P78560 (CRADD_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 107.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Death domain-containing protein CRADD Alternative name(s): Caspase and RIP adapter with death domain RIP-associated protein with a death domain | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 199 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. |
| Subunit structure | |
| Tissue specificity | Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. |
| Domain | Contains a death domain involved in the binding of RIP protein. The CARD domain mediates the interaction with caspase-2. |
| Sequence similarities | Contains 1 CARD domain. Contains 1 death domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW cellular response to mechanical stimulusInferred from expression pattern. Source: UniProtKB induction of apoptosis via death domain receptorsTraceable author statement. Source: ProtInc signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | intracellular Inferred from electronic annotation. Source: InterPro |
| Molecular function | death domain binding Inferred from physical interaction Ref.1. Source: BHF-UCL protease bindingInferred from physical interaction Ref.1. Source: BHF-UCL protein binding, bridgingInferred from physical interaction Ref.1. Source: BHF-UCL |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CASP2 | P42575 | 9 | EBI-520375,EBI-520342 | |
| PIDD | Q9HB75 | 6 | EBI-520375,EBI-520427 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 199 | 199 | Death domain-containing protein CRADD | PRO_0000079326 | ||||||||||||||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||||||||||||||
| Domain | 1 – 91 | 91 | CARD | |||||||||||||||||||||||||||||||||||
| Domain | 116 – 188 | 73 | Death | |||||||||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||||||||
| Helix | 5 – 18 | 14 | ||||||||||||||||||||||||||||||||||||
| Helix | 27 – 33 | 7 | ||||||||||||||||||||||||||||||||||||
| Helix | 38 – 44 | 7 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 48 – 50 | 3 | ||||||||||||||||||||||||||||||||||||
| Helix | 51 – 60 | 10 | ||||||||||||||||||||||||||||||||||||
| Turn | 61 – 63 | 3 | ||||||||||||||||||||||||||||||||||||
| Helix | 69 – 75 | 7 | ||||||||||||||||||||||||||||||||||||
| Helix | 79 – 92 | 14 | ||||||||||||||||||||||||||||||||||||
| Helix | 110 – 112 | 3 | ||||||||||||||||||||||||||||||||||||
| Helix | 117 – 126 | 10 | ||||||||||||||||||||||||||||||||||||
| Helix | 131 – 137 | 7 | ||||||||||||||||||||||||||||||||||||
| Helix | 142 – 151 | 10 | ||||||||||||||||||||||||||||||||||||
| Helix | 156 – 171 | 16 | ||||||||||||||||||||||||||||||||||||
| Helix | 172 – 174 | 3 | ||||||||||||||||||||||||||||||||||||
| Helix | 177 – 186 | 10 | ||||||||||||||||||||||||||||||||||||
| Helix | 192 – 197 | 6 | ||||||||||||||||||||||||||||||||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP." Ahmad M., Srinivasula S.M., Wang L., Talanian R.V., Litwack G., Fernandes-Alnemri T., Alnemri E.S. Cancer Res. 57:615-619(1997) [PubMed: 9044836] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "RAIDD is a new 'death' adaptor molecule." Duan H., Dixit V.M. Nature 385:86-89(1997) [PubMed: 8985253] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon. |
| [4] | "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress." Tinel A., Tschopp J. Science 304:843-846(2004) [PubMed: 15073321] [Abstract] Cited for: INTERACTION WITH LRDD. |
| [5] | "Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage." Vakifahmetoglu H., Olsson M., Orrenius S., Zhivotovsky B. Oncogene 25:5683-5692(2006) [PubMed: 16652156] [Abstract] Cited for: INTERACTION WITH LRDD. |
| [6] | "Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment." Chou J.J., Matsuo H., Duan H., Wagner G. Cell 94:171-180(1998) [PubMed: 9695946] [Abstract] Cited for: STRUCTURE BY NMR OF 1-100. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | U84388 mRNA. Translation: AAC50952.1. U79115 mRNA. Translation: AAB42217.1. BC017042 mRNA. Translation: AAH17042.1. | ||||||||||||||||||||||||
| IPI | IPI00020364. | ||||||||||||||||||||||||
| RefSeq | NP_003796.1. NM_003805.3. | ||||||||||||||||||||||||
| UniGene | Hs.38533. Hs.591016. | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||||||||
| ProteinModelPortal | P78560. | ||||||||||||||||||||||||
| SMR | P78560. Positions 1-100, 109-199. | ||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||
| IntAct | P78560. 11 interactions. | ||||||||||||||||||||||||
| MINT | MINT-1520976. | ||||||||||||||||||||||||
| STRING | P78560. | ||||||||||||||||||||||||
Polymorphism databases | |||||||||||||||||||||||||
| DMDM | 2498833. | ||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||
| PRIDE | P78560. | ||||||||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENST00000332896; ENSP00000327647; ENSG00000169372. | ||||||||||||||||||||||||
| GeneID | 8738. | ||||||||||||||||||||||||
| KEGG | hsa:8738. | ||||||||||||||||||||||||
| UCSC | uc001tda.1. human. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| CTD | 8738. | ||||||||||||||||||||||||
| GeneCards | GC12P094004. | ||||||||||||||||||||||||
| H-InvDB | HIX0010886. | ||||||||||||||||||||||||
| HGNC | HGNC:2340. CRADD. | ||||||||||||||||||||||||
| HPA | CAB005337. | ||||||||||||||||||||||||
| MIM | 603454. gene. | ||||||||||||||||||||||||
| neXtProt | NX_P78560. | ||||||||||||||||||||||||
| PharmGKB | PA26860. | ||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| eggNOG | prNOG05544. | ||||||||||||||||||||||||
| HOGENOM | HBG281400. | ||||||||||||||||||||||||
| HOVERGEN | HBG051112. | ||||||||||||||||||||||||
| InParanoid | P78560. | ||||||||||||||||||||||||
| OMA | GKQATFQ. | ||||||||||||||||||||||||
| OrthoDB | EOG4JT06K. | ||||||||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||||||||
| Pathway_Interaction_DB | caspase_pathway. Caspase cascade in apoptosis. ceramidepathway. Ceramide signaling pathway. hivnefpathway. HIV-1 Nef: Negative effector of Fas and TNF-alpha. | ||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||
| ArrayExpress | P78560. | ||||||||||||||||||||||||
| Bgee | P78560. | ||||||||||||||||||||||||
| CleanEx | HS_CRADD. | ||||||||||||||||||||||||
| Genevestigator | P78560. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR001315. CARD. IPR000488. Death. IPR011029. DEATH-like. [Graphical view] | ||||||||||||||||||||||||
| Gene3D | G3DSA:1.10.533.10. DEATH_like. 2 hits. | ||||||||||||||||||||||||
| KO | K02832. | ||||||||||||||||||||||||
| Pfam | PF00619. CARD. 1 hit. PF00531. Death. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| SMART | SM00114. CARD. 1 hit. SM00005. DEATH. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| SUPFAM | SSF47986. DEATH_like. 2 hits. | ||||||||||||||||||||||||
| PROSITE | PS50209. CARD. 1 hit. PS50017. DEATH_DOMAIN. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other | |||||||||||||||||||||||||
| NextBio | 32779. | ||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||
Entry information
| Entry name | CRADD_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P78560 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with