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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Orotidine 5'-phosphate decarboxylase (URA3)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46SubstrateBy similarity1
Active sitei105Proton donorPROSITE-ProRule annotation1
Binding sitei346SubstrateBy similarity1
Binding sitei365SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
ORF Names:SMAC_07225
OrganismiSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Taxonomic identifieri771870 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria
Proteomesi
  • UP000001881 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:SMAC_07225.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346851 – 396Orotidine 5'-phosphate decarboxylaseAdd BLAST396

Interactioni

Protein-protein interaction databases

STRINGi771870.XP_003344657.1.

Structurei

3D structure databases

ProteinModelPortaliP78748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 70Substrate bindingBy similarity3
Regioni103 – 112Substrate bindingBy similarity10

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1377. Eukaryota.
COG0284. LUCA.
InParanoidiP78748.
KOiK13421.
OrthoDBiEOG092C3SZ1.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTQQPHWS LQKSFAERVE SSSHPLTSYL FRLMEVKQSN LCLSADVEHA
60 70 80 90 100
RELLALADKI GPSIVVLKTH YDLITGWDYH PHTGTGAKLA ALARKHGFLI
110 120 130 140 150
FEDRKFVDIG STVQKQYTAG TARIVEWAHI TNADIHAGEA MVSAMAQAAQ
160 170 180 190 200
KWRERIPYEV KTSVSVGTPV ADQFADEEAE DQVDELRKIV PRENSTSKEK
210 220 230 240 250
DTDGRKGSIV SITTVTQTYE PADSPRLAKT ISEGDEAVFP GIEEAPLDRG
260 270 280 290 300
LLILAQMSSK GCLMDGKYTW ECVKAARKNK DFVMGYVAQQ NLNGITKEDL
310 320 330 340 350
APGYEDGETS TEEEAQADNF IHMTPGCKLP PPGEEAPQGD GLGQQYNTPD
360 370 380 390
NLVNIKGTDI AIVGRGIITA SDPPAEAERY RRKAWKAYQD RRERLA
Length:396
Mass (Da):43,764
Last modified:March 8, 2011 - v2
Checksum:i0AF26D344BBC7888
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45A → D in CAA94305 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70291 Genomic DNA. Translation: CAA94305.1.
CABT02000042 Genomic DNA. Translation: CCC13658.1.
RefSeqiXP_003344657.1. XM_003344609.1.

Genome annotation databases

EnsemblFungiiCCC13658; CCC13658; SMAC_07225.
GeneIDi10801959.
KEGGismp:SMAC_07225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70291 Genomic DNA. Translation: CAA94305.1.
CABT02000042 Genomic DNA. Translation: CCC13658.1.
RefSeqiXP_003344657.1. XM_003344609.1.

3D structure databases

ProteinModelPortaliP78748.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi771870.XP_003344657.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCCC13658; CCC13658; SMAC_07225.
GeneIDi10801959.
KEGGismp:SMAC_07225.

Organism-specific databases

EuPathDBiFungiDB:SMAC_07225.

Phylogenomic databases

eggNOGiKOG1377. Eukaryota.
COG0284. LUCA.
InParanoidiP78748.
KOiK13421.
OrthoDBiEOG092C3SZ1.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYRF_SORMK
AccessioniPrimary (citable) accession number: P78748
Secondary accession number(s): D1ZSM5, F7W814
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 8, 2011
Last modified: September 7, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.