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Protein

Acid trehalase

Gene

treA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei584Proton donorBy similarity1

GO - Molecular functioni

  • alpha,alpha-trehalase activity Source: AspGD
  • carbohydrate binding Source: InterPro

GO - Biological processi

  • trehalose catabolic process Source: AspGD

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH65 Glycoside Hydrolase Family 65
mycoCLAPiTRE65A_EMENI

Names & Taxonomyi

Protein namesi
Recommended name:
Acid trehalase (EC:3.2.1.28)
Alternative name(s):
Alpha,alpha-trehalase
Alpha,alpha-trehalose glucohydrolase
Gene namesi
Name:treA
ORF Names:AN9340
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VIII
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001210922 – 1054Acid trehalaseAdd BLAST1033

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi493N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi513N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi570N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi578N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi618N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi644N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi665N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi734N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi803N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi826N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi838N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi903N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi937N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi966N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi992N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00001124

Structurei

3D structure databases

ProteinModelPortaliP78617
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni448 – 449Substrate bindingBy similarity2
Regioni650 – 651Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 65 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000178675
InParanoidiP78617
OrthoDBiEOG092C052Z

Family and domain databases

Gene3Di1.50.10.10, 1 hit
2.70.98.40, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR011013 Gal_mutarotase_sf_dom
IPR005195 Glyco_hydro_65_M
IPR005196 Glyco_hydro_65_N
IPR037018 Glyco_hydro_65_N_sf
PfamiView protein in Pfam
PF03632 Glyco_hydro_65m, 1 hit
PF03636 Glyco_hydro_65N, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
SSF74650 SSF74650, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P78617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFKSVFTLL PLLAQLPSGG ASLPNNHGRV ENCVRNHDGI HKFRHSNNTY
60 70 80 90 100
QSMFPGVTWD EDQWVLTTSS LDQGHYQSRG SVANGYIGIS VSSVGPFFEL
110 120 130 140 150
DLPVAGDVIN GWPLYSRRQS FATISGFFDI QAETNGSNFP WMNQYGGESV
160 170 180 190 200
ISGVPHWSGL ILDLGDDDYL DSTVDNVTLS DFKSSYDFKA GVLSWSYTWT
210 220 230 240 250
PAGDKGSYAI TYRLFANKLN VNQAVVDMEI TPSQDGHATI VNVLDGYSAV
260 270 280 290 300
RTDFVESQED DGAIYSAVRP WGIPDVSAYF YANITGSKHV DLSSRRLIHG
310 320 330 340 350
KPYVSANESS IAQAADVNFV ANEKVRITKF VGAASTDAFP DPQATAKRAV
360 370 380 390 400
SEALDAGYQR SLRSHVQEWA SIMHEDSVDR YVNPTTGKLP DDDNIINSAI
410 420 430 440 450
IAVANTYYLL QNTVGKNAIR AAQDAPLNVN SFSVGGLVSD SYAGLVFWDA
460 470 480 490 500
DVWMQPGLVA SHPEAAQAVT NYRTKLYPQA KKNIETTYTG SKNATYIDPS
510 520 530 540 550
AAIYPWTSGR FGNCTGTGAC WDYQYHLNGD IGLSLIYQWV VSGDTNTFRE
560 570 580 590 600
KHFPIYDSVA ALYGSIVERN GSYWTLTNMT DPDEYANHID AGGFTMPMIS
610 620 630 640 650
ETLEYANQFR QQFGLEPNET WTEISENVLV LRENGVTLEY TTMNGTAAVK
660 670 680 690 700
QADIVLVTYP LVYDNYTAET ALTDLDYYAN RQSADGPAMT WAIFSIAAGA
710 720 730 740 750
VSPSGCSAYT YHQYSYAPYA RAPFFQLSEQ MLDNASINGG THPAYPFLTG
760 770 780 790 800
HGGANQVVLF GYLGLRLLPD DAIHIEPNLP PQIPYVKYRT FYWRGWPISA
810 820 830 840 850
QSNYTHTVLQ RSQSAPLDTA DRRFANTSIP VFVGLADNAT LHHLPPHGPL
860 870 880 890 900
TVRNREIGTI NTIEDNLIQC SPVSSTDAFE QGQFPISVVD GATSTRWQPS
910 920 930 940 950
SSNASAVTVN LGSTTGRSVQ TVASGFHFDW AAAPPVNASV IFHDTPLSDP
960 970 980 990 1000
VAALSSPGPH VRIVANLTNI EQSGPYDPEA TDLNEIKIPV GNTTRIELAQ
1010 1020 1030 1040 1050
EVPVGRYATL VISGNQALAQ ADGEDHVGAT VAEWAILGPK SGSPRRRIQP

VPLL
Length:1,054
Mass (Da):115,111
Last modified:May 1, 1997 - v1
Checksum:iB2B26466CA0992F1
GO

Sequence cautioni

The sequence CBF87435 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAA66407 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75428 Genomic DNA Translation: AAB57642.1
AACD01000172 Genomic DNA Translation: EAA66407.1 Sequence problems.
BN001308 Genomic DNA Translation: CBF87435.1 Sequence problems.
PIRiT18304
RefSeqiXP_682609.1, XM_677517.1

Genome annotation databases

EnsemblFungiiCADANIAT00001124; CADANIAP00001124; CADANIAG00001124
EAA66407; EAA66407; AN9340.2
GeneIDi2867940
KEGGiani:AN9340.2

Similar proteinsi

Entry informationi

Entry nameiTREA_EMENI
AccessioniPrimary (citable) accession number: P78617
Secondary accession number(s): C8VR42, Q5AQU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health