P78559 (MAP1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Microtubule-associated protein 1A
Short name=MAP-1A

Alternative name(s):
Proliferation-related protein p80

Cleaved into the following 2 chains:

1. MAP1A heavy chain
2. MAP1 light chain LC2

Gene names

Name:	MAP1A
Synonyms:	MAP1L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2803 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Subunit structure	3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with TIAM2. Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D By similarity.
Subcellular location	Cytoplasm › cytoskeleton Probable.
Tissue specificity	Brain.
Domain	The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.
Post-translational modification	Phosphorylated by CSNK1D By similarity. LC2 is generated from MAP1A by proteolytic processing.
Sequence similarities	Belongs to the MAP1 family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	microtubule cytoskeleton organization Inferred from electronic annotation. Source: InterPro sensory perception of sound Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Traceable author statement Ref.1. Source: ProtInc
Molecular_function	structural molecule activity Non-traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DISC1	Q9NRI5	3	EBI-929047,EBI-529989

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P78559-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P78559-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2752-2752: Q → QSV

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2803	2803	Microtubule-associated protein 1A		PRO_0000018600
	Chain	1 – 2566	2566	MAP1A heavy chain		PRO_0000418376
	Chain	2567 – 2803	237	MAP1 light chain LC2		PRO_0000018601
Regions
	Repeat	415 – 417	3	1
	Repeat	420 – 422	3	2
	Repeat	427 – 429	3	3
	Repeat	431 – 433	3	4
	Repeat	436 – 438	3	5
	Repeat	440 – 442	3	6
	Repeat	444 – 446	3	7
	Repeat	449 – 451	3	8
	Repeat	539 – 541	3	9
	Region	415 – 541	127	9 X 3 AA repeats of K-K-[DE]
	Compositional bias	309 – 496	188	Lys-rich (basic)
Amino acid modifications
	Modified residue	114	1	Phosphoserine By similarity
	Modified residue	177	1	Phosphotyrosine By similarity
	Modified residue	526	1	Phosphoserine By similarity
	Modified residue	527	1	Phosphoserine By similarity
	Modified residue	612	1	Phosphoserine Ref.9 Ref.12 Ref.15
	Modified residue	616	1	Phosphothreonine Ref.9 Ref.12 Ref.15
	Modified residue	644	1	Phosphoserine By similarity
	Modified residue	667	1	Phosphoserine Ref.12
	Modified residue	896	1	Phosphoserine Ref.12
