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Protein

Protein BTG2

Gene

BTG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.By similarity5 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159388-MONOMER.
ReactomeiR-HSA-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
SIGNORiP78543.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG2
Alternative name(s):
BTG family member 2
NGF-inducible anti-proliferative protein PC3
Gene namesi
Name:BTG2
Synonyms:PC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1131. BTG2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi53H → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication1
Mutagenesisi65Y → A: Abolishes interaction with CNOT7 and CNOT8. 2 Publications1
Mutagenesisi75D → A: Abolishes interaction with CNOT7 and CNOT8. 1 Publication1
Mutagenesisi103W → A: Abolishes interaction with CNOT7 and CNOT8; impairs anti-proliferative activity. 2 Publications1
Mutagenesisi105D → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication1
Mutagenesisi115E → A: Impairs interaction with CNOT7. Inhibits CNOT7 mRNA deadenylase activity. 1 Publication1
Mutagenesisi147S → A: Impairs phosphorylation by MAPK1 and MAPK3, and decreases PIN1-binding. 1 Publication1
Mutagenesisi148P → A: Impairs PIN1-binding. 1 Publication1
Mutagenesisi149S → A: Impairs phosphorylation by MAPK14, and decreases PIN1-binding. 1 Publication1

Organism-specific databases

DisGeNETi7832.
OpenTargetsiENSG00000159388.
PharmGKBiPA25451.

Polymorphism and mutation databases

BioMutaiBTG2.
DMDMi3023409.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438041 – 158Protein BTG2Add BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147Phosphoserine; by MAPK1 and MAPK31 Publication1
Modified residuei149Phosphoserine; by MAPK141 Publication1

Post-translational modificationi

Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP78543.
PaxDbiP78543.
PeptideAtlasiP78543.
PRIDEiP78543.

PTM databases

iPTMnetiP78543.
PhosphoSitePlusiP78543.

Expressioni

Gene expression databases

BgeeiENSG00000159388.
CleanExiHS_BTG2.
GenevisibleiP78543. HS.

Organism-specific databases

HPAiHPA002355.

Interactioni

Subunit structurei

Interacts with PRKCABP (By similarity). Interacts with CNOT7 and CNOT8; indicative for an association with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization.By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102754EBI-1047576,EBI-608057
CNOT7Q9UIV17EBI-1047576,EBI-2105113
Cnot7Q608095EBI-1047576,EBI-2104739From a different organism.
CNOT8Q9UFF95EBI-1047576,EBI-742299

Protein-protein interaction databases

BioGridi113593. 19 interactors.
IntActiP78543. 5 interactors.
MINTiMINT-155716.
STRINGi9606.ENSP00000290551.

Structurei

Secondary structure

1158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 27Combined sources18
Helixi32 – 50Combined sources19
Turni59 – 62Combined sources4
Helixi63 – 66Combined sources4
Beta strandi71 – 73Combined sources3
Helixi76 – 84Combined sources9
Helixi89 – 95Combined sources7
Beta strandi100 – 105Combined sources6
Beta strandi108 – 114Combined sources7
Beta strandi119 – 124Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DJUX-ray2.26B7-128[»]
3E9VX-ray1.70A8-127[»]
ProteinModelPortaliP78543.
SMRiP78543.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78543.

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiP78543.
KOiK14443.
OMAiMLTCKNQ.
OrthoDBiEOG091G0RS0.
PhylomeDBiP78543.
TreeFamiTF105272.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR033328. BTG2.
[Graphical view]
PANTHERiPTHR22978:SF29. PTHR22978:SF29. 1 hit.
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGKGTDML PEIAAAVGFL SSLLRTRGCV SEQRLKVFSG ALQEALTEHY
60 70 80 90 100
KHHWFPEKPS KGSGYRCIRI NHKMDPIISR VASQIGLSQP QLHQLLPSEL
110 120 130 140 150
TLWVDPYEVS YRIGEDGSIC VLYEEAPLAA SCGLLTCKNQ VLLGRSSPSK

NYVMAVSS
Length:158
Mass (Da):17,416
Last modified:May 1, 1997 - v1
Checksum:iFFAA1844CC360209
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048437153V → M.Corresponds to variant rs12039961dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72649 mRNA. Translation: AAB37580.1.
Y09943 mRNA. Translation: CAA71074.1.
AF361937 Genomic DNA. Translation: AAL05626.1.
AL513326 Genomic DNA. Translation: CAH70451.1.
CH471067 Genomic DNA. Translation: EAW91475.1.
CH471067 Genomic DNA. Translation: EAW91476.1.
BC105948 mRNA. Translation: AAI05949.1.
BC105949 mRNA. Translation: AAI05950.1.
CCDSiCCDS1437.1.
RefSeqiNP_006754.1. NM_006763.2.
UniGeneiHs.519162.

Genome annotation databases

EnsembliENST00000290551; ENSP00000290551; ENSG00000159388.
ENST00000475157; ENSP00000433553; ENSG00000159388.
GeneIDi7832.
KEGGihsa:7832.
UCSCiuc001gzq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72649 mRNA. Translation: AAB37580.1.
Y09943 mRNA. Translation: CAA71074.1.
AF361937 Genomic DNA. Translation: AAL05626.1.
AL513326 Genomic DNA. Translation: CAH70451.1.
CH471067 Genomic DNA. Translation: EAW91475.1.
CH471067 Genomic DNA. Translation: EAW91476.1.
BC105948 mRNA. Translation: AAI05949.1.
BC105949 mRNA. Translation: AAI05950.1.
CCDSiCCDS1437.1.
RefSeqiNP_006754.1. NM_006763.2.
UniGeneiHs.519162.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DJUX-ray2.26B7-128[»]
3E9VX-ray1.70A8-127[»]
ProteinModelPortaliP78543.
SMRiP78543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113593. 19 interactors.
IntActiP78543. 5 interactors.
MINTiMINT-155716.
STRINGi9606.ENSP00000290551.

PTM databases

iPTMnetiP78543.
PhosphoSitePlusiP78543.

Polymorphism and mutation databases

BioMutaiBTG2.
DMDMi3023409.

Proteomic databases

MaxQBiP78543.
PaxDbiP78543.
PeptideAtlasiP78543.
PRIDEiP78543.

Protocols and materials databases

DNASUi7832.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290551; ENSP00000290551; ENSG00000159388.
ENST00000475157; ENSP00000433553; ENSG00000159388.
GeneIDi7832.
KEGGihsa:7832.
UCSCiuc001gzq.4. human.

Organism-specific databases

CTDi7832.
DisGeNETi7832.
GeneCardsiBTG2.
HGNCiHGNC:1131. BTG2.
HPAiHPA002355.
MIMi601597. gene.
neXtProtiNX_P78543.
OpenTargetsiENSG00000159388.
PharmGKBiPA25451.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiP78543.
KOiK14443.
OMAiMLTCKNQ.
OrthoDBiEOG091G0RS0.
PhylomeDBiP78543.
TreeFamiTF105272.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159388-MONOMER.
ReactomeiR-HSA-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
SIGNORiP78543.

Miscellaneous databases

ChiTaRSiBTG2. human.
EvolutionaryTraceiP78543.
GeneWikiiBTG2.
GenomeRNAii7832.
PROiP78543.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159388.
CleanExiHS_BTG2.
GenevisibleiP78543. HS.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR033328. BTG2.
[Graphical view]
PANTHERiPTHR22978:SF29. PTHR22978:SF29. 1 hit.
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBTG2_HUMAN
AccessioniPrimary (citable) accession number: P78543
Secondary accession number(s): A0A024R986, Q3KR25, Q5VUT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.