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P78695

- GRP78_NEUCR

UniProt

P78695 - GRP78_NEUCR

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Protein

78 kDa glucose-regulated protein homolog

Gene

grp78

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

GO - Molecular functioni

  1. ATPase activity Source: EnsemblFungi
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: EnsemblFungi
  2. karyogamy involved in conjugation with cellular fusion Source: EnsemblFungi
  3. posttranslational protein targeting to membrane, translocation Source: EnsemblFungi
  4. response to unfolded protein Source: EnsemblFungi
  5. SRP-dependent cotranslational protein targeting to membrane, translocation Source: EnsemblFungi
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name:
BiP
Gene namesi
Name:grp78
ORF Names:NCU03982
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 5, Linkage Group VI

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. luminal surveillance complex Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 66162978 kDa glucose-regulated protein homologPRO_0000013583Add
BLAST

Proteomic databases

PRIDEiP78695.

Interactioni

Protein-protein interaction databases

IntActiP78695. 4 interactions.
MINTiMINT-4653640.
STRINGi5141.NCU03982.1.

Structurei

3D structure databases

ProteinModelPortaliP78695.
SMRiP78695. Positions 39-579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi658 – 6614Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228135.
InParanoidiP78695.
KOiK09490.
OMAiPKGTIYS.
OrthoDBiEOG728916.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P78695 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEHRTRSWAL GLSILGFFAL LFSAGFVQQA HANDTEAMGT VIGIDLGTTY
60 70 80 90 100
SCVGVMQKGK VEILVNDQGN RITPSYVAFT DEERLVGDAA KNQAAANPHR
110 120 130 140 150
TIFDIKRLIG RKFSDKDVQN DIKHFPYKVV SKDDKPVVKV EVKGEEKTFT
160 170 180 190 200
PEEISAMILG KMKETAEGYL GKKVTHAVVT VPAYFNDNQR QATKDAGMIA
210 220 230 240 250
GLNVLRIVNE PTAAAIAYGL DKTGEERQII VYDLGGGTFD VSLLSIEQGV
260 270 280 290 300
FEVLSTAGDT HLGGEDFDQR IINHFAKLFN KKHGVDVTKD AKAMGKLKRE
310 320 330 340 350
AEKAKRTLSS QMSTRIEIEA FYDGKDFSET LTRAKFEELN NDLFKKTLKP
360 370 380 390 400
VEQVLKDAKV SKSEIDDIVL VGGSTRIPKV QALIEEFFNG KKASKGINPD
410 420 430 440 450
EAVAFGAAVQ AGVLSGEEGT EDIVLMDVNP LTLGIETTGG VMTKLIPRNT
460 470 480 490 500
PIPTRKSQIF STAADNQPVV LIQVYEGERS MTKDNNLLGK FELTGIPPAP
510 520 530 540 550
RGVPQIEVSF ELDANGILKV SAHDKGTGKA ESITITNDKG RLTQEEIDRM
560 570 580 590 600
VAEAEKYAEE DKATRERIEA RNGLENYAFS LKNQVNDEDG LGGKIDEEDK
610 620 630 640 650
ETILDAVKEA QDWLEENAAT ASAEDFDEQK EKLSNVAYPI TSKLYSQGGA
660
GDDEPAGHDE L
Length:661
Mass (Da):72,332
Last modified:March 15, 2004 - v3
Checksum:i90963337AF327DEA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271Y → N in CAA70214. (PubMed:9545520)Curated
Sequence conflicti527 – 5271T → N in CAA70214. (PubMed:9545520)Curated
Sequence conflicti538 – 5381D → E in CAA70214. (PubMed:9545520)Curated
Sequence conflicti617 – 6171N → ND in CAA70214. (PubMed:9545520)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09011 Genomic DNA. Translation: CAA70214.1.
CM002241 Genomic DNA. Translation: EAA27331.1.
PIRiT50464.
RefSeqiXP_956567.1. XM_951474.2.
UniGeneiNcr.23205.

Genome annotation databases

EnsemblFungiiEFNCRT00000003679; EFNCRP00000003679; EFNCRG00000003675.
GeneIDi3872714.
KEGGincr:NCU03982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09011 Genomic DNA. Translation: CAA70214.1 .
CM002241 Genomic DNA. Translation: EAA27331.1 .
PIRi T50464.
RefSeqi XP_956567.1. XM_951474.2.
UniGenei Ncr.23205.

3D structure databases

ProteinModelPortali P78695.
SMRi P78695. Positions 39-579.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P78695. 4 interactions.
MINTi MINT-4653640.
STRINGi 5141.NCU03982.1.

Proteomic databases

PRIDEi P78695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000003679 ; EFNCRP00000003679 ; EFNCRG00000003675 .
GeneIDi 3872714.
KEGGi ncr:NCU03982.

Phylogenomic databases

eggNOGi COG0443.
HOGENOMi HOG000228135.
InParanoidi P78695.
KOi K09490.
OMAi PKGTIYS.
OrthoDBi EOG728916.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of a glucose-regulated gene (grp78) of Neurospora crassa."
    Techel D., Hafker T., Muschner S., Reimann M., Li Y., Monnerjahn C., Rensing L.
    Biochim. Biophys. Acta 1397:21-26(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Bd-A / FGSC 1858.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiGRP78_NEUCR
AccessioniPrimary (citable) accession number: P78695
Secondary accession number(s): Q7RV55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: March 15, 2004
Last modified: October 29, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3