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Protein

Microtubule-associated protein 1A

Gene

MAP1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.

GO - Molecular functioni

  • microtubule binding Source: InterPro
  • structural molecule activity Source: ProtInc

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 1A
Short name:
MAP-1A
Alternative name(s):
Proliferation-related protein p80
Cleaved into the following 2 chains:
Gene namesi
Name:MAP1A
Synonyms:MAP1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000166963.12.
HGNCiHGNC:6835. MAP1A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi4130.
OpenTargetsiENSG00000166963.

Chemistry databases

DrugBankiDB01196. Estramustine.

Polymorphism and mutation databases

BioMutaiMAP1A.
DMDMi313104325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000186001 – 2803Microtubule-associated protein 1AAdd BLAST2803
ChainiPRO_00004183761 – 2566MAP1A heavy chainAdd BLAST2566
ChainiPRO_00000186012567 – 2803MAP1 light chain LC2Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114PhosphoserineHMP:1
Modified residuei117PhosphoserineND:1
Modified residuei118PhosphoserineHMP:1
Modified residuei121PhosphoserineHMP:1
Modified residuei155PhosphoserineHMP:1
Modified residuei177PhosphotyrosineHMP:1
Modified residuei319PhosphoserineHMP:1
Modified residuei322PhosphoserineHMP:1
Modified residuei384PhosphoserineHMP:1
Modified residuei504PhosphothreonineND:1
Modified residuei526PhosphoserineND:1
Modified residuei527PhosphoserineND:1
Modified residuei605PhosphoserineND:1
Modified residuei612PhosphoserineND:1
Modified residuei616PhosphothreonineND:1
Modified residuei644PhosphoserineND:1
Modified residuei667PhosphoserineND:1
Modified residuei787PhosphoserineND:1
Modified residuei874PhosphoserineHMP:1
Modified residuei877PhosphoserineHMP:1
Modified residuei878PhosphoserineHMP:1
Modified residuei891PhosphoserineHMP:1
Modified residuei894PhosphothreonineHMP:1
Modified residuei896PhosphoserineND:1
Modified residuei900PhosphoserineHMP:1
Modified residuei909PhosphoserineND:1
Modified residuei986PhosphoserineND:1
Modified residuei996PhosphoserineHMP:1
Modified residuei1004PhosphoserineHMP:1
Modified residuei1013PhosphoserineHMP:1
Modified residuei1019PhosphoserineHMP:1
Modified residuei1029PhosphoserineHMP:1
Modified residuei1069PhosphoserineND:1
Modified residuei1144PhosphoserineHMP:1
Modified residuei1146PhosphoserineHMP:1
Modified residuei1160PhosphoserineND:1
Modified residuei1172PhosphoserineND:1
Modified residuei1190PhosphoserineND:1
Modified residuei1200PhosphoserineND:1
Modified residuei1203PhosphoserineND:1
Modified residuei1209PhosphoserineHMP:1
Modified residuei1218PhosphoserineND:1
Modified residuei1221PhosphoserineHMP:1
Modified residuei1264PhosphoserineHMP:1
Modified residuei1326PhosphoserineND:1
Modified residuei1329PhosphoserineND:1
Modified residuei1544PhosphoserineHMP:1
Modified residuei1600PhosphoserineND:1
Modified residuei1626PhosphoserineND:1
Modified residuei1654PhosphoserineND:1
Modified residuei1675PhosphoserineND:1
Modified residuei1749PhosphoserineND:1
Modified residuei1762PhosphoserineND:1
Modified residuei1776PhosphoserineND:1
Modified residuei1791PhosphoserineND:1
Modified residuei1797PhosphoserineND:1
Modified residuei1801PhosphoserineND:1
Modified residuei1812PhosphoserineHMP:1
Modified residuei1818PhosphoserineND:1
Modified residuei1931PhosphoserineHMP:1
Modified residuei1957PhosphothreonineND:1
Modified residuei2022PhosphoserineND:1
Modified residuei2058PhosphothreonineHMP:1
Modified residuei2074PhosphoserineND:1
Modified residuei2104PhosphoserineND:1
Modified residuei2106PhosphoserineND:1
Modified residuei2108PhosphoserineHMP:1
Modified residuei2235PhosphoserineHMP:1
Modified residuei2252PhosphoserineHMP:1
Modified residuei2256PhosphoserineHMP:1
Modified residuei2259PhosphoserineHMP:1
Modified residuei2260PhosphoserineHMP:1
Modified residuei2449PhosphoserineND:1
Modified residuei2649PhosphoserineND:1
Modified residuei2664PhosphoserineND:1

Post-translational modificationi

Phosphorylated by CSNK1D.HMP:
LC2 is generated from MAP1A by proteolytic processing.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP78559.
MaxQBiP78559.
PaxDbiP78559.
PeptideAtlasiP78559.
PRIDEiP78559.

PTM databases

iPTMnetiP78559.
PhosphoSitePlusiP78559.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000166963.
CleanExiHS_MAP1A.
ExpressionAtlasiP78559. baseline and differential.
GenevisibleiP78559. HS.

Organism-specific databases

HPAiHPA039063.
HPA039064.
HPA066488.

Interactioni

Subunit structurei

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with TIAM2. Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D (By similarity).HMP:

Binary interactionsi

WithEntry#Exp.IntActNotes
DISC1Q9NRI53EBI-929047,EBI-529989

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110303. 24 interactors.
DIPiDIP-36377N.
IntActiP78559. 14 interactors.
MINTiMINT-1203375.
STRINGi9606.ENSP00000300231.

Structurei

3D structure databases

ProteinModelPortaliP78559.
SMRiP78559.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati415 – 41713
Repeati420 – 42223
Repeati427 – 42933
Repeati431 – 43343
Repeati436 – 43853
Repeati440 – 44263
Repeati444 – 44673
Repeati449 – 45183
Repeati539 – 54193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni415 – 5419 X 3 AA repeats of K-K-[DE]Add BLAST127

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi309 – 496Lys-rich (basic)Add BLAST188

Domaini

The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.

Sequence similaritiesi

Belongs to the MAP1 family.IKR:

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3592. Eukaryota.
ENOG410XRYM. LUCA.
GeneTreeiENSGT00550000074593.
HOGENOMiHOG000231839.
HOVERGENiHBG052408.
InParanoidiP78559.
KOiK10429.
PhylomeDBiP78559.
TreeFamiTF350229.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiView protein in InterPro
IPR026074. MAP1.
IPR015656. MAP1A.
IPR036866. Metallo-hydrolase/OxRdtase.
PANTHERiPTHR13843. PTHR13843. 2 hits.
PTHR13843:SF6. PTHR13843:SF6. 2 hits.
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P78559-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGVAEFSEY VSETVDVPSP FDLLEPPTSG GFLKLSKPCC YIFPGGRGDS
60 70 80 90 100
ALFAVNGFNI LVDGGSDRKS CFWKLVRHLD RIDSVLLTHI GADNLPGING
110 120 130 140 150
LLQRKVAELE EEQSQGSSSY SDWVKNLISP ELGVVFFNVP EKLRLPDASR
160 170 180 190 200
KAKRSIEEAC LTLQHLNRLG IQAEPLYRVV SNTIEPLTLF HKMGVGRLDM
210 220 230 240 250
YVLNPVKDSK EMQFLMQKWA GNSKAKTGIV LPNGKEAEIS VPYLTSITAL
260 270 280 290 300
VVWLPANPTE KIVRVLFPGN APQNKILEGL EKLRHLDFLR YPVATQKDLA
310 320 330 340 350
SGAVPTNLKP SKIKQRADSK ESLKATTKTA VSKLAKREEV VEEGAKEARS
360 370 380 390 400
ELAKELAKTE KKAKESSEKP PEKPAKPERV KTESSEALKA EKRKLIKDKV
410 420 430 440 450
GKKHLKEKIS KLEEKKDKEK KEIKKERKEL KKDEGRKEEK KDAKKEEKRK
460 470 480 490 500
DTKPELKKIS KPDLKPFTPE VRKTLYKAKV PGRVKIDRSR AIRGEKELSS
510 520 530 540 550
EPQTPPAQKG TVPLPTISGH RELVLSSPED LTQDFEEMKR EERALLAEQR
560 570 580 590 600
DTGLGDKPFP LDTAEEGPPS TAIQGTPPSV PGLGQEEHVM KEKELVPEVP
610 620 630 640 650
EEQGSKDRGL DSGAETEEEK DTWEEKKQRE AERLPDRTEA REESEPEVKE
660 670 680 690 700
DVIEKAELEE MEEVHPSDEE EEDATKAEGF YQKHMQEPLK VTPRSREAFG
710 720 730 740 750
GRELGLQGKA PEKETSLFLS SLTTPAGATE HVSYIQDETI PGYSETEQTI
760 770 780 790 800
SDEEIHDEPE ERPAPPRFHT STYDLPGPEG AGPFEASQPA DSAVPATSGK
810 820 830 840 850
VYGTPETELT YPTNIVAAPL AEEEHVSSAT SITECDKLSS FATSVAEDQS
860 870 880 890 900
VASLTAPQTE ETGKSSLLLD TVTSIPSSRT EATQGLDYVP SAGTISPTSS
910 920 930 940 950
LEEDKGFKSP PCEDFSVTGE SEKRGEIIGK GLSGERAVEE EEEETANVEM
960 970 980 990 1000
SEKLCSQYGT PVFSAPGHAL HPGEPALGEA EERCLSPDDS TVKMASPPPS
1010 1020 1030 1040 1050
GPPSATHTPF HQSPVEEKSE PQDFQEADSW GDTKRTPGVG KEDAAEETVK
1060 1070 1080 1090 1100
PGPEEGTLEK EEKVPPPRSP QAQEAPVNID EGLTGCTIQL LPAQDKAIVF
1110 1120 1130 1140 1150
EIMEAGEPTG PILGAEALPG GLRTLPQEPG KPQKDEVLRY PDRSLSPEDA
1160 1170 1180 1190 1200
ESLSVLSVPS PDTANQEPTP KSPCGLTEQY LHKDRWPEVS PEDTQSLSLS
1210 1220 1230 1240 1250
EESPSKETSL DVSSKQLSPE SLGTLQFGEL NLGKEEMGHL MQAEDTSHHT
1260 1270 1280 1290 1300
APMSVPEPHA ATASPPTDGT TRYSAQTDIT DDSLDRKSPA SSFSHSTPSG
1310 1320 1330 1340 1350
NGKYLPGAIT SPDEHILTPD SSFSKSPESL PGPALEDIAI KWEDKVPGLK
1360 1370 1380 1390 1400
DRTSEQKKEP EPKDEVLQQK DKTLEHKEVV EPKDTAIYQK DEALHVKNEA
1410 1420 1430 1440 1450
VKQQDKALEQ KGRDLEQKDT ALEQKDKALE PKDKDLEEKD KALEQKDKIP
1460 1470 1480 1490 1500
EEKDKALEQK DTALEQKDKA LEPKDKDLEQ KDRVLEQKEK IPEEKDKALD
1510 1520 1530 1540 1550
QKVRSVEHKA PEDTVAEMKD RDLEQTDKAP EQKHQAQEQK DKVSEKKDQA
1560 1570 1580 1590 1600
LEQKYWALGQ KDEALEQNIQ ALEENHQTQE QESLVQEDKT RKPKMLEEKS
1610 1620 1630 1640 1650
PEKVKAMEEK LEALLEKTKA LGLEESLVQE GRAREQEEKY WRGQDVVQEW
1660 1670 1680 1690 1700
QETSPTREEP AGEQKELAPA WEDTSPEQDN RYWRGREDVA LEQDTYWREL
1710 1720 1730 1740 1750
SCERKVWFPH ELDGQGARPH YTEERESTFL DEGPDDEQEV PLREHATRSP
1760 1770 1780 1790 1800
WASDFKDFQE SSPQKGLEVE RWLAESPVGL PPEEEDKLTR SPFEIISPPA
1810 1820 1830 1840 1850
SPPEMVGQRV PSAPGQESPI PDPKLMPHMK NEPTTPSWLA DIPPWVPKDR
1860 1870 1880 1890 1900
PLPPAPLSPA PGPPTPAPES HTPAPFSWGT AEYDSVVAAV QEGAAELEGG
1910 1920 1930 1940 1950
PYSPLGKDYR KAEGEREEEG RAEAPDKSSH SSKVPEASKS HATTEPEQTE
1960 1970 1980 1990 2000
PEQREPTPYP DERSFQYADI YEQMMLTGLG PACPTREPPL GAAGDWPPCL
2010 2020 2030 2040 2050
STKEAAAGRN TSAEKELSSP ISPKSLQSDT PTFSYAALAG PTVPPRPEPG
2060 2070 2080 2090 2100
PSMEPSLTPP AVPPRAPILS KGPSPPLNGN ILSCSPDRRS PSPKESGRSH
2110 2120 2130 2140 2150
WDDSTSDSEL EKGAREQPEK EAQSPSPPHP IPMGSPTLWP ETEAHVSPPL
2160 2170 2180 2190 2200
DSHLGPARPS LDFPASAFGF SSLQPAPPQL PSPAEPRSAP CGSLAFSGDR
2210 2220 2230 2240 2250
ALALAPGPPT RTRHDEYLEV TKAPSLDSSL PQLPSPSSPG APLLSNLPRP
2260 2270 2280 2290 2300
ASPALSEGSS SEATTPVISS VAERFSPSLE AAEQESGELD PGMEPAAHSL
2310 2320 2330 2340 2350
WDLTPLSPAP PASLDLALAP APSLPGDMGD GILPCHLECS EAATEKPSPF
2360 2370 2380 2390 2400
QVPSEDCAAN GPTETSPNPP GPAPAKAENE EAAACPAWER GAWPEGAERS
2410 2420 2430 2440 2450
SRPDTLLSPE QPVCPAGGSG GPPSSASPEV EAGPQGCATE PRPHRGELSP
2460 2470 2480 2490 2500
SFLNPPLPPS IDDRDLSTEE VRLVGRGGRR RVGGPGTTGG PCPVTDETPP
2510 2520 2530 2540 2550
TSASDSGSSQ SDSDVPPETE ECPSITAEAA LDSDEDGDFL PVDKAGGVSG
2560 2570 2580 2590 2600
THHPRPGHDP PPLPQPDPRP SPPRPDVCMA DPEGLSSESG RVERLREKEK
2610 2620 2630 2640 2650
VQGRVGRRAP GKAKPASPAR RLDLRGKRSP TPGKGPADRA SRAPPRPRST
2660 2670 2680 2690 2700
TSQVTPAEEK DGHSPMSKGL VNGLKAGPMA LSSKGSSGAP VYVDLAYIPN
2710 2720 2730 2740 2750
HCSGKTADLD FFRRVRASYY VVSGNDPANG EPSRAVLDAL LEGKAQWGEN
2760 2770 2780 2790 2800
LQVTLIPTHD TEVTREWYQQ THEQQQQLNV LVLASSSTVV MQDESFPACK

IEF
Length:2,803
Mass (Da):305,485
Last modified:November 30, 2010 - v6
Checksum:i94733902420F1FFE
GO
Isoform 2 (identifier: P78559-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2752-2752: Q → QSV

Show »
Length:2,805
Mass (Da):305,671
Checksum:i28E9817E8116EF8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134 – 135VV → IP in CAA87104 (Ref. 5) IKR:2
Sequence conflicti249A → G in CAA87104 (Ref. 5) IKR:1
Sequence conflicti263V → A in CAA87104 (Ref. 5) IKR:1
Sequence conflicti296Q → H in AAD00355 (Ref. 4) IKR:1
Sequence conflicti311S → G in CAA87104 (Ref. 5) IKR:1
Sequence conflicti324K → Q in AAD00355 (Ref. 4) IKR:1
Sequence conflicti414 – 419EKKDKE → KKKRNS in CAA87104 (Ref. 5) IKR:6
Sequence conflicti424K → P in AAB41132 (PubMed:8812494).IKR:1
Sequence conflicti424K → P in AAB41133 (PubMed:8812494).IKR:1
Sequence conflicti426E → D in AAD00355 (Ref. 4) IKR:1
Sequence conflicti431K → Q in AAD00355 (Ref. 4) IKR:1
Sequence conflicti439E → D in AAD00355 (Ref. 4) IKR:1
Sequence conflicti444K → R in AAD00355 (Ref. 4) IKR:1
Sequence conflicti452 – 453TK → SS in AAD00355 (Ref. 4) IKR:2
Sequence conflicti457K → R in AAD00355 (Ref. 4) IKR:1
Sequence conflicti682Q → P in AAB41132 (PubMed:8812494).IKR:1
Sequence conflicti682Q → P in AAB41133 (PubMed:8812494).IKR:1
Sequence conflicti1025Q → K in AAB41132 (PubMed:8812494).IKR:1
Sequence conflicti1025Q → K in AAB41133 (PubMed:8812494).IKR:1
Sequence conflicti1303 – 1313KYLPGAITSPD → EVLTWGDHQALN in AAD00355 (Ref. 4) IKR:Add BLAST11
Sequence conflicti1335 – 1341Missing in AAD00355 (Ref. 4) IKR:7
Sequence conflicti1368Q → T in AAD00355 (Ref. 4) IKR:1
Sequence conflicti1470A → T in AAD00355 (Ref. 4) IKR:1
Sequence conflicti1714G → V in AAB41132 (PubMed:8812494).IKR:1
Sequence conflicti1714G → V in AAB41133 (PubMed:8812494).IKR:1
Sequence conflicti1869E → A in AAA81362 (PubMed:7629894).IKR:1
Sequence conflicti1879 – 1883GTAEY → AHSRV in AAA81362 (PubMed:7629894).IKR:5
Sequence conflicti2118P → A in AAB41132 (PubMed:8812494).IKR:1
Sequence conflicti2118P → A in AAB41133 (PubMed:8812494).IKR:1
Sequence conflicti2174Q → E in AAB41132 (PubMed:8812494).IKR:1
Sequence conflicti2174Q → E in AAB41133 (PubMed:8812494).IKR:1
Sequence conflicti2613A → D in AAB41132 (PubMed:8812494).IKR:1
Sequence conflicti2613A → D in AAB41133 (PubMed:8812494).IKR:1
Sequence conflicti2616A → V in AAB41132 (PubMed:8812494).IKR:1
Sequence conflicti2616A → V in AAB41133 (PubMed:8812494).IKR:1
Sequence conflicti2636P → S in AAB41132 (PubMed:8812494).IKR:1
Sequence conflicti2636P → S in AAB41133 (PubMed:8812494).IKR:1
Sequence conflicti2640A → V in AAB41132 (PubMed:8812494).IKR:1
Sequence conflicti2640A → V in AAB41133 (PubMed:8812494).IKR:1
Sequence conflicti2647P → S in AAB41132 (PubMed:8812494).IKR:1
Sequence conflicti2647P → S in AAB41133 (PubMed:8812494).IKR:1
Sequence conflicti2702C → W in AAB41132 (PubMed:8812494).IKR:1
Sequence conflicti2702C → W in AAB41133 (PubMed:8812494).IKR:1
Isoform 2 (identifier: P78559-2)
Sequence conflicti2753S → V in AAB41132 (PubMed:8812494).IKR:1
Sequence conflicti2753S → V in AAB41133 (PubMed:8812494).IKR:1
Sequence conflicti2754V → K in AAB41132 (PubMed:8812494).IKR:1
Sequence conflicti2754V → K in AAB41133 (PubMed:8812494).IKR:1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03970572F → L1 PublicationCorresponds to variant dbSNP:rs2584695Ensembl.1
Natural variantiVAR_039706335A → S1 PublicationCorresponds to variant dbSNP:rs1060935Ensembl.1
Natural variantiVAR_039707336K → T1 PublicationCorresponds to variant dbSNP:rs1060936Ensembl.1
Natural variantiVAR_039708353A → S1 PublicationCorresponds to variant dbSNP:rs1060937Ensembl.1
Natural variantiVAR_039709357A → S1 PublicationCorresponds to variant dbSNP:rs1060938Ensembl.1
Natural variantiVAR_039710364K → Q1 PublicationCorresponds to variant dbSNP:rs2602129Ensembl.1
Natural variantiVAR_039711485K → Q. Corresponds to variant dbSNP:rs2584715Ensembl.1
Natural variantiVAR_039712830T → A. Corresponds to variant dbSNP:rs3803337Ensembl.1
Natural variantiVAR_0397131078N → S. Corresponds to variant dbSNP:rs8034794Ensembl.1
Natural variantiVAR_0397141102I → T. Corresponds to variant dbSNP:rs8036179Ensembl.1
Natural variantiVAR_0397151185R → H. Corresponds to variant dbSNP:rs3803335Ensembl.1
Natural variantiVAR_0397161245D → N. Corresponds to variant dbSNP:rs12912505Ensembl.1
Natural variantiVAR_0397171461D → N. Corresponds to variant dbSNP:rs2245715Ensembl.1
Natural variantiVAR_0397181553Q → H. Corresponds to variant dbSNP:rs2584717Ensembl.1
Natural variantiVAR_0397191605K → N. Corresponds to variant dbSNP:rs2584697Ensembl.1
Natural variantiVAR_0397201650W → C1 PublicationCorresponds to variant dbSNP:rs1060943Ensembl.1
Natural variantiVAR_0397211690A → S1 PublicationCorresponds to variant dbSNP:rs1060946Ensembl.1
Natural variantiVAR_0397221827P → A. Corresponds to variant dbSNP:rs2229014Ensembl.1
Natural variantiVAR_0397231881A → P1 PublicationCorresponds to variant dbSNP:rs1060950Ensembl.1
Natural variantiVAR_0397241912A → V1 PublicationCorresponds to variant dbSNP:rs2584718Ensembl.1
Natural variantiVAR_0397251938S → R1 PublicationCorresponds to variant dbSNP:rs2584719Ensembl.1
Natural variantiVAR_0397262056S → R. Corresponds to variant dbSNP:rs1060953Ensembl.1
Natural variantiVAR_0397272214H → Y1 PublicationCorresponds to variant dbSNP:rs1060955Ensembl.1
Natural variantiVAR_0397282327D → V. Corresponds to variant dbSNP:rs8026745Ensembl.1
Natural variantiVAR_0594322405T → I. Corresponds to variant dbSNP:rs8027254Ensembl.1
Natural variantiVAR_0561222461I → T. Corresponds to variant dbSNP:rs8028849Ensembl.1
Natural variantiVAR_0594332465D → N. Corresponds to variant dbSNP:rs8027916Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0402402752Q → QSV in isoform 2. IKR:1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38291 Genomic DNA. Translation: AAB41132.1.
U38292 mRNA. Translation: AAB41133.1.
AC019011 Genomic DNA. No translation available.
AF200415 mRNA. Translation: AAF08305.2.
U80458 mRNA. Translation: AAD00355.1.
Z47038 Genomic DNA. Translation: CAA87104.1.
U14577 mRNA. Translation: AAA81362.1.
CCDSiCCDS42031.1. [P78559-1]
PIRiI38857.
RefSeqiNP_002364.5. NM_002373.5. [P78559-1]
UniGeneiHs.194301.
Hs.619338.

Genome annotation databases

EnsembliENST00000300231; ENSP00000300231; ENSG00000166963. [P78559-1]
GeneIDi4130.
KEGGihsa:4130.
UCSCiuc001zrt.4. human. [P78559-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMAP1A_HUMAN
AccessioniPrimary (citable) accession number: P78559
Secondary accession number(s): O95643
, Q12973, Q15882, Q9UJT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 30, 2010
Last modified: October 25, 2017
This is version 155 of the entry and version 6 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families