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Protein

Probable acetyl-coenzyme A synthetase

Gene

SPCC191.02c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei320Coenzyme ABy similarity1
Binding sitei510ATPBy similarity1
Binding sitei525ATPBy similarity1
Binding sitei533Coenzyme A; via carbonyl oxygenBy similarity1
Binding sitei536ATPBy similarity1
Binding sitei594Coenzyme ABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi395 – 397ATPBy similarity3
Nucleotide bindingi419 – 424ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acetyl-coenzyme A synthetase (EC:6.2.1.1)
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene namesi
ORF Names:SPCC191.02c, SPCC417.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC191.02c.
PomBaseiSPCC191.02c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • mitochondrion Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002084191 – 662Probable acetyl-coenzyme A synthetaseAdd BLAST662

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei596Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP78773.
PRIDEiP78773.

PTM databases

iPTMnetiP78773.

Interactioni

Protein-protein interaction databases

MINTiMINT-4691192.

Structurei

3D structure databases

ProteinModelPortaliP78773.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 204Coenzyme A bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000229981.
InParanoidiP78773.
KOiK01895.
OMAiCPDVEHV.
OrthoDBiEOG092C0Z1N.
PhylomeDBiP78773.

Family and domain databases

CDDicd05966. ACS. 1 hit.
InterProiIPR011904. Ac_CoA_lig.
IPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKNPVDHTL IIEPPVRLHG DPTVPKPNIA SLDEYKRMYE ESINDPSTFW
60 70 80 90 100
GNMARDMMTW DKQFSTVVQG SIDKADSAWF ADGAISPCYN LVDRHAIARP
110 120 130 140 150
DAVALIYEAD EPNQGRYITY RELLASVSQC AGALQSMGVG MGDRVAIYMP
160 170 180 190 200
MIPETIIAML AIVRLGAIHS VIFAGFSAES VADRVNDSEC KVIITADESH
210 220 230 240 250
RGGKRIPLKG VVNKALTECP TIKKVLVFQR SAEPTASMVE GRDVWWHDII
260 270 280 290 300
PKFPRYCPPA VVNPEHPLFL LYTSGSTGKP KGVVHCTGGY LLGAAATCKY
310 320 330 340 350
VFDLHPTDRM GCAGDVGWIT GHTYIVYGPL MLGAATLVFE STPAYPDYSR
360 370 380 390 400
YWSVVERHRL TQWYIAPTAI RLLQRAGNEF VKHDRSSLRV LGSVGEPIAP
410 420 430 440 450
ESFMWYYEVV GEKRCAVADT YWQTETGSHI VTSLGPVTPM KPGSATLPFF
460 470 480 490 500
GIDAVIIDPL TGKIIEGNDV EGVLAIRSPW PSAARTVWRG HDRYIDTYLK
510 520 530 540 550
PYPGFYFTGD GATRDKDGYI WIRGRVDDVV NISGHRLSTA EIEAALLSHD
560 570 580 590 600
AVAESAVVGV HDELTGQAVN AFILLKPGYE ATVELEKELI MAVRSTIGPF
610 620 630 640 650
ASPRKLIFSD LPKTRSGKIM RRILRKILAG EVDQIGDLST LADPKVVEHI
660
IHAVHYAHQK KP
Length:662
Mass (Da):73,036
Last modified:May 1, 2000 - v2
Checksum:i02FD119ABB622583
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA22660.1.
D89121 mRNA. Translation: BAA13783.1.
PIRiT41215.
RefSeqiNP_588291.2. NM_001023281.2.

Genome annotation databases

EnsemblFungiiSPCC191.02c.1; SPCC191.02c.1:pep; SPCC191.02c.
GeneIDi2539546.
KEGGispo:SPCC191.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA22660.1.
D89121 mRNA. Translation: BAA13783.1.
PIRiT41215.
RefSeqiNP_588291.2. NM_001023281.2.

3D structure databases

ProteinModelPortaliP78773.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4691192.

PTM databases

iPTMnetiP78773.

Proteomic databases

MaxQBiP78773.
PRIDEiP78773.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC191.02c.1; SPCC191.02c.1:pep; SPCC191.02c.
GeneIDi2539546.
KEGGispo:SPCC191.02c.

Organism-specific databases

EuPathDBiFungiDB:SPCC191.02c.
PomBaseiSPCC191.02c.

Phylogenomic databases

HOGENOMiHOG000229981.
InParanoidiP78773.
KOiK01895.
OMAiCPDVEHV.
OrthoDBiEOG092C0Z1N.
PhylomeDBiP78773.

Enzyme and pathway databases

ReactomeiR-SPO-71384. Ethanol oxidation.

Miscellaneous databases

PROiP78773.

Family and domain databases

CDDicd05966. ACS. 1 hit.
InterProiIPR011904. Ac_CoA_lig.
IPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACSA_SCHPO
AccessioniPrimary (citable) accession number: P78773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.