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Protein

Actin-related protein 2/3 complex subunit 1

Gene

arc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

GO - Biological processi

  • actin cortical patch assembly Source: PomBase
  • Arp2/3 complex-mediated actin nucleation Source: PomBase
  • mitotic cytokinesis Source: PomBase
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene namesi
Name:arc1
Synonyms:sop2
ORF Names:SPBC14C8.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC14C8.06.
PomBaseiSPBC14C8.06. arc1.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: PomBase
  • Arp2/3 protein complex Source: PomBase
  • cell division site Source: PomBase
  • cell tip Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508581 – 377Actin-related protein 2/3 complex subunit 1Add BLAST377

Proteomic databases

MaxQBiP78774.
PRIDEiP78774.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of arp2, act2, arc1/p41-ARC, arc2/p34-ARC, arc3/p21-ARC, arc4/p20-ARC and arc5/p16-ARC.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276546. 3 interactors.
IntActiP78774. 3 interactors.
MINTiMINT-4691204.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DWLX-ray3.78C/H1-377[»]
ProteinModelPortaliP78774.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78774.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 48WD 1Add BLAST40
Repeati53 – 92WD 2Add BLAST40
Repeati98 – 139WD 3Add BLAST42
Repeati144 – 183WD 4Add BLAST40
Repeati203 – 242WD 5Add BLAST40
Repeati342 – 376WD 6Add BLAST35

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000181752.
InParanoidiP78774.
KOiK05757.
OMAiHGRIVTC.
OrthoDBiEOG092C2XMA.
PhylomeDBiP78774.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSQVLHIL PKPSYEHAFN SQRTEFVTTT ATNQVELYEQ DGNGWKHART
60 70 80 90 100
FSDHDKIVTC VDWAPKSNRI VTCSQDRNAY VYEKRPDGTW KQTLVLLRLN
110 120 130 140 150
RAATFVRWSP NEDKFAVGSG ARVISVCYFE QENDWWVSKH LKRPLRSTIL
160 170 180 190 200
SLDWHPNNVL LAAGCADRKA YVLSAYVRDV DAKPEASVWG SRLPFNTVCA
210 220 230 240 250
EYPSGGWVHA VGFSPSGNAL AYAGHDSSVT IAYPSAPEQP PRALITVKLS
260 270 280 290 300
QLPLRSLLWA NESAIVAAGY NYSPILLQGN ESGWAHTRDL DAGTSKTSFT
310 320 330 340 350
HTGNTGEGRE EEGPVSFTAL RSTFRNMDLK GSSQSISSLP TVHQNMIATL
360 370
RPYAGTPGNI TAFTSSGTDG RVVLWTL
Length:377
Mass (Da):41,597
Last modified:January 11, 2001 - v3
Checksum:iC7016B4E6BEAA94D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100N → D in BAA13784 (PubMed:9501991).Curated1
Sequence conflicti232A → G in BAA13784 (PubMed:9501991).Curated1
Sequence conflicti306G → V in CAA70202 (PubMed:8978670).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08998 Genomic DNA. Translation: CAA70202.1.
CU329671 Genomic DNA. Translation: CAA18424.1.
D89122 mRNA. Translation: BAA13784.1.
PIRiT39434.
T42364.
T45528.
RefSeqiNP_595909.1. NM_001021817.2.

Genome annotation databases

EnsemblFungiiSPBC14C8.06.1; SPBC14C8.06.1:pep; SPBC14C8.06.
GeneIDi2540002.
KEGGispo:SPBC14C8.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08998 Genomic DNA. Translation: CAA70202.1.
CU329671 Genomic DNA. Translation: CAA18424.1.
D89122 mRNA. Translation: BAA13784.1.
PIRiT39434.
T42364.
T45528.
RefSeqiNP_595909.1. NM_001021817.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DWLX-ray3.78C/H1-377[»]
ProteinModelPortaliP78774.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276546. 3 interactors.
IntActiP78774. 3 interactors.
MINTiMINT-4691204.

Proteomic databases

MaxQBiP78774.
PRIDEiP78774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC14C8.06.1; SPBC14C8.06.1:pep; SPBC14C8.06.
GeneIDi2540002.
KEGGispo:SPBC14C8.06.

Organism-specific databases

EuPathDBiFungiDB:SPBC14C8.06.
PomBaseiSPBC14C8.06. arc1.

Phylogenomic databases

HOGENOMiHOG000181752.
InParanoidiP78774.
KOiK05757.
OMAiHGRIVTC.
OrthoDBiEOG092C2XMA.
PhylomeDBiP78774.

Miscellaneous databases

EvolutionaryTraceiP78774.
PROiP78774.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARPC1_SCHPO
AccessioniPrimary (citable) accession number: P78774
Secondary accession number(s): O60088
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 11, 2001
Last modified: November 2, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.