P78509 (RELN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Reelin
EC=3.4.21.-

Gene names

Name:

RELN

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	3460 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation By similarity.
Subunit structure	Binds to the ectodomains of VLDLR and LRP8/APOER2 By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Tissue specificity	Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Expression is reduced to about 50% in patients with schizophrenia. Also expressed in fetal and adult liver. Ref.5
Developmental stage	Expressed in fetal and postnatal brain and liver. Expression in postnatal human brain is high in the cerebellum.
Domain	The basic C-terminal region is essential for secretion By similarity.
Polymorphism	A polymorphic GGC triplet repeat located in the 5'-UTR region of RELN gene, which harbors in the normal population 8 to 10 repeats, is significantly increased in autistic patients to carry 4 to 23 additional repeats.
Involvement in disease	Lissencephaly 2 (LIS2) [MIM:257320]: A classic type lissencephaly associated with ataxia, mental retardation, seizures and abnormalities of the cerebellum, hippocampus and brainstem. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6
Sequence similarities	Belongs to the reelin family. Contains 16 BNR repeats. Contains 8 EGF-like domains. Contains 1 reelin domain.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Lissencephaly
Domain	EGF-like domain Repeat Signal
Ligand	Calcium Metal-binding Zinc
Molecular function	Developmental protein Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	N-methyl-D-aspartate receptor clustering Inferred from electronic annotation. Source: Compara associative learning Inferred from electronic annotation. Source: Compara axon guidance Inferred from sequence or structural similarity. Source: UniProtKB cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW cerebral cortex tangential migration Inferred from sequence or structural similarity. Source: UniProtKB dendrite development Inferred from electronic annotation. Source: Compara glial cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB hippocampus development Inferred from sequence or structural similarity. Source: BHF-UCL long-term memory Inferred from electronic annotation. Source: Compara neuron migration Inferred from sequence or structural similarity. Source: UniProtKB peptidyl-tyrosine phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of CREB transcription factor activity Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of TOR signaling cascade Inferred from electronic annotation. Source: Compara positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of dendritic spine morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of excitatory postsynaptic membrane potential Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of long-term synaptic potentiation Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of neuron projection development Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of phosphatidylinositol 3-kinase cascade Inferred from electronic annotation. Source: Compara positive regulation of protein tyrosine kinase activity Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of small GTPase mediated signal transduction Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of synapse maturation Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of synaptic transmission, glutamatergic Inferred from sequence or structural similarity. Source: BHF-UCL postsynaptic density protein 95 clustering Inferred from electronic annotation. Source: Compara proteolysis Inferred from electronic annotation. Source: UniProtKB-KW receptor localization to synapse Inferred from electronic annotation. Source: Compara reelin-mediated signaling pathway Inferred from sequence or structural similarity PubMed 10571240. Source: BHF-UCL regulation of N-methyl-D-aspartate selective glutamate receptor activity Inferred from sequence or structural similarity. Source: BHF-UCL regulation of behavior Inferred from sequence or structural similarity. Source: BHF-UCL response to pain Inferred from sequence or structural similarity. Source: UniProtKB spinal cord patterning Inferred from sequence or structural similarity. Source: UniProtKB ventral spinal cord development Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB dendrite Inferred from sequence or structural similarity. Source: UniProtKB extracellular space Inferred from sequence or structural similarity. Source: UniProtKB proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine/tyrosine kinase activity Inferred from sequence or structural similarity. Source: UniProtKB serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW very-low-density lipoprotein particle receptor binding Inferred from sequence or structural similarity PubMed 10571240. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P78509-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P78509-2)

The sequence of this isoform differs from the canonical sequence as follows:
     3428-3429: Missing.

Isoform 3 (identifier: P78509-3)

The sequence of this isoform differs from the canonical sequence as follows:
     3428-3460: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 3460	3435	Reelin		PRO_0000030304
Regions
	Domain	26 – 190	165	Reelin
	Repeat	592 – 603	12	BNR 1
	Domain	670 – 701	32	EGF-like 1
	Repeat	798 – 809	12	BNR 2
	Repeat	951 – 962	12	BNR 3
	Domain	1029 – 1060	32	EGF-like 2
	Repeat	1156 – 1167	12	BNR 4
	Repeat	1322 – 1333	12	BNR 5
	Domain	1408 – 1441	34	EGF-like 3
	Repeat	1534 – 1545	12	BNR 6
	Repeat	1685 – 1696	12	BNR 7
	Domain	1764 – 1795	32	EGF-like 4
	Repeat	1883 – 1894	12	BNR 8
	Repeat	2042 – 2053	12	BNR 9
	Domain	2128 – 2160	33	EGF-like 5
	Repeat	2249 – 2260	12	BNR 10
	Repeat	2398 – 2409	12	BNR 11
	Domain	2477 – 2508	32	EGF-like 6
	Repeat	2597 – 2608	12	BNR 12
	Repeat	2777 – 2788	12	BNR 13
	Domain	2852 – 2883	32	EGF-like 7
	Repeat	2978 – 2989	12	BNR 14
	Repeat	3142 – 3154	13	BNR 15
	Domain	3227 – 3259	33	EGF-like 8
	Repeat	3362 – 3373	12	BNR 16
	Compositional bias	3431 – 3460	30	Arg-rich (basic)
Sites
	Metal binding	2060	1	Zinc 1 By similarity
	Metal binding	2073	1	Zinc 1 By similarity
	Metal binding	2178	1	Zinc 1 By similarity
	Metal binding	2263	1	Zinc 1 By similarity
	Metal binding	2396	1	Zinc 2 By similarity
	Metal binding	2398	1	Zinc 2 By similarity
	Metal binding	2459	1	Zinc 2 By similarity
Amino acid modifications
	Glycosylation	140	1	N-linked (GlcNAc...) Potential
	Glycosylation	257	1	N-linked (GlcNAc...) Potential
	Glycosylation	289	1	N-linked (GlcNAc...) Potential
	Glycosylation	305	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	628	1	N-linked (GlcNAc...) Potential
	Glycosylation	1266	1	N-linked (GlcNAc...) Potential
	Glycosylation	1599	1	N-linked (GlcNAc...) Potential
	Glycosylation	1749	1	N-linked (GlcNAc...) Potential
	Glycosylation	1920	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	2144	1	N-linked (GlcNAc...) Potential
	Glycosylation	2268	1	N-linked (GlcNAc...) Potential
	Glycosylation	2316	1	N-linked (GlcNAc...) Potential
	Glycosylation	2568	1	N-linked (GlcNAc...) Potential
	Glycosylation	2961	1	N-linked (GlcNAc...) Potential
	Glycosylation	3015	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	3072	1	N-linked (GlcNAc...) Potential
	Glycosylation	3184	1	N-linked (GlcNAc...) Potential
	Glycosylation	3411	1	N-linked (GlcNAc...) Potential
	Glycosylation	3438	1	N-linked (GlcNAc...) Potential
	Disulfide bond	40 ↔ 126		By similarity
	Disulfide bond	154 ↔ 178		By similarity
	Disulfide bond	539 ↔ 580		By similarity
	Disulfide bond	608 ↔ 613		By similarity
	Disulfide bond	674 ↔ 684		By similarity
	Disulfide bond	691 ↔ 700		By similarity
	Disulfide bond	894 ↔ 936		By similarity
	Disulfide bond	967 ↔ 974		By similarity
	Disulfide bond	1033 ↔ 1043		By similarity
	Disulfide bond	1050 ↔ 1059		By similarity
	Disulfide bond	1270 ↔ 1309		By similarity
	Disulfide bond	1338 ↔ 1347		By similarity
	Disulfide bond	1632 ↔ 1672		By similarity
	Disulfide bond	1701 ↔ 1708		By similarity
	Disulfide bond	2132 ↔ 2142		By similarity
	Disulfide bond	2136 ↔ 2148		By similarity
	Disulfide bond	2150 ↔ 2159		By similarity
	Disulfide bond	2194 ↔ 2234		By similarity
	Disulfide bond	2347 ↔ 2386		By similarity
	Disulfide bond	2392 ↔ 2558		By similarity
	Disulfide bond	2543 ↔ 2583		By similarity
	Disulfide bond	2793 ↔ 2800		By similarity
	Disulfide bond	2856 ↔ 2866		By similarity
	Disulfide bond	2860 ↔ 2871		By similarity
	Disulfide bond	2873 ↔ 2882		By similarity
	Disulfide bond	2918 ↔ 2965		By similarity
	Disulfide bond	3159 ↔ 3169		By similarity
	Disulfide bond	3231 ↔ 3241		By similarity
	Disulfide bond	3235 ↔ 3247		By similarity
	Disulfide bond	3249 ↔ 3258		By similarity
	Disulfide bond	3295 ↔ 3345		By similarity
Natural variations
	Alternative sequence	3428 – 3460	33	Missing in isoform 3.		VSP_005576
	Alternative sequence	3428 – 3429	2	Missing in isoform 2.		VSP_005575
	Natural variant	978	1	T → A. Corresponds to variant rs3025962 [ dbSNP | Ensembl ].		VAR_047977
	Natural variant	997	1	L → V. Corresponds to variant rs362691 [ dbSNP | Ensembl ].		VAR_047978
	Natural variant	1703	1	P → R. Corresponds to variant rs2229860 [ dbSNP | Ensembl ].		VAR_057712
Experimental info
	Sequence conflict	752	1	D → E in AAC51105. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 9A398EC17FA4EE1B	FASTA	3,460	388,388
	10 20 30 40 50 60 MERSGWARQT FLLALLLGAT LRARAAAGYY PRFSPFFFLC THHGELEGDG EQGEVLISLH 70 80 90 100 110 120 IAGNPTYYVP GQEYHVTIST STFFDGLLVT GLYTSTSVQA SQSIGGSSAF GFGIMSDHQF 130 140 150 160 170 180 GNQFMCSVVA SHVSHLPTTN LSFIWIAPPA GTGCVNFMAT ATHRGQVIFK DALAQQLCEQ 190 200 210 220 230 240 GAPTDVTVHP HLAEIHSDSI ILRDDFDSYH QLQLNPNIWV ECNNCETGEQ CGAIMHGNAV 250 260 270 280 290 300 TFCEPYGPRE LITTGLNTTT ASVLQFSIGS GSCRFSYSDP SIIVLYAKNN SADWIQLEKI 310 320 330 340 350 360 RAPSNVSTII HILYLPEDAK GENVQFQWKQ ENLRVGEVYE ACWALDNILI INSAHRQVVL 370 380 390 400 410 420 EDSLDPVDTG NWLFFPGATV KHSCQSDGNS IYFHGNEGSE FNFATTRDVD LSTEDIQEQW 430 440 450 460 470 480 SEEFESQPTG WDVLGAVIGT ECGTIESGLS MVFLKDGERK LCTPSMDTTG YGNLRFYFVM 490 500 510 520 530 540 GGICDPGNSH ENDIILYAKI EGRKEHITLD TLSYSSYKVP SLVSVVINPE LQTPATKFCL 550 560 570 580 590 600 RQKNHQGHNR NVWAVDFFHV LPVLPSTMSH MIQFSINLGC GTHQPGNSVS LEFSTNHGRS 610 620 630 640 650 660 WSLLHTECLP EICAGPHLPH STVYSSENYS GWNRITIPLP NAALTRNTRI RWRQTGPILG 670 680 690 700 710 720 NMWAIDNVYI GPSCLKFCSG RGQCTRHGCK CDPGFSGPAC EMASQTFPMF ISESFGSSRL 730 740 750 760 770 780 SSYHNFYSIR GAEVSFGCGV LASGKALVFN KDGRRQLITS FLDSSQSRFL QFTLRLGSKS 790 800 810 820 830 840 VLSTCRAPDQ PGEGVLLHYS YDNGITWKLL EHYSYLSYHE PRIISVELPG DAKQFGIQFR 850 860 870 880 890 900 WWQPYHSSQR EDVWAIDEII MTSVLFNSIS LDFTNLVEVT QSLGFYLGNV QPYCGHDWTL 910 920 930 940 950 960 CFTGDSKLAS SMRYVETQSM QIGASYMIQF SLVMGCGQKY TPHMDNQVKL EYSTNHGLTW 970 980 990 1000 1010 1020 HLVQEECLPS MPSCQEFTSA SIYHASEFTQ WRRVIVLLPQ KTWSSATRFR WSQSYYTAQD 1030 1040 1050 1060 1070 1080 EWALDSIYIG QQCPNMCSGH GSCDHGICRC DQGYQGTECH PEAALPSTIM SDFENQNGWE 1090 1100 1110 1120 1130 1140 SDWQEVIGGE IVKPEQGCGV ISSGSSLYFS KAGKRQLVSW DLDTSWVDFV QFYIQIGGES 1150 1160 1170 1180 1190 1200 ASCNKPDSRE EGVLLQYSNN GGIQWHLLAE MYFSDFSKPR FVYLELPAAA KTPCTRFRWW 1210 1220 1230 1240 1250 1260 QPVFSGEDYD QWAVDDIIIL SEKQKQIIPV INPTLPQNFY EKPAFDYPMN QMSVWLMLAN 1270 1280 1290 1300 1310 1320 EGMVKNETFC AATPSAMIFG KSDGDRFAVT RDLTLKPGYV LQFKLNIGCA NQFSSTAPVL 1330 1340 1350 1360 1370 1380 LQYSHDAGMS WFLVKEGCYP ASAGKGCEGN SRELSEPTMY HTGDFEEWTR ITIVIPRSLA 1390 1400 1410 1420 1430 1440 SSKTRFRWIQ ESSSQKNVPP FGLDGVYISE PCPSYCSGHG DCISGVCFCD LGYTAAQGTC 1450 1460 1470 1480 1490 1500 VSNVPNHNEM FDRFEGKLSP LWYKITGAQV GTGCGTLNDG KSLYFNGPGK REARTVPLDT 1510 1520 1530 1540 1550 1560 RNIRLVQFYI QIGSKTSGIT CIKPRTRNEG LIVQYSNDNG ILWHLLRELD FMSFLEPQII 1570 1580 1590 1600 1610 1620 SIDLPQDAKT PATAFRWWQP QHGKHSAQWA LDDVLIGMND SSQTGFQDKF DGSIDLQANW 1630 1640 1650 1660 1670 1680 YRIQGGQVDI DCLSMDTALI FTENIGKPRY AETWDFHVSA STFLQFEMSM GCSKPFSNSH 1690 1700 1710 1720 1730 1740 SVQLQYSLNN GKDWHLVTEE CVPPTIGCLH YTESSIYTSE RFQNWKRITV YLPLSTISPR 1750 1760 1770 1780 1790 1800 TRFRWIQANY TVGADSWAID NVVLASGCPW MCSGRGICDA GRCVCDRGFG GPYCVPVVPL 1810 1820 1830 1840 1850 1860 PSILKDDFNG NLHPDLWPEV YGAERGNLNG ETIKSGTSLI FKGEGLRMLI SRDLDCTNTM 1870 1880 1890 1900 1910 1920 YVQFSLRFIA KSTPERSHSI