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P78695 (GRP78_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
78 kDa glucose-regulated protein homolog

Short name=GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name=BiP
Gene names
Name:grp78
ORF Names:NCU03982
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length661 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the heat shock protein 70 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 66162978 kDa glucose-regulated protein homolog
PRO_0000013583

Regions

Motif658 – 6614Prevents secretion from ER Potential

Experimental info

Sequence conflict1271Y → N in CAA70214. Ref.1
Sequence conflict5271T → N in CAA70214. Ref.1
Sequence conflict5381D → E in CAA70214. Ref.1
Sequence conflict6171N → ND in CAA70214. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P78695 [UniParc].

Last modified March 15, 2004. Version 3.
Checksum: 90963337AF327DEA

FASTA66172,332
        10         20         30         40         50         60 
MEHRTRSWAL GLSILGFFAL LFSAGFVQQA HANDTEAMGT VIGIDLGTTY SCVGVMQKGK 

        70         80         90        100        110        120 
VEILVNDQGN RITPSYVAFT DEERLVGDAA KNQAAANPHR TIFDIKRLIG RKFSDKDVQN 

       130        140        150        160        170        180 
DIKHFPYKVV SKDDKPVVKV EVKGEEKTFT PEEISAMILG KMKETAEGYL GKKVTHAVVT 

       190        200        210        220        230        240 
VPAYFNDNQR QATKDAGMIA GLNVLRIVNE PTAAAIAYGL DKTGEERQII VYDLGGGTFD 

       250        260        270        280        290        300 
VSLLSIEQGV FEVLSTAGDT HLGGEDFDQR IINHFAKLFN KKHGVDVTKD AKAMGKLKRE 

       310        320        330        340        350        360 
AEKAKRTLSS QMSTRIEIEA FYDGKDFSET LTRAKFEELN NDLFKKTLKP VEQVLKDAKV 

       370        380        390        400        410        420 
SKSEIDDIVL VGGSTRIPKV QALIEEFFNG KKASKGINPD EAVAFGAAVQ AGVLSGEEGT 

       430        440        450        460        470        480 
EDIVLMDVNP LTLGIETTGG VMTKLIPRNT PIPTRKSQIF STAADNQPVV LIQVYEGERS 

       490        500        510        520        530        540 
MTKDNNLLGK FELTGIPPAP RGVPQIEVSF ELDANGILKV SAHDKGTGKA ESITITNDKG 

       550        560        570        580        590        600 
RLTQEEIDRM VAEAEKYAEE DKATRERIEA RNGLENYAFS LKNQVNDEDG LGGKIDEEDK 

       610        620        630        640        650        660 
ETILDAVKEA QDWLEENAAT ASAEDFDEQK EKLSNVAYPI TSKLYSQGGA GDDEPAGHDE 


L 

« Hide

References

« Hide 'large scale' references
[1]"Molecular analysis of a glucose-regulated gene (grp78) of Neurospora crassa."
Techel D., Hafker T., Muschner S., Reimann M., Li Y., Monnerjahn C., Rensing L.
Biochim. Biophys. Acta 1397:21-26(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Bd-A / FGSC 1858.
[2]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y09011 Genomic DNA. Translation: CAA70214.1.
CM002241 Genomic DNA. Translation: EAA27331.1.
PIRT50464.
RefSeqXP_956567.1. XM_951474.2.
UniGeneNcr.23205.

3D structure databases

ProteinModelPortalP78695.
SMRP78695. Positions 39-579.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP78695. 4 interactions.
MINTMINT-4653640.
STRING5141.NCU03982.1.

Proteomic databases

PRIDEP78695.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000003679; EFNCRP00000003679; EFNCRG00000003675.
GeneID3872714.
KEGGncr:NCU03982.

Phylogenomic databases

eggNOGCOG0443.
HOGENOMHOG000228135.
KOK09490.
OMAHANDTEA.
OrthoDBEOG728916.

Family and domain databases

InterProIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGRP78_NEUCR
AccessionPrimary (citable) accession number: P78695
Secondary accession number(s): Q7RV55
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: March 15, 2004
Last modified: April 16, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families