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Protein

Actin-related protein 2/3 complex subunit 1

Gene

arc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Biological processi

  • actin cortical patch assembly Source: PomBase
  • Arp2/3 complex-mediated actin nucleation Source: PomBase
  • endocytosis Source: PomBase
  • mitotic cytokinesis Source: PomBase
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene namesi
Name:arc1
Synonyms:sop2
ORF Names:SPBC14C8.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC14C8.06.
PomBaseiSPBC14C8.06. arc1.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: PomBase
  • Arp2/3 protein complex Source: PomBase
  • cell division site Source: PomBase
  • cell tip Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Actin-related protein 2/3 complex subunit 1PRO_0000050858Add
BLAST

Proteomic databases

MaxQBiP78774.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of arp2, act2, arc1/p41-ARC, arc2/p34-ARC, arc3/p21-ARC, arc4/p20-ARC and arc5/p16-ARC.1 Publication

Protein-protein interaction databases

BioGridi276546. 3 interactions.
IntActiP78774. 3 interactions.
MINTiMINT-4691204.

Structurei

Secondary structure

1
377
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 85
Beta strandi21 – 277
Beta strandi31 – 333
Beta strandi37 – 393
Beta strandi58 – 636
Turni65 – 673
Beta strandi70 – 745
Beta strandi77 – 815
Beta strandi93 – 953
Beta strandi124 – 1263
Beta strandi139 – 1413
Beta strandi158 – 1636
Beta strandi171 – 1755
Beta strandi195 – 2006
Beta strandi227 – 2304
Beta strandi241 – 2433
Beta strandi250 – 2523
Beta strandi256 – 2616
Beta strandi264 – 2685
Beta strandi275 – 2773
Beta strandi340 – 3423
Beta strandi347 – 3548
Beta strandi362 – 3665
Beta strandi372 – 3754

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DWLX-ray3.78C/H1-377[»]
ProteinModelPortaliP78774.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78774.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati9 – 4840WD 1Add
BLAST
Repeati53 – 9240WD 2Add
BLAST
Repeati98 – 13942WD 3Add
BLAST
Repeati144 – 18340WD 4Add
BLAST
Repeati203 – 24240WD 5Add
BLAST
Repeati342 – 37635WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000181752.
InParanoidiP78774.
KOiK05757.
OMAiINEIRVY.
OrthoDBiEOG7XSTQ5.
PhylomeDBiP78774.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSQVLHIL PKPSYEHAFN SQRTEFVTTT ATNQVELYEQ DGNGWKHART
60 70 80 90 100
FSDHDKIVTC VDWAPKSNRI VTCSQDRNAY VYEKRPDGTW KQTLVLLRLN
110 120 130 140 150
RAATFVRWSP NEDKFAVGSG ARVISVCYFE QENDWWVSKH LKRPLRSTIL
160 170 180 190 200
SLDWHPNNVL LAAGCADRKA YVLSAYVRDV DAKPEASVWG SRLPFNTVCA
210 220 230 240 250
EYPSGGWVHA VGFSPSGNAL AYAGHDSSVT IAYPSAPEQP PRALITVKLS
260 270 280 290 300
QLPLRSLLWA NESAIVAAGY NYSPILLQGN ESGWAHTRDL DAGTSKTSFT
310 320 330 340 350
HTGNTGEGRE EEGPVSFTAL RSTFRNMDLK GSSQSISSLP TVHQNMIATL
360 370
RPYAGTPGNI TAFTSSGTDG RVVLWTL
Length:377
Mass (Da):41,597
Last modified:January 11, 2001 - v3
Checksum:iC7016B4E6BEAA94D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001N → D in BAA13784 (PubMed:9501991).Curated
Sequence conflicti232 – 2321A → G in BAA13784 (PubMed:9501991).Curated
Sequence conflicti306 – 3061G → V in CAA70202 (PubMed:8978670).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08998 Genomic DNA. Translation: CAA70202.1.
CU329671 Genomic DNA. Translation: CAA18424.1.
D89122 mRNA. Translation: BAA13784.1.
PIRiT39434.
T42364.
T45528.
RefSeqiNP_595909.1. NM_001021817.2.

Genome annotation databases

EnsemblFungiiSPBC14C8.06.1; SPBC14C8.06.1:pep; SPBC14C8.06.
GeneIDi2540002.
KEGGispo:SPBC14C8.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08998 Genomic DNA. Translation: CAA70202.1.
CU329671 Genomic DNA. Translation: CAA18424.1.
D89122 mRNA. Translation: BAA13784.1.
PIRiT39434.
T42364.
T45528.
RefSeqiNP_595909.1. NM_001021817.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DWLX-ray3.78C/H1-377[»]
ProteinModelPortaliP78774.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276546. 3 interactions.
IntActiP78774. 3 interactions.
MINTiMINT-4691204.

Proteomic databases

MaxQBiP78774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC14C8.06.1; SPBC14C8.06.1:pep; SPBC14C8.06.
GeneIDi2540002.
KEGGispo:SPBC14C8.06.

Organism-specific databases

EuPathDBiFungiDB:SPBC14C8.06.
PomBaseiSPBC14C8.06. arc1.

Phylogenomic databases

HOGENOMiHOG000181752.
InParanoidiP78774.
KOiK05757.
OMAiINEIRVY.
OrthoDBiEOG7XSTQ5.
PhylomeDBiP78774.

Miscellaneous databases

EvolutionaryTraceiP78774.
NextBioi20801145.
PROiP78774.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function."
    Balasubramanian M.K., Feoktostiva A., McCollum D., Gould K.L.
    EMBO J. 15:6426-6437(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-239.
    Strain: PR745.
  4. "A mutant of arp2p causes partial disassembly of the Arp2/3 complex and loss of cortical actin function in fission yeast."
    Morrell J.L., Morphew M., Gould K.L.
    Mol. Biol. Cell 10:4201-4215(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE ARP2/3 COMPLEX.

Entry informationi

Entry nameiARPC1_SCHPO
AccessioniPrimary (citable) accession number: P78774
Secondary accession number(s): O60088
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 11, 2001
Last modified: May 11, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.