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P78748 (PYRF_SORMK) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
ORF Names:SMAC_07225
OrganismSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell) [Complete proteome]
Taxonomic identifier771870 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Orotidine 5'-phosphate decarboxylase
PRO_0000134685

Regions

Region68 – 703Substrate binding By similarity
Region103 – 11210Substrate binding By similarity

Sites

Active site1051Proton donor By similarity
Binding site461Substrate By similarity
Binding site3461Substrate By similarity
Binding site3651Substrate By similarity

Experimental info

Sequence conflict451A → D in CAA94305. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P78748 [UniParc].

Last modified March 8, 2011. Version 2.
Checksum: 0AF26D344BBC7888

FASTA39643,764
        10         20         30         40         50         60 
MSTTQQPHWS LQKSFAERVE SSSHPLTSYL FRLMEVKQSN LCLSADVEHA RELLALADKI 

        70         80         90        100        110        120 
GPSIVVLKTH YDLITGWDYH PHTGTGAKLA ALARKHGFLI FEDRKFVDIG STVQKQYTAG 

       130        140        150        160        170        180 
TARIVEWAHI TNADIHAGEA MVSAMAQAAQ KWRERIPYEV KTSVSVGTPV ADQFADEEAE 

       190        200        210        220        230        240 
DQVDELRKIV PRENSTSKEK DTDGRKGSIV SITTVTQTYE PADSPRLAKT ISEGDEAVFP 

       250        260        270        280        290        300 
GIEEAPLDRG LLILAQMSSK GCLMDGKYTW ECVKAARKNK DFVMGYVAQQ NLNGITKEDL 

       310        320        330        340        350        360 
APGYEDGETS TEEEAQADNF IHMTPGCKLP PPGEEAPQGD GLGQQYNTPD NLVNIKGTDI 

       370        380        390 
AIVGRGIITA SDPPAEAERY RRKAWKAYQD RRERLA 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and cloning of the Sordaria macrospora ura3 gene and its heterologous expression in Aspergillus niger."
Nowrousian M., Kueck U.
Fungal Genet. Newsl. 45:34-37(1998)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.
[2]"De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis."
Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.
PLoS Genet. 6:E1000891-E1000891(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z70291 Genomic DNA. Translation: CAA94305.1.
CABT02000042 Genomic DNA. Translation: CCC13658.1.
RefSeqXP_003344657.1. XM_003344609.1.

3D structure databases

ProteinModelPortalP78748.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID10801959.
KEGGsmp:SMAC_07225.

Phylogenomic databases

KOK13421.
OrthoDBEOG7CVQ76.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 2 hits.
InterProIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 2 hits.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_SORMK
AccessionPrimary (citable) accession number: P78748
Secondary accession number(s): D1ZSM5, F7W814
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 8, 2011
Last modified: November 13, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways