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Reviewed, UniProtKB/Swiss-Prot P78545 (ELF3_HUMAN)

Last modified July 7, 2009. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    ETS-related transcription factor Elf-3
Alternative name(s):
    E74-like factor 3
    Epithelium-specific Ets transcription factor 1
      Short name=ESE-1
    Epithelium-restricted Ets protein ESX
    Epithelial-restricted with serine box
Gene names
Name: ELF3
Synonyms: ERT, ESX, JEN
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development By similarity. Ref.6 Ref.20 Ref.23 Ref.28 Ref.24 Ref.1 Ref.2 Ref.3 Ref.4 Ref.21 Ref.27 Ref.14 Ref.5 Ref.13 Ref.15 Ref.16 Ref.18 Ref.19 Ref.22 Ref.25 Ref.26

Subunit structure

Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3. Ref.6 Ref.20 Ref.23 Ref.28

Subcellular location

Cytoplasm. Nucleus. Note: Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism. Ref.6 Ref.28 Ref.24

Tissue specificity

Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin. Ref.1 Ref.2 Ref.3 Ref.4

Induction

Transcriptionally regulated by ERBB2 receptor signaling in breast cancer epithelial cells. Up-regulated by phorbol-12-myristate-13-acetate (PMA) in bronchial epithelial cells. By retinoic acid in MCF-7 mammary epithelial cells (at protein level). Ref.17 Ref.21 Ref.27

Sequence similarities

Belongs to the ETS family.

Contains 1 ETS DNA-binding domain.

Contains 1 PNT (pointed) domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms may exist.
Isoform 1 Ref.1 (identifier: P78545-1)

Also known as: ESE-1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 (identifier: P78545-2)

Also known as: ESE-1a;

The sequence of this isoform differs from the canonical sequence as follows:
     173-195: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371ETS-related transcription factor Elf-3
PRO_0000287681

Regions

Domain46 – 13287PNT
DNA binding273 – 35583ETS

Natural variations

Alternative sequence173 – 19523Missing in isoform 2. Ref.1
VSP_052433
Natural variant3171Q → K: dbSNP rs1135542.
VAR_048945

Experimental info

Mutagenesis247 – 2504RGRP → AAAA: No effect on transcriptional repression on KRT4 promoter. Ref.14
Mutagenesis3151W → A: Partially abrogates repressive effect on the KRT4 promoter; when associated with A-319. Ref.14
Mutagenesis3191K → A: Partially abrogates repressive effect on the KRT4 promoter; when associated with A-315. Ref.14
Mutagenesis334 – 3374RYYY → AAAA: Partially abrogates repressive effect on the KRT4 promoter. Ref.14
Sequence conflict31A → T in AAM70481. Ref.8
Sequence conflict55 – 562EK → GE in CAD29859. Ref.7
Sequence conflict681S → L in AAM70481. Ref.8
Sequence conflict129 – 1302TS → SA in CAD29859. Ref.7
Sequence conflict1341D → Y in AAM70481. Ref.8
Sequence conflict160 – 1612DQ → GE in CAD29859. Ref.7
Sequence conflict2011T → A in CAD29859. Ref.7
Sequence conflict2421H → L in CAG33387. Ref.9
Sequence conflict2441K → E in CAD97611. Ref.10
Sequence conflict2571Y → C in AAM70481. Ref.8
Sequence conflict2691A → G in CAD29859. Ref.7

Secondary structure

................ 371
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (ESE-1b) [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 81A23A7DECBE2EF9

FASTA37141,454
        10         20         30         40         50         60 
MAATCEISNI FSNYFSAMYS SEDSTLASVP PAATFGADDL VLTLSNPQMS LEGTEKASWL 

        70         80         90        100        110        120 
GEQPQFWSKT QVLDWISYQV EKNKYDASAI DFSRCDMDGA TLCNCALEEL RLVFGPLGDQ 

       130        140        150        160        170        180 
LHAQLRDLTS SSSDELSWII ELLEKDGMAF QEALDPGPFD QGSPFAQELL DDGQQASPYH 

       190        200        210        220        230        240 
PGSCGAGAPS PGSSDVSTAG TGASRSSHSS DSGGSDVDLD PTDGKLFPSD GFRDCKKGDP 

       250        260        270        280        290        300 
KHGKRKRGRP RKLSKEYWDC LEGKKSKHAP RGTHLWEFIR DILIHPELNE GLMKWENRHE 

       310        320        330        340        350        360 
GVFKFLRSEA VAQLWGQKKK NSNMTYEKLS RAMRYYYKRE ILERVDGRRL VYKFGKNSSG 

       370 
WKEEEVLQSR N 

« Hide

Isoform 2 (ESE-1a).

Checksum: AE2A6D3633CA305E
Show »

FASTA34839,357

References

« Hide 'large scale' references
[1]"Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family."
Oettgen P., Alani R.M., Barcinski M.A., Brown L., Akbarali Y., Boltax J., Kunsch C., Munger K., Libermann T.A.
Mol. Cell. Biol. 17:4419-4433(1997) [PubMed: 9234700] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[2]"The expression of a novel, epithelium-specific ets transcription factor is restricted to the most differentiated layers in the epidermis."
Andreoli J.M., Jang S.-I., Chung E., Coticchia C.M., Steinert P.M., Markova N.G.
Nucleic Acids Res. 25:4287-4295(1997) [PubMed: 9336459] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[3]"ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis."
Chang C.-H., Scott G.K., Kuo W.-L., Xiong X., Suzdaltseva Y., Park J.W., Sayre P., Erny K., Collins C., Gray J.W., Benz C.C.
Oncogene 14:1617-1622(1997) [PubMed: 9129154] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
Tissue: Placenta.
[4]"A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer."
Tymms M.J., Ng A.Y.N., Thomas R.S., Schutte B.C., Zhou J., Eyre H.J., Sutherland G.R., Seth A., Rosenberg M., Papas T., Debouck C., Kola I.
Oncogene 15:2449-2462(1997) [PubMed: 9395241] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
Tissue: Fetal lung.
[5]"A novel ets-related transcription factor, ERT/ESX/ESE-1, regulates expression of the transforming growth factor-beta type II receptor."
Choi S.-G., Yi Y., Kim Y.-S., Kato M., Chang J., Chung H.-W., Hahm K.-B., Yang H.-K., Rhee H.H., Bang Y.-J., Kim S.-J.
J. Biol. Chem. 273:110-117(1998) [PubMed: 9417054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
Tissue: Placenta.
[6]"Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP)."
Chang C.-H., Scott G.K., Baldwin M.A., Benz C.C.
Oncogene 18:3682-3695(1999) [PubMed: 10391676] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), FUNCTION, INTERACTION WITH TBP, SUBCELLULAR LOCATION.
[7]"Human aminopeptidase B (rnpep) on chromosome 1q32.2: complementary DNA, genomic structure and expression."
Piesse C., Tymms M., Garrafa E., Gouzy C., Lacasa M., Cadel S., Cohen P., Foulon T.
Gene 292:129-140(2002) [PubMed: 12119107] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[8]"Partially unspliced and fully spliced ELF3 mRNA, including a new Alu element in human breast cancer."
Kaplan M.H., Wang X.P., Xu H.P., Dosik M.H.
Breast Cancer Res. Treat. 83:171-187(2004) [PubMed: 14997048] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
Tissue: Mammary cancer.
[9]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[10]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Retina.
[11]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.
[13]"Over-expression of ERT(ESX/ESE-1/ELF3), an ets-related transcription factor, induces endogenous TGF-beta type II receptor expression and restores the TGF-beta signaling pathway in Hs578t human breast cancer cells."
Chang J., Lee C., Hahm K.-B., Yi Y., Choi S.-G., Kim S.-J.
Oncogene 19:151-154(2000) [PubMed: 10644990] [Abstract]
Cited for: FUNCTION.
[14]"Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation."
Brembeck F.H., Opitz O.G., Libermann T.A., Rustgi A.K.
Oncogene 19:1941-1949(2000) [PubMed: 10773884] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF 247-ARG--PRO-250; TRP-315; LYS-319 AND 334-ARG--TYR-337.
[15]"ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene."
Rudders S., Gaspar J., Madore R., Voland C., Grall F., Patel A., Pellacani A., Perrella M.A., Libermann T.A., Oettgen P.
J. Biol. Chem. 276:3302-3309(2001) [PubMed: 11036073] [Abstract]
Cited for: FUNCTION.
[16]"Sequence-specific enhancer binding protein is responsible for the differential expression of ERT/ESX/ELF-3/ESE-1/jen gene in human gastric cancer cell lines: implication for the loss of TGF-beta type II receptor expression."
Park S.H., Kim Y.S., Park B.-K., Hougaard S., Kim S.-J.
Oncogene 20:1235-1245(2001) [PubMed: 11313868] [Abstract]
Cited for: FUNCTION.
[17]"ErbB2 activation of ESX gene expression."
Neve R.M., Ylstra B., Chang C.-H., Albertson D.G., Benz C.C.
Oncogene 21:3934-3938(2002) [PubMed: 12032832] [Abstract]
Cited for: INDUCTION.
[18]"The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression."
Eckel K.L., Tentler J.J., Cappetta G.J., Diamond S.E., Gutierrez-Hartmann A.
DNA Cell Biol. 22:79-94(2003) [PubMed: 12713734] [Abstract]
Cited for: FUNCTION.
[19]"ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells."
Kwon J.H., Keates S., Simeonidis S., Grall F., Libermann T.A., Keates A.C.
J. Biol. Chem. 278:875-884(2003) [PubMed: 12414801] [Abstract]
Cited for: FUNCTION.
[20]"Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation."
Cabral A., Fischer D.F., Vermeij W.P., Backendorf C.
J. Biol. Chem. 278:17792-17799(2003) [PubMed: 12624109] [Abstract]
Cited for: FUNCTION, SUBUNIT.
[21]"Interplay between proximal and distal promoter elements is required for squamous differentiation marker induction in the bronchial epithelium: role for ESE-1, Sp1, and AP-1 proteins."
Reddy S.P.M., Vuong H., Adiseshaiah P.
J. Biol. Chem. 278:21378-21387(2003) [PubMed: 12682075] [Abstract]
Cited for: FUNCTION, INDUCTION.
[22]"ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation."
Brown C., Gaspar J., Pettit A., Lee R., Gu X., Wang H., Manning C., Voland C., Goldring S.R., Goldring M.B., Libermann T.A., Gravallese E.M., Oettgen P.
J. Biol. Chem. 279:12794-12803(2004) [PubMed: 14715662] [Abstract]
Cited for: FUNCTION.
[23]"Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86."
Wang H., Fang R., Cho J.-Y., Libermann T.A., Oettgen P.
J. Biol. Chem. 279:25241-25250(2004) [PubMed: 15075319] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CREBBP; EP300; XRCC5 AND XRCC6.
[24]"The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism."
Prescott J.D., Koto K.S.N., Singh M., Gutierrez-Hartmann A.
Mol. Cell. Biol. 24:5548-5564(2004) [PubMed: 15169914] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[25]"ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells."
Schedin P.J., Eckel-Mahan K.L., McDaniel S.M., Prescott J.D., Brodsky K.S., Tentler J.J., Gutierrez-Hartmann A.
Oncogene 23:1766-1779(2004) [PubMed: 14767472] [Abstract]
Cited for: FUNCTION.
[26]"The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes."
Grall F.T., Prall W.C., Wei W., Gu X., Cho J.-Y., Choy B.K., Zerbini L.F., Inan M.S., Goldring S.R., Gravallese E.M., Goldring M.B., Oettgen P., Libermann T.A.
FEBS J. 272:1676-1687(2005) [PubMed: 15794755] [Abstract]
Cited for: FUNCTION.
[27]"Identification of an epithelial-specific enhancer regulating ESX expression."
Neve R.M., Parmar H., Amend C., Chen C., Rizzino A., Benz C.C.
Gene 367:118-125(2006) [PubMed: 16307850] [Abstract]
Cited for: FUNCTION, INDUCTION.
[28]"Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3."
Kohno Y., Okamoto T., Ishibe T., Nagayama S., Shima Y., Nishijo K., Shibata K.R., Fukiage K., Otsuka S., Uejima D., Araki N., Naka N., Nakashima Y., Aoyama T., Nakayama T., Nakamura T., Toguchida J.
J. Biol. Chem. 281:38941-38950(2006) [PubMed: 17060315] [Abstract]
Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
[29]"Solution structure of the N-terminal SAM-domain of E74-like factor 3."
RIKEN structural genomics initiative (RSGI)
Submitted (JUL-2007) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 45-132.
+Additional computationally mapped references.

Cross-references

Sequence databases

U73843 mRNA. Translation: AAB65823.1.
U73844 mRNA. Translation: AAB65824.1.
U97156 mRNA. Translation: AAC51884.1.
U66894 mRNA. Translation: AAB58075.1.
AF016295 mRNA. Translation: AAB96586.1.
AF017307 mRNA. Translation: AAB67238.1.
AF110184 Genomic DNA. Translation: AAD45237.1.
BN000001 Genomic DNA. Translation: CAD29859.1.
AF517841 mRNA. Translation: AAM70481.1.
CR457106 mRNA. Translation: CAG33387.1.
BX537368 mRNA. Translation: CAD97611.1.
AL691482 Genomic DNA. Translation: CAI14961.1.
BC003569 mRNA. Translation: AAH03569.1.
IPIIPI00004581.
IPI00844532.
RefSeqNP_001107781.1.
NP_004424.3.
UniGeneHs.67928

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2E8PNMR-A48-132[»]
ModBaseSearch...

Protein-protein interaction databases

IntActP78545. 29 interactions.

PTM databases

PhosphoSiteP78545.

Proteomic databases

PRIDEP78545.

Genome annotation databases

EnsemblENSG00000163435. Homo sapiens. [Contig view]
GeneID1999.
KEGGhsa:1999.
UCSCuc001gxg.2. human.

Organism-specific databases

GeneCardsGC01P200243.
H-InvDBHIX0001469.
HGNCHGNC:3318. ELF3.
HPAHPA003316.
HPA003479.
MIM602191. gene.
PharmGKBPA27746.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP78545.
HOVERGENP78545.
OMAP78545. DSGGSDV.

Gene expression databases

ArrayExpressP78545.
BgeeP78545.
CleanExHS_ELF3.

Family and domain databases

InterProIPR017956. AT_hook_DNA-bd_CS.
IPR000418. Ets.
IPR003118. SAM_PNT.
IPR013761. SAM_type.
IPR011991. Wing_hlx_DNA_bd.
[Graphical view]
Gene3DG3DSA:1.10.150.50. SAM_type. 1 hit.
G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PfamPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSPR00454. ETSDOMAIN.
SMARTSM00384. AT_hook. 1 hit.
SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
PROSITEPS00345. ETS_DOMAIN_1. False negative.
PS00346. ETS_DOMAIN_2. False negative.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio8087.
SOURCESearch...

Entry information

Entry nameELF3_HUMAN
AccessionPrimary (citable) accession number: P78545
Secondary accession number(s): Q6IAP8 expand/collapse secondary AC list , Q7RU03, Q7Z3X2, Q8NFG2, Q99718
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 1, 1997
Last modified: July 7, 2009
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents