SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P78524

- ST5_HUMAN

UniProt

P78524 - ST5_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Suppression of tumorigenicity 5 protein
Gene
ST5, DENND2B, HTS1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.3 Publications

GO - Molecular functioni

  1. Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  1. positive regulation of ERK1 and ERK2 cascade Source: MGI
  2. regulation of Rab GTPase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Suppression of tumorigenicity 5 protein
Alternative name(s):
DENN domain-containing protein 2B
HeLa tumor suppression 1
Gene namesi
Name:ST5
Synonyms:DENND2B, HTS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:11350. ST5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36172.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11371137Suppression of tumorigenicity 5 protein
PRO_0000247448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei622 – 6221Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP78524.
PaxDbiP78524.
PRIDEiP78524.

PTM databases

PhosphoSiteiP78524.

Expressioni

Tissue specificityi

Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level).1 Publication

Gene expression databases

ArrayExpressiP78524.
BgeeiP78524.
CleanExiHS_ST5.
GenevestigatoriP78524.

Organism-specific databases

HPAiHPA046796.

Interactioni

Subunit structurei

Isoform 1 interacts with the SH3 domain of ABL1.1 Publication

Protein-protein interaction databases

BioGridi112642. 5 interactions.
IntActiP78524. 5 interactions.
MINTiMINT-1184327.

Structurei

3D structure databases

ProteinModelPortaliP78524.
SMRiP78524. Positions 736-1089.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini709 – 78476UDENN
Add
BLAST
Domaini791 – 975185DENN
Add
BLAST
Domaini1022 – 108968dDENN
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni401 – 44747Interaction with ABL1
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 9361Pro-rich
Add
BLAST
Compositional biasi350 – 43485Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 dDENN domain.
Contains 1 DENN domain.
Contains 1 uDENN domain.

Phylogenomic databases

eggNOGiNOG247048.
HOVERGENiHBG079980.
InParanoidiP78524.
OMAiDRKYNNP.
OrthoDBiEOG79GT6H.
PhylomeDBiP78524.
TreeFamiTF320336.

Family and domain databases

InterProiIPR005112. dDENN_dom.
IPR001194. DENN_dom.
IPR005113. uDENN_dom.
[Graphical view]
PfamiPF03455. dDENN. 1 hit.
PF02141. DENN. 1 hit.
PF03456. uDENN. 1 hit.
[Graphical view]
SMARTiSM00801. dDENN. 1 hit.
SM00799. DENN. 1 hit.
SM00800. uDENN. 1 hit.
[Graphical view]
PROSITEiPS50947. DDENN. 1 hit.
PS50211. DENN. 1 hit.
PS50946. UDENN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform 1 (identifier: P78524-1) [UniParc]FASTAAdd to Basket

Also known as: p126

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTMTANKNSS ITHGAGGTKA PRGTLSRSQS VSPPPVLSPP RSPIYPLSDS     50
ETSACRYPSH SSSRVLLKDR HPPAPSPQNP QDPSPDTSPP TCPFKTASFG 100
YLDRSPSACK RDAQKESVQG AAQDVAGVAA CLPLAQSTPF PGPAAGPRGV 150
LLTRTGTRAH SLGIREKISA WEGRREASPR MSMCGEKREG SGSEWAASEG 200
CPSLGCPSVV PSPCSSEKTF DFKGLRRMSR TFSECSYPET EEEGEALPVR 250
DSFYRLEKRL GRSEPSAFLR GHGSRKESSA VLSRIQKIEQ VLKEQPGRGL 300
PQLPSSCYSV DRGKRKTGTL GSLEEPAGGA SVSAGSRAVG VAGVAGEAGP 350
PPEREGSGST KPGTPGNSPS SQRLPSKSSL DPAVNPVPKP KRTFEYEADK 400
NPKSKPSNGL PPSPTPAAPP PLPSTPAPPV TRRPKKDMRG HRKSQSRKSF 450
EFEDASSLQS LYPSSPTENG TENQPKFGSK STLEENAYED IVGDLPKENP 500
YEDVDLKSRR AGRKSQQLSE NSLDSLHRMW SPQDRKYNSP PTQLSLKPNS 550
QSLRSGNWSE RKSHRLPRLP KRHSHDDMLL LAQLSLPSSP SSLNEDSLST 600
TSELLSSRRA RRIPKLVQRI NSIYNAKRGK KRLKKLSMSS IETASLRDEN 650
SESESDSDDR FKAHTQRLVH IQSMLKRAPS YRTLELELLE WQERELFEYF 700
VVVSLKKKPS RNTYLPEVSY QFPKLDRPTK QMREAEERLK AIPQFCFPDA 750
KDWLPVSEYS SETFSFMLTG EDGSRRFGYC RRLLPSGKGP RLPEVYCVIS 800
RLGCFGLFSK VLDEVERRRG ISAALVYPFM RSLMESPFPA PGKTIKVKTF 850
LPGAGNEVLE LRRPMDSRLE HVDFECLFTC LSVRQLIRIF ASLLLERRVI 900
FVADKLSTLS SCSHAVVALL YPFSWQHTFI PVLPASMIDI VCCPTPFLVG 950
LLSSSLPKLK ELPVEEALMV NLGSDRFIRQ MDDEDTLLPR KLQAALEQAL 1000
ERKNELISQD SDSDSDDECN TLNGLVSEVF IRFFVETVGH YSLFLTQSEK 1050
GERAFQREAF RKSVASKSIR RFLEVFMESQ MFAGFIQDRE LRKCRAKGLF 1100
EQRVEQYLEE LPDTEQSGMN KFLRGLGNKM KFLHKKN 1137

Note: Produced by alternative promoter usage.

