Reviewed,
UniProtKB/Swiss-Prot P78560 (CRADD_HUMAN)
Last modified
July 7, 2009.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Death domain-containing protein CRADD Alternative name(s): Caspase and RIP adapter with death domain RIP-associated protein with a death domain | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 199 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruites caspase-2 to the TNFR-1 signalling complex. |
| Subunit structure | |
| Tissue specificity | Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. |
| Domain | Contains a death domain involved in the binding of RIP protein. The CARD domain mediates the interaction with caspase-2. |
| Sequence similarities | Contains 1 CARD domain. Contains 1 death domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | apoptosis Inferred from electronic annotation. Source: UniProtKB-KW induction of apoptosis via death domain receptors Ref.1Traceable author statement. Source: ProtInc proteolysisInferred from electronic annotation. Source: InterPro signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | intracellular Inferred from electronic annotation. Source: InterPro |
| Molecular function | cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro death domain binding Ref.1Inferred from physical interaction. Source: UniProtKB protease binding Ref.1Inferred from physical interaction. Source: UniProtKB protein binding, bridging Ref.1Inferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CASP2 | P42575 | 3 | EBI-520375,EBI-520342 | |
| LRDD | Q9HB75 | 1 | EBI-520375,EBI-520427 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 199 | 199 | Death domain-containing protein CRADD | PRO_0000079326 | ||||||||||||||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||||||||||||||
| Domain | 1 – 91 | 91 | CARD | |||||||||||||||||||||||||||||||||||
| Domain | 116 – 188 | 73 | Death | |||||||||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||||||||
| Helix | 5 – 18 | 14 | ||||||||||||||||||||||||||||||||||||
| Helix | 27 – 33 | 7 | ||||||||||||||||||||||||||||||||||||
| Helix | 38 – 44 | 7 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 48 – 50 | 3 | ||||||||||||||||||||||||||||||||||||
| Helix | 51 – 60 | 10 | ||||||||||||||||||||||||||||||||||||
| Turn | 61 – 63 | 3 | ||||||||||||||||||||||||||||||||||||
| Helix | 69 – 75 | 7 | ||||||||||||||||||||||||||||||||||||
| Helix | 79 – 92 | 14 | ||||||||||||||||||||||||||||||||||||
| Helix | 110 – 112 | 3 | ||||||||||||||||||||||||||||||||||||
| Helix | 117 – 126 | 10 | ||||||||||||||||||||||||||||||||||||
| Helix | 131 – 137 | 7 | ||||||||||||||||||||||||||||||||||||
| Helix | 142 – 151 | 10 | ||||||||||||||||||||||||||||||||||||
| Helix | 156 – 171 | 16 | ||||||||||||||||||||||||||||||||||||
| Helix | 172 – 174 | 3 | ||||||||||||||||||||||||||||||||||||
| Helix | 177 – 186 | 10 | ||||||||||||||||||||||||||||||||||||
| Helix | 192 – 197 | 6 | ||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP." Ahmad M., Srinivasula S.M., Wang L., Talanian R.V., Litwack G., Fernandes-Alnemri T., Alnemri E.S. Cancer Res. 57:615-619(1997) [PubMed: 9044836] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "RAIDD is a new 'death' adaptor molecule." Duan H., Dixit V.M. Nature 385:86-89(1997) [PubMed: 8985253] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon. |
| [4] | "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress." Tinel A., Tschopp J. Science 304:843-846(2004) [PubMed: 15073321] [Abstract] Cited for: INTERACTION WITH LRDD. |
| [5] | "Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage." Vakifahmetoglu H., Olsson M., Orrenius S., Zhivotovsky B. Oncogene 25:5683-5692(2006) [PubMed: 16652156] [Abstract] Cited for: INTERACTION WITH LRDD. |
| [6] | "Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment." Chou J.J., Matsuo H., Duan H., Wagner G. Cell 94:171-180(1998) [PubMed: 9695946] [Abstract] Cited for: STRUCTURE BY NMR OF 1-100. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| U84388 mRNA. Translation: AAC50952.1. U79115 mRNA. Translation: AAB42217.1. BC017042 mRNA. Translation: AAH17042.1. | |||||||||||||||||||||||||
| IPI | IPI00020364. | ||||||||||||||||||||||||
| RefSeq | NP_003796.1. | ||||||||||||||||||||||||
| UniGene | Hs.38533 Hs.591016 Hs.715196 | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| SMR | P78560. Positions 1-100. | ||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||
| IntAct | P78560. 6 interactions. | ||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||
| PRIDE | P78560. | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENSG00000169372. Homo sapiens. [Contig view] | ||||||||||||||||||||||||
| GeneID | 8738. | ||||||||||||||||||||||||
| KEGG | hsa:8738. | ||||||||||||||||||||||||
| UCSC | uc001tda.1. human. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| GeneCards | GC12P092573. | ||||||||||||||||||||||||
| H-InvDB | HIX0010886. | ||||||||||||||||||||||||
| HGNC | HGNC:2340. CRADD. | ||||||||||||||||||||||||
| HPA | CAB005337. | ||||||||||||||||||||||||
| MIM | 603454. gene. | ||||||||||||||||||||||||
| PharmGKB | PA26860. | ||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| HOGENOM | P78560. | ||||||||||||||||||||||||
| HOVERGEN | P78560. | ||||||||||||||||||||||||
| OMA | P78560. ILTENHV. | ||||||||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||||||||
| Pathway_Interaction_DB | caspase_pathway. Caspase cascade in apoptosis. ceramidepathway. Ceramide signaling pathway. hivnefpathway. HIV-1 Nef: Negative effector of Fas and TNF-alpha. | ||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||
| ArrayExpress | P78560. | ||||||||||||||||||||||||
| Bgee | P78560. | ||||||||||||||||||||||||
| CleanEx | HS_CRADD. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR001315. CARD. IPR000488. Death. IPR011029. DEATH-like. IPR002398. Pept_C14_p45. [Graphical view] | ||||||||||||||||||||||||
| Gene3D | G3DSA:1.10.533.10. DEATH_like. 2 hits. | ||||||||||||||||||||||||
| PANTHER | PTHR10454. Pept_C14_p45. 1 hit. | ||||||||||||||||||||||||
| Pfam | PF00619. CARD. 1 hit. PF00531. Death. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| SMART | SM00114. CARD. 1 hit. SM00005. DEATH. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| PROSITE | PS50209. CARD. 1 hit. PS50017. DEATH_DOMAIN. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||
| NextBio | 32779. | ||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||
Entry information
| Entry name | CRADD_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P78560 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


