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P78748

- PYRF_SORMK

UniProt

P78748 - PYRF_SORMK

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461SubstrateBy similarity
Active sitei105 – 1051Proton donorPROSITE-ProRule annotation
Binding sitei346 – 3461SubstrateBy similarity
Binding sitei365 – 3651SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
ORF Names:SMAC_07225
OrganismiSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Taxonomic identifieri771870 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria
ProteomesiUP000001881: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Orotidine 5'-phosphate decarboxylasePRO_0000134685Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP78748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 703Substrate bindingBy similarity
Regioni103 – 11210Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

InParanoidiP78748.
KOiK13421.
OrthoDBiEOG7CVQ76.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78748-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTTQQPHWS LQKSFAERVE SSSHPLTSYL FRLMEVKQSN LCLSADVEHA
60 70 80 90 100
RELLALADKI GPSIVVLKTH YDLITGWDYH PHTGTGAKLA ALARKHGFLI
110 120 130 140 150
FEDRKFVDIG STVQKQYTAG TARIVEWAHI TNADIHAGEA MVSAMAQAAQ
160 170 180 190 200
KWRERIPYEV KTSVSVGTPV ADQFADEEAE DQVDELRKIV PRENSTSKEK
210 220 230 240 250
DTDGRKGSIV SITTVTQTYE PADSPRLAKT ISEGDEAVFP GIEEAPLDRG
260 270 280 290 300
LLILAQMSSK GCLMDGKYTW ECVKAARKNK DFVMGYVAQQ NLNGITKEDL
310 320 330 340 350
APGYEDGETS TEEEAQADNF IHMTPGCKLP PPGEEAPQGD GLGQQYNTPD
360 370 380 390
NLVNIKGTDI AIVGRGIITA SDPPAEAERY RRKAWKAYQD RRERLA
Length:396
Mass (Da):43,764
Last modified:March 8, 2011 - v2
Checksum:i0AF26D344BBC7888
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451A → D in CAA94305. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z70291 Genomic DNA. Translation: CAA94305.1.
CABT02000042 Genomic DNA. Translation: CCC13658.1.
RefSeqiXP_003344657.1. XM_003344609.1.

Genome annotation databases

GeneIDi10801959.
KEGGismp:SMAC_07225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z70291 Genomic DNA. Translation: CAA94305.1 .
CABT02000042 Genomic DNA. Translation: CCC13658.1 .
RefSeqi XP_003344657.1. XM_003344609.1.

3D structure databases

ProteinModelPortali P78748.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10801959.
KEGGi smp:SMAC_07225.

Phylogenomic databases

InParanoidi P78748.
KOi K13421.
OrthoDBi EOG7CVQ76.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 2 hits.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and cloning of the Sordaria macrospora ura3 gene and its heterologous expression in Aspergillus niger."
    Nowrousian M., Kueck U.
    Fungal Genet. Newsl. 45:34-37(1998)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.
  2. "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis."
    Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.
    PLoS Genet. 6:E1000891-E1000891(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.

Entry informationi

Entry nameiPYRF_SORMK
AccessioniPrimary (citable) accession number: P78748
Secondary accession number(s): D1ZSM5, F7W814
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 8, 2011
Last modified: October 29, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3