BTG2

Functionⁱ

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.By similarity5 Publications

GO - Molecular functionⁱ

transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

anterior/posterior pattern specification Source: Ensembl
associative learning Source: Ensembl
cellular response to DNA damage stimulus
Source: MGI
Inferred from direct assayⁱ
- 8944033
central nervous system neuron development Source: Ensembl
dentate gyrus development Source: Ensembl
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
DNA repair
Source: ProtInc
Traceable author statementⁱ
- 8944033
negative regulation of cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23236473
negative regulation of neural precursor cell proliferation Source: Ensembl
negative regulation of neuron apoptotic process Source: Ensembl
negative regulation of translation
Source: UniProtKB
Inferred from direct assayⁱ
- 23236473
neuron projection development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18773938
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
Source: MGI
Inferred from direct assayⁱ
- 18337750
protein methylation Source: Ensembl
response to electrical stimulus Source: Ensembl
response to mechanical stimulus Source: Ensembl
response to organic cyclic compound Source: Ensembl
response to peptide hormone Source: Ensembl
skeletal muscle cell differentiation Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Biological process	Transcription, Transcription regulation

Biological process

Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
SIGNORⁱ	P78543.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein BTG2 Alternative name(s): BTG family member 2 NGF-inducible anti-proliferative protein PC3
Gene namesⁱ	Name:BTG2 Synonyms:PC3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1131. BTG2.

HGNCⁱ

HGNC:1131. BTG2.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytosol Source: Reactome
extracellular exosome
Source: UniProtKB
Inferred from direct assayⁱ
- 19056867

Complete GO annotation...

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	53	H → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication	1
Mutagenesisⁱ	65	Y → A: Abolishes interaction with CNOT7 and CNOT8. 2 Publications	1
Mutagenesisⁱ	75	D → A: Abolishes interaction with CNOT7 and CNOT8. 1 Publication	1
Mutagenesisⁱ	103	W → A: Abolishes interaction with CNOT7 and CNOT8; impairs anti-proliferative activity. 2 Publications	1
Mutagenesisⁱ	105	D → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication	1
Mutagenesisⁱ	115	E → A: Impairs interaction with CNOT7. Inhibits CNOT7 mRNA deadenylase activity. 1 Publication	1
Mutagenesisⁱ	147	S → A: Impairs phosphorylation by MAPK1 and MAPK3, and decreases PIN1-binding. 1 Publication	1
Mutagenesisⁱ	148	P → A: Impairs PIN1-binding. 1 Publication	1
Mutagenesisⁱ	149	S → A: Impairs phosphorylation by MAPK14, and decreases PIN1-binding. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7832.
Open Targets More...OpenTargetsⁱ	ENSG00000159388.
PharmGKBⁱ	PA25451.

Polymorphism and mutation databases

BioMutaⁱ	BTG2.
DMDMⁱ	3023409.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000143804	1 – 158	Protein BTG2Add BLAST		158

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	147	Phosphoserine; by MAPK1 and MAPK31 Publication		1
Modified residueⁱ	149	Phosphoserine; by MAPK141 Publication		1

Post-translational modificationⁱ

Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P78543.
PaxDbⁱ	P78543.
PeptideAtlas More...PeptideAtlasⁱ	P78543.
PRIDEⁱ	P78543.

PTM databases

iPTMnetⁱ	P78543.
PhosphoSitePlusⁱ	P78543.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000159388.
CleanExⁱ	HS_BTG2.
Genevisibleⁱ	P78543. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA002355.

HPAⁱ

HPA002355.

Interactionⁱ

Subunit structureⁱ

Interacts with PRKCABP (By similarity). Interacts with CNOT7 and CNOT8; indicative for an association with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization.By similarity6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AR	P10275	4	EBI-1047576,EBI-608057
CNOT7	Q9UIV1	7	EBI-1047576,EBI-2105113
Cnot7	Q60809	5	EBI-1047576,EBI-2104739	From Mus musculus.
CNOT8	Q9UFF9	5	EBI-1047576,EBI-742299

Show more details

Protein-protein interaction databases

BioGridⁱ	113593. 18 interactors.
IntActⁱ	P78543. 5 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-155716.
STRINGⁱ	9606.ENSP00000290551.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	10 – 27	Combined sources	18
Helixⁱ	32 – 50	Combined sources	19
Turnⁱ	59 – 62	Combined sources	4
Helixⁱ	63 – 66	Combined sources	4
Beta strandⁱ	71 – 73	Combined sources	3
Helixⁱ	76 – 84	Combined sources	9
Helixⁱ	89 – 95	Combined sources	7
Beta strandⁱ	100 – 105	Combined sources	6
Beta strandⁱ	108 – 114	Combined sources	7
Beta strandⁱ	119 – 124	Combined sources	6

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3DJU	X-ray	2.26	B	7-128	[»]
	3E9V	X-ray	1.70	A	8-127	[»]
ProteinModelPortalⁱ	P78543.
SMRⁱ	P78543.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P78543.

EvolutionaryTraceⁱ

P78543.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4006. Eukaryota. ENOG410ZZC0. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074461.
HOGENOMⁱ	HOG000290200.
HOVERGENⁱ	HBG004907.
InParanoidⁱ	P78543.
KEGG Orthology (KO) More...KOⁱ	K14443.
OMAⁱ	PSKNYIM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RS0.
PhylomeDBⁱ	P78543.
TreeFamⁱ	TF105272.

Family and domain databases

InterProⁱ	View protein in InterPro IPR002087. Anti_prolifrtn. IPR033328. BTG2.
PANTHERⁱ	PTHR22978:SF34. PTHR22978:SF34. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07742. BTG. 1 hit.
PRINTSⁱ	PR00310. ANTIPRLFBTG1.
SMARTⁱ	View protein in SMART SM00099. btg1. 1 hit.
SUPFAMⁱ	SSF160696. SSF160696. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00960. BTG_1. 1 hit. PS01203. BTG_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P78543-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSHGKGTDML PEIAAAVGFL SSLLRTRGCV SEQRLKVFSG ALQEALTEHY 
        60         70         80         90        100
KHHWFPEKPS KGSGYRCIRI NHKMDPIISR VASQIGLSQP QLHQLLPSEL 
       110        120        130        140        150
TLWVDPYEVS YRIGEDGSIC VLYEEAPLAA SCGLLTCKNQ VLLGRSSPSK 

NYVMAVSS

Length:158

Mass (Da):17,416

Last modified:May 1, 1997 - v1

Checksum:ⁱFFAA1844CC360209

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048437	153	V → M. Corresponds to variant dbSNP:rs12039961Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U72649 mRNA. Translation: AAB37580.1. Y09943 mRNA. Translation: CAA71074.1. AF361937 Genomic DNA. Translation: AAL05626.1. AL513326 Genomic DNA. Translation: CAH70451.1. CH471067 Genomic DNA. Translation: EAW91475.1. CH471067 Genomic DNA. Translation: EAW91476.1. BC105948 mRNA. Translation: AAI05949.1. BC105949 mRNA. Translation: AAI05950.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1437.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_006754.1. NM_006763.2.
UniGeneⁱ	Hs.519162.

Genome annotation databases

Ensemblⁱ	ENST00000290551; ENSP00000290551; ENSG00000159388. ENST00000475157; ENSP00000433553; ENSG00000159388.
GeneIDⁱ	7832.
KEGGⁱ	hsa:7832.
UCSC genome browser More...UCSCⁱ	uc001gzq.4. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U72649 mRNA. Translation: AAB37580.1. Y09943 mRNA. Translation: CAA71074.1. AF361937 Genomic DNA. Translation: AAL05626.1. AL513326 Genomic DNA. Translation: CAH70451.1. CH471067 Genomic DNA. Translation: EAW91475.1. CH471067 Genomic DNA. Translation: EAW91476.1. BC105948 mRNA. Translation: AAI05949.1. BC105949 mRNA. Translation: AAI05950.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1437.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_006754.1. NM_006763.2.
UniGeneⁱ	Hs.519162.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3DJU	X-ray	2.26	B	7-128	[»]
	3E9V	X-ray	1.70	A	8-127	[»]
ProteinModelPortalⁱ	P78543.
SMRⁱ	P78543.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113593. 18 interactors.
IntActⁱ	P78543. 5 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-155716.
STRINGⁱ	9606.ENSP00000290551.

PTM databases

iPTMnetⁱ	P78543.
PhosphoSitePlusⁱ	P78543.

Polymorphism and mutation databases

BioMutaⁱ	BTG2.
DMDMⁱ	3023409.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P78543.
PaxDbⁱ	P78543.
PeptideAtlas More...PeptideAtlasⁱ	P78543.
PRIDEⁱ	P78543.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7832.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000290551; ENSP00000290551; ENSG00000159388. ENST00000475157; ENSP00000433553; ENSG00000159388.
GeneIDⁱ	7832.
KEGGⁱ	hsa:7832.
UCSC genome browser More...UCSCⁱ	uc001gzq.4. human.

Organism-specific databases

CTDⁱ	7832.
DisGeNET More...DisGeNETⁱ	7832.
GeneCardsⁱ	BTG2.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1131. BTG2.
Human Protein Atlas More...HPAⁱ	HPA002355.
MIMⁱ	601597. gene.
neXtProtⁱ	NX_P78543.
Open Targets More...OpenTargetsⁱ	ENSG00000159388.
PharmGKBⁱ	PA25451.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4006. Eukaryota. ENOG410ZZC0. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074461.
HOGENOMⁱ	HOG000290200.
HOVERGENⁱ	HBG004907.
InParanoidⁱ	P78543.
KEGG Orthology (KO) More...KOⁱ	K14443.
OMAⁱ	PSKNYIM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RS0.
PhylomeDBⁱ	P78543.
TreeFamⁱ	TF105272.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
SIGNORⁱ	P78543.

Miscellaneous databases

ChiTaRSⁱ	BTG2. human.
EvolutionaryTraceⁱ	P78543.
GeneWikiⁱ	BTG2.
GenomeRNAiⁱ	7832.
Protein Ontology More...PROⁱ	PR:P78543.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000159388.
CleanExⁱ	HS_BTG2.
Genevisibleⁱ	P78543. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR002087. Anti_prolifrtn. IPR033328. BTG2.
PANTHERⁱ	PTHR22978:SF34. PTHR22978:SF34. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07742. BTG. 1 hit.
PRINTSⁱ	PR00310. ANTIPRLFBTG1.
SMARTⁱ	View protein in SMART SM00099. btg1. 1 hit.
SUPFAMⁱ	SSF160696. SSF160696. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00960. BTG_1. 1 hit. PS01203. BTG_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BTG2_HUMAN
Accessionⁱ	P78543Primary (citable) accession number: P78543 Secondary accession number(s): A0A024R986, Q3KR25, Q5VUT0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	May 1, 1997
	Last modified:	June 7, 2017
	This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P78543 (BTG2_HUMAN)

Your basket is currently empty.

Protein BTG2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