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P78589 (FDFT_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Squalene synthase

Short name=SQS
Short name=SS
EC=2.5.1.21
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
Gene names
Name:ERG9
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol By similarity.

Catalytic activity

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactor

Magnesium By similarity.

Pathway

Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the phytoene/squalene synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Squalene synthase
PRO_0000067447

Regions

Transmembrane295 – 31521Helical; Potential
Transmembrane428 – 44821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P78589 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 357C11E2918E4863

FASTA44851,171
        10         20         30         40         50         60 
MGKFLQLLSH PTELKAVIQL FGFRQPLHPG KRDVNDKELG RCYELLNLTS RSFAAVIEEL 

        70         80         90        100        110        120 
HPELRDAVMI FYLVLRALDT IEDDMTIKSS IKIPLLREFD TKLNTKNWTF DGYGPNEKDR 

       130        140        150        160        170        180 
TVLVEFDKIL NVYHRLKPQY QDIIKSITFK MGNGMADYIL DEEFNVYGVA TVEDYNLYCH 

       190        200        210        220        230        240 
YVAGLVGEGL TNLFVLANFG DKTLTENNFA KADSMGLFLQ KTNIIRDYHE DLQDGRSFWP 

       250        260        270        280        290        300 
REIWSKYTEN LQDFHKVKTP AKEFAGVSCI NELVLNALGH VTDCLDYLSL VKDPSSFSFC 

       310        320        330        340        350        360 
AIPQVMAVAT LAEVYNNPKV LHGVVKIRKG TTCRLILESR TLPGVVKIFK EYIQVINHKS 

       370        380        390        400        410        420 
SVRDPNYLKI GIKCGEIEQY CEMIYPNKQA LPPSMKSLPE NKFTKIVASR ESIDLSVQRR 

       430        440 
IEPGNFNCNV VLFGIGALIL SLIYFVLY 

« Hide

References

[1]"Cloning of Candida albicans squalene synthase gene."
Ishii N., Arisawa M., Aoki Y.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 10259 / CBS 5796 / DSM 5817 / JCM 2078 / NBRC 1060.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D89610 Genomic DNA. Translation: BAA13995.1.

3D structure databases

ProteinModelPortalP78589.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1562.

Enzyme and pathway databases

UniPathwayUPA00767; UER00751.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR01559. squal_synth. 1 hit.
PROSITEPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDFT_CANAX
AccessionPrimary (citable) accession number: P78589
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways