P78600 (SYPC_CANAX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proline--tRNA ligase, cytoplasmic
EC=6.1.1.15

Alternative name(s):
Prolyl-tRNA synthetase
Short name=ProRS

Gene names

Name:

PRS

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	575 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Gene Ontology (GO)
Biological process	prolyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW proline-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 575	575	Proline--tRNA ligase, cytoplasmic		PRO_0000139353

Sequences

	Sequence		Length	Mass (Da)
	P78600 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 477BE339CC4F6368	FASTA	575	66,209
	10 20 30 40 50 60 MIIIKRFLHI KTVPKSYGNQ LSKFKYSKQI PTHEVLTKLG YITYPRAGLV NWSKMGLLIQ 70 80 90 100 110 120 NKISQIIRQR MDEIQFEEVS LSLISHKELW KLTNRWDQEE IFKLVGDEYL LVPTAEEEIT 130 140 150 160 170 180 NYVKKQFLES YKNFPLALYQ INPKFRNEKR PRGGLLRGKE FLMKDAYSFD LNESEAMKTY 190 200 210 220 230 240 EKVVGAYHKI FQDLGIPYVK AEADSGDIGG SLSHEWHYLN SSGEDTVFEC NECHNVSNME 250 260 270 280 290 300 KALSYPKEID ETIEVSVIYF TTEDKSTLIC AYYPSNRVLE PKFIQNEIPD IDLDSINDLS 310 320 330 340 350 360 EFNHDISTRI VRIMDSRLSS RSKFPDFPIS NFINRSLITT LTDIPIVLAQ EGEICGHCEE 370 380 390 400 410 420 GKLSASSAIE VGHTFYLGDK YSKPLDLEVD VPTSNNSIEK QRIMMGCYGI GISRIIAAIA 430 440 450 460 470 480 EINRDEKGLK WPRSIAPWEV TVVEVSKQKQ LKNVNDNNHH NNPQDNFQEI YNILNQANID 490 500 510 520 530 540 YRLDNRSDSM GKKLKQSDLL GIPLSIILGN QYPIIEIEVR GNKKNNNNNS WLQSYTENKD 550 560 570 QFDWKVETDA QGNDTKHYIH KDGLVTVVNS LLNDM

References

[1]	"Isolation of a putative prolyl-tRNA synthetase (CaPRS) gene from Candida albicans." Sentandreu M., Elorza M.V., Sentandreu R. Yeast 13:1375-1381(1997) [PubMed: 9392082] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 26555.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U86341 Genomic DNA. Translation: AAC49876.1.
3D structure databases
ProteinModelPortal	P78600.
ModBase	Search...
Protein-protein interaction databases
STRING	P78600.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002314. aa-tRNA-synt_IIb_cons-dom. IPR006195. aa-tRNA-synth_II. IPR004154. Anticodon-bd. IPR002316. Pro-tRNA-synth_IIa. IPR004500. Pro-tRNA-synth_IIa_bac-type. [Graphical view]
Gene3D	G3DSA:3.40.50.800. Anticodon_bd. 1 hit.
PANTHER	PTHR11451:SF3. PTHR11451:SF3. 1 hit.
Pfam	PF03129. HGTP_anticodon. 1 hit. PF00587. tRNA-synt_2b. 1 hit. [Graphical view]
PRINTS	PR01046. TRNASYNTHPRO.
SUPFAM	SSF52954. Anticodon_bd. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYPC_CANAX

Accession

Primary (citable) accession number: P78600

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program