LLQFSISGGI TWHLMDEFYF PQTTNILFIN VPLPYTAQTN 1930 1940 1950 1960 1970 1980 ATRFRLWQPY NNGKKEEIWI VDDFIIDGNN VNNPVMLLDT FDFGPREDNW FFYPGGNIGL 1990 2000 2010 2020 2030 2040 YCPYSSKGAP EEDSAMVFVS NEVGEHSITT RDLNVNENTI IQFEINVGCS TDSSSADPVR 2050 2060 2070 2080 2090 2100 LEFSRDFGAT WHLLLPLCYH SSSHVSSLCS TEHHPSSTYY AGTMQGWRRE VVHFGKLHLC 2110 2120 2130 2140 2150 2160 GSVRFRWYQG FYPAGSQPVT WAIDNVYIGP QCEEMCNGQG SCINGTKCIC DPGYSGPTCK 2170 2180 2190 2200 2210 2220 ISTKNPDFLK DDFEGQLESD RFLLMSGGKP SRKCGILSSG NNLFFNEDGL RMLMTRDLDL 2230 2240 2250 2260 2270 2280 SHARFVQFFM RLGCGKGVPD PRSQPVLLQY SLNGGLSWSL LQEFLFSNSS NVGRYIALEI 2290 2300 2310 2320 2330 2340 PLKARSGSTR LRWWQPSENG HFYSPWVIDQ ILIGGNISGN TVLEDDFTTL DSRKWLLHPG 2350 2360 2370 2380 2390 2400 GTKMPVCGST GDALVFIEKA STRYVVSTDV AVNEDSFLQI DFAASCSVTD SCYAIELEYS 2410 2420 2430 2440 2450 2460 VDLGLSWHPL VRDCLPTNVE CSRYHLQRIL VSDTFNKWTR ITLPLPPYTR SQATRFRWHQ 2470 2480 2490 2500 2510 2520 PAPFDKQQTW AIDNVYIGDG CIDMCSGHGR CIQGNCVCDE QWGGLYCDDP ETSLPTQLKD 2530 2540 2550 2560 2570 2580 NFNRAPSSQN WLTVNGGKLS TVCGAVASGM ALHFSGGCSR LLVTVDLNLT NAEFIQFYFM 2590 2600 2610 2620 2630 2640 YGCLITPNNR NQGVLLEYSV NGGITWNLLM EIFYDQYSKP GFVNILLPPD AKEIATRFRW 2650 2660 2670 2680 2690 2700 WQPRHDGLDQ NDWAIDNVLI SGSADQRTVM LDTFSSAPVP QHERSPADAG PVGRIAFDMF 2710 2720 2730 2740 2750 2760 MEDKTSVNEH WLFHDDCTVE RFCDSPDGVM LCGSHDGREV YAVTHDLTPT EGWIMQFKIS 2770 2780 2790 2800 2810 2820 VGCKVSEKIA QNQIHVQYST DFGVSWNYLV PQCLPADPKC SGSVSQPSVF FPTKGWKRIT 2830 2840 2850 2860 2870 2880 YPLPESLVGN PVRFRFYQKY SDMQWAIDNF YLGPGCLDNC RGHGDCLREQ CICDPGYSGP 2890 2900 2910 2920 2930 2940 NCYLTHTLKT FLKERFDSEE IKPDLWMSLE GGSTCTECGI LAEDTALYFG GSTVRQAVTQ 2950 2960 2970 2980 2990 3000 DLDLRGAKFL QYWGRIGSEN NMTSCHRPIC RKEGVLLDYS TDGGITWTLL HEMDYQKYIS 3010 3020 3030 3040 3050 3060 VRHDYILLPE DALTNTTRLR WWQPFVISNG IVVSGVERAQ WALDNILIGG AEINPSQLVD 3070 3080 3090 3100 3110 3120 TFDDEGTSHE ENWSFYPNAV RTAGFCGNPS FHLYWPNKKK DKTHNALSSR ELIIQPGYMM 3130 3140 3150 3160 3170 3180 QFKIVVGCEA TSCGDLHSVM LEYTKDARSD SWQLVQTQCL PSSSNSIGCS PFQFHEATIY 3190 3200 3210 3220 3230 3240 NSVNSSSWKR ITIQLPDHVS SSATQFRWIQ KGEETEKQSW AIDHVYIGEA CPKLCSGHGY 3250 3260 3270 3280 3290 3300 CTTGAICICD ESFQGDDCSV FSHDLPSYIK DNFESARVTE ANWETIQGGV IGSGCGQLAP 3310 3320 3330 3340 3350 3360 YAHGDSLYFN GCQIRQAATK PLDLTRASKI MFVLQIGSMS QTDSCNSDLS GPHAVDKAVL 3370 3380 3390 3400 3410 3420 LQYSVNNGIT WHVIAQHQPK DFTQAQRVSY NVPLEARMKG VLLRWWQPRH NGTGHDQWAL 3430 3440 3450 3460 DHVEVVLVST RKQNYMMNFS RQHGLRHFYN RRRRSLRRYP
	Isoform 2 [UniParc]. Checksum: A67B9EAF1DAE6F69	FASTA	3,458	388,201
	10 20 30 40 50 60 MERSGWARQT FLLALLLGAT LRARAAAGYY PRFSPFFFLC THHGELEGDG EQGEVLISLH 70 80 90 100 110 120 IAGNPTYYVP GQEYHVTIST STFFDGLLVT GLYTSTSVQA SQSIGGSSAF GFGIMSDHQF 130 140 150 160 170 180 GNQFMCSVVA SHVSHLPTTN LSFIWIAPPA GTGCVNFMAT ATHRGQVIFK DALAQQLCEQ 190 200 210 220 230 240 GAPTDVTVHP HLAEIHSDSI ILRDDFDSYH QLQLNPNIWV ECNNCETGEQ CGAIMHGNAV 250 260 270 280 290 300 TFCEPYGPRE LITTGLNTTT ASVLQFSIGS GSCRFSYSDP SIIVLYAKNN SADWIQLEKI 310 320 330 340 350 360 RAPSNVSTII HILYLPEDAK GENVQFQWKQ ENLRVGEVYE ACWALDNILI INSAHRQVVL 370 380 390 400 410 420 EDSLDPVDTG NWLFFPGATV KHSCQSDGNS IYFHGNEGSE FNFATTRDVD LSTEDIQEQW 430 440 450 460 470 480 SEEFESQPTG WDVLGAVIGT ECGTIESGLS MVFLKDGERK LCTPSMDTTG YGNLRFYFVM 490 500 510 520 530 540 GGICDPGNSH ENDIILYAKI EGRKEHITLD TLSYSSYKVP SLVSVVINPE LQTPATKFCL 550 560 570 580 590 600 RQKNHQGHNR NVWAVDFFHV LPVLPSTMSH MIQFSINLGC GTHQPGNSVS LEFSTNHGRS 610 620 630 640 650 660 WSLLHTECLP EICAGPHLPH STVYSSENYS GWNRITIPLP NAALTRNTRI RWRQTGPILG 670 680 690 700 710 720 NMWAIDNVYI GPSCLKFCSG RGQCTRHGCK CDPGFSGPAC EMASQTFPMF ISESFGSSRL 730 740 750 760 770 780 SSYHNFYSIR GAEVSFGCGV LASGKALVFN KDGRRQLITS FLDSSQSRFL QFTLRLGSKS 790 800 810 820 830 840 VLSTCRAPDQ PGEGVLLHYS YDNGITWKLL EHYSYLSYHE PRIISVELPG DAKQFGIQFR 850 860 870 880 890 900 WWQPYHSSQR EDVWAIDEII MTSVLFNSIS LDFTNLVEVT QSLGFYLGNV QPYCGHDWTL 910 920 930 940 950 960 CFTGDSKLAS SMRYVETQSM QIGASYMIQF SLVMGCGQKY TPHMDNQVKL EYSTNHGLTW 970 980 990 1000 1010 1020 HLVQEECLPS MPSCQEFTSA SIYHASEFTQ WRRVIVLLPQ KTWSSATRFR WSQSYYTAQD 1030 1040 1050 1060 1070 1080 EWALDSIYIG QQCPNMCSGH GSCDHGICRC DQGYQGTECH PEAALPSTIM SDFENQNGWE 1090 1100 1110 1120 1130 1140 SDWQEVIGGE IVKPEQGCGV ISSGSSLYFS KAGKRQLVSW DLDTSWVDFV QFYIQIGGES 1150 1160 1170 1180 1190 1200 ASCNKPDSRE EGVLLQYSNN GGIQWHLLAE MYFSDFSKPR FVYLELPAAA KTPCTRFRWW 1210 1220 1230 1240 1250 1260 QPVFSGEDYD QWAVDDIIIL SEKQKQIIPV INPTLPQNFY EKPAFDYPMN QMSVWLMLAN 1270 1280 1290 1300 1310 1320 EGMVKNETFC AATPSAMIFG KSDGDRFAVT RDLTLKPGYV LQFKLNIGCA NQFSSTAPVL 1330 1340 1350 1360 1370 1380 LQYSHDAGMS WFLVKEGCYP ASAGKGCEGN SRELSEPTMY HTGDFEEWTR ITIVIPRSLA 1390 1400 1410 1420 1430 1440 SSKTRFRWIQ ESSSQKNVPP FGLDGVYISE PCPSYCSGHG DCISGVCFCD LGYTAAQGTC 1450 1460 1470 1480 1490 1500 VSNVPNHNEM FDRFEGKLSP LWYKITGAQV GTGCGTLNDG KSLYFNGPGK REARTVPLDT 1510 1520 1530 1540 1550 1560 RNIRLVQFYI QIGSKTSGIT CIKPRTRNEG LIVQYSNDNG ILWHLLRELD FMSFLEPQII 1570 1580 1590 1600 1610 1620 SIDLPQDAKT PATAFRWWQP QHGKHSAQWA LDDVLIGMND SSQTGFQDKF DGSIDLQANW 1630 1640 1650 1660 1670 1680 YRIQGGQVDI DCLSMDTALI FTENIGKPRY AETWDFHVSA STFLQFEMSM GCSKPFSNSH 1690 1700 1710 1720 1730 1740 SVQLQYSLNN GKDWHLVTEE CVPPTIGCLH YTESSIYTSE RFQNWKRITV YLPLSTISPR 1750 1760 1770 1780 1790 1800 TRFRWIQANY TVGADSWAID NVVLASGCPW MCSGRGICDA GRCVCDRGFG GPYCVPVVPL 1810 1820 1830 1840 1850 1860 PSILKDDFNG NLHPDLWPEV YGAERGNLNG ETIKSGTSLI FKGEGLRMLI SRDLDCTNTM 1870 1880 1890 1900 1910 1920 YVQFSLRFIA KSTPERSHSI LLQFSISGGI TWHLMDEFYF PQTTNILFIN VPLPYTAQTN 1930 1940 1950 1960 1970 1980 ATRFRLWQPY NNGKKEEIWI VDDFIIDGNN VNNPVMLLDT FDFGPREDNW FFYPGGNIGL 1990 2000 2010 2020 2030 2040 YCPYSSKGAP EEDSAMVFVS NEVGEHSITT RDLNVNENTI IQFEINVGCS TDSSSADPVR 2050 2060 2070 2080 2090 2100 LEFSRDFGAT WHLLLPLCYH SSSHVSSLCS TEHHPSSTYY AGTMQGWRRE VVHFGKLHLC 2110 2120 2130 2140 2150 2160 GSVRFRWYQG FYPAGSQPVT WAIDNVYIGP QCEEMCNGQG SCINGTKCIC DPGYSGPTCK 2170 2180 2190 2200 2210 2220 ISTKNPDFLK DDFEGQLESD RFLLMSGGKP SRKCGILSSG NNLFFNEDGL RMLMTRDLDL 2230 2240 2250 2260 2270 2280 SHARFVQFFM RLGCGKGVPD PRSQPVLLQY SLNGGLSWSL LQEFLFSNSS NVGRYIALEI 2290 2300 2310 2320 2330 2340 PLKARSGSTR LRWWQPSENG HFYSPWVIDQ ILIGGNISGN TVLEDDFTTL DSRKWLLHPG 2350 2360 2370 2380 2390 2400 GTKMPVCGST GDALVFIEKA STRYVVSTDV AVNEDSFLQI DFAASCSVTD SCYAIELEYS 2410 2420 2430 2440 2450 2460 VDLGLSWHPL VRDCLPTNVE CSRYHLQRIL VSDTFNKWTR ITLPLPPYTR SQATRFRWHQ 2470 2480 2490 2500 2510 2520 PAPFDKQQTW AIDNVYIGDG CIDMCSGHGR CIQGNCVCDE QWGGLYCDDP ETSLPTQLKD 2530 2540 2550 2560 2570 2580 NFNRAPSSQN WLTVNGGKLS TVCGAVASGM ALHFSGGCSR LLVTVDLNLT NAEFIQFYFM 2590 2600 2610 2620 2630 2640 YGCLITPNNR NQGVLLEYSV NGGITWNLLM EIFYDQYSKP GFVNILLPPD AKEIATRFRW 2650 2660 2670 2680 2690 2700 WQPRHDGLDQ NDWAIDNVLI SGSADQRTVM LDTFSSAPVP QHERSPADAG PVGRIAFDMF 2710 2720 2730 2740 2750 2760 MEDKTSVNEH WLFHDDCTVE RFCDSPDGVM LCGSHDGREV YAVTHDLTPT EGWIMQFKIS 2770 2780 2790 2800 2810 2820 VGCKVSEKIA QNQIHVQYST DFGVSWNYLV PQCLPADPKC SGSVSQPSVF FPTKGWKRIT 2830 2840 2850 2860 2870 2880 YPLPESLVGN PVRFRFYQKY SDMQWAIDNF YLGPGCLDNC RGHGDCLREQ CICDPGYSGP 2890 2900 2910 2920 2930 2940 NCYLTHTLKT FLKERFDSEE IKPDLWMSLE GGSTCTECGI LAEDTALYFG GSTVRQAVTQ 2950 2960 2970 2980 2990 3000 DLDLRGAKFL QