Reviewed, UniProtKB/Swiss-Prot P78545 (ELF3_HUMAN)

Names and origin

Protein names

Recommended name:
    ETS-related transcription factor Elf-3
Alternative name(s):
    E74-like factor 3
    Epithelium-specific Ets transcription factor 1
      Short name=ESE-1
    Epithelium-restricted Ets protein ESX
    Epithelial-restricted with serine box

Gene names

Name:	ELF3
Synonyms:	ERT, ESX, JEN

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development By similarity. Ref.6 Ref.20 Ref.23 Ref.28 Ref.24 Ref.1 Ref.2 Ref.3 Ref.4 Ref.21 Ref.27 Ref.14 Ref.5 Ref.13 Ref.15 Ref.16 Ref.18 Ref.19 Ref.22 Ref.25 Ref.26
Subunit structure	Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3. Ref.6 Ref.20 Ref.23 Ref.28
Subcellular location	Cytoplasm. Nucleus. Note: Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism. Ref.6 Ref.28 Ref.24
Tissue specificity	Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin. Ref.1 Ref.2 Ref.3 Ref.4
Induction	Transcriptionally regulated by ERBB2 receptor signaling in breast cancer epithelial cells. Up-regulated by phorbol-12-myristate-13-acetate (PMA) in bronchial epithelial cells. By retinoic acid in MCF-7 mammary epithelial cells (at protein level). Ref.17 Ref.21 Ref.27
Sequence similarities	Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain.

Ontologies

Keywords
Biological process	Differentiation Inflammatory response Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	DNA-binding
Molecular function	Activator Developmental protein Repressor
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	epidermis development Ref.1 Non-traceable author statement. Source: UniProtKB epithelial cell differentiation Ref.1 Inferred from expression pattern. Source: UniProtKB inflammatory response Ref.22 Inferred from expression pattern. Source: UniProtKB mammary gland involution Inferred from sequence or structural similarity. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleus Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription coactivator activity Ref.1 Ref.20 Inferred from direct assay. Source: UniProtKB transcription factor activity Ref.1 Non-traceable author statement. Source: UniProtKB transcription repressor activity Ref.14 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATIC	P31939	1	EBI-1057285,EBI-1048599
CALR	P27797	1	EBI-1057285,EBI-1049597
EEF1D	P29692	1	EBI-1057285,EBI-358607
EHF	Q9NZC4	1	EBI-1057285,EBI-1053347
GANAB	Q14697	1	EBI-1057285,EBI-348004
ISG15	P05161	1	EBI-1057285,EBI-746466
KRT31	Q15323	1	EBI-1057285,EBI-948001
KRT82	Q9NSB4	1	EBI-1057285,EBI-1045341
P4HB	P07237	1	EBI-1057285,EBI-395883
TARS	P26639	1	EBI-1057285,EBI-1042683

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms may exist.

Isoform 1 Ref.1 (identifier: P78545-1)

Also known as: ESE-1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.1 (identifier: P78545-2)

Also known as: ESE-1a;

The sequence of this isoform differs from the canonical sequence as follows:
     173-195: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 371

371

ETS-related transcription factor Elf-3

PRO_0000287681

Regions

Domain

46 – 132

87

PNT

DNA binding

273 – 355

83

ETS

Natural variations

Alternative sequence

173 – 195

23

Missing in isoform 2. Ref.1

VSP_052433

Natural variant

317

1

Q → K: dbSNP rs1135542.

VAR_048945

Experimental info

Mutagenesis

247 – 250

4

RGRP → AAAA: No effect on transcriptional repression on KRT4 promoter. Ref.14

Mutagenesis

315

1

W → A: Partially abrogates repressive effect on the KRT4 promoter; when associated with A-319. Ref.14

Mutagenesis

319

1

K → A: Partially abrogates repressive effect on the KRT4 promoter; when associated with A-315. Ref.14

Mutagenesis

334 – 337

4

RYYY → AAAA: Partially abrogates repressive effect on the KRT4 promoter. Ref.14

Sequence conflict

3

1

A → T in AAM70481. Ref.8

Sequence conflict

55 – 56

2

EK → GE in CAD29859. Ref.7

Sequence conflict

68

1

S → L in AAM70481. Ref.8

Sequence conflict

129 – 130

2

TS → SA in CAD29859. Ref.7

Sequence conflict

134

1

D → Y in AAM70481. Ref.8

Sequence conflict

160 – 161

2

DQ → GE in CAD29859. Ref.7

Sequence conflict

201

1

T → A in CAD29859. Ref.7

Sequence conflict

242

1

H → L in CAG33387. Ref.9

Sequence conflict

244

1

K → E in CAD97611. Ref.10

Sequence conflict

257

1

Y → C in AAM70481. Ref.8

Sequence conflict

269

1

A → G in CAD29859. Ref.7

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

371

Helix Strand Turn

Details...

Beta strand

60 – 62

3

Helix

64 – 66

3

Helix

69 – 82

14

Turn

92 – 94

3

Helix

100 – 104

5

Helix

107 – 113

7

Helix

115 – 117

3

Helix

118 – 130

13

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (ESE-1b) [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 81A23A7DECBE2EF9	FASTA	371	41,454
	10 20 30 40 50 60 MAATCEISNI FSNYFSAMYS SEDSTLASVP PAATFGADDL VLTLSNPQMS LEGTEKASWL 70 80 90 100 110 120 GEQPQFWSKT QVLDWISYQV EKNKYDASAI DFSRCDMDGA TLCNCALEEL RLVFGPLGDQ 130 140 150 160 170 180 LHAQLRDLTS SSSDELSWII ELLEKDGMAF QEALDPGPFD QGSPFAQELL DDGQQASPYH 190 200 210 220 230 240 PGSCGAGAPS PGSSDVSTAG TGASRSSHSS DSGGSDVDLD PTDGKLFPSD GFRDCKKGDP 250 260 270 280 290 300 KHGKRKRGRP RKLSKEYWDC LEGKKSKHAP RGTHLWEFIR DILIHPELNE GLMKWENRHE 310 320 330 340 350 360 GVFKFLRSEA VAQLWGQKKK NSNMTYEKLS RAMRYYYKRE ILERVDGRRL VYKFGKNSSG 370 WKEEEVLQSR N
	Isoform 2 (ESE-1a). Checksum: AE2A6D3633CA305E	FASTA	348	39,357
	10 20 30 40 50 60 MAATCEISNI FSNYFSAMYS SEDSTLASVP PAATFGADDL VLTLSNPQMS LEGTEKASWL 70 80 90 100 110 120 GEQPQFWSKT QVLDWISYQV EKNKYDASAI DFSRCDMDGA TLCNCALEEL RLVFGPLGDQ 130 140 150 160 170 180 LHAQLRDLTS SSSDELSWII ELLEKDGMAF QEALDPGPFD QGSPFAQELL DDVSTAGTGA 190 200 210 220 230 240 SRSSHSSDSG GSDVDLDPTD GKLFPSDGFR DCKKGDPKHG KRKRGRPRKL SKEYWDCLEG 250 260 270 280 290 300 KKSKHAPRGT HLWEFIRDIL IHPELNEGLM KWENRHEGVF KFLRSEAVAQ LWGQKKKNSN 310 320 330 340 MTYEKLSRAM RYYYKREILE RVDGRRLVYK FGKNSSGWKE EEVLQSRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family." Oettgen P., Alani R.M., Barcinski M.A., Brown L., Akbarali Y., Boltax J., Kunsch C., Munger K., Libermann T.A. Mol. Cell. Biol. 17:4419-4433(1997) [PubMed: 9234700] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[2]	"The expression of a novel, epithelium-specific ets transcription factor is restricted to the most differentiated layers in the epidermis." Andreoli J.M., Jang S.-I., Chung E., Coticchia C.M., Steinert P.M., Markova N.G. Nucleic Acids Res. 25:4287-4295(1997) [PubMed: 9336459] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[3]	"ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis." Chang C.-H., Scott G.K., Kuo W.-L., Xiong X., Suzdaltseva Y., Park J.W., Sayre P., Erny K., Collins C., Gray J.W., Benz C.C. Oncogene 14:1617-1622(1997) [PubMed: 9129154] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Placenta.
[4]	"A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer." Tymms M.J., Ng A.Y.N., Thomas R.S., Schutte B.C., Zhou J., Eyre H.J., Sutherland G.R., Seth A., Rosenberg M., Papas T., Debouck C., Kola I. Oncogene 15:2449-2462(1997) [PubMed: 9395241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Fetal lung.
[5]	"A novel ets-related transcription factor, ERT/ESX/ESE-1, regulates expression of the transforming growth factor-beta type II receptor." Choi S.-G., Yi Y., Kim Y.-S., Kato M., Chang J., Chung H.-W., Hahm K.-B., Yang H.-K., Rhee H.H., Bang Y.-J., Kim S.-J. J. Biol. Chem. 273:110-117(1998) [PubMed: 9417054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION. Tissue: Placenta.
[6]	"Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP)." Chang C.-H., Scott G.K., Baldwin M.A., Benz C.C. Oncogene 18:3682-3695(1999) [PubMed: 10391676] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), FUNCTION, INTERACTION WITH TBP, SUBCELLULAR LOCATION.
[7]	"Human aminopeptidase B (rnpep) on chromosome 1q32.2: complementary DNA, genomic structure and expression." Piesse C., Tymms M., Garrafa E., Gouzy C., Lacasa M., Cadel S., Cohen P., Foulon T. Gene 292:129-140(2002) [PubMed: 12119107] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[8]	"Partially unspliced and fully spliced ELF3 mRNA, including a new Alu element in human breast cancer." Kaplan M.H., Wang X.P., Xu H.P., Dosik M.H. Breast Cancer Res. Treat. 83:171-187(2004) [PubMed: 14997048] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING. Tissue: Mammary cancer.
[9]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[10]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Retina.
[11]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[13]	"Over-expression of ERT(ESX/ESE-1/ELF3), an ets-related transcription factor, induces endogenous TGF-beta type II receptor expression and restores the TGF-beta signaling pathway in Hs578t human breast cancer cells." Chang J., Lee C., Hahm K.-B., Yi Y., Choi S.-G., Kim S.-J. Oncogene 19:151-154(2000) [PubMed: 10644990] [Abstract] Cited for: FUNCTION.
[14]	"Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation." Brembeck F.H., Opitz O.G., Libermann T.A., Rustgi A.K. Oncogene 19:1941-1949(2000) [PubMed: 10773884] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF 247-ARG--PRO-250; TRP-315; LYS-319 AND 334-ARG--TYR-337.
[15]	"ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene." Rudders S., Gaspar J., Madore R., Voland C., Grall F., Patel A., Pellacani A., Perrella M.A., Libermann T.A., Oettgen P. J. Biol. Chem. 276:3302-3309(2001) [PubMed: 11036073] [Abstract] Cited for: FUNCTION.
[16]	"Sequence-specific enhancer binding protein is responsible for the differential expression of ERT/ESX/ELF-3/ESE-1/jen gene in human gastric cancer cell lines: implication for the loss of TGF-beta type II receptor expression." Park S.H., Kim Y.S., Park B.-K., Hougaard S., Kim S.-J. Oncogene 20:1235-1245(2001) [PubMed: 11313868] [Abstract] Cited for: FUNCTION.
[17]	"ErbB2 activation of ESX gene expression." Neve R.M., Ylstra B., Chang C.-H., Albertson D.G., Benz C.C. Oncogene 21:3934-3938(2002) [PubMed: 12032832] [Abstract] Cited for: INDUCTION.
[18]	"The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression." Eckel K.L., Tentler J.J., Cappetta G.J., Diamond S.E., Gutierrez-Hartmann A. DNA Cell Biol. 22:79-94(2003) [PubMed: 12713734] [Abstract] Cited for: FUNCTION.
[19]	"ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells." Kwon J.H., Keates S., Simeonidis S., Grall F., Libermann T.A., Keates A.C. J. Biol. Chem. 278:875-884(2003) [PubMed: 12414801] [Abstract] Cited for: FUNCTION.
[20]	"Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation." Cabral A., Fischer D.F., Vermeij W.P., Backendorf C. J. Biol. Chem. 278:17792-17799(2003) [PubMed: 12624109] [Abstract] Cited for: FUNCTION, SUBUNIT.
[21]	"Interplay between proximal and distal promoter elements is required for squamous differentiation marker induction in the bronchial epithelium: role for ESE-1, Sp1, and AP-1 proteins." Reddy S.P.M., Vuong H., Adiseshaiah P. J. Biol. Chem. 278:21378-21387(2003) [PubMed: 12682075] [Abstract] Cited for: FUNCTION, INDUCTION.
[22]	"ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation." Brown C., Gaspar J., Pettit A., Lee R., Gu X., Wang H., Manning C., Voland C., Goldring S.R., Goldring M.B., Libermann T.A., Gravallese E.M., Oettgen P. J. Biol. Chem. 279:12794-12803(2004) [PubMed: 14715662] [Abstract] Cited for: FUNCTION.
[23]	"Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86." Wang H., Fang R., Cho J.-Y., Libermann T.A., Oettgen P. J. Biol. Chem. 279:25241-25250(2004) [PubMed: 15075319] [Abstract] Cited for: FUNCTION, INTERACTION WITH CREBBP; EP300; XRCC5 AND XRCC6.
[24]	"The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism." Prescott J.D., Koto K.S.N., Singh M., Gutierrez-Hartmann A. Mol. Cell. Biol. 24:5548-5564(2004) [PubMed: 15169914] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[25]	"ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells." Schedin P.J., Eckel-Mahan K.L., McDaniel S.M., Prescott J.D., Brodsky K.S., Tentler J.J., Gutierrez-Hartmann A. Oncogene 23:1766-1779(2004) [PubMed: 14767472] [Abstract] Cited for: FUNCTION.
[26]	"The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes." Grall F.T., Prall W.C., Wei W., Gu X., Cho J.-Y., Choy B.K., Zerbini L.F., Inan M.S., Goldring S.R., Gravallese E.M., Goldring M.B., Oettgen P., Libermann T.A. FEBS J. 272:1676-1687(2005) [PubMed: 15794755] [Abstract] Cited for: FUNCTION.
[27]	"Identification of an epithelial-specific enhancer regulating ESX expression." Neve R.M., Parmar H., Amend C., Chen C., Rizzino A., Benz C.C. Gene 367:118-125(2006) [PubMed: 16307850] [Abstract] Cited for: FUNCTION, INDUCTION.
[28]	"Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3." Kohno Y., Okamoto T., Ishibe T., Nagayama S., Shima Y., Nishijo K., Shibata K.R., Fukiage K., Otsuka S., Uejima D., Araki N., Naka N., Nakashima Y., Aoyama T., Nakayama T., Nakamura T., Toguchida J. J. Biol. Chem. 281:38941-38950(2006) [PubMed: 17060315] [Abstract] Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
[29]	"Solution structure of the N-terminal SAM-domain of E74-like factor 3." RIKEN structural genomics initiative (RSGI) Submitted (JUL-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 45-132.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

U73843 mRNA. Translation: AAB65823.1.
U73844 mRNA. Translation: AAB65824.1.
U97156 mRNA. Translation: AAC51884.1.
U66894 mRNA. Translation: AAB58075.1.
AF016295 mRNA. Translation: AAB96586.1.
AF017307 mRNA. Translation: AAB67238.1.
AF110184 Genomic DNA. Translation: AAD45237.1.
BN000001 Genomic DNA. Translation: CAD29859.1.
AF517841 mRNA. Translation: AAM70481.1.
CR457106 mRNA. Translation: CAG33387.1.
BX537368 mRNA. Translation: CAD97611.1.
AL691482 Genomic DNA. Translation: CAI14961.1.
BC003569 mRNA. Translation: AAH03569.1.

IPI

IPI00004581.
IPI00844532.

RefSeq

NP_001107781.1.
NP_004424.3.

UniGene

Hs.67928

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2E8P	NMR	-	A	48-132	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

P78545. 29 interactions.

PTM databases

PhosphoSite

P78545.

Proteomic databases

PRIDE

P78545.

Genome annotation databases

Ensembl

ENSG00000163435. Homo sapiens. [Contig view]

GeneID

1999.

KEGG

hsa:1999.

UCSC

uc001gxg.2. human.

Organism-specific databases

GeneCards

GC01P200243.

H-InvDB

HIX0001469.

HGNC

HGNC:3318. ELF3.

HPA

HPA003316.
HPA003479.

MIM

602191. gene.

PharmGKB

PA27746.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P78545.

HOVERGEN

P78545.

OMA

P78545. DSGGSDV.

Gene expression databases

ArrayExpress

P78545.

Bgee

P78545.

CleanEx

HS_ELF3.

Family and domain databases

InterPro

IPR017956. AT_hook_DNA-bd_CS.
IPR000418. Ets.
IPR003118. SAM_PNT.
IPR013761. SAM_type.
IPR011991. Wing_hlx_DNA_bd.
[Graphical view]

Gene3D

G3DSA:1.10.150.50. SAM_type. 1 hit.
G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.

Pfam

PF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]

PRINTS

PR00454. ETSDOMAIN.

SMART

SM00384. AT_hook. 1 hit.
SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]

PROSITE

PS00345. ETS_DOMAIN_1. False negative.
PS00346. ETS_DOMAIN_2. False negative.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

8087.

SOURCE

Search...

Entry information

Entry name

ELF3_HUMAN

Accession

Primary (citable) accession number: P78545
Secondary accession number(s): Q6IAP8 , Q7RU03, Q7Z3X2, Q8NFG2, Q99718

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 1, 1997
Last modified:	July 7, 2009
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)