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P78574 (CATA_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Catalase A
EC=1.11.1.6
Alternative name(s):
Fast catalase
Gene names
Name:catA
ORF Names:AFUA_6G03890
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length750 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activity

2 H2O2 = O2 + 2 H2O.

Cofactor

Heme group.

Sequence similarities

Belongs to the catalase family.

Ontologies

Keywords
   Biological processHydrogen peroxide
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processhydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncatalase activity

Inferred from electronic annotation. Source: EC

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 750750Catalase A
PRO_0000084915

Sites

Active site931 By similarity
Active site1661 By similarity
Metal binding3801Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict3281D → N in AAB47761. Ref.1
Sequence conflict4621S → N in AAB47761. Ref.1
Sequence conflict5771F → S in AAB47761. Ref.1
Sequence conflict604 – 6052DG → T in AAB47761. Ref.1
Sequence conflict6811D → H in AAB47761. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P78574 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 95AA8090D28BA007

FASTA75084,633
        10         20         30         40         50         60 
MATKIAGGLH RAQEVLQNTS SKSKKLVDLE RDTADAHTQQ PLTTDHGVRV SNTDQWLRVT 

        70         80         90        100        110        120 
NDRRTGPSLL EDQIAREKIH RFDHERIPER VVHARGTGAF GNFKLKESIE DLTYAGVLTD 

       130        140        150        160        170        180 
TSRNTPVFVR FSTVQGSRGS ADTVRDVRGF AVKFYTDEGN WDIVGNNIPV FFIQDAVKFP 

       190        200        210        220        230        240 
DFVHAVKPEP HNEVPQAQTA HNNFWDFVYL HPEATHMFMW AMSDRAIPRS YRMMQGFGVN 

       250        260        270        280        290        300 
TFALVNKEGK RHFVKFHWIP HLGVHSLVWD EALKLGGQDP DFHRKDLMEA IDNKAYPKWD 

       310        320        330        340        350        360 
FAIQVIPEEK QDDFEFDILD ATKIWPEDLV PLRVIGELEL NRNVDEFFPQ TEQVAFCTSH 

       370        380        390        400        410        420 
IVPGIDFTDD PLLQGRNFSY FDTQISRLGI NWEELPINRP VCPVLNHNRD GQMRHRITQG 

       430        440        450        460        470        480 
TVNYWPNRFE AVPPTGTKGS GVGGGFTTYP QRVEGIKNRA LSDKFREHHN QAQLFYNSMS 

       490        500        510        520        530        540 
EHEKLHMKKA FSFELDHCDD PTVYERLAGH RLAEIDLELA QKVAEMVGAP IPAKALKQNH 

       550        560        570        580        590        600 
GRRAPHLSQT EFIPKNPTIA SRRIAIIIGD GYDPVAFTGL KTAIKAASAL PFIIGTKRSA 

       610        620        630        640        650        660 
IYADGEDKTS SKGIIPDHHY DGQRSTMFDA TFIPGGPHVA TLRQNGQIKY WISETFGHLK 

       670        680        690        700        710        720 
ALGATGEAVD LVKETLSGTL DVQVASSQSP EPVEWYGVVT AGGKQKPESF KESVQILKGA 

       730        740        750 
TDFVGKFFYQ ISQHRNYQRE LDGLASTIAF

« Hide

References

« Hide 'large scale' references
[1]"Cloning, sequencing and characterization of Aspergillus fumigatus catalase genes."
Wysong D.R., Diamond R.D., Robbins P.W.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U87630 Genomic DNA. Translation: AAB47761.1.
AAHF01000012 Genomic DNA. Translation: EAL85650.1.
RefSeqXP_747688.1. XM_742595.1.

3D structure databases

ProteinModelPortalP78574.
SMRP78574. Positions 42-750.
ModBaseSearch...

Protein-protein interaction databases

STRINGP78574.

Protein family/group databases

PeroxiBase5205. AfumKat01.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00000630; CADAFUAP00000630; CADAFUAG00000630.
GeneID3505035.
GenomeReviewsGene locus catA in contig CM000174_GR.
KEGGafm:AFUA_6G03890.

Phylogenomic databases

eggNOGfuNOG06986.
GeneTreeEFGT00050000004867.
HOGENOMHBG339355.
OMARRDLWEN.
OrthoDBEOG4B8NN5.

Family and domain databases

InterProIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024712. Catalase_clade2.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
Gene3DG3DSA:2.40.180.10. Catalase_N. 1 hit.
KOK03781.
PANTHERPTHR11465. Catalase. 1 hit.
PfamPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFPIRSF038927. Catalase_clade2. 1 hit.
PRINTSPR00067. CATALASE.
SMARTSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMSSF56634. Catalase_N. 1 hit.
PROSITEPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCATA_ASPFU
AccessionPrimary (citable) accession number: P78574
Secondary accession number(s): Q4WD88
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 6, 2005
Last modified: January 25, 2012
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents