statusi: Complete.

P78780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKKVGILG ATGTVGQRFI TLLSDHPEFK IAVLGASARS AGKPYAVATK
60 70 80 90 100
WKQSIAMPKE ISQMSVKACD PKEFSECDIV FSGLDADFAG EIEKSFRDAN
110 120 130 140 150
LVIVSNAKNY RREPTVPLVV PTVNTDHLDV IKYQRQENKL DRGCIITNSN
160 170 180 190 200
CSTAAVVVPL KALQDAFGPI AQTNVVSMQA ISGAGYPGVS SLDILDNIVP
210 220 230 240 250
FIGGEEEKIE WETRKILGSV NSTISGYELT DNVVSAQCNR VPVIDGHLMC
260 270 280 290 300
ISVKFAKTSP TPDQVREVLA NYVSEPQKLG CYSAPKQAIY VFDDSTPDRP
310 320 330 340 350
QPRLDRNNEN GYAVSVGRIR SDSIFDIKFV SLVHNTVLGA AGAGILNAEV

AVKKGLM
Length:357
Mass (Da):38,550
Last modified:May 1, 1999 - v2
Checksum:iD3B0478617AE2848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA19314.1
D89129 mRNA Translation: BAA13791.1
PIRiT41167
T42373
RefSeqiNP_588552.1, NM_001023539.2

Genome annotation databases

EnsemblFungiiSPCC1827.06c.1; SPCC1827.06c.1:pep; SPCC1827.06c
GeneIDi2539267
KEGGispo:SPCC1827.06c

Similar proteinsi

Entry informationi

Entry nameiDHAS_SCHPO
AccessioniPrimary (citable) accession number: P78780
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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