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P78724 (PYRF_HANAN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismHansenula anomala (Yeast) (Candida pelliculosa)
Taxonomic identifier4927 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeWickerhamomyces

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Orotidine 5'-phosphate decarboxylase
PRO_0000134661

Regions

Region60 – 623Substrate binding By similarity
Region92 – 10110Substrate binding By similarity

Sites

Active site941Proton donor By similarity
Binding site381Substrate By similarity
Binding site2181Substrate By similarity
Binding site2361Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P78724 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: A0F416956D8355FB

FASTA26729,152
        10         20         30         40         50         60 
MVQTLTYPQR AEAHPSPLAK RLFGVMESKK SNLCASIDVR TTKEFLELVD TLGPYICLVK 

        70         80         90        100        110        120 
THIDIIDDFS IEGTIEPLKK LASKHNFLIF EDRKFADIGN TVKAQYSGGA FKIATWSDIT 

       130        140        150        160        170        180 
NAHGVTGEGI VRGLKEAASE VSQEPRGLLM LAELSSKGSL AKGEYTKQTV DIAKTDKDFV 

       190        200        210        220        230        240 
IGFIAQNDMG GRDEGFDWLI MTPGVGLDDK GDGLGQQYRS VSEVVAGGSD IIIVGRGLFG 

       250        260 
KGRDPKVEGE RYRSAGWNAY LKRTSQI 

« Hide

References

[1]Perez J.A., Rodriguez J., Ruiz T., Rodriguez L.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 8168 / CBS 5759 / JCM 3585 / NRRL Y-366.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y09221 Genomic DNA. Translation: CAA70421.1.

3D structure databases

ProteinModelPortalP78724.
SMRP78724. Positions 6-266.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_HANAN
AccessionPrimary (citable) accession number: P78724
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 16, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways