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Reviewed, UniProtKB/Swiss-Prot P78589 (FDFT_CANAL)

Last modified October 13, 2009. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Squalene synthetase
      Short name=SQS
      Short name=SS
    EC=2.5.1.21
Alternative name(s):
    Farnesyl-diphosphate farnesyltransferase
    FPP:FPP farnesyltransferase
Gene names
Name: ERG9
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

2 farnesyl diphosphate = diphosphate + presqualene diphosphate.

Presqualene diphosphate + NAD(P)H = squalene + diphosphate + NAD(P)+.

Cofactor

Magnesium.

Pathway

Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the phytoene/squalene synthetase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Squalene synthetase
PRO_0000067447

Regions

Transmembrane295 – 31521 Potential
Transmembrane428 – 44821 Potential

Sequences

Sequence LengthMass (Da)Tools
P78589-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 357C11E2918E4863

FASTA44851,171
        10         20         30         40         50         60 
MGKFLQLLSH PTELKAVIQL FGFRQPLHPG KRDVNDKELG RCYELLNLTS RSFAAVIEEL 

        70         80         90        100        110        120 
HPELRDAVMI FYLVLRALDT IEDDMTIKSS IKIPLLREFD TKLNTKNWTF DGYGPNEKDR 

       130        140        150        160        170        180 
TVLVEFDKIL NVYHRLKPQY QDIIKSITFK MGNGMADYIL DEEFNVYGVA TVEDYNLYCH 

       190        200        210        220        230        240 
YVAGLVGEGL TNLFVLANFG DKTLTENNFA KADSMGLFLQ KTNIIRDYHE DLQDGRSFWP 

       250        260        270        280        290        300 
REIWSKYTEN LQDFHKVKTP AKEFAGVSCI NELVLNALGH VTDCLDYLSL VKDPSSFSFC 

       310        320        330        340        350        360 
AIPQVMAVAT LAEVYNNPKV LHGVVKIRKG TTCRLILESR TLPGVVKIFK EYIQVINHKS 

       370        380        390        400        410        420 
SVRDPNYLKI GIKCGEIEQY CEMIYPNKQA LPPSMKSLPE NKFTKIVASR ESIDLSVQRR 

       430        440 
IEPGNFNCNV VLFGIGALIL SLIYFVLY 

« Hide

References

[1]"Cloning of Candida albicans squalene synthase gene."
Ishii N., Arisawa M., Aoki Y.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 10259 / CBS 5796 / IFO 1060 / JCM 2078.

Cross-references

Sequence databases

D89610 Genomic DNA. Translation: BAA13995.1.

3D structure databases

HSSPHSSP built from PDB template 1EZF based on UniProtKB P37268.
ModBaseSearch...

Enzyme and pathway databases

BRENDA2.5.1.21. 1124.

Family and domain databases

InterProIPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
TIGRFAMsTIGR01559. squal_synth. 1 hit.
PROSITEPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDFT_CANAL
AccessionPrimary (citable) accession number: P78589
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 13, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

Candida albicans

Candida albicans: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents