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P78748

- PYRF_SORMK

UniProt

P78748 - PYRF_SORMK

Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei46 – 461SubstrateBy similarity
    Active sitei105 – 1051Proton donorPROSITE-ProRule annotation
    Binding sitei346 – 3461SubstrateBy similarity
    Binding sitei365 – 3651SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:URA3
    ORF Names:SMAC_07225
    OrganismiSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
    Taxonomic identifieri771870 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria
    ProteomesiUP000001881: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Orotidine 5'-phosphate decarboxylasePRO_0000134685Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP78748.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni68 – 703Substrate bindingBy similarity
    Regioni103 – 11210Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Phylogenomic databases

    KOiK13421.
    OrthoDBiEOG7CVQ76.

    Family and domain databases

    Gene3Di3.20.20.70. 2 hits.
    InterProiIPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 2 hits.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P78748-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTTQQPHWS LQKSFAERVE SSSHPLTSYL FRLMEVKQSN LCLSADVEHA    50
    RELLALADKI GPSIVVLKTH YDLITGWDYH PHTGTGAKLA ALARKHGFLI 100
    FEDRKFVDIG STVQKQYTAG TARIVEWAHI TNADIHAGEA MVSAMAQAAQ 150
    KWRERIPYEV KTSVSVGTPV ADQFADEEAE DQVDELRKIV PRENSTSKEK 200
    DTDGRKGSIV SITTVTQTYE PADSPRLAKT ISEGDEAVFP GIEEAPLDRG 250
    LLILAQMSSK GCLMDGKYTW ECVKAARKNK DFVMGYVAQQ NLNGITKEDL 300
    APGYEDGETS TEEEAQADNF IHMTPGCKLP PPGEEAPQGD GLGQQYNTPD 350
    NLVNIKGTDI AIVGRGIITA SDPPAEAERY RRKAWKAYQD RRERLA 396
    Length:396
    Mass (Da):43,764
    Last modified:March 8, 2011 - v2
    Checksum:i0AF26D344BBC7888
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti45 – 451A → D in CAA94305. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70291 Genomic DNA. Translation: CAA94305.1.
    CABT02000042 Genomic DNA. Translation: CCC13658.1.
    RefSeqiXP_003344657.1. XM_003344609.1.

    Genome annotation databases

    GeneIDi10801959.
    KEGGismp:SMAC_07225.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70291 Genomic DNA. Translation: CAA94305.1 .
    CABT02000042 Genomic DNA. Translation: CCC13658.1 .
    RefSeqi XP_003344657.1. XM_003344609.1.

    3D structure databases

    ProteinModelPortali P78748.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 10801959.
    KEGGi smp:SMAC_07225.

    Phylogenomic databases

    KOi K13421.
    OrthoDBi EOG7CVQ76.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 2 hits.
    InterProi IPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 2 hits.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and cloning of the Sordaria macrospora ura3 gene and its heterologous expression in Aspergillus niger."
      Nowrousian M., Kueck U.
      Fungal Genet. Newsl. 45:34-37(1998)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.
    2. "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis."
      Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.
      PLoS Genet. 6:E1000891-E1000891(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.

    Entry informationi

    Entry nameiPYRF_SORMK
    AccessioniPrimary (citable) accession number: P78748
    Secondary accession number(s): D1ZSM5, F7W814
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3