Reviewed, UniProtKB/Swiss-Prot P78611 (CHSD_EMENI)

Names and origin

Protein names

Recommended name:
    Chitin synthase D
    EC=2.4.1.16
Alternative name(s):
    Chitin-UDP acetyl-glucosaminyl transferase D
    Class-V chitin synthase D

Gene names

Name:	chsD
Synonyms:	chsE
ORF Names:	AN1555

Organism

Emericella nidulans (Aspergillus nidulans) [Complete proteome]

Taxonomic identifier

162425 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella

Protein attributes

Sequence length	1184 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Plays a major role in cell wall biogenesis.
Catalytic activity	UDP-N-acetyl-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the chitin synthase family. Class V subfamily.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chitin synthase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1184	1184	Chitin synthase D		PRO_0000193693
Regions
	Transmembrane	221 – 241	21	Potential
	Transmembrane	476 – 496	21	Potential
	Transmembrane	1039 – 1059	21	Potential
	Transmembrane	1073 – 1093	21	Potential
	Transmembrane	1097 – 1117	21	Potential
Experimental info
	Sequence conflict	606	1	L → S in BAA11866. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P78611-1 [UniParc]. Last modified May 26, 2009. Version 3. Checksum: BC1676F95F17004B	FASTA	1,184	133,531
	10 20 30 40 50 60 MSLPQRPGKT SPRREETSAF REPSRRRRRE SDSLSNNDPT SPRHHRHHRS HSSRHQHDID 70 80 90 100 110 120 EERAEEGGIR RKRSLVKPER GRMDPSHPNY LYRQKTQNMP TYNPMTGNEP LIHEEGEAET 130 140 150 160 170 180 NSTPSMDSKR KDALYGAHGN VNKPMERVPT RHRSKKRKGS RKISKREAAA EKRRRKAMEQ 190 200 210 220 230 240 VRPPSLWTTY CSVITFWAPD FVLKCFGMPQ KAQRSAWREK IGLISIILMI AAFVGFLTFG 250 260 270 280 290 300 FTATVCGTPP TRLKINEIGS GYMIFHGQAY DLTKSTHPAA AGIPDMTNVL YDLPHKYGGQ 310 320 330 340 350 360 DGSFFFQEVN GACKGLITRT ENSDIPTNSN GDLAWYFPCH AFNQDGSSEP NTTVSYYNGW 370 380 390 400 410 420 ACHTSGSARK SFYSLKNSGD VYFTWEDTKN TSRKLAVYSG NVLDLNLLNW FDDTQVNYPT 430 440 450 460 470 480 KFKDLRDNDD IRGVDLTYYF QTGEDKQIGK CLSQIIKVGS IDTDTVGCIA SQVVLYVSLI 490 500 510 520 530 540 FILSIVIVKF AFALLFQWFL APRFAAQKTS MGAVDSKARN QQIEDWSNDI YRPGPRLADP 550 560 570 580 590 600 VPGDRMSKRA SFLPTTSRFS SPYTVSNGGK QKPQWVTMAS QNSTTRLVPP ASGTTPSIYR 610 620 630 640 650 660 QSHNGLGNVS VDNSRLNPSA SRTSLVQDSR YSTVIPDSEG IGSAGYVHEL VVPQPPPDWQ 670 680 690 700 710 720 PYGFPLAHAM CLVTCYSEGE EGIRTTLDSI ALTDYPNSHK SIVVICDGII KGKGEEFSTP 730 740 750 760 770 780 DIVLRMMRDP IIPPEEVEAF SYVAVATGSK RHNMAKVYAG FYDYGEHSII PVEKQQRVPM 790 800 810 820 830 840 MIIVKCGTPA EATAAKPGNR GKRDSQIILM SFLQKVMFDE RMTELEYEMF NGLLHVTGIP 850 860 870 880 890 900 PDFYEVVLMV DADTKVFPDS LTHMISAMVK DPEVMGLCGE TKIANKTDSW VTMIQVFEYF 910 920 930 940 950 960 VSHHQSKAFE SVFGGVTCLP GCFSMYRIKA PKGGQNYWVP ILANPDIVEH YSENVVDTLH 970 980 990 1000 1010 1020 KKNLLLLGED RYLSTLMLRT FPKRKQIFVP QAVCKTVVPD KFMVLLSQRR RWINSTVHNL 1030 1040 1050 1060 1070 1080 MELVLVRDLC GTFCFSMQFV IFVELVGTVV LPAAISFTIY VVVSSIIKQP VQIIPLVLLA 1090 1100 1110 1120 1130 1140 LILGLPGVLV VVTAHRLVYV LWMLVYLISL PIWNFVLPTY AYWKFDDFSW GDTRKTAGEK 1150 1160 1170 1180 DKGHEDGEGE FDSSKITMKR WRDFEKGMSM LTVLHDARTA NDIY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Aspergillus nidulans genes chsA and chsD encode chitin synthases which have redundant functions in conidia formation." Motoyama T., Fujiwara M., Kojima N., Horiuchi H., Ohta A., Takagi M. Mol. Gen. Genet. 251:442-450(1996) [PubMed: 8709948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: FGSC 89.
[2]	Erratum Motoyama T., Fujiwara M., Kojima N., Horiuchi H., Ohta A., Takagi M. Mol. Gen. Genet. 253:520-528(1997) [PubMed: 9037115] [Abstract]
[3]	Motoyama T., Fujiwara M., Kojima N., Horiuchi H., Ohta A., Takagi M. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	"The chsD and chsE genes of Aspergillus nidulans and their roles in chitin synthesis." Specht C.A., Liu Y., Robbins P.W., Bulawa C.E., Iartchouk N., Winter K.R., Riggle P.J., Rhodes J.C., Dodge C.L., Culp D.W., Borgia P.T. Fungal Genet. Biol. 20:153-167(1996) [PubMed: 8810520] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: FGSC 4.
[5]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC 4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D83246 Genomic DNA. Translation: BAA11866.2. U52362 Genomic DNA. Translation: AAA97482.1. AACD01000025 Genomic DNA. Translation: EAA64262.1.
PIR	JC6079.
RefSeq	XP_659159.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT2. Glycosyltransferase Family 2.
Genome annotation databases
GeneID	2875763.
KEGG	ani:AN1555.2.
Family and domain databases
InterPro	IPR004835. Chitin_synth_fng. IPR001199. Cyt_B5. [Graphical view]
Pfam	PF03142. Chitin_synth_2. 1 hit. PF00173. Cyt-b5. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHSD_EMENI

Accession

Primary (citable) accession number: P78611
Secondary accession number(s): Q00744, Q5BD25

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 26, 2009
Last modified:	October 13, 2009
This is version 56 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)