	Modified residue	996	1	Phosphoserine By similarity
	Modified residue	1008	1	Phosphothreonine Ref.12
	Modified residue	1013	1	Phosphoserine Ref.12
	Modified residue	1069	1	Phosphoserine Ref.12
	Modified residue	1160	1	Phosphoserine Ref.12
	Modified residue	1218	1	Phosphoserine Ref.12
	Modified residue	1326	1	Phosphoserine Ref.9
	Modified residue	1329	1	Phosphoserine Ref.9
	Modified residue	1654	1	Phosphoserine Ref.12
	Modified residue	1675	1	Phosphoserine Ref.12
	Modified residue	1776	1	Phosphoserine Ref.12
	Modified residue	1791	1	Phosphoserine Ref.12
	Modified residue	1797	1	Phosphoserine Ref.12
	Modified residue	1801	1	Phosphoserine Ref.12
	Modified residue	2022	1	Phosphoserine Ref.7 Ref.9 Ref.12
	Modified residue	2104	1	Phosphoserine Ref.12
	Modified residue	2108	1	Phosphoserine By similarity
	Modified residue	2449	1	Phosphoserine Ref.12
Natural variations
	Alternative sequence	2752	1	Q → QSV in isoform 2.		VSP_040240
	Natural variant	72	1	F → L. Ref.1 Corresponds to variant rs2584695 [ dbSNP | Ensembl ].		VAR_039705
	Natural variant	335	1	A → S. Ref.1 Corresponds to variant rs1060935 [ dbSNP | Ensembl ].		VAR_039706
	Natural variant	336	1	K → T. Ref.1 Corresponds to variant rs1060936 [ dbSNP | Ensembl ].		VAR_039707
	Natural variant	353	1	A → S. Ref.1 Corresponds to variant rs1060937 [ dbSNP | Ensembl ].		VAR_039708
	Natural variant	357	1	A → S. Ref.1 Corresponds to variant rs1060938 [ dbSNP | Ensembl ].		VAR_039709
	Natural variant	364	1	K → Q. Ref.1 Corresponds to variant rs2602129 [ dbSNP | Ensembl ].		VAR_039710
	Natural variant	485	1	K → Q. Corresponds to variant rs2584715 [ dbSNP | Ensembl ].		VAR_039711
	Natural variant	830	1	T → A. Corresponds to variant rs3803337 [ dbSNP | Ensembl ].		VAR_039712
	Natural variant	1078	1	N → S. Corresponds to variant rs8034794 [ dbSNP | Ensembl ].		VAR_039713
	Natural variant	1102	1	I → T. Corresponds to variant rs8036179 [ dbSNP | Ensembl ].		VAR_039714
	Natural variant	1185	1	R → H. Corresponds to variant rs3803335 [ dbSNP | Ensembl ].		VAR_039715
	Natural variant	1245	1	D → N. Corresponds to variant rs12912505 [ dbSNP | Ensembl ].		VAR_039716
	Natural variant	1461	1	D → N. Corresponds to variant rs2245715 [ dbSNP | Ensembl ].		VAR_039717
	Natural variant	1553	1	Q → H. Corresponds to variant rs2584717 [ dbSNP | Ensembl ].		VAR_039718
	Natural variant	1605	1	K → N. Corresponds to variant rs2584697 [ dbSNP | Ensembl ].		VAR_039719
	Natural variant	1650	1	W → C. Ref.1 Corresponds to variant rs1060943 [ dbSNP | Ensembl ].		VAR_039720
	Natural variant	1690	1	A → S. Ref.1 Corresponds to variant rs1060946 [ dbSNP | Ensembl ].		VAR_039721
	Natural variant	1827	1	P → A. Corresponds to variant rs2229014 [ dbSNP | Ensembl ].		VAR_039722
	Natural variant	1881	1	A → P. Ref.1 Corresponds to variant rs1060950 [ dbSNP | Ensembl ].		VAR_039723
	Natural variant	1912	1	A → V. Ref.1 Corresponds to variant rs2584718 [ dbSNP | Ensembl ].		VAR_039724
	Natural variant	1938	1	S → R. Ref.1 Corresponds to variant rs2584719 [ dbSNP | Ensembl ].		VAR_039725
	Natural variant	2056	1	S → R. Corresponds to variant rs1060953 [ dbSNP | Ensembl ].		VAR_039726
	Natural variant	2214	1	H → Y. Ref.1 Corresponds to variant rs1060955 [ dbSNP | Ensembl ].		VAR_039727
	Natural variant	2327	1	D → V. Corresponds to variant rs8026745 [ dbSNP | Ensembl ].		VAR_039728
	Natural variant	2405	1	T → I. Corresponds to variant rs8027254 [ dbSNP | Ensembl ].		VAR_059432
	Natural variant	2461	1	I → T. Corresponds to variant rs8028849 [ dbSNP | Ensembl ].		VAR_056122
	Natural variant	2465	1	D → N. Corresponds to variant rs8027916 [ dbSNP | Ensembl ].		VAR_059433
Experimental info
	Sequence conflict	134 – 135	2	VV → IP in CAA87104. Ref.5
	Sequence conflict	249	1	A → G in CAA87104. Ref.5
	Sequence conflict	263	1	V → A in CAA87104. Ref.5
	Sequence conflict	296	1	Q → H in AAD00355. Ref.4
	Sequence conflict	311	1	S → G in CAA87104. Ref.5
	Sequence conflict	324	1	K → Q in AAD00355. Ref.4
	Sequence conflict	414 – 419	6	EKKDKE → KKKRNS in CAA87104. Ref.5
	Sequence conflict	424	1	K → P in AAB41132. Ref.1
	Sequence conflict	424	1	K → P in AAB41133. Ref.1
	Sequence conflict	426	1	E → D in AAD00355. Ref.4
	Sequence conflict	431	1	K → Q in AAD00355. Ref.4
	Sequence conflict	439	1	E → D in AAD00355. Ref.4
	Sequence conflict	444	1	K → R in AAD00355. Ref.4
	Sequence conflict	452 – 453	2	TK → SS in AAD00355. Ref.4
	Sequence conflict	457	1	K → R in AAD00355. Ref.4
	Sequence conflict	682	1	Q → P in AAB41132. Ref.1
	Sequence conflict	682	1	Q → P in AAB41133. Ref.1
	Sequence conflict	1025	1	Q → K in AAB41132. Ref.1
	Sequence conflict	1025	1	Q → K in AAB41133. Ref.1
	Sequence conflict	1303 – 1313	11	KYLPGAITSPD → EVLTWGDHQALN in AAD00355. Ref.4
	Sequence conflict	1335 – 1341	7	Missing in AAD00355. Ref.4
	Sequence conflict	1368	1	Q → T in AAD00355. Ref.4
	Sequence conflict	1470	1	A → T in AAD00355. Ref.4
	Sequence conflict	1714	1	G → V in AAB41132. Ref.1
	Sequence conflict	1714	1	G → V in AAB41133. Ref.1
	Sequence conflict	1869	1	E → A in AAA81362. Ref.6
	Sequence conflict	1879 – 1883	5	GTAEY → AHSRV in AAA81362. Ref.6
	Sequence conflict	2118	1	P → A in AAB41132. Ref.1
	Sequence conflict	2118	1	P → A in AAB41133. Ref.1
	Sequence conflict	2174	1	Q → E in AAB41132. Ref.1
	Sequence conflict	2174	1	Q → E in AAB41133. Ref.1
	Sequence conflict	2613	1	A → D in AAB41132. Ref.1
	Sequence conflict	2613	1	A → D in AAB41133. Ref.1
	Sequence conflict	2616	1	A → V in AAB41132. Ref.1
	Sequence conflict	2616	1	A → V in AAB41133. Ref.1
	Sequence conflict	2636	1	P → S in AAB41132. Ref.1
	Sequence conflict	2636	1	P → S in AAB41133. Ref.1
	Sequence conflict	2640	1	A → V in AAB41132. Ref.1
	Sequence conflict	2640	1	A → V in AAB41133. Ref.1
	Sequence conflict	2647	1	P → S in AAB41132. Ref.1
	Sequence conflict	2647	1	P → S in AAB41133. Ref.1
	Sequence conflict	2702	1	C → W in AAB41132. Ref.1
	Sequence conflict	2702	1	C → W in AAB41133. Ref.1
Isoform 2:
	Sequence conflict	2753	1	S → V in AAB41132. Ref.1
	Sequence conflict	2753	1	S → V in AAB41133. Ref.1
	Sequence conflict	2754	1	V → K in AAB41132. Ref.1
	Sequence conflict	2754	1	V → K in AAB41133. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 30, 2010. Version 6. Checksum: 94733902420F1FFE	FASTA	2,803	305,485
	10 20 30 40 50 60 MDGVAEFSEY VSETVDVPSP FDLLEPPTSG GFLKLSKPCC YIFPGGRGDS ALFAVNGFNI 70 80 90 100 110 120 LVDGGSDRKS CFWKLVRHLD RIDSVLLTHI GADNLPGING LLQRKVAELE EEQSQGSSSY 130 140 150 160 170 180 SDWVKNLISP ELGVVFFNVP EKLRLPDASR KAKRSIEEAC LTLQHLNRLG IQAEPLYRVV 190 200 210 220 230 240 SNTIEPLTLF HKMGVGRLDM YVLNPVKDSK EMQFLMQKWA GNSKAKTGIV LPNGKEAEIS 250 260 270 280 290 300 VPYLTSITAL VVWLPANPTE KIVRVLFPGN APQNKILEGL EKLRHLDFLR YPVATQKDLA 310 320 330 340 350 360 SGAVPTNLKP SKIKQRADSK ESLKATTKTA VSKLAKREEV VEEGAKEARS ELAKELAKTE 370 380 390 400 410 420 KKAKESSEKP PEKPAKPERV KTESSEALKA EKRKLIKDKV GKKHLKEKIS KLEEKKDKEK 430 440 450 460 470 480 KEIKKERKEL KKDEGRKEEK KDAKKEEKRK DTKPELKKIS KPDLKPFTPE VRKTLYKAKV 490 500 510 520 530 540 PGRVKIDRSR AIRGEKELSS EPQTPPAQKG TVPLPTISGH RELVLSSPED LTQDFEEMKR 550 560 570 580 590 600 EERALLAEQR DTGLGDKPFP LDTAEEGPPS TAIQGTPPSV PGLGQEEHVM KEKELVPEVP 610 620 630 640 650 660 EEQGSKDRGL DSGAETEEEK DTWEEKKQRE AERLPDRTEA REESEPEVKE DVIEKAELEE 670 680 690 700 710 720 MEEVHPSDEE EEDATKAEGF YQKHMQEPLK VTPRSREAFG GRELGLQGKA PEKETSLFLS 730 740 750 760 770 780 SLTTPAGATE HVSYIQDETI PGYSETEQTI SDEEIHDEPE ERPAPPRFHT STYDLPGPEG 790 800 810 820 830 840 AGPFEASQPA DSAVPATSGK VYGTPETELT YPTNIVAAPL AEEEHVSSAT SITECDKLSS 850 860 870 880 890 900 FATSVAEDQS VASLTAPQTE ETGKSSLLLD TVTSIPSSRT EATQGLDYVP SAGTISPTSS 910 920 930 940 950 960 LEEDKGFKSP PCEDFSVTGE SEKRGEIIGK GLSGERAVEE EEEETANVEM SEKLCSQYGT 970 980 990 1000 1010 1020 PVFSAPGHAL HPGEPALGEA EERCLSPDDS TVKMASPPPS GPPSATHTPF HQSPVEEKSE 1030 1040 1050 1060 1070 1080 PQDFQEADSW GDTKRTPGVG KEDAAEETVK PGPEEGTLEK EEKVPPPRSP QAQEAPVNID 1090 1100 1110 1120 1130 1140 EGLTGCTIQL LPAQDKAIVF EIMEAGEPTG PILGAEALPG GLRTLPQEPG KPQKDEVLRY 1150 1160 1170 1180 1190 1200 PDRSLSPEDA ESLSVLSVPS PDTANQEPTP KSPCGLTEQY LHKDRWPEVS PEDTQSLSLS 1210 1220 1230 1240 1250 1260 EESPSKETSL DVSSKQLSPE SLGTLQFGEL NLGKEEMGHL MQAEDTSHHT APMSVPEPHA 1270 1280 1290 1300 1310 1320 ATASPPTDGT TRYSAQTDIT DDSLDRKSPA SSFSHSTPSG NGKYLPGAIT SPDEHILTPD 1330 1340 1350 1360 1370 1380 SSFSKSPESL PGPALEDIAI KWEDKVPGLK DRTSEQKKEP EPKDEVLQQK DKTLEHKEVV 1390 1400 1410 1420 1430 1440 EPKDTAIYQK DEALHVKNEA VKQQDKALEQ KGRDLEQKDT ALEQKDKALE PKDKDLEEKD 1450 1460 1470 1480 1490 1500 KALEQKDKIP EEKDKALEQK DTALEQKDKA LEPKDKDLEQ KDRVLEQKEK IPEEKDKALD 1510 1520 1530 1540 1550 1560 QKVRSVEHKA PEDTVAEMKD RDLEQTDKAP EQKHQAQEQK DKVSEKKDQA LEQKYWALGQ 1570 1580 1590 1600 1610 1620 KDEALEQNIQ ALEENHQTQE QESLVQEDKT RKPKMLEEKS PEKVKAMEEK LEALLEKTKA 1630 1640 1650 1660 1670 1680 LGLEESLVQE GRAREQEEKY WRGQDVVQEW QETSPTREEP AGEQKELAPA WEDTSPEQDN 1690 1700 1710 1720 1730 1740 RYWRGREDVA LEQDTYWREL SCERKVWFPH ELDGQGARPH YTEERESTFL DEGPDDEQEV 1750 1760 1770 1780 1790 1800 PLREHATRSP WASDFKDFQE SSPQKGLEVE RWLAESPVGL PPEEEDKLTR SPFEIISPPA 1810 1820 1830 1840 1850 1860 SPPEMVGQRV PSAPGQESPI PDPKLMPHMK NEPTTPSWLA DIPPWVPKDR PLPPAPLSPA 1870 1880 1890 1900 1910 1920 PGPPTPAPES HTPAPFSWGT AEYDSVVAAV QEGAAELEGG PYSPLGKDYR KAEGEREEEG 1930 1940 1950 1960 1970 1980 RAEAPDKSSH SSKVPEASKS HATTEPEQTE PEQREPTPYP DERSFQYADI YEQMMLTGLG 1990 2000 2010 2020 2030 2040 PACPTREPPL GAAGDWPPCL STKEAAAGRN TSAEKELSSP ISPKSLQSDT PTFSYAALAG 2050 2060 2070 2080 2090 2100 PTVPPRPEPG PSMEPSLTPP AVPPRAPILS KGPSPPLNGN ILSCSPDRRS PSPKESGRSH 2110 2120 2130 2140 2150 2160 WDDSTSDSEL EKGAREQPEK EAQSPSPPHP IPMGSPTLWP ETEAHVSPPL DSHLGPARPS 2170 2180 2190 2200 2210 2220 LDFPASAFGF SSLQPAPPQL PSPAEPRSAP CGSLAFSGDR ALALAPGPPT RTRHDEYLEV 2230 2240 2250 2260 2270 2280 TKAPSLDSSL PQLPSPSSPG APLLSNLPRP ASPALSEGSS SEATTPVISS VAERFSPSLE 2290 2300 2310 2320 2330 2340 AAEQESGELD PGMEPAAHSL WDLTPLSPAP PASLDLALAP APSLPGDMGD GILPCHLECS 2350 2360 2370 2380 2390 2400 EAATEKPSPF QVPSEDCAAN GPTETSPNPP GPAPAKAENE EAAACPAWER GAWPEGAERS 2410 2420 2430 2440 2450 2460 SRPDTLLSPE QPVCPAGGSG GPPSSASPEV EAGPQGCATE PRPHRGELSP SFLNPPLPPS 2470 2480 2490 2500 2510 2520 IDDRDLSTEE VRLVGRGGRR RVGGPGTTGG PCPVTDETPP TSASDSGSSQ SDSDVPPETE 2530 2540 2550 2560 2570 2580 ECPSITAEAA LDSDEDGDFL PVDKAGGVSG THHPRPGHDP PPLPQPDPRP SPPRPDVCMA 2590 2600 2610 2620 2630 2640 DPEGLSSESG RVERLREKEK VQGRVGRRAP GKAKPASPAR RLDLRGKRSP TPGKGPADRA 2650 2660 2670 2680 2690 2700 SRAPPRPRST TSQVTPAEEK DGHSPMSKGL VNGLKAGPMA LSSKGSSGAP VYVDLAYIPN 2710 2720 2730 2740 2750 2760 HCSGKTADLD FFRRVRASYY VVSGNDPANG EPSRAVLDAL LEGKAQWGEN LQVTLIPTHD 2770 2780 2790 2800 TEVTREWYQQ THEQQQQLNV LVLASSSTVV MQDESFPACK IEF
	Isoform 2 [UniParc]. Checksum: 28E9817E8116EF8A	FASTA	2,805	305,671
	10 20 30 40 50 60 MDGVAEFSEY VSETVDVPSP FDLLEPPTSG GFLKLSKPCC YIFPGGRGDS ALFAVNGFNI 70 80 90 100 110 120 LVDGGSDRKS CFWKLVRHLD RIDSVLLTHI GADNLPGING LLQRKVAELE EEQSQGSSSY 130 140 150 160 170 180 SDWVKNLISP ELGVVFFNVP EKLRLPDASR KAKRSIEEAC LTLQHLNRLG IQAEPLYRVV 190 200 210 220 230 240 SNTIEPLTLF HKMGVGRLDM YVLNPVKDSK EMQFLMQKWA GNSKAKTGIV LPNGKEAEIS 250 260 270 280 290 300 VPYLTSITAL VVWLPANPTE KIVRVLFPGN APQNKILEGL EKLRHLDFLR YPVATQKDLA 310 320 330 340 350 360 SGAVPTNLKP SKIKQRADSK ESLKATTKTA VSKLAKREEV VEEGAKEARS ELAKELAKTE 370 380 390 400 410 420 KKAKESSEKP PEKPAKPERV KTESSEALKA EKRKLIKDKV GKKHLKEKIS KLEEKKDKEK 430 440 450 460 470 480 KEIKKERKEL KKDEGRKEEK KDAKKEEKRK DTKPELKKIS KPDLKPFTPE VRKTLYKAKV 490 500 510 520 530 540 PGRVKIDRSR AIRGEKELSS EPQTPPAQKG TVPLPTISGH RELVLSSPED LTQDFEEMKR 550 560 570 580 590 600 EERALLAEQR DTGLGDKPFP LDTAEEGPPS TAIQGTPPSV PGLGQEEHVM KEKELVPEVP 610 620 630 640 650 660 EEQGSKDRGL DSGAETEEEK DTWEEKKQRE AERLPDRTEA REESEPEVKE DVIEKAELEE 670 680 690 700 710 720 MEEVHPSDEE EEDATKAEGF YQKHMQEPLK VTPRSREAFG GRELGLQGKA PEKETSLFLS 730 740 750 760 770 780 SLTTPAGATE HVSYIQDETI PGYSETEQTI SDEEIHDEPE ERPAPPRFHT STYDLPGPEG 790 800 810 820 830 840 AGPFEASQPA DSAVPATSGK VYGTPETELT YPTNIVAAPL AEEEHVSSAT SITECDKLSS 850 860 870 880 890 900 FATSVAEDQS VASLTAPQTE ETGKSSLLLD TVTSIPSSRT EATQGLDYVP SAGTISPTSS 910 920 930 940 950 960 LEEDKGFKSP PCEDFSVTGE SEKRGEIIGK GLSGERAVEE EEEETANVEM SEKLCSQYGT 970 980 990 1000 1010 1020 PVFSAPGHAL HPGEPALGEA EERCLSPDDS TVKMASPPPS GPPSATHTPF HQSPVEEKSE 1030 1040 1050 1060 1070 1080 PQDFQEADSW GDTKRTPGVG KEDAAEETVK PGPEEGTLEK EEKVPPPRSP QAQEAPVNID 1090 1100 1110 1120 1130 1140 EGLTGCTIQL LPAQDKAIVF EIMEAGEPTG PILGAEALPG GLRTLPQEPG KPQKDEVLRY 1150 1160 1170 1180 1190 1200 PDRSLSPEDA ESLSVLSVPS PDTANQEPTP KSPCGLTEQY LHKDRWPEVS PEDTQSLSLS 1210 1220 1230 1240 1250 1260 EESPSKETSL DVSSKQLSPE SLGTLQFGEL NLGKEEMGHL MQAEDTSHHT APMSVPEPHA 1270 1280 1290 1300 1310 1320 ATASPPTDGT TRYSAQTDIT DDSLDRKSPA SSFSHSTPSG NGKYLPGAIT SPDEHILTPD 1330 1340 1350 1360 1370 1380 SSFSKSPESL PGPALEDIAI KWEDKVPGLK DRTSEQKKEP EPKDEVLQQK DKTLEHKEVV 1390 1400 1410 1420 1430 1440 EPKDTAIYQK DEALHVKNEA VKQQDKALEQ KGRDLEQKDT ALEQKDKALE PKDKDLEEKD 1450 1460 1470 1480 1490 1500 KALEQKDKIP EEKDKALEQK DTALEQKDKA LEPKDKDLEQ KDRVLEQKEK IPEEKDKALD 1510 1520 1530 1540 1550 1560 QKVRSVEHKA PEDTVAEMKD RDLEQTDKAP EQKHQAQEQK DKVSEKKDQA LEQKYWALGQ 1570 1580 1590 1600 1610 1620 KDEALEQNIQ ALEENHQTQE QESLVQEDKT RKPKMLEEKS PEKVKAMEEK LEALLEKTKA 1630 1640 1650 1660 1670 1680 LGLEESLVQE GRAREQEEKY WRGQDVVQEW QETSPTREEP AGEQKELAPA WEDTSPEQDN 1690 1700 1710 1720 1730 1740 RYWRGREDVA LEQDTYWREL SCERKVWFPH ELDGQGARPH YTEERESTFL DEGPDDEQEV 1750 1760 1770 1780 1790 1800 PLREHATRSP WASDFKDFQE SSPQKGLEVE RWLAESPVGL PPEEEDKLTR SPFEIISPPA 1810 1820 1830 1840 1850 1860 SPPEMVGQRV PSAPGQESPI PDPKLMPHMK NEPTTPSWLA DIPPWVPKDR PLPPAPLSPA 1870 1880 1890 1900 1910 1920 PGPPTPAPES HTPAPFSWGT AEYDSVVAAV QEGAAELEGG PYSPLGKDYR KAEGEREEEG 1930 1940 1950 1960 1970 1980 RAEAPDKSSH SSKVPEASKS HATTEPEQTE PEQREPTPYP DERSFQYADI YEQMMLTGLG 1990 2000 2010 2020 2030 2040 PACPTREPPL GAAGDWPPCL STKEAAAGRN TSAEKELSSP ISPKSLQSDT PTFSYAALAG 2050 2060 2070 2080 2090 2100 PTVPPRPEPG PSMEPSLTPP AVPPRAPILS KGPSPPLNGN ILSCSPDRRS PSPKESGRSH 2110 2120 2130 2140 2150 2160 WDDSTSDSEL EKGAREQPEK EAQSPSPPHP IPMGSPTLWP ETEAHVSPPL DSHLGPARPS 2170 2180 2190 2200 2210 2220 LDFPASAFGF SSLQPAPPQL PSPAEPRSAP CGSLAFSGDR ALALAPGPPT RTRHDEYLEV 2230 2240 2250 2260 2270 2280 TKAPSLDSSL PQLPSPSSPG APLLSNLPRP ASPALSEGSS SEATTPVISS VAERFSPSLE 2290 2300 2310 2320 2330 2340 AAEQESGELD PGMEPAAHSL WDLTPLSPAP PASLDLALAP APSLPGDMGD GILPCHLECS 2350 2360 2370 2380 2390 2400 EAATEKPSPF QVPSEDCAAN GPTETSPNPP GPAPAKAENE EAAACPAWER GAWPEGAERS 2410 2420 2430 2440 2450 2460 SRPDTLLSPE QPVCPAGGSG GPPSSASPEV EAGPQGCATE PRPHRGELSP SFLNPPLPPS 2470 2480 2490 2500 2510 2520 IDDRDLSTEE VRLVGRGGRR RVGGPGTTGG PCPVTDETPP TSASDSGSSQ SDSDVPPETE 2530 2540 2550 2560 2570 2580 ECPSITAEAA LDSDEDGDFL PVDKAGGVSG THHPRPGHDP PPLPQPDPRP SPPRPDVCMA 2590 2600 2610 2620 2630 2640 DPEGLSSESG RVERLREKEK VQGRVGRRAP GKAKPASPAR RLDLRGKRSP TPGKGPADRA 2650 2660 2670 2680 2690 2700 SRAPPRPRST TSQVTPAEEK DGHSPMSKGL VNGLKAGPMA LSSKGSSGAP VYVDLAYIPN 2710 2720 2730 2740 2750 2760 HCSGKTADLD FFRRVRASYY VVSGNDPANG EPSRAVLDAL LEGKAQWGEN LQSVVTLIPT 2770 2780 2790 2800 HDTEVTREWY QQTHEQQQQL NVLVLASSST VVMQDESFPA CKIEF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression." Fink J.K., Jones S.M., Esposito C., Wilkowski J. Genomics 35:577-585(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS LEU-72; SER-335; THR-336; SER-353; SER-357; GLN-364; CYS-1650; SER-1690; PRO-1881; VAL-1912; ARG-1938 AND TYR-2214.
[2]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Identification of a novel protein (P80) in ovarian carcinoma cells." Chen Z.C., Fadiel A., Naftolin F. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1825. Tissue: Ovarian carcinoma.
[4]	"Microtubule associated protein 1A (MAP1A) in human brain -- DNA sequence and physiological role." Ohtani K., Rutherford T., Sakamoto H., Naftolin F. Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 78-1687. Tissue: Brain.
[5]	Chiannilkulchai N., Pasturaud P., Richard I., Auffray C., Beckmann J.S. Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-419. Tissue: Fetal muscle.
[6]	"Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15." Fukuyama R., Rapoport S.I. J. Neurosci. Res. 40:820-825(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1607-1883. Tissue: Brain.
[7]	"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry." Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C. Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2022, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[8]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-612; THR-616; SER-1326; SER-1329 AND SER-2022, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Embryonic kidney.
[11]	"MAP1 structural organization in Drosophila: in vivo analysis of FUTSCH reveals heavy- and light-chain subunits generated by proteolytic processing at a conserved cleavage site." Zou B., Yan H., Kawasaki F., Ordway R.W. Biochem. J. 414:63-71(2008) [PubMed] [Europe PMC] [Abstract] Cited for: CLEAVAGE SITE.
[12]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-612; THR-616; SER-667; SER-896; THR-1008; SER-1013; SER-1069; SER-1160; SER-1218; SER-1654; SER-1675; SER-1776; SER-1791; SER-1797; SER-1801; SER-2022; SER-2104 AND SER-2449, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-612 AND THR-616, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U38291 Genomic DNA. Translation: AAB41132.1. U38292 mRNA. Translation: AAB41133.1. AC019011 Genomic DNA. No translation available. AF200415 mRNA. Translation: AAF08305.2. U80458 mRNA. Translation: AAD00355.1. Z47038 Genomic DNA. Translation: CAA87104.1. U14577 mRNA. Translation: AAA81362.1.
IPI	IPI00020356. IPI00887765.
PIR	I38857.
RefSeq	NP_002364.5. NM_002373.5.
UniGene	Hs.194301. Hs.619338.
3D structure databases
ProteinModelPortal	P78559.
ModBase	Search...
Protein-protein interaction databases
IntAct	P78559. 8 interactions.
MINT	MINT-1203375.
STRING	9606.ENSP00000300231.
PTM databases
PhosphoSite	P78559.
Polymorphism databases
DMDM	172046662.
Proteomic databases
PaxDb	P78559.
PRIDE	P78559.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300231; ENSP00000300231; ENSG00000166963.
GeneID	4130.
KEGG	hsa:4130.
UCSC	uc001zrt.3. human.
Organism-specific databases
CTD	4130.
GeneCards	GC15P043803.
HGNC	HGNC:6835. MAP1A.
HPA	HPA039064.
MIM	600178. gene.
neXtProt	NX_P78559.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000231839.
HOVERGEN	HBG052408.
KO	K10429.
Gene expression databases
ArrayExpress	P78559.
Bgee	P78559.
CleanEx	HS_MAP1A.
Genevestigator	P78559.
GermOnline	ENSG00000166963. Homo sapiens.
Family and domain databases
InterPro	IPR026074. MAP1. IPR015656. MAP1A. [Graphical view]
PANTHER	PTHR13843. PTHR13843. 1 hit. PTHR13843:SF6. PTHR13843:SF6. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	MAP1A. human.
DrugBank	DB01196. Estramustine.
GenomeRNAi	4130.
NextBio	16214.
SOURCE	Search...

Entry information

Entry name

MAP1A_HUMAN

Accession

Primary (citable) accession number: P78559
Secondary accession number(s): O95643 , Q12973, Q15882, Q9UJT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 113 of the entry and version 6 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.