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P78556

- CCL20_HUMAN

UniProt

P78556 - CCL20_HUMAN

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Protein

C-C motif chemokine 20

Gene

CCL20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213.1 Publication

GO - Molecular functioni

  1. chemokine activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cell chemotaxis Source: GOC
  3. chemokinesis Source: Ensembl
  4. chemotaxis Source: ProtInc
  5. defense response to bacterium Source: UniProtKB-KW
  6. immune response Source: ProtInc
  7. inflammatory response Source: ProtInc
  8. positive regulation of T cell migration Source: MGI
  9. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 20
Alternative name(s):
Beta-chemokine exodus-1
CC chemokine LARC
Liver and activation-regulated chemokine
Macrophage inflammatory protein 3 alpha
Short name:
MIP-3-alpha
Small-inducible cytokine A20
Cleaved into the following 3 chains:
Gene namesi
Name:CCL20
Synonyms:LARC, MIP3A, SCYA20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:10619. CCL20.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35551.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 9670C-C motif chemokine 20PRO_0000005217Add
BLAST
Chaini27 – 9367CCL20(1-67)PRO_0000041854Add
BLAST
Chaini27 – 9064CCL20(1-64)PRO_0000041855Add
BLAST
Chaini28 – 9669CCL20(2-70)PRO_0000041856Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 58
Disulfide bondi33 ↔ 74

Post-translational modificationi

C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP78556.
PRIDEiP78556.

Miscellaneous databases

PMAP-CutDBP78556.

Expressioni

Tissue specificityi

Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.

Inductioni

By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate (PMA) in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10.

Gene expression databases

BgeeiP78556.
CleanExiHS_CCL20.
GenevestigatoriP78556.

Interactioni

Subunit structurei

Binds to and activate CCR6.

Binary interactionsi

WithEntry#Exp.IntActNotes
RALBP1Q153112EBI-3913209,EBI-749285

Protein-protein interaction databases

BioGridi112267. 3 interactions.
DIPiDIP-5864N.
IntActiP78556. 3 interactions.
MINTiMINT-1525084.
STRINGi9606.ENSP00000351671.

Structurei

Secondary structure

1
96
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi43 – 453
Beta strandi46 – 527
Turni54 – 574
Beta strandi58 – 603
Beta strandi62 – 676
Beta strandi72 – 754
Helixi80 – 8910

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M8AX-ray1.70A/B27-96[»]
2HCIX-ray1.81A/B27-95[»]
2JYONMR-A27-96[»]
ProteinModelPortaliP78556.
SMRiP78556. Positions 31-91.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78556.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44269.
GeneTreeiENSGT00530000064223.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP78556.
KOiK14625.
OMAiACDINAV.
OrthoDBiEOG7B31QP.
PhylomeDBiP78556.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P78556-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCCTKSLLLA ALMSVLLLHL CGESEAASNF DCCLGYTDRI LHPKFIVGFT
60 70 80 90
RQLANEGCDI NAIIFHTKKK LSVCANPKQT WVKYIVRLLS KKVKNM
Length:96
Mass (Da):10,762
Last modified:May 1, 1997 - v1
Checksum:i1ED19EC2E1AC70AD
GO
Isoform 2 (identifier: P78556-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: Missing.

Show »
Length:95
Mass (Da):10,691
Checksum:iBFDB243C51B59960
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471V → M.
Corresponds to variant rs1049617 [ dbSNP | Ensembl ].
VAR_011915

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei26 – 261Missing in isoform 2. 3 PublicationsVSP_001061

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77035 mRNA. Translation: AAC50943.1.
D86955 mRNA. Translation: BAA13191.1.
U64197 mRNA. Translation: AAB61534.1.
AC073065 Genomic DNA. Translation: AAX93214.1.
BC020698 mRNA. Translation: AAH20698.1.
CCDSiCCDS2469.1. [P78556-1]
CCDS46536.1. [P78556-2]
RefSeqiNP_001123518.1. NM_001130046.1. [P78556-2]
NP_004582.1. NM_004591.2. [P78556-1]
UniGeneiHs.75498.

Genome annotation databases

EnsembliENST00000358813; ENSP00000351671; ENSG00000115009. [P78556-1]
ENST00000409189; ENSP00000386273; ENSG00000115009. [P78556-2]
GeneIDi6364.
KEGGihsa:6364.
UCSCiuc002vpl.2. human. [P78556-1]
uc002vpm.2. human. [P78556-2]

Polymorphism databases

DMDMi2829668.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL20 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77035 mRNA. Translation: AAC50943.1 .
D86955 mRNA. Translation: BAA13191.1 .
U64197 mRNA. Translation: AAB61534.1 .
AC073065 Genomic DNA. Translation: AAX93214.1 .
BC020698 mRNA. Translation: AAH20698.1 .
CCDSi CCDS2469.1. [P78556-1 ]
CCDS46536.1. [P78556-2 ]
RefSeqi NP_001123518.1. NM_001130046.1. [P78556-2 ]
NP_004582.1. NM_004591.2. [P78556-1 ]
UniGenei Hs.75498.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1M8A X-ray 1.70 A/B 27-96 [» ]
2HCI X-ray 1.81 A/B 27-95 [» ]
2JYO NMR - A 27-96 [» ]
ProteinModelPortali P78556.
SMRi P78556. Positions 31-91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112267. 3 interactions.
DIPi DIP-5864N.
IntActi P78556. 3 interactions.
MINTi MINT-1525084.
STRINGi 9606.ENSP00000351671.

Polymorphism databases

DMDMi 2829668.

Proteomic databases

PaxDbi P78556.
PRIDEi P78556.

Protocols and materials databases

DNASUi 6364.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358813 ; ENSP00000351671 ; ENSG00000115009 . [P78556-1 ]
ENST00000409189 ; ENSP00000386273 ; ENSG00000115009 . [P78556-2 ]
GeneIDi 6364.
KEGGi hsa:6364.
UCSCi uc002vpl.2. human. [P78556-1 ]
uc002vpm.2. human. [P78556-2 ]

Organism-specific databases

CTDi 6364.
GeneCardsi GC02P228678.
HGNCi HGNC:10619. CCL20.
MIMi 601960. gene.
neXtProti NX_P78556.
PharmGKBi PA35551.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44269.
GeneTreei ENSGT00530000064223.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi P78556.
KOi K14625.
OMAi ACDINAV.
OrthoDBi EOG7B31QP.
PhylomeDBi P78556.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTracei P78556.
GeneWikii CCL20.
GenomeRNAii 6364.
NextBioi 24728.
PMAP-CutDB P78556.
PROi P78556.
SOURCEi Search...

Gene expression databases

Bgeei P78556.
CleanExi HS_CCL20.
Genevestigatori P78556.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta."
    Rossi D.L., Vicari A.P., Franz-Bacon K., McClanahan T.K., Zlotnik A.
    J. Immunol. 158:1033-1036(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2."
    Hieshima K., Imai T., Opdenakker G., van Damme J., Kusuda J., Tei H., Sakaki Y., Takatsuki K., Miura R., Yoshie O., Nomiyama H.
    J. Biol. Chem. 272:5846-5853(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF N-TERMINUS.
    Tissue: Liver.
  3. "Cloning and characterization of Exodus, a novel beta-chemokine."
    Hromas R.A., Gray P.W., Chantry D., Godiska R., Krathwohl M., Fife K., Bell G.I., Takeda J., Aronica S., Gordon M., Cooper S., Broxmeyer H.E., Klemsz M.J.
    Blood 89:3315-3322(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Pancreas.
  4. "Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/ exodus/SCYA20, showing gene structure, splice variants, and chromosome localization."
    Nelson R.T., Boyd J., Gladue R.P., Paradis T., Thomas R., Cunningham A.C., Lira P., Brissette W.H., Hayes L., Hames L.M., Neote K.S., McColl S.R.
    Genomics 73:28-37(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Liver.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Liver.
  7. "Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells."
    Schutyser E., Struyf S., Menten P., Lenaerts J.-P., Conings R., Put W., Wuyts A., Proost P., Van Damme J.
    J. Immunol. 165:4470-4477(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF CCL20(1-67); CCL20(1-64) AND CCL20(2-70), PROTEOLYTIC PROCESSING OF C-TERMINAL.
  8. "The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins."
    Hoover D.M., Boulegue C., Yang D., Oppenheim J.J., Tucker K., Lu W., Lubkowski J.
    J. Biol. Chem. 277:37647-37654(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 27-96, FUNCTION AS AN ANTIMICROBIAL PROTEIN.

Entry informationi

Entry nameiCCL20_HUMAN
AccessioniPrimary (citable) accession number: P78556
Secondary accession number(s): Q53S51, Q99664
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3