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P78524

- ST5_HUMAN

UniProt

P78524 - ST5_HUMAN

Protein

Suppression of tumorigenicity 5 protein

Gene

ST5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.3 Publications

    GO - Molecular functioni

    1. Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of ERK1 and ERK2 cascade Source: MGI
    2. positive regulation of Rab GTPase activity Source: GOC

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Suppression of tumorigenicity 5 protein
    Alternative name(s):
    DENN domain-containing protein 2B
    HeLa tumor suppression 1
    Gene namesi
    Name:ST5
    Synonyms:DENND2B, HTS1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:11350. ST5.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36172.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11371137Suppression of tumorigenicity 5 proteinPRO_0000247448Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei622 – 6221Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP78524.
    PaxDbiP78524.
    PRIDEiP78524.

    PTM databases

    PhosphoSiteiP78524.

    Expressioni

    Tissue specificityi

    Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiP78524.
    BgeeiP78524.
    CleanExiHS_ST5.
    GenevestigatoriP78524.

    Organism-specific databases

    HPAiHPA046796.

    Interactioni

    Subunit structurei

    Isoform 1 interacts with the SH3 domain of ABL1.1 Publication

    Protein-protein interaction databases

    BioGridi112642. 5 interactions.
    IntActiP78524. 5 interactions.
    MINTiMINT-1184327.

    Structurei

    3D structure databases

    ProteinModelPortaliP78524.
    SMRiP78524. Positions 736-1089.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini709 – 78476UDENNAdd
    BLAST
    Domaini791 – 975185DENNPROSITE-ProRule annotationAdd
    BLAST
    Domaini1022 – 108968dDENNPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni401 – 44747Interaction with ABL1Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi33 – 9361Pro-richAdd
    BLAST
    Compositional biasi350 – 43485Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 dDENN domain.PROSITE-ProRule annotation
    Contains 1 DENN domain.PROSITE-ProRule annotation
    Contains 1 uDENN domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG247048.
    HOVERGENiHBG079980.
    InParanoidiP78524.
    OMAiDRKYNNP.
    OrthoDBiEOG79GT6H.
    PhylomeDBiP78524.
    TreeFamiTF320336.

    Family and domain databases

    InterProiIPR005112. dDENN_dom.
    IPR001194. DENN_dom.
    IPR005113. uDENN_dom.
    [Graphical view]
    PfamiPF03455. dDENN. 1 hit.
    PF02141. DENN. 1 hit.
    PF03456. uDENN. 1 hit.
    [Graphical view]
    SMARTiSM00801. dDENN. 1 hit.
    SM00799. DENN. 1 hit.
    SM00800. uDENN. 1 hit.
    [Graphical view]
    PROSITEiPS50947. DDENN. 1 hit.
    PS50211. DENN. 1 hit.
    PS50946. UDENN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform 1 (identifier: P78524-1) [UniParc]FASTAAdd to Basket

    Also known as: p126

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTMTANKNSS ITHGAGGTKA PRGTLSRSQS VSPPPVLSPP RSPIYPLSDS     50
    ETSACRYPSH SSSRVLLKDR HPPAPSPQNP QDPSPDTSPP TCPFKTASFG 100
    YLDRSPSACK RDAQKESVQG AAQDVAGVAA CLPLAQSTPF PGPAAGPRGV 150
    LLTRTGTRAH SLGIREKISA WEGRREASPR MSMCGEKREG SGSEWAASEG 200
    CPSLGCPSVV PSPCSSEKTF DFKGLRRMSR TFSECSYPET EEEGEALPVR 250
    DSFYRLEKRL GRSEPSAFLR GHGSRKESSA VLSRIQKIEQ VLKEQPGRGL 300
    PQLPSSCYSV DRGKRKTGTL GSLEEPAGGA SVSAGSRAVG VAGVAGEAGP 350
    PPEREGSGST KPGTPGNSPS SQRLPSKSSL DPAVNPVPKP KRTFEYEADK 400
    NPKSKPSNGL PPSPTPAAPP PLPSTPAPPV TRRPKKDMRG HRKSQSRKSF 450
    EFEDASSLQS LYPSSPTENG TENQPKFGSK STLEENAYED IVGDLPKENP 500
    YEDVDLKSRR AGRKSQQLSE NSLDSLHRMW SPQDRKYNSP PTQLSLKPNS 550
    QSLRSGNWSE RKSHRLPRLP KRHSHDDMLL LAQLSLPSSP SSLNEDSLST 600
    TSELLSSRRA RRIPKLVQRI NSIYNAKRGK KRLKKLSMSS IETASLRDEN 650
    SESESDSDDR FKAHTQRLVH IQSMLKRAPS YRTLELELLE WQERELFEYF 700
    VVVSLKKKPS RNTYLPEVSY QFPKLDRPTK QMREAEERLK AIPQFCFPDA 750
    KDWLPVSEYS SETFSFMLTG EDGSRRFGYC RRLLPSGKGP RLPEVYCVIS 800
    RLGCFGLFSK VLDEVERRRG ISAALVYPFM RSLMESPFPA PGKTIKVKTF 850
    LPGAGNEVLE LRRPMDSRLE HVDFECLFTC LSVRQLIRIF ASLLLERRVI 900
    FVADKLSTLS SCSHAVVALL YPFSWQHTFI PVLPASMIDI VCCPTPFLVG 950
    LLSSSLPKLK ELPVEEALMV NLGSDRFIRQ MDDEDTLLPR KLQAALEQAL 1000
    ERKNELISQD SDSDSDDECN TLNGLVSEVF IRFFVETVGH YSLFLTQSEK 1050
    GERAFQREAF RKSVASKSIR RFLEVFMESQ MFAGFIQDRE LRKCRAKGLF 1100
    EQRVEQYLEE LPDTEQSGMN KFLRGLGNKM KFLHKKN 1137

    Note: Produced by alternative promoter usage.

    Length:1,137
    Mass (Da):126,485
    Last modified:January 11, 2011 - v3
    Checksum:i96ACD16E0602479E
    GO
    Isoform 2 (identifier: P78524-2) [UniParc]FASTAAdd to Basket

    Also known as: p82

    The sequence of this isoform differs from the canonical sequence as follows:
         28-447: Missing.

    Note: Produced by alternative splicing of isoform 1.

    Show »
    Length:717
    Mass (Da):82,079
    Checksum:i0329586AEE3E05BE
    GO
    Isoform 3 (identifier: P78524-3) [UniParc]FASTAAdd to Basket

    Also known as: p70

    The sequence of this isoform differs from the canonical sequence as follows:
         1-528: Missing.

    Note: Produced by alternative promoter usage.

    Show »
    Length:609
    Mass (Da):70,245
    Checksum:i59F8FB669B1058E5
    GO

    Sequence cautioni

    The sequence AAC50925.1 differs from that shown. Reason: Frameshift at positions 159 and 169.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti113 – 1131A → T in AAC50925. (PubMed:8972856)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti316 – 3161K → N.1 Publication
    Corresponds to variant rs3794153 [ dbSNP | Ensembl ].
    VAR_027101
    Natural varianti399 – 3991D → E.2 Publications
    Corresponds to variant rs3812762 [ dbSNP | Ensembl ].
    VAR_027102
    Natural varianti620 – 6201I → T.1 Publication
    Corresponds to variant rs17853683 [ dbSNP | Ensembl ].
    VAR_027103
    Natural varianti657 – 6571S → F.
    Corresponds to variant rs11042047 [ dbSNP | Ensembl ].
    VAR_030642
    Natural varianti774 – 7741S → G.1 Publication
    Corresponds to variant rs17853682 [ dbSNP | Ensembl ].
    VAR_027104

