Reviewed, UniProtKB/Swiss-Prot P78599 (DCOR_CANAL)

Names and origin

Protein names

Recommended name:
    Ornithine decarboxylase
      Short name=ODC
    EC=4.1.1.17

Gene names

Name:	SPE1
Synonyms:	ORD1
ORF Names:	CaO19.6032, CaO19.13453

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-ornithine = putrescine + CO2.
Cofactor	Pyridoxal phosphate.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	polyamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ornithine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Ornithine decarboxylase		PRO_0000149905
Sites
	Active site	417	1	Proton donor; shared with dimeric partner By similarity
Amino acid modifications
	Modified residue	106	1	N6-(pyridoxal phosphate)lysine By similarity
Experimental info
	Sequence conflict	95	1	I → S in CAA64451. Ref.2
	Sequence conflict	164	1	D → N in CAA64451. Ref.2
	Sequence conflict	228	1	G → S in CAA64451. Ref.2
	Sequence conflict	342	1	N → H in CAA64451. Ref.2
	Sequence conflict	399 – 401	3	Missing in CAA64451. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P78599-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 7A74BEE5580924CE	FASTA	473	52,905
	10 20 30 40 50 60 MKHTIIENEP EIKLQNDLNH HIEISPNTKT TNGTTTTTTT LNVNKTLKAI DLIETSIKNH 70 80 90 100 110 120 ISTIDHENCL PNDEDSFFVC DLGEIINSVN QWQQILPMVQ PYYAVKCNSN PQILTTLSEL 130 140 150 160 170 180 GVNFDCASKN EIDLVLSLGI HQAHERIIYA NPCKTNSFIR HAADENVNLT TVDNVHELYK 190 200 210 220 230 240 LAKFHPHCKI LIRLITDDST AQCQLSTKFG CDLNTAIGEI LPKAKELGLQ VHGVAFHVGS 250 260 270 280 290 300 GAKDFSSIYQ AIKDSRILFD EMLSMGFTPK LLDIGGGFER ETFPQSSQMV KFALEKFFPI 310 320 330 340 350 360 EFSQSNEIKF IAEPGRFMVA NAFTLITHII ARRDLPTGGN NNNNDMTPSA MLYINDGVYG 370 380 390 400 410 420 NLNCILFDHQ TPKVYVLTNE NQLFYKQEMM RSLSVNNNNN NNNKTDGFKF SIWGPTCDGL 430 440 450 460 470 DCVSSLAKLS KNVQVGDWLF FENVGAYTSC ASTKFNGLSS GETKTLYVNS NEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and sequence of the gene encoding ornithine decarboxylase, SPE1, from Candida albicans by complementation of a spe1 delta strain of Saccharomyces cerevisiae." McNemar M.D., Gorman J.A., Buckley H.R. Yeast 13:1383-1389(1997) [PubMed: 9392083] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The ornithine decarboxylase gene from Candida albicans. Sequence analysis and expression during dimorphism." Lopez M.C., Garcia S., Ruiz-Herrera J., Dominguez A. Curr. Genet. 32:108-114(1997) [PubMed: 9294258] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 26555.
[3]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U85005 Genomic DNA. Translation: AAC49877.1. X94994 Genomic DNA. Translation: CAA64451.1. AACQ01000036 Genomic DNA. Translation: EAK99988.1. AACQ01000035 Genomic DNA. Translation: EAL00093.1.
RefSeq	XP_718892.1. XP_718994.1.
3D structure databases
HSSP	HSSP built from PDB template 1F3T based on UniProtKB P07805.
ModBase	Search...
Genome annotation databases
GeneID	3639327. 3639405.
KEGG	cal:CaO19.13453. cal:CaO19.6032.
Organism-specific databases
CGD	CAL0005099. SPE1.
Phylogenomic databases
OMA	CILFDHQ.
Enzyme and pathway databases
BRENDA	4.1.1.17. 1124.
Family and domain databases
InterPro	IPR000183. De-COase2. IPR002433. Orn_de-COase. [Graphical view]
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PRINTS	PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCOR_CANAL

Accession

Primary (citable) accession number: P78599
Secondary accession number(s): P78592, Q5ABD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	November 3, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)