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P78552

- I13R1_HUMAN

UniProt

P78552 - I13R1_HUMAN

Protein

Interleukin-13 receptor subunit alpha-1

Gene

IL13RA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

    GO - Molecular functioni

    1. cytokine receptor activity Source: InterPro
    2. interleukin-13 receptor activity Source: Ensembl
    3. protein binding Source: IntAct

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: ProtInc
    2. positive regulation of B cell proliferation Source: Ensembl
    3. positive regulation of immunoglobulin production Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    SignaLinkiP78552.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-13 receptor subunit alpha-1
    Short name:
    IL-13 receptor subunit alpha-1
    Short name:
    IL-13R subunit alpha-1
    Short name:
    IL-13R-alpha-1
    Short name:
    IL-13RA1
    Alternative name(s):
    Cancer/testis antigen 19
    Short name:
    CT19
    CD_antigen: CD213a1
    Gene namesi
    Name:IL13RA1
    Synonyms:IL13R, IL13RA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:5974. IL13RA1.

    Subcellular locationi

    GO - Cellular componenti

    1. interleukin-13 receptor complex Source: ProtInc
    2. membrane Source: InterPro
    3. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA200.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 427406Interleukin-13 receptor subunit alpha-1PRO_0000010939Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi62 ↔ 1021 Publication
    Disulfide bondi95 ↔ 1171 Publication
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi134 ↔ 1441 Publication
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi173 ↔ 1851 Publication
    Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi257 ↔ 3201 Publication
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi282 ↔ 2961 Publication
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP78552.
    PaxDbiP78552.
    PRIDEiP78552.

    PTM databases

    PhosphoSiteiP78552.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.

    Gene expression databases

    ArrayExpressiP78552.
    BgeeiP78552.
    CleanExiHS_IL13RA1.
    GenevestigatoriP78552.

    Organism-specific databases

    HPAiHPA001008.
    HPA001587.

    Interactioni

    Subunit structurei

    Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IL13P352254EBI-1391535,EBI-1647828
    IL4P051123EBI-1391535,EBI-367025
    TRAF3IP1Q8TDR03EBI-1391535,EBI-928811

    Protein-protein interaction databases

    BioGridi109811. 5 interactions.
    DIPiDIP-3225N.
    IntActiP78552. 6 interactions.
    STRINGi9606.ENSP00000360730.

    Structurei

    Secondary structure

    1
    427
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi36 – 438
    Turni44 – 463
    Beta strandi47 – 537
    Beta strandi66 – 683
    Helixi71 – 733
    Beta strandi77 – 8711
    Beta strandi94 – 1007
    Beta strandi114 – 1185
    Turni125 – 1273
    Beta strandi130 – 1378
    Turni138 – 1403
    Beta strandi141 – 1477
    Beta strandi158 – 1669
    Beta strandi176 – 1794
    Beta strandi182 – 1887
    Beta strandi202 – 2087
    Beta strandi216 – 2205
    Beta strandi222 – 2276
    Beta strandi232 – 2398
    Beta strandi242 – 2487
    Helixi252 – 2554
    Beta strandi258 – 2658
    Beta strandi267 – 2693
    Beta strandi273 – 2786
    Beta strandi285 – 2884
    Beta strandi292 – 2998
    Beta strandi309 – 3168
    Helixi318 – 3203
    Beta strandi334 – 3374

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3BPNX-ray3.02C29-342[»]
    3BPOX-ray3.00C29-342[»]
    4HWBX-ray2.61A223-336[»]
    ProteinModelPortaliP78552.
    SMRiP78552. Positions 30-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP78552.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 343322ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini368 – 42760CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei344 – 36724HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 12390Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini128 – 22699Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini227 – 339113Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi327 – 3315WSXWS motif
    Motifi374 – 3829Box 1 motif

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

    Sequence similaritiesi

    Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44457.
    HOGENOMiHOG000230941.
    HOVERGENiHBG052060.
    InParanoidiP78552.
    KOiK05076.
    OMAiNKLCYED.
    OrthoDBiEOG71P2B1.
    PhylomeDBiP78552.
    TreeFamiTF331549.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015321. IL-6_rcpt_alpha-bd.
    IPR003532. Short_hematopoietin_rcpt_2_CS.
    [Graphical view]
    PfamiPF09240. IL6Ra-bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 3 hits.
    PS01356. HEMATOPO_REC_S_F2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P78552-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEWPARLCGL WALLLCAGGG GGGGGAAPTE TQPPVTNLSV SVENLCTVIW    50
    TWNPPEGASS NCSLWYFSHF GDKQDKKIAP ETRRSIEVPL NERICLQVGS 100
    QCSTNESEKP SILVEKCISP PEGDPESAVT ELQCIWHNLS YMKCSWLPGR 150
    NTSPDTNYTL YYWHRSLEKI HQCENIFREG QYFGCSFDLT KVKDSSFEQH 200
    SVQIMVKDNA GKIKPSFNIV PLTSRVKPDP PHIKNLSFHN DDLYVQWENP 250
    QNFISRCLFY EVEVNNSQTE THNVFYVQEA KCENPEFERN VENTSCFMVP 300
    GVLPDTLNTV RIRVKTNKLC YEDDKLWSNW SQEMSIGKKR NSTLYITMLL 350
    IVPVIVAGAI IVLLLYLKRL KIIIFPPIPD PGKIFKEMFG DQNDDTLHWK 400
    KYDIYEKQTK EETDSVVLIE NLKKASQ 427
    Length:427
    Mass (Da):48,760
    Last modified:May 1, 1997 - v1
    Checksum:i5983B3E8F554107B
    GO
    Isoform 2 (identifier: P78552-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         278-279: QE → RF
         280-427: Missing.

    Show »
    Length:279
    Mass (Da):31,659
    Checksum:iE74141FE9F8E9EBB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti130 – 1301T → I in AAB37127. (PubMed:8910586)Curated
    Sequence conflicti358 – 3581G → D in AAB37127. (PubMed:8910586)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei278 – 2792QE → RF in isoform 2. 1 PublicationVSP_055587
    Alternative sequencei280 – 427148Missing in isoform 2. 1 PublicationVSP_055588Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10659 mRNA. Translation: CAA71669.1.
    Y09328 mRNA. Translation: CAA70508.1.
    U62858 mRNA. Translation: AAB37127.1.
    U81379 mRNA. Translation: AAD00510.3.
    U81380 mRNA. Translation: AAD00511.2.
    AK313467 mRNA. Translation: BAG36253.1.
    AL391280 Genomic DNA. Translation: CAI41410.1.
    CH471161 Genomic DNA. Translation: EAW89893.1.
    BC009960 mRNA. Translation: AAH09960.1.
    CCDSiCCDS14573.1.
    RefSeqiNP_001551.1. NM_001560.2.
    UniGeneiHs.496646.

    Genome annotation databases

    EnsembliENST00000371642; ENSP00000360705; ENSG00000131724. [P78552-2]
    ENST00000371666; ENSP00000360730; ENSG00000131724. [P78552-1]
    GeneIDi3597.
    KEGGihsa:3597.
    UCSCiuc004eqs.3. human.

    Polymorphism databases

    DMDMi2494718.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10659 mRNA. Translation: CAA71669.1 .
    Y09328 mRNA. Translation: CAA70508.1 .
    U62858 mRNA. Translation: AAB37127.1 .
    U81379 mRNA. Translation: AAD00510.3 .
    U81380 mRNA. Translation: AAD00511.2 .
    AK313467 mRNA. Translation: BAG36253.1 .
    AL391280 Genomic DNA. Translation: CAI41410.1 .
    CH471161 Genomic DNA. Translation: EAW89893.1 .
    BC009960 mRNA. Translation: AAH09960.1 .
    CCDSi CCDS14573.1.
    RefSeqi NP_001551.1. NM_001560.2.
    UniGenei Hs.496646.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3BPN X-ray 3.02 C 29-342 [» ]
    3BPO X-ray 3.00 C 29-342 [» ]
    4HWB X-ray 2.61 A 223-336 [» ]
    ProteinModelPortali P78552.
    SMRi P78552. Positions 30-338.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109811. 5 interactions.
    DIPi DIP-3225N.
    IntActi P78552. 6 interactions.
    STRINGi 9606.ENSP00000360730.

    PTM databases

    PhosphoSitei P78552.

    Polymorphism databases

    DMDMi 2494718.

    Proteomic databases

    MaxQBi P78552.
    PaxDbi P78552.
    PRIDEi P78552.

    Protocols and materials databases

    DNASUi 3597.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371642 ; ENSP00000360705 ; ENSG00000131724 . [P78552-2 ]
    ENST00000371666 ; ENSP00000360730 ; ENSG00000131724 . [P78552-1 ]
    GeneIDi 3597.
    KEGGi hsa:3597.
    UCSCi uc004eqs.3. human.

    Organism-specific databases

    CTDi 3597.
    GeneCardsi GC0XP117861.
    HGNCi HGNC:5974. IL13RA1.
    HPAi HPA001008.
    HPA001587.
    MIMi 300119. gene.
    neXtProti NX_P78552.
    PharmGKBi PA200.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44457.
    HOGENOMi HOG000230941.
    HOVERGENi HBG052060.
    InParanoidi P78552.
    KOi K05076.
    OMAi NKLCYED.
    OrthoDBi EOG71P2B1.
    PhylomeDBi P78552.
    TreeFami TF331549.

    Enzyme and pathway databases

    SignaLinki P78552.

    Miscellaneous databases

    ChiTaRSi IL13RA1. human.
    EvolutionaryTracei P78552.
    GeneWikii Interleukin_13_receptor,_alpha_1.
    GenomeRNAii 3597.
    NextBioi 14057.
    PROi P78552.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P78552.
    Bgeei P78552.
    CleanExi HS_IL13RA1.
    Genevestigatori P78552.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015321. IL-6_rcpt_alpha-bd.
    IPR003532. Short_hematopoietin_rcpt_2_CS.
    [Graphical view ]
    Pfami PF09240. IL6Ra-bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 3 hits.
    PS01356. HEMATOPO_REC_S_F2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex."
      Miloux B., Laurent P., Bonnin O., Lupker J., Caput D., Vita N., Ferrara P.
      FEBS Lett. 401:163-166(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Carcinoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: B-cell.
    3. "cDNA cloning and characterization of the human interleukin 13 receptor alpha chain."
      Aman M.J., Tayebi N., Obiri N.I., Puri R.K., Modi W.S., Leonard W.J.
      J. Biol. Chem. 271:29265-29270(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: T-cell.
    4. Wada M., Hisano T., Kuwano M.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hippocampus.
    6. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pancreas.
    9. "MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network."
      Ling L., Goeddel D.V.
      J. Biol. Chem. 275:23852-23860(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRAF3IP1.
    10. "Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system."
      LaPorte S.L., Juo Z.S., Vaclavikova J., Colf L.A., Qi X., Heller N.M., Keegan A.D., Garcia K.C.
      Cell 132:259-272(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 29-342 IN COMPLEXES WITH IL4; IL4RA AND IL13, DISULFIDE BONDS, SUBUNIT.

    Entry informationi

    Entry nameiI13R1_HUMAN
    AccessioniPrimary (citable) accession number: P78552
    Secondary accession number(s): O95646
    , Q5JSL4, Q99656, Q9UDY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3