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 528528Missing in isoform 3. 2 PublicationsVSP_019987Add
    BLAST
    Alternative sequencei28 – 447420Missing in isoform 2. 2 PublicationsVSP_019988Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15131 mRNA. Translation: AAC50925.1. Frameshift.
    U15779 mRNA. Translation: AAB97097.1.
    U15780 mRNA. Translation: AAC50926.1.
    AJ400879 Genomic DNA. Translation: CAC35387.1.
    AK127763 mRNA. Translation: BAG54568.1.
    AK312758 mRNA. Translation: BAG35624.1.
    AC026894 Genomic DNA. No translation available.
    AC091053 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68618.1.
    BC036655 mRNA. Translation: AAH36655.1.
    S45936 mRNA. Translation: AAB23647.1.
    CCDSiCCDS7791.1. [P78524-1]
    CCDS7792.1. [P78524-2]
    PIRiA49013.
    RefSeqiNP_005409.3. NM_005418.3. [P78524-1]
    NP_631896.1. NM_139157.2. [P78524-2]
    NP_998783.1. NM_213618.1. [P78524-1]
    XP_005253136.1. XM_005253079.1. [P78524-1]
    XP_005253137.1. XM_005253080.1. [P78524-1]
    XP_005253140.1. XM_005253083.1. [P78524-2]
    XP_005253141.1. XM_005253084.1. [P78524-2]
    XP_006718347.1. XM_006718284.1. [P78524-1]
    XP_006718348.1. XM_006718285.1. [P78524-1]
    UniGeneiHs.117715.

    Genome annotation databases

    EnsembliENST00000313726; ENSP00000319678; ENSG00000166444. [P78524-1]
    ENST00000357665; ENSP00000350294; ENSG00000166444. [P78524-1]
    ENST00000526757; ENSP00000435097; ENSG00000166444. [P78524-2]
    ENST00000530438; ENSP00000436802; ENSG00000166444. [P78524-2]
    ENST00000530991; ENSP00000432887; ENSG00000166444. [P78524-3]
    ENST00000534127; ENSP00000433528; ENSG00000166444. [P78524-1]
    GeneIDi6764.
    KEGGihsa:6764.
    UCSCiuc001mgt.3. human. [P78524-1]
    uc001mgu.3. human. [P78524-2]

    Polymorphism databases

    DMDMi317373507.

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15131 mRNA. Translation: AAC50925.1 . Frameshift.
    U15779 mRNA. Translation: AAB97097.1 .
    U15780 mRNA. Translation: AAC50926.1 .
    AJ400879 Genomic DNA. Translation: CAC35387.1 .
    AK127763 mRNA. Translation: BAG54568.1 .
    AK312758 mRNA. Translation: BAG35624.1 .
    AC026894 Genomic DNA. No translation available.
    AC091053 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68618.1 .
    BC036655 mRNA. Translation: AAH36655.1 .
    S45936 mRNA. Translation: AAB23647.1 .
    CCDSi CCDS7791.1. [P78524-1 ]
    CCDS7792.1. [P78524-2 ]
    PIRi A49013.
    RefSeqi NP_005409.3. NM_005418.3. [P78524-1 ]
    NP_631896.1. NM_139157.2. [P78524-2 ]
    NP_998783.1. NM_213618.1. [P78524-1 ]
    XP_005253136.1. XM_005253079.1. [P78524-1 ]
    XP_005253137.1. XM_005253080.1. [P78524-1 ]
    XP_005253140.1. XM_005253083.1. [P78524-2 ]
    XP_005253141.1. XM_005253084.1. [P78524-2 ]
    XP_006718347.1. XM_006718284.1. [P78524-1 ]
    XP_006718348.1. XM_006718285.1. [P78524-1 ]
    UniGenei Hs.117715.

    3D structure databases

    ProteinModelPortali P78524.
    SMRi P78524. Positions 736-1089.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112642. 5 interactions.
    IntActi P78524. 5 interactions.
    MINTi MINT-1184327.

    PTM databases

    PhosphoSitei P78524.

    Polymorphism databases

    DMDMi 317373507.

    Proteomic databases

    MaxQBi P78524.
    PaxDbi P78524.
    PRIDEi P78524.

    Protocols and materials databases

    DNASUi 6764.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313726 ; ENSP00000319678 ; ENSG00000166444 . [P78524-1 ]
    ENST00000357665 ; ENSP00000350294 ; ENSG00000166444 . [P78524-1 ]
    ENST00000526757 ; ENSP00000435097 ; ENSG00000166444 . [P78524-2 ]
    ENST00000530438 ; ENSP00000436802 ; ENSG00000166444 . [P78524-2 ]
    ENST00000530991 ; ENSP00000432887 ; ENSG00000166444 . [P78524-3 ]
    ENST00000534127 ; ENSP00000433528 ; ENSG00000166444 . [P78524-1 ]
    GeneIDi 6764.
    KEGGi hsa:6764.
    UCSCi uc001mgt.3. human. [P78524-1 ]
    uc001mgu.3. human. [P78524-2 ]

    Organism-specific databases

    CTDi 6764.
    GeneCardsi GC11M008714.
    H-InvDB HIX0026155.
    HGNCi HGNC:11350. ST5.
    HPAi HPA046796.
    MIMi 140750. gene.
    neXtProti NX_P78524.
    PharmGKBi PA36172.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG247048.
    HOVERGENi HBG079980.
    InParanoidi P78524.
    OMAi DRKYNNP.
    OrthoDBi EOG79GT6H.
    PhylomeDBi P78524.
    TreeFami TF320336.

    Miscellaneous databases

    ChiTaRSi ST5. human.
    GeneWikii ST5_(gene).
    GenomeRNAii 6764.
    NextBioi 26398.
    PROi P78524.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P78524.
    Bgeei P78524.
    CleanExi HS_ST5.
    Genevestigatori P78524.

    Family and domain databases

    InterProi IPR005112. dDENN_dom.
    IPR001194. DENN_dom.
    IPR005113. uDENN_dom.
    [Graphical view ]
    Pfami PF03455. dDENN. 1 hit.
    PF02141. DENN. 1 hit.
    PF03456. uDENN. 1 hit.
    [Graphical view ]
    SMARTi SM00801. dDENN. 1 hit.
    SM00799. DENN. 1 hit.
    SM00800. uDENN. 1 hit.
    [Graphical view ]
    PROSITEi PS50947. DDENN. 1 hit.
    PS50211. DENN. 1 hit.
    PS50946. UDENN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential expression of the human ST5 gene in HeLa-fibroblast hybrid cell lines mediated by YY1: evidence that YY1 plays a part in tumor suppression."
      Lichy J.H., Majidi M., Elbaum J., Tsai M.M.
      Nucleic Acids Res. 24:4700-4708(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT GLU-399.
    2. "Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7."
      Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A., Zabel B., Hankeln T., Schmidt E.R.
      Cytogenet. Cell Genet. 93:284-290(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-399.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Brain and Spleen.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASN-316; THR-620 AND GLY-774.
      Tissue: Testis.
    7. "Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells."
      Lichy J.H., Modi W.S., Seuanez H.N., Howley P.M.
      Cell Growth Differ. 3:541-548(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 493-1137.
    8. "Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5."
      Majidi M., Hubbs A.E., Lichy J.H.
      J. Biol. Chem. 273:16608-16614(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ABL1.
    9. "Expression of an isoform of the novel signal transduction protein ST5 is linked to cell morphology."
      Hubbs A.E., Majidi M., Lichy J.H.
      Oncogene 18:2519-2525(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-622, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."
      Yoshimura S., Gerondopoulos A., Linford A., Rigden D.J., Barr F.A.
      J. Cell Biol. 191:367-381(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS GUANYL-NUCLEOTIDE EXCHANGE FACTOR.

    Entry informationi

    Entry nameiST5_HUMAN
    AccessioniPrimary (citable) accession number: P78524
    Secondary accession number(s): B2R6X7
    , B3KXQ6, P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3