Probable ferric reductase transmembrane component - Candida albicans (Yeast)

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P78588 (FREL_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 63. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Probable ferric reductase transmembrane component
EC=1.16.1.7

Alternative name(s):
Ferric-chelate reductase

Gene names

Name:

CFL1

Organism

Candida albicans (Yeast)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	669 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 Fe²⁺ + NAD⁺ + H⁺ = 2 Fe³⁺ + NADH.
Cofactor	FAD Probable.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ferric reductase (FRE) family. Contains 1 FAD-binding FR-type domain. Contains 1 ferric oxidoreductase domain.

Ontologies

Keywords
Biological process	Electron transport Ion transport Iron transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	FAD Iron NAD
Molecular function	Oxidoreductase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW ion transport Inferred from electronic annotation. Source: UniProtKB-KW iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro ferric-chelate reductase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

669

Probable ferric reductase transmembrane component

PRO_0000210151

Regions

Transmembrane

21

Helical; Potential

Transmembrane

21

Helical; Potential

Transmembrane

21

Helical; Potential

Transmembrane

21

Helical; Potential

Transmembrane

21

Helical; Potential

Transmembrane

21

Helical; Potential

Transmembrane

21

Helical; Potential

Domain

135

Ferric oxidoreductase

Domain

119

FAD-binding FR-type

Nucleotide binding

6

FAD Potential

Compositional bias

13

Poly-Ser

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P78588 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: E3373CF93EAC2A83
Show »

669

74,748

        10         20         30         40         50         60 
MTESKFHAKY DKIQAEFKTN GTEYAKMTTK SSSGSKTSTS ASKSSKSTGS SNASKSSTNA 

        70         80         90        100        110        120 
HGSNSSTSST SSSSSKSGKG NSGTSTTETI TTPLLIDYKK FTPYKDAYQM SNNNFNLSIN 

       130        140        150        160        170        180 
YGSGLLGYWA GILAIAIFAN MIKKMFPSLT NNLSGSISNL FRKHLFLPAT FRKKKAQEFS 

       190        200        210        220        230        240 
IGVYGFFDGL IPTRLETIIV VIFVVLTGLF SALHIHHVKD NPQYATKNAE LGHLIADRTG 

       250        260        270        280        290        300 
ILGTFLIPLL ILFGGRNNFL QWLTGWDFAT FIMYHRWISR VDVLLIIVHA ITFSVSDKAT 

       310        320        330        340        350        360 
GKYKNRMKRD FMIWGTVSTI CGGFILFQAM LFFRRKCYEV FFLIHIVLVV FFVVGGYYHL 

       370        380        390        400        410        420 
ESQGYGDFMW AAIAVWAFDR VVRLGRIFFF GARKATVSIK GDDTLKIEVP KPKYWKSVAG 

       430        440        450        460        470        480 
GHAFIHFLKP TLFLQSHPFT FTTTESNDKI VLYAKIKNGI TSNIAKYLSP LPGNTATIRV 

       490        500        510        520        530        540 
LVEGPYGEPS SAGRNCKNVV FVAGGNGIPG IYSECVDLAK KSKNQSIKLI WIIRHWKSLS 

       550        560        570        580        590        600 
WFTEELEYLK KTNVQSTIYV TQPQDCSGLE CFEHDVSFEK KSDEKDSVES SQYSLISNIK 

       610        620        630        640        650        660 
QGLSHVEFIE GRPDISTQVE QEVKQADGAI GFVTCGHPAM VDELRFAVTQ NLNVSKHRVE 


YHEQLQTWA

References

[1]

"Isolation of the mRNA-capping enzyme and ferric-reductase-related genes from Candida albicans."
Yamada-Okabe T., Shimmi O., Doi R., Mizumoto K., Arisawa M., Yamada-Okabe H.
Microbiology 142:2515-2523(1996) [PubMed: 8828219] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 10259 / CBS 5796 / DSM 5817 / JCM 2078 / NBRC 1060.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D83181 Genomic DNA. Translation: BAA11834.1.
3D structure databases
ProteinModelPortal	P78588.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR013112. FAD-bd_8. IPR017927. Fd_Rdtase_FAD-bd. IPR013121. Fe_red_NAD-bd_6. IPR013130. Flavoprotein_TM. [Graphical view]
Pfam	PF08022. FAD_binding_8. 1 hit. PF01794. Ferric_reduct. 1 hit. PF08030. NAD_binding_6. 1 hit. [Graphical view]
PROSITE	PS51384. FAD_FR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FREL_CANAX

Accession

Primary (citable) accession number: P78588

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	October 19, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents