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Protein

Microtubule-associated protein 1A

Gene

MAP1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.

GO - Molecular functioni

  • structural molecule activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166963-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 1A
Short name:
MAP-1A
Alternative name(s):
Proliferation-related protein p80
Cleaved into the following 2 chains:
Gene namesi
Name:MAP1A
Synonyms:MAP1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:6835. MAP1A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • microtubule Source: UniProtKB-KW
  • microtubule associated complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi4130.
OpenTargetsiENSG00000166963.

Chemistry databases

DrugBankiDB01196. Estramustine.

Polymorphism and mutation databases

BioMutaiMAP1A.
DMDMi313104325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000186001 – 2803Microtubule-associated protein 1AAdd BLAST2803
ChainiPRO_00004183761 – 2566MAP1A heavy chainAdd BLAST2566
ChainiPRO_00000186012567 – 2803MAP1 light chain LC2Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114PhosphoserineBy similarity1
Modified residuei117PhosphoserineCombined sources1
Modified residuei118PhosphoserineBy similarity1
Modified residuei121PhosphoserineBy similarity1
Modified residuei155PhosphoserineBy similarity1
Modified residuei177PhosphotyrosineBy similarity1
Modified residuei319PhosphoserineBy similarity1
Modified residuei322PhosphoserineBy similarity1
Modified residuei384PhosphoserineBy similarity1
Modified residuei504PhosphothreonineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1
Modified residuei612PhosphoserineCombined sources1
Modified residuei616PhosphothreonineCombined sources1
Modified residuei644PhosphoserineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei787PhosphoserineCombined sources1
Modified residuei874PhosphoserineBy similarity1
Modified residuei877PhosphoserineBy similarity1
Modified residuei878PhosphoserineBy similarity1
Modified residuei891PhosphoserineBy similarity1
Modified residuei894PhosphothreonineBy similarity1
Modified residuei896PhosphoserineCombined sources1
Modified residuei900PhosphoserineBy similarity1
Modified residuei909PhosphoserineCombined sources1
Modified residuei986PhosphoserineCombined sources1
Modified residuei996PhosphoserineBy similarity1
Modified residuei1004PhosphoserineBy similarity1
Modified residuei1013PhosphoserineBy similarity1
Modified residuei1019PhosphoserineBy similarity1
Modified residuei1029PhosphoserineBy similarity1
Modified residuei1069PhosphoserineCombined sources1
Modified residuei1144PhosphoserineBy similarity1
Modified residuei1146PhosphoserineBy similarity1
Modified residuei1160PhosphoserineCombined sources1
Modified residuei1172PhosphoserineCombined sources1
Modified residuei1190PhosphoserineCombined sources1
Modified residuei1200PhosphoserineCombined sources1
Modified residuei1203PhosphoserineCombined sources1
Modified residuei1209PhosphoserineBy similarity1
Modified residuei1218PhosphoserineCombined sources1
Modified residuei1221PhosphoserineBy similarity1
Modified residuei1264PhosphoserineBy similarity1
Modified residuei1326PhosphoserineCombined sources1
Modified residuei1329PhosphoserineCombined sources1
Modified residuei1544PhosphoserineBy similarity1
Modified residuei1600PhosphoserineCombined sources1
Modified residuei1626PhosphoserineCombined sources1
Modified residuei1654PhosphoserineCombined sources1
Modified residuei1675PhosphoserineCombined sources1
Modified residuei1749PhosphoserineCombined sources1
Modified residuei1762PhosphoserineCombined sources1
Modified residuei1776PhosphoserineCombined sources1
Modified residuei1791PhosphoserineCombined sources1
Modified residuei1797PhosphoserineCombined sources1
Modified residuei1801PhosphoserineCombined sources1
Modified residuei1812PhosphoserineBy similarity1
Modified residuei1818PhosphoserineCombined sources1
Modified residuei1931PhosphoserineBy similarity1
Modified residuei1957PhosphothreonineCombined sources1
Modified residuei2022PhosphoserineCombined sources1
Modified residuei2058PhosphothreonineBy similarity1
Modified residuei2074PhosphoserineCombined sources1
Modified residuei2104PhosphoserineCombined sources1
Modified residuei2106PhosphoserineCombined sources1
Modified residuei2108PhosphoserineBy similarity1
Modified residuei2235PhosphoserineBy similarity1
Modified residuei2252PhosphoserineBy similarity1
Modified residuei2256PhosphoserineBy similarity1
Modified residuei2259PhosphoserineBy similarity1
Modified residuei2260PhosphoserineBy similarity1
Modified residuei2449PhosphoserineCombined sources1
Modified residuei2649PhosphoserineCombined sources1
Modified residuei2664PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CSNK1D.By similarity
LC2 is generated from MAP1A by proteolytic processing.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP78559.
MaxQBiP78559.
PaxDbiP78559.
PeptideAtlasiP78559.
PRIDEiP78559.

PTM databases

iPTMnetiP78559.
PhosphoSitePlusiP78559.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000166963.
CleanExiHS_MAP1A.
ExpressionAtlasiP78559. baseline and differential.
GenevisibleiP78559. HS.

Organism-specific databases

HPAiHPA039063.
HPA039064.

Interactioni

Subunit structurei

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with TIAM2. Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DISC1Q9NRI53EBI-929047,EBI-529989

Protein-protein interaction databases

BioGridi110303. 24 interactors.
DIPiDIP-36377N.
IntActiP78559. 11 interactors.
MINTiMINT-1203375.
STRINGi9606.ENSP00000300231.

Structurei

3D structure databases

ProteinModelPortaliP78559.
SMRiP78559.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati415 – 41713
Repeati420 – 42223
Repeati427 – 42933
Repeati431 – 43343
Repeati436 – 43853
Repeati440 – 44263
Repeati444 – 44673
Repeati449 – 45183
Repeati539 – 54193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni415 – 5419 X 3 AA repeats of K-K-[DE]Add BLAST127

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi309 – 496Lys-rich (basic)Add BLAST188

Domaini

The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.

Sequence similaritiesi

Belongs to the MAP1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3592. Eukaryota.
ENOG410XRYM. LUCA.
GeneTreeiENSGT00550000074593.
HOGENOMiHOG000231839.
HOVERGENiHBG052408.
InParanoidiP78559.
KOiK10429.
PhylomeDBiP78559.
TreeFamiTF350229.

Family and domain databases

Gene3Di3.60.15.10. 2 hits.
InterProiIPR026074. MAP1.
IPR015656. MAP1A.
IPR001279. Metallo-B-lactamas.
[Graphical view]
PANTHERiPTHR13843. PTHR13843. 1 hit.
PTHR13843:SF6. PTHR13843:SF6. 1 hit.
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P78559-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGVAEFSEY VSETVDVPSP FDLLEPPTSG GFLKLSKPCC YIFPGGRGDS
60 70 80 90 100
ALFAVNGFNI LVDGGSDRKS CFWKLVRHLD RIDSVLLTHI GADNLPGING
110 120 130 140 150
LLQRKVAELE EEQSQGSSSY SDWVKNLISP ELGVVFFNVP EKLRLPDASR
160 170 180 190 200
KAKRSIEEAC LTLQHLNRLG IQAEPLYRVV SNTIEPLTLF HKMGVGRLDM
210 220 230 240 250
YVLNPVKDSK EMQFLMQKWA GNSKAKTGIV LPNGKEAEIS VPYLTSITAL
260 270 280 290 300
VVWLPANPTE KIVRVLFPGN APQNKILEGL EKLRHLDFLR YPVATQKDLA
310 320 330 340 350
SGAVPTNLKP SKIKQRADSK ESLKATTKTA VSKLAKREEV VEEGAKEARS
360 370 380 390 400
ELAKELAKTE KKAKESSEKP PEKPAKPERV KTESSEALKA EKRKLIKDKV
410 420 430 440 450
GKKHLKEKIS KLEEKKDKEK KEIKKERKEL KKDEGRKEEK KDAKKEEKRK
460 470 480 490 500
DTKPELKKIS KPDLKPFTPE VRKTLYKAKV PGRVKIDRSR AIRGEKELSS
510 520 530 540 550
EPQTPPAQKG TVPLPTISGH RELVLSSPED LTQDFEEMKR EERALLAEQR
560 570 580 590 600
DTGLGDKPFP LDTAEEGPPS TAIQGTPPSV PGLGQEEHVM KEKELVPEVP
610 620 630 640 650
EEQGSKDRGL DSGAETEEEK DTWEEKKQRE AERLPDRTEA REESEPEVKE
660 670 680 690 700
DVIEKAELEE MEEVHPSDEE EEDATKAEGF YQKHMQEPLK VTPRSREAFG
710 720 730 740 750
GRELGLQGKA PEKETSLFLS SLTTPAGATE HVSYIQDETI PGYSETEQTI
760 770 780 790 800
SDEEIHDEPE ERPAPPRFHT STYDLPGPEG AGPFEASQPA DSAVPATSGK
810 820 830 840 850
VYGTPETELT YPTNIVAAPL AEEEHVSSAT SITECDKLSS FATSVAEDQS
860 870 880 890 900
VASLTAPQTE ETGKSSLLLD TVTSIPSSRT EATQGLDYVP SAGTISPTSS
910 920 930 940 950
LEEDKGFKSP PCEDFSVTGE SEKRGEIIGK GLSGERAVEE EEEETANVEM
960 970 980 990 1000
SEKLCSQYGT PVFSAPGHAL HPGEPALGEA EERCLSPDDS TVKMASPPPS
1010 1020 1030 1040 1050
GPPSATHTPF HQSPVEEKSE PQDFQEADSW GDTKRTPGVG KEDAAEETVK
1060 1070 1080 1090 1100
PGPEEGTLEK EEKVPPPRSP QAQEAPVNID EGLTGCTIQL LPAQDKAIVF
1110 1120 1130 1140 1150
EIMEAGEPTG PILGAEALPG GLRTLPQEPG KPQKDEVLRY PDRSLSPEDA
1160 1170 1180 1190 1200
ESLSVLSVPS PDTANQEPTP KSPCGLTEQY LHKDRWPEVS PEDTQSLSLS
1210 1220 1230 1240 1250
EESPSKETSL DVSSKQLSPE SLGTLQFGEL NLGKEEMGHL MQAEDTSHHT
1260 1270 1280 1290 1300
APMSVPEPHA ATASPPTDGT TRYSAQTDIT DDSLDRKSPA SSFSHSTPSG
1310 1320 1330 1340 1350
NGKYLPGAIT SPDEHILTPD SSFSKSPESL PGPALEDIAI KWEDKVPGLK
1360 1370 1380 1390 1400
DRTSEQKKEP EPKDEVLQQK DKTLEHKEVV EPKDTAIYQK DEALHVKNEA
1410 1420 1430 1440 1450
VKQQDKALEQ KGRDLEQKDT ALEQKDKALE PKDKDLEEKD KALEQKDKIP
1460 1470 1480 1490 1500
EEKDKALEQK DTALEQKDKA LEPKDKDLEQ KDRVLEQKEK IPEEKDKALD
1510 1520 1530 1540 1550
QKVRSVEHKA PEDTVAEMKD RDLEQTDKAP EQKHQAQEQK DKVSEKKDQA
1560 1570 1580 1590 1600
LEQKYWALGQ KDEALEQNIQ ALEENHQTQE QESLVQEDKT RKPKMLEEKS
1610 1620 1630 1640 1650
PEKVKAMEEK LEALLEKTKA LGLEESLVQE GRAREQEEKY WRGQDVVQEW
1660 1670 1680 1690 1700
QETSPTREEP AGEQKELAPA WEDTSPEQDN RYWRGREDVA LEQDTYWREL
1710 1720 1730 1740 1750
SCERKVWFPH ELDGQGARPH YTEERESTFL DEGPDDEQEV PLREHATRSP
1760 1770 1780 1790 1800
WASDFKDFQE SSPQKGLEVE RWLAESPVGL PPEEEDKLTR SPFEIISPPA
1810 1820 1830 1840 1850
SPPEMVGQRV PSAPGQESPI PDPKLMPHMK NEPTTPSWLA DIPPWVPKDR
1860 1870 1880 1890 1900
PLPPAPLSPA PGPPTPAPES HTPAPFSWGT AEYDSVVAAV QEGAAELEGG
1910 1920 1930 1940 1950
PYSPLGKDYR KAEGEREEEG RAEAPDKSSH SSKVPEASKS HATTEPEQTE
1960 1970 1980 1990 2000
PEQREPTPYP DERSFQYADI YEQMMLTGLG PACPTREPPL GAAGDWPPCL
2010 2020 2030 2040 2050
STKEAAAGRN TSAEKELSSP ISPKSLQSDT PTFSYAALAG PTVPPRPEPG
2060 2070 2080 2090 2100
PSMEPSLTPP AVPPRAPILS KGPSPPLNGN ILSCSPDRRS PSPKESGRSH
2110 2120 2130 2140 2150
WDDSTSDSEL EKGAREQPEK EAQSPSPPHP IPMGSPTLWP ETEAHVSPPL
2160 2170 2180 2190 2200
DSHLGPARPS LDFPASAFGF SSLQPAPPQL PSPAEPRSAP CGSLAFSGDR
2210 2220 2230 2240 2250
ALALAPGPPT RTRHDEYLEV TKAPSLDSSL PQLPSPSSPG APLLSNLPRP
2260 2270 2280 2290 2300
ASPALSEGSS SEATTPVISS VAERFSPSLE AAEQESGELD PGMEPAAHSL
2310 2320 2330 2340 2350
WDLTPLSPAP PASLDLALAP APSLPGDMGD GILPCHLECS EAATEKPSPF
2360 2370 2380 2390 2400
QVPSEDCAAN GPTETSPNPP GPAPAKAENE EAAACPAWER GAWPEGAERS
2410 2420 2430 2440 2450
SRPDTLLSPE QPVCPAGGSG GPPSSASPEV EAGPQGCATE PRPHRGELSP
2460 2470 2480 2490 2500
SFLNPPLPPS IDDRDLSTEE VRLVGRGGRR RVGGPGTTGG PCPVTDETPP
2510 2520 2530 2540 2550
TSASDSGSSQ SDSDVPPETE ECPSITAEAA LDSDEDGDFL PVDKAGGVSG
2560 2570 2580 2590 2600
THHPRPGHDP PPLPQPDPRP SPPRPDVCMA DPEGLSSESG RVERLREKEK
2610 2620 2630 2640 2650
VQGRVGRRAP GKAKPASPAR RLDLRGKRSP TPGKGPADRA SRAPPRPRST
2660 2670 2680 2690 2700
TSQVTPAEEK DGHSPMSKGL VNGLKAGPMA LSSKGSSGAP VYVDLAYIPN
2710 2720 2730 2740 2750
HCSGKTADLD FFRRVRASYY VVSGNDPANG EPSRAVLDAL LEGKAQWGEN
2760 2770 2780 2790 2800
LQVTLIPTHD TEVTREWYQQ THEQQQQLNV LVLASSSTVV MQDESFPACK

IEF
Length:2,803
Mass (Da):305,485
Last modified:November 30, 2010 - v6
Checksum:i94733902420F1FFE
GO
Isoform 2 (identifier: P78559-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2752-2752: Q → QSV

Show »
Length:2,805
Mass (Da):305,671
Checksum:i28E9817E8116EF8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134 – 135VV → IP in CAA87104 (Ref. 5) Curated2
Sequence conflicti249A → G in CAA87104 (Ref. 5) Curated1
Sequence conflicti263V → A in CAA87104 (Ref. 5) Curated1
Sequence conflicti296Q → H in AAD00355 (Ref. 4) Curated1
Sequence conflicti311S → G in CAA87104 (Ref. 5) Curated1
Sequence conflicti324K → Q in AAD00355 (Ref. 4) Curated1
Sequence conflicti414 – 419EKKDKE → KKKRNS in CAA87104 (Ref. 5) Curated6
Sequence conflicti424K → P in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti424K → P in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti426E → D in AAD00355 (Ref. 4) Curated1
Sequence conflicti431K → Q in AAD00355 (Ref. 4) Curated1
Sequence conflicti439E → D in AAD00355 (Ref. 4) Curated1
Sequence conflicti444K → R in AAD00355 (Ref. 4) Curated1
Sequence conflicti452 – 453TK → SS in AAD00355 (Ref. 4) Curated2
Sequence conflicti457K → R in AAD00355 (Ref. 4) Curated1
Sequence conflicti682Q → P in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti682Q → P in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti1025Q → K in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti1025Q → K in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti1303 – 1313KYLPGAITSPD → EVLTWGDHQALN in AAD00355 (Ref. 4) CuratedAdd BLAST11
Sequence conflicti1335 – 1341Missing in AAD00355 (Ref. 4) Curated7
Sequence conflicti1368Q → T in AAD00355 (Ref. 4) Curated1
Sequence conflicti1470A → T in AAD00355 (Ref. 4) Curated1
Sequence conflicti1714G → V in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti1714G → V in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti1869E → A in AAA81362 (PubMed:7629894).Curated1
Sequence conflicti1879 – 1883GTAEY → AHSRV in AAA81362 (PubMed:7629894).Curated5
Sequence conflicti2118P → A in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2118P → A in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2174Q → E in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2174Q → E in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2613A → D in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2613A → D in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2616A → V in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2616A → V in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2636P → S in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2636P → S in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2640A → V in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2640A → V in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2647P → S in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2647P → S in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2702C → W in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2702C → W in AAB41133 (PubMed:8812494).Curated1
Isoform 2 (identifier: P78559-2)
Sequence conflicti2753S → V in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2753S → V in AAB41133 (PubMed:8812494).Curated1
Sequence conflicti2754V → K in AAB41132 (PubMed:8812494).Curated1
Sequence conflicti2754V → K in AAB41133 (PubMed:8812494).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03970572F → L.1 PublicationCorresponds to variant rs2584695dbSNPEnsembl.1
Natural variantiVAR_039706335A → S.1 PublicationCorresponds to variant rs1060935dbSNPEnsembl.1
Natural variantiVAR_039707336K → T.1 PublicationCorresponds to variant rs1060936dbSNPEnsembl.1
Natural variantiVAR_039708353A → S.1 PublicationCorresponds to variant rs1060937dbSNPEnsembl.1
Natural variantiVAR_039709357A → S.1 PublicationCorresponds to variant rs1060938dbSNPEnsembl.1
Natural variantiVAR_039710364K → Q.1 PublicationCorresponds to variant rs2602129dbSNPEnsembl.1
Natural variantiVAR_039711485K → Q.Corresponds to variant rs2584715dbSNPEnsembl.1
Natural variantiVAR_039712830T → A.Corresponds to variant rs3803337dbSNPEnsembl.1
Natural variantiVAR_0397131078N → S.Corresponds to variant rs8034794dbSNPEnsembl.1
Natural variantiVAR_0397141102I → T.Corresponds to variant rs8036179dbSNPEnsembl.1
Natural variantiVAR_0397151185R → H.Corresponds to variant rs3803335dbSNPEnsembl.1
Natural variantiVAR_0397161245D → N.Corresponds to variant rs12912505dbSNPEnsembl.1
Natural variantiVAR_0397171461D → N.Corresponds to variant rs2245715dbSNPEnsembl.1
Natural variantiVAR_0397181553Q → H.Corresponds to variant rs2584717dbSNPEnsembl.1
Natural variantiVAR_0397191605K → N.Corresponds to variant rs2584697dbSNPEnsembl.1
Natural variantiVAR_0397201650W → C.1 PublicationCorresponds to variant rs1060943dbSNPEnsembl.1
Natural variantiVAR_0397211690A → S.1 PublicationCorresponds to variant rs1060946dbSNPEnsembl.1
Natural variantiVAR_0397221827P → A.Corresponds to variant rs2229014dbSNPEnsembl.1
Natural variantiVAR_0397231881A → P.1 PublicationCorresponds to variant rs1060950dbSNPEnsembl.1
Natural variantiVAR_0397241912A → V.1 PublicationCorresponds to variant rs2584718dbSNPEnsembl.1
Natural variantiVAR_0397251938S → R.1 PublicationCorresponds to variant rs2584719dbSNPEnsembl.1
Natural variantiVAR_0397262056S → R.Corresponds to variant rs1060953dbSNPEnsembl.1
Natural variantiVAR_0397272214H → Y.1 PublicationCorresponds to variant rs1060955dbSNPEnsembl.1
Natural variantiVAR_0397282327D → V.Corresponds to variant rs8026745dbSNPEnsembl.1
Natural variantiVAR_0594322405T → I.Corresponds to variant rs8027254dbSNPEnsembl.1
Natural variantiVAR_0561222461I → T.Corresponds to variant rs8028849dbSNPEnsembl.1
Natural variantiVAR_0594332465D → N.Corresponds to variant rs8027916dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0402402752Q → QSV in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38291 Genomic DNA. Translation: AAB41132.1.
U38292 mRNA. Translation: AAB41133.1.
AC019011 Genomic DNA. No translation available.
AF200415 mRNA. Translation: AAF08305.2.
U80458 mRNA. Translation: AAD00355.1.
Z47038 Genomic DNA. Translation: CAA87104.1.
U14577 mRNA. Translation: AAA81362.1.
CCDSiCCDS42031.1. [P78559-1]
PIRiI38857.
RefSeqiNP_002364.5. NM_002373.5. [P78559-1]
UniGeneiHs.194301.
Hs.619338.

Genome annotation databases

EnsembliENST00000300231; ENSP00000300231; ENSG00000166963. [P78559-1]
GeneIDi4130.
KEGGihsa:4130.
UCSCiuc001zrt.4. human. [P78559-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38291 Genomic DNA. Translation: AAB41132.1.
U38292 mRNA. Translation: AAB41133.1.
AC019011 Genomic DNA. No translation available.
AF200415 mRNA. Translation: AAF08305.2.
U80458 mRNA. Translation: AAD00355.1.
Z47038 Genomic DNA. Translation: CAA87104.1.
U14577 mRNA. Translation: AAA81362.1.
CCDSiCCDS42031.1. [P78559-1]
PIRiI38857.
RefSeqiNP_002364.5. NM_002373.5. [P78559-1]
UniGeneiHs.194301.
Hs.619338.

3D structure databases

ProteinModelPortaliP78559.
SMRiP78559.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110303. 24 interactors.
DIPiDIP-36377N.
IntActiP78559. 11 interactors.
MINTiMINT-1203375.
STRINGi9606.ENSP00000300231.

Chemistry databases

DrugBankiDB01196. Estramustine.

PTM databases

iPTMnetiP78559.
PhosphoSitePlusiP78559.

Polymorphism and mutation databases

BioMutaiMAP1A.
DMDMi313104325.

Proteomic databases

EPDiP78559.
MaxQBiP78559.
PaxDbiP78559.
PeptideAtlasiP78559.
PRIDEiP78559.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300231; ENSP00000300231; ENSG00000166963. [P78559-1]
GeneIDi4130.
KEGGihsa:4130.
UCSCiuc001zrt.4. human. [P78559-1]

Organism-specific databases

CTDi4130.
DisGeNETi4130.
GeneCardsiMAP1A.
HGNCiHGNC:6835. MAP1A.
HPAiHPA039063.
HPA039064.
MIMi600178. gene.
neXtProtiNX_P78559.
OpenTargetsiENSG00000166963.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3592. Eukaryota.
ENOG410XRYM. LUCA.
GeneTreeiENSGT00550000074593.
HOGENOMiHOG000231839.
HOVERGENiHBG052408.
InParanoidiP78559.
KOiK10429.
PhylomeDBiP78559.
TreeFamiTF350229.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166963-MONOMER.

Miscellaneous databases

ChiTaRSiMAP1A. human.
GeneWikiiMAP1A.
GenomeRNAii4130.
PROiP78559.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166963.
CleanExiHS_MAP1A.
ExpressionAtlasiP78559. baseline and differential.
GenevisibleiP78559. HS.

Family and domain databases

Gene3Di3.60.15.10. 2 hits.
InterProiIPR026074. MAP1.
IPR015656. MAP1A.
IPR001279. Metallo-B-lactamas.
[Graphical view]
PANTHERiPTHR13843. PTHR13843. 1 hit.
PTHR13843:SF6. PTHR13843:SF6. 1 hit.
SUPFAMiSSF56281. SSF56281. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMAP1A_HUMAN
AccessioniPrimary (citable) accession number: P78559
Secondary accession number(s): O95643
, Q12973, Q15882, Q9UJT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 148 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.