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P78695

- GRP78_NEUCR

UniProt

P78695 - GRP78_NEUCR

Protein

78 kDa glucose-regulated protein homolog

Gene

grp78

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 3 (15 Mar 2004)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

    GO - Molecular functioni

    1. ATPase activity Source: EnsemblFungi
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. ER-associated ubiquitin-dependent protein catabolic process Source: EnsemblFungi
    2. karyogamy involved in conjugation with cellular fusion Source: EnsemblFungi
    3. posttranslational protein targeting to membrane, translocation Source: EnsemblFungi
    4. response to unfolded protein Source: EnsemblFungi
    5. SRP-dependent cotranslational protein targeting to membrane, translocation Source: EnsemblFungi

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    78 kDa glucose-regulated protein homolog
    Short name:
    GRP-78
    Alternative name(s):
    Immunoglobulin heavy chain-binding protein homolog
    Short name:
    BiP
    Gene namesi
    Name:grp78
    ORF Names:NCU03982
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 5, Linkage Group VI

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. luminal surveillance complex Source: EnsemblFungi

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 66162978 kDa glucose-regulated protein homologPRO_0000013583Add
    BLAST

    Proteomic databases

    PRIDEiP78695.

    Interactioni

    Protein-protein interaction databases

    IntActiP78695. 4 interactions.
    MINTiMINT-4653640.
    STRINGi5141.NCU03982.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP78695.
    SMRiP78695. Positions 39-579.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi658 – 6614Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0443.
    HOGENOMiHOG000228135.
    KOiK09490.
    OMAiPKGTIYS.
    OrthoDBiEOG728916.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P78695-1 [UniParc]FASTAAdd to Basket

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    MEHRTRSWAL GLSILGFFAL LFSAGFVQQA HANDTEAMGT VIGIDLGTTY    50
    SCVGVMQKGK VEILVNDQGN RITPSYVAFT DEERLVGDAA KNQAAANPHR 100
    TIFDIKRLIG RKFSDKDVQN DIKHFPYKVV SKDDKPVVKV EVKGEEKTFT 150
    PEEISAMILG KMKETAEGYL GKKVTHAVVT VPAYFNDNQR QATKDAGMIA 200
    GLNVLRIVNE PTAAAIAYGL DKTGEERQII VYDLGGGTFD VSLLSIEQGV 250
    FEVLSTAGDT HLGGEDFDQR IINHFAKLFN KKHGVDVTKD AKAMGKLKRE 300
    AEKAKRTLSS QMSTRIEIEA FYDGKDFSET LTRAKFEELN NDLFKKTLKP 350
    VEQVLKDAKV SKSEIDDIVL VGGSTRIPKV QALIEEFFNG KKASKGINPD 400
    EAVAFGAAVQ AGVLSGEEGT EDIVLMDVNP LTLGIETTGG VMTKLIPRNT 450
    PIPTRKSQIF STAADNQPVV LIQVYEGERS MTKDNNLLGK FELTGIPPAP 500
    RGVPQIEVSF ELDANGILKV SAHDKGTGKA ESITITNDKG RLTQEEIDRM 550
    VAEAEKYAEE DKATRERIEA RNGLENYAFS LKNQVNDEDG LGGKIDEEDK 600
    ETILDAVKEA QDWLEENAAT ASAEDFDEQK EKLSNVAYPI TSKLYSQGGA 650
    GDDEPAGHDE L 661
    Length:661
    Mass (Da):72,332
    Last modified:March 15, 2004 - v3
    Checksum:i90963337AF327DEA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti127 – 1271Y → N in CAA70214. (PubMed:9545520)Curated
    Sequence conflicti527 – 5271T → N in CAA70214. (PubMed:9545520)Curated
    Sequence conflicti538 – 5381D → E in CAA70214. (PubMed:9545520)Curated
    Sequence conflicti617 – 6171N → ND in CAA70214. (PubMed:9545520)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09011 Genomic DNA. Translation: CAA70214.1.
    CM002241 Genomic DNA. Translation: EAA27331.1.
    PIRiT50464.
    RefSeqiXP_956567.1. XM_951474.2.
    UniGeneiNcr.23205.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000003679; EFNCRP00000003679; EFNCRG00000003675.
    GeneIDi3872714.
    KEGGincr:NCU03982.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09011 Genomic DNA. Translation: CAA70214.1 .
    CM002241 Genomic DNA. Translation: EAA27331.1 .
    PIRi T50464.
    RefSeqi XP_956567.1. XM_951474.2.
    UniGenei Ncr.23205.

    3D structure databases

    ProteinModelPortali P78695.
    SMRi P78695. Positions 39-579.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P78695. 4 interactions.
    MINTi MINT-4653640.
    STRINGi 5141.NCU03982.1.

    Proteomic databases

    PRIDEi P78695.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000003679 ; EFNCRP00000003679 ; EFNCRG00000003675 .
    GeneIDi 3872714.
    KEGGi ncr:NCU03982.

    Phylogenomic databases

    eggNOGi COG0443.
    HOGENOMi HOG000228135.
    KOi K09490.
    OMAi PKGTIYS.
    OrthoDBi EOG728916.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of a glucose-regulated gene (grp78) of Neurospora crassa."
      Techel D., Hafker T., Muschner S., Reimann M., Li Y., Monnerjahn C., Rensing L.
      Biochim. Biophys. Acta 1397:21-26(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Bd-A / FGSC 1858.
    2. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiGRP78_NEUCR
    AccessioniPrimary (citable) accession number: P78695
    Secondary accession number(s): Q7RV55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: March 15, 2004
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3