Length:1,137
Mass (Da):126,485
Last modified:January 11, 2011 - v3
Checksum:i96ACD16E0602479E
GO
Isoform 2 (identifier: P78524-2) [UniParc]FASTAAdd to Basket

Also known as: p82

The sequence of this isoform differs from the canonical sequence as follows:
     28-447: Missing.

Note: Produced by alternative splicing of isoform 1.

Show »
Length:717
Mass (Da):82,079
Checksum:i0329586AEE3E05BE
GO
Isoform 3 (identifier: P78524-3) [UniParc]FASTAAdd to Basket

Also known as: p70

The sequence of this isoform differs from the canonical sequence as follows:
     1-528: Missing.

Note: Produced by alternative promoter usage.

Show »
Length:609
Mass (Da):70,245
Checksum:i59F8FB669B1058E5
GO

Sequence cautioni

The sequence AAC50925.1 differs from that shown. Reason: Frameshift at positions 159 and 169.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti316 – 3161K → N.1 Publication
Corresponds to variant rs3794153 [ dbSNP | Ensembl ].
VAR_027101
Natural varianti399 – 3991D → E.2 Publications
Corresponds to variant rs3812762 [ dbSNP | Ensembl ].
VAR_027102
Natural varianti620 – 6201I → T.1 Publication
Corresponds to variant rs17853683 [ dbSNP | Ensembl ].
VAR_027103
Natural varianti657 – 6571S → F.
Corresponds to variant rs11042047 [ dbSNP | Ensembl ].
VAR_030642
Natural varianti774 – 7741S → G.1 Publication
Corresponds to variant rs17853682 [ dbSNP | Ensembl ].
VAR_027104

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 528528Missing in isoform 3.
VSP_019987Add
BLAST
Alternative sequencei28 – 447420Missing in isoform 2.
VSP_019988Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131A → T in AAC50925. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15131 mRNA. Translation: AAC50925.1. Frameshift.
U15779 mRNA. Translation: AAB97097.1.
U15780 mRNA. Translation: AAC50926.1.
AJ400879 Genomic DNA. Translation: CAC35387.1.
AK127763 mRNA. Translation: BAG54568.1.
AK312758 mRNA. Translation: BAG35624.1.
AC026894 Genomic DNA. No translation available.
AC091053 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68618.1.
BC036655 mRNA. Translation: AAH36655.1.
S45936 mRNA. Translation: AAB23647.1.
CCDSiCCDS7791.1. [P78524-1]
CCDS7792.1. [P78524-2]
PIRiA49013.
RefSeqiNP_005409.3. NM_005418.3. [P78524-1]
NP_631896.1. NM_139157.2. [P78524-2]
NP_998783.1. NM_213618.1. [P78524-1]
XP_005253136.1. XM_005253079.1. [P78524-1]
XP_005253137.1. XM_005253080.1. [P78524-1]
XP_005253140.1. XM_005253083.1. [P78524-2]
XP_005253141.1. XM_005253084.1. [P78524-2]
XP_006718347.1. XM_006718284.1. [P78524-1]
XP_006718348.1. XM_006718285.1. [P78524-1]
UniGeneiHs.117715.

Genome annotation databases

EnsembliENST00000313726; ENSP00000319678; ENSG00000166444. [P78524-1]
ENST00000357665; ENSP00000350294; ENSG00000166444. [P78524-1]
ENST00000526757; ENSP00000435097; ENSG00000166444. [P78524-2]
ENST00000530438; ENSP00000436802; ENSG00000166444. [P78524-2]
ENST00000530991; ENSP00000432887; ENSG00000166444. [P78524-3]
ENST00000534127; ENSP00000433528; ENSG00000166444. [P78524-1]
GeneIDi6764.
KEGGihsa:6764.
UCSCiuc001mgt.3. human. [P78524-1]
uc001mgu.3. human. [P78524-2]

Polymorphism databases

DMDMi317373507.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15131 mRNA. Translation: AAC50925.1 . Frameshift.
U15779 mRNA. Translation: AAB97097.1 .
U15780 mRNA. Translation: AAC50926.1 .
AJ400879 Genomic DNA. Translation: CAC35387.1 .
AK127763 mRNA. Translation: BAG54568.1 .
AK312758 mRNA. Translation: BAG35624.1 .
AC026894 Genomic DNA. No translation available.
AC091053 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68618.1 .
BC036655 mRNA. Translation: AAH36655.1 .
S45936 mRNA. Translation: AAB23647.1 .
CCDSi CCDS7791.1. [P78524-1 ]
CCDS7792.1. [P78524-2 ]
PIRi A49013.
RefSeqi NP_005409.3. NM_005418.3. [P78524-1 ]
NP_631896.1. NM_139157.2. [P78524-2 ]
NP_998783.1. NM_213618.1. [P78524-1 ]
XP_005253136.1. XM_005253079.1. [P78524-1 ]
XP_005253137.1. XM_005253080.1. [P78524-1 ]
XP_005253140.1. XM_005253083.1. [P78524-2 ]
XP_005253141.1. XM_005253084.1. [P78524-2 ]
XP_006718347.1. XM_006718284.1. [P78524-1 ]
XP_006718348.1. XM_006718285.1. [P78524-1 ]
UniGenei Hs.117715.

3D structure databases

ProteinModelPortali P78524.
SMRi P78524. Positions 736-1089.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112642. 5 interactions.
IntActi P78524. 5 interactions.
MINTi MINT-1184327.

PTM databases

PhosphoSitei P78524.

Polymorphism databases

DMDMi 317373507.

Proteomic databases

MaxQBi P78524.
PaxDbi P78524.
PRIDEi P78524.

Protocols and materials databases

DNASUi 6764.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313726 ; ENSP00000319678 ; ENSG00000166444 . [P78524-1 ]
ENST00000357665 ; ENSP00000350294 ; ENSG00000166444 . [P78524-1 ]
ENST00000526757 ; ENSP00000435097 ; ENSG00000166444 . [P78524-2 ]
ENST00000530438 ; ENSP00000436802 ; ENSG00000166444 . [P78524-2 ]
ENST00000530991 ; ENSP00000432887 ; ENSG00000166444 . [P78524-3 ]
ENST00000534127 ; ENSP00000433528 ; ENSG00000166444 . [P78524-1 ]
GeneIDi 6764.
KEGGi hsa:6764.
UCSCi uc001mgt.3. human. [P78524-1 ]
uc001mgu.3. human. [P78524-2 ]

Organism-specific databases

CTDi 6764.
GeneCardsi GC11M008714.
H-InvDB HIX0026155.
HGNCi HGNC:11350. ST5.
HPAi HPA046796.
MIMi 140750. gene.
neXtProti NX_P78524.
PharmGKBi PA36172.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG247048.
HOVERGENi HBG079980.
InParanoidi P78524.
OMAi DRKYNNP.
OrthoDBi EOG79GT6H.
PhylomeDBi P78524.
TreeFami TF320336.

Miscellaneous databases

ChiTaRSi ST5. human.
GeneWikii ST5_(gene).
GenomeRNAii 6764.
NextBioi 26398.
PROi P78524.
SOURCEi Search...

Gene expression databases

ArrayExpressi P78524.
Bgeei P78524.
CleanExi HS_ST5.
Genevestigatori P78524.

Family and domain databases

InterProi IPR005112. dDENN_dom.
IPR001194. DENN_dom.
IPR005113. uDENN_dom.
[Graphical view ]
Pfami PF03455. dDENN. 1 hit.
PF02141. DENN. 1 hit.
PF03456. uDENN. 1 hit.
[Graphical view ]
SMARTi SM00801. dDENN. 1 hit.
SM00799. DENN. 1 hit.
SM00800. uDENN. 1 hit.
[Graphical view ]
PROSITEi PS50947. DDENN. 1 hit.
PS50211. DENN. 1 hit.
PS50946. UDENN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression of the human ST5 gene in HeLa-fibroblast hybrid cell lines mediated by YY1: evidence that YY1 plays a part in tumor suppression."
    Lichy J.H., Majidi M., Elbaum J., Tsai M.M.
    Nucleic Acids Res. 24:4700-4708(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT GLU-399.
  2. "Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7."
    Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A., Zabel B., Hankeln T., Schmidt E.R.
    Cytogenet. Cell Genet. 93:284-290(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-399.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain and Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASN-316; THR-620 AND GLY-774.
    Tissue: Testis.
  7. "Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells."
    Lichy J.H., Modi W.S., Seuanez H.N., Howley P.M.
    Cell Growth Differ. 3:541-548(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 493-1137.
  8. "Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5."
    Majidi M., Hubbs A.E., Lichy J.H.
    J. Biol. Chem. 273:16608-16614(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ABL1.
  9. "Expression of an isoform of the novel signal transduction protein ST5 is linked to cell morphology."
    Hubbs A.E., Majidi M., Lichy J.H.
    Oncogene 18:2519-2525(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-622, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."
    Yoshimura S., Gerondopoulos A., Linford A., Rigden D.J., Barr F.A.
    J. Cell Biol. 191:367-381(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS GUANYL-NUCLEOTIDE EXCHANGE FACTOR.

Entry informationi

Entry nameiST5_HUMAN
AccessioniPrimary (citable) accession number: P78524
Secondary accession number(s): B2R6X7
, B3KXQ6, P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi