P78545 (ELF3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ETS-related transcription factor Elf-3

Alternative name(s):
E74-like factor 3
Epithelial-restricted with serine box
Epithelium-restricted Ets protein ESX
Epithelium-specific Ets transcription factor 1
Short name=ESE-1

Gene names

Name:	ELF3
Synonyms:	ERT, ESX, JEN

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development By similarity. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.15 Ref.16 Ref.17 Ref.18 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30
Subunit structure	Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3. Ref.6 Ref.22 Ref.25 Ref.30
Subcellular location	Cytoplasm. Nucleus. Note: Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism. Ref.6 Ref.26 Ref.30
Tissue specificity	Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin. Ref.1 Ref.2 Ref.3 Ref.4
Induction	Transcriptionally regulated by ERBB2 receptor signaling in breast cancer epithelial cells. Up-regulated by phorbol 12-myristate 13-acetate (PMA) in bronchial epithelial cells. By retinoic acid in MCF-7 mammary epithelial cells (at protein level). Ref.19 Ref.23 Ref.29
Domain	the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Ref.31
Sequence similarities	Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain.

Ontologies

Keywords
Biological process	Differentiation Inflammatory response Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	DNA-binding
Molecular function	Activator Developmental protein Repressor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blastocyst development Inferred from electronic annotation. Source: Compara epidermis development Non-traceable author statement Ref.1. Source: UniProtKB epithelial cell differentiation Inferred from expression pattern Ref.1. Source: UniProtKB extracellular matrix organization Inferred from electronic annotation. Source: Compara inflammatory response Inferred from expression pattern Ref.24. Source: UniProtKB mammary gland involution Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription, DNA-dependent Inferred from direct assay Ref.16. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from direct assay Ref.1. Source: UniProtKB transcription from RNA polymerase II promoter Traceable author statement Ref.1. Source: ProtInc
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA nucleus Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Non-traceable author statement Ref.1. Source: UniProtKB transcription coactivator activity Inferred from direct assay Ref.22. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms may exist.

Isoform 1 Ref.1 (identifier: P78545-1)

Also known as: ESE-1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.1 (identifier: P78545-2)

Also known as: ESE-1a;

The sequence of this isoform differs from the canonical sequence as follows:
     173-195: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 371

371

ETS-related transcription factor Elf-3

PRO_0000287681

Regions

Domain

46 – 132

87

PNT

DNA binding

273 – 355

83

ETS

Motif

137 – 145

9

9aaTAD

Natural variations

Alternative sequence

173 – 195

23

Missing in isoform 2. Ref.1

VSP_052433

Natural variant

317

1

Q → K.
Corresponds to variant rs1135542 [ dbSNP | Ensembl ].

VAR_048945

Experimental info

Mutagenesis

247 – 250

4

RGRP → AAAA: No effect on transcriptional repression on KRT4 promoter. Ref.16

Mutagenesis

315

1

W → A: Partially abrogates repressive effect on the KRT4 promoter; when associated with A-319. Ref.16

Mutagenesis

319

1

K → A: Partially abrogates repressive effect on the KRT4 promoter; when associated with A-315. Ref.16

Mutagenesis

334 – 337

4

RYYY → AAAA: Partially abrogates repressive effect on the KRT4 promoter. Ref.16

Sequence conflict

3

1

A → T in AAM70481. Ref.8

Sequence conflict

55 – 56

2

EK → GE in CAD29859. Ref.7

Sequence conflict

68

1

S → L in AAM70481. Ref.8

Sequence conflict

129 – 130

2

TS → SA in CAD29859. Ref.7

Sequence conflict

134

1

D → Y in AAM70481. Ref.8

Sequence conflict

160 – 161

2

DQ → GE in CAD29859. Ref.7

Sequence conflict

201

1

T → A in CAD29859. Ref.7

Sequence conflict

242

1

H → L in CAG33387. Ref.9

Sequence conflict

244

1

K → E in CAD97611. Ref.11

Sequence conflict

257

1

Y → C in AAM70481. Ref.8

Sequence conflict

269

1

A → G in CAD29859. Ref.7

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

371

Helix Strand Turn

Details...

Beta strand

60 – 62

3

Helix

64 – 66

3

Helix

69 – 82

14

Turn

92 – 94

3

Helix

100 – 104

5

Helix

107 – 113

7

Helix

115 – 117

3

Helix

118 – 130

13

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (ESE-1b) [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 81A23A7DECBE2EF9	FASTA	371	41,454
	10 20 30 40 50 60 MAATCEISNI FSNYFSAMYS SEDSTLASVP PAATFGADDL VLTLSNPQMS LEGTEKASWL 70 80 90 100 110 120 GEQPQFWSKT QVLDWISYQV EKNKYDASAI DFSRCDMDGA TLCNCALEEL RLVFGPLGDQ 130 140 150 160 170 180 LHAQLRDLTS SSSDELSWII ELLEKDGMAF QEALDPGPFD QGSPFAQELL DDGQQASPYH 190 200 210 220 230 240 PGSCGAGAPS PGSSDVSTAG TGASRSSHSS DSGGSDVDLD PTDGKLFPSD GFRDCKKGDP 250 260 270 280 290 300 KHGKRKRGRP RKLSKEYWDC LEGKKSKHAP RGTHLWEFIR DILIHPELNE GLMKWENRHE 310 320 330 340 350 360 GVFKFLRSEA VAQLWGQKKK NSNMTYEKLS RAMRYYYKRE ILERVDGRRL VYKFGKNSSG 370 WKEEEVLQSR N
	Isoform 2 (ESE-1a) [UniParc]. Checksum: AE2A6D3633CA305E	FASTA	348	39,357
	10 20 30 40 50 60 MAATCEISNI FSNYFSAMYS SEDSTLASVP PAATFGADDL VLTLSNPQMS LEGTEKASWL 70 80 90 100 110 120 GEQPQFWSKT QVLDWISYQV EKNKYDASAI DFSRCDMDGA TLCNCALEEL RLVFGPLGDQ 130 140 150 160 170 180 LHAQLRDLTS SSSDELSWII ELLEKDGMAF QEALDPGPFD QGSPFAQELL DDVSTAGTGA 190 200 210 220 230 240 SRSSHSSDSG GSDVDLDPTD GKLFPSDGFR DCKKGDPKHG KRKRGRPRKL SKEYWDCLEG 250 260 270 280 290 300 KKSKHAPRGT HLWEFIRDIL IHPELNEGLM KWENRHEGVF KFLRSEAVAQ LWGQKKKNSN 310 320 330 340 MTYEKLSRAM RYYYKREILE RVDGRRLVYK FGKNSSGWKE EEVLQSRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family." Oettgen P., Alani R.M., Barcinski M.A., Brown L., Akbarali Y., Boltax J., Kunsch C., Munger K., Libermann T.A. Mol. Cell. Biol. 17:4419-4433(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[2]	"The expression of a novel, epithelium-specific ets transcription factor is restricted to the most differentiated layers in the epidermis." Andreoli J.M., Jang S.-I., Chung E., Coticchia C.M., Steinert P.M., Markova N.G. Nucleic Acids Res. 25:4287-4295(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[3]	"ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis." Chang C.-H., Scott G.K., Kuo W.-L., Xiong X., Suzdaltseva Y., Park J.W., Sayre P., Erny K., Collins C., Gray J.W., Benz C.C. Oncogene 14:1617-1622(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Placenta.
[4]	"A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer." Tymms M.J., Ng A.Y.N., Thomas R.S., Schutte B.C., Zhou J., Eyre H.J., Sutherland G.R., Seth A., Rosenberg M., Papas T., Debouck C., Kola I. Oncogene 15:2449-2462(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Fetal lung.
[5]	"A novel ets-related transcription factor, ERT/ESX/ESE-1, regulates expression of the transforming growth factor-beta type II receptor." Choi S.-G., Yi Y., Kim Y.-S., Kato M., Chang J., Chung H.-W., Hahm K.-B., Yang H.-K., Rhee H.H., Bang Y.-J., Kim S.-J. J. Biol. Chem. 273:110-117(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION. Tissue: Placenta.
[6]	"Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP)." Chang C.-H., Scott G.K., Baldwin M.A., Benz C.C. Oncogene 18:3682-3695(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), FUNCTION, INTERACTION WITH TBP, SUBCELLULAR LOCATION.
[7]	"Human aminopeptidase B (rnpep) on chromosome 1q32.2: complementary DNA, genomic structure and expression." Piesse C., Tymms M., Garrafa E., Gouzy C., Lacasa M., Cadel S., Cohen P., Foulon T. Gene 292:129-140(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[8]	"Partially unspliced and fully spliced ELF3 mRNA, including a new Alu element in human breast cancer." Kaplan M.H., Wang X.P., Xu H.P., Dosik M.H. Breast Cancer Res. Treat. 83:171-187(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING. Tissue: Mammary cancer.
[9]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[10]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Urinary bladder.
[11]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Retina.
[12]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[13]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[14]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[15]	"Over-expression of ERT(ESX/ESE-1/ELF3), an ets-related transcription factor, induces endogenous TGF-beta type II receptor expression and restores the TGF-beta signaling pathway in Hs578t human breast cancer cells." Chang J., Lee C., Hahm K.-B., Yi Y., Choi S.-G., Kim S.-J. Oncogene 19:151-154(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[16]	"Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation." Brembeck F.H., Opitz O.G., Libermann T.A., Rustgi A.K. Oncogene 19:1941-1949(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF 247-ARG--PRO-250; TRP-315; LYS-319 AND 334-ARG--TYR-337.
[17]	"ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene." Rudders S., Gaspar J., Madore R., Voland C., Grall F., Patel A., Pellacani A., Perrella M.A., Libermann T.A., Oettgen P. J. Biol. Chem. 276:3302-3309(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[18]	"Sequence-specific enhancer binding protein is responsible for the differential expression of ERT/ESX/ELF-3/ESE-1/jen gene in human gastric cancer cell lines: implication for the loss of TGF-beta type II receptor expression." Park S.H., Kim Y.S., Park B.-K., Hougaard S., Kim S.-J. Oncogene 20:1235-1245(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[19]	"ErbB2 activation of ESX gene expression." Neve R.M., Ylstra B., Chang C.-H., Albertson D.G., Benz C.C. Oncogene 21:3934-3938(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[20]	"The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression." Eckel K.L., Tentler J.J., Cappetta G.J., Diamond S.E., Gutierrez-Hartmann A. DNA Cell Biol. 22:79-94(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[21]	"ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells." Kwon J.H., Keates S., Simeonidis S., Grall F., Libermann T.A., Keates A.C. J. Biol. Chem. 278:875-884(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[22]	"Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation." Cabral A., Fischer D.F., Vermeij W.P., Backendorf C. J. Biol. Chem. 278:17792-17799(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT.
[23]	"Interplay between proximal and distal promoter elements is required for squamous differentiation marker induction in the bronchial epithelium: role for ESE-1, Sp1, and AP-1 proteins." Reddy S.P.M., Vuong H., Adiseshaiah P. J. Biol. Chem. 278:21378-21387(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION.
[24]	"ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation." Brown C., Gaspar J., Pettit A., Lee R., Gu X., Wang H., Manning C., Voland C., Goldring S.R., Goldring M.B., Libermann T.A., Gravallese E.M., Oettgen P. J. Biol. Chem. 279:12794-12803(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[25]	"Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86." Wang H., Fang R., Cho J.-Y., Libermann T.A., Oettgen P. J. Biol. Chem. 279:25241-25250(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CREBBP; EP300; XRCC5 AND XRCC6.
[26]	"The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism." Prescott J.D., Koto K.S.N., Singh M., Gutierrez-Hartmann A. Mol. Cell. Biol. 24:5548-5564(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[27]	"ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells." Schedin P.J., Eckel-Mahan K.L., McDaniel S.M., Prescott J.D., Brodsky K.S., Tentler J.J., Gutierrez-Hartmann A. Oncogene 23:1766-1779(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[28]	"The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes." Grall F.T., Prall W.C., Wei W., Gu X., Cho J.-Y., Choy B.K., Zerbini L.F., Inan M.S., Goldring S.R., Gravallese E.M., Goldring M.B., Oettgen P., Libermann T.A. FEBS J. 272:1676-1687(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[29]	"Identification of an epithelial-specific enhancer regulating ESX expression." Neve R.M., Parmar H., Amend C., Chen C., Rizzino A., Benz C.C. Gene 367:118-125(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION.
[30]	"Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3." Kohno Y., Okamoto T., Ishibe T., Nagayama S., Shima Y., Nishijo K., Shibata K.R., Fukiage K., Otsuka S., Uejima D., Araki N., Naka N., Nakashima Y., Aoyama T., Nakayama T., Nakamura T., Toguchida J. J. Biol. Chem. 281:38941-38950(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
[31]	"Nine-amino-acid transactivation domain: establishment and prediction utilities." Piskacek S., Gregor M., Nemethova M., Grabner M., Kovarik P., Piskacek M. Genomics 89:756-768(2007) [PubMed] [Europe PMC] [Abstract] Cited for: DOMAIN.
[32]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[33]	"Solution structure of the N-terminal SAM-domain of E74-like factor 3." RIKEN structural genomics initiative (RSGI) Submitted (JUL-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 45-132.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U73843 mRNA. Translation: AAB65823.1.
U73844 mRNA. Translation: AAB65824.1.
U97156 mRNA. Translation: AAC51884.1.
U66894 mRNA. Translation: AAB58075.1.
AF016295 mRNA. Translation: AAB96586.1.
AF017307 mRNA. Translation: AAB67238.1.
AF110184 Genomic DNA. Translation: AAD45237.1.
BN000001 Genomic DNA. Translation: CAD29859.1.
AF517841 mRNA. Translation: AAM70481.1.
CR457106 mRNA. Translation: CAG33387.1.
AK312273 mRNA. Translation: BAG35203.1.
BX537368 mRNA. Translation: CAD97611.1.
AL691482 Genomic DNA. Translation: CAI14961.1.
CH471067 Genomic DNA. Translation: EAW91389.1.
BC003569 mRNA. Translation: AAH03569.1.

IPI

IPI00004581.
IPI00844532.

RefSeq

NP_001107781.1. NM_001114309.1.
NP_004424.3. NM_004433.4.

UniGene

Hs.730618.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2E8P	NMR	-	A	48-132	[»]

ProteinModelPortal

P78545.

ModBase

Search...

Protein-protein interaction databases

IntAct

P78545. 2 interactions.

STRING

9606.ENSP00000352673.

PTM databases

PhosphoSite

P78545.

Polymorphism databases

DMDM

74739735.

Proteomic databases

PaxDb

P78545.

PRIDE

P78545.

Protocols and materials databases

DNASU

1999.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000359651; ENSP00000352673; ENSG00000163435.
ENST00000367283; ENSP00000356252; ENSG00000163435.
ENST00000367284; ENSP00000356253; ENSG00000163435.

GeneID

1999.

KEGG

hsa:1999.

UCSC

uc001gxg.4. human.

Organism-specific databases

CTD

1999.

GeneCards

GC01P201977.

HGNC

HGNC:3318. ELF3.

HPA

HPA003316.
HPA003479.

MIM

602191. gene.

neXtProt

NX_P78545.

PharmGKB

PA27746.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG299956.

HOVERGEN

HBG074143.

InParanoid

P78545.

KO

K09429.

OMA

QLWSKAQ.

OrthoDB

EOG4KH2W1.

PhylomeDB

P78545.

Gene expression databases

ArrayExpress

P78545.

Bgee

P78545.

CleanEx

HS_ELF3.

Genevestigator

P78545.

Family and domain databases

Gene3D

1.10.10.10. 1 hit.
1.10.150.50. 1 hit.

InterPro

IPR017956. AT_hook_DNA-bd_motif.
IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]

Pfam

PF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]

PRINTS

PR00454. ETSDOMAIN.

SMART

SM00384. AT_hook. 1 hit.
SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]

SUPFAM

SSF47769. SAM_homology. 1 hit.

PROSITE

PS00345. ETS_DOMAIN_1. False negative.
PS00346. ETS_DOMAIN_2. False negative.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P78545.

ChEMBL

CHEMBL1075147.

ChiTaRS

ELF3. human.

EvolutionaryTrace

P78545.

GenomeRNAi

1999.

NextBio

8087.

SOURCE

Search...

Entry information

Entry name

ELF3_HUMAN

Accession

Primary (citable) accession number: P78545
Secondary accession number(s): B2R5Q6 , Q6IAP8, Q7RU03, Q7Z3X2, Q8NFG2, Q99718

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 1, 1997
Last modified:	May 1, 2013
This is version 124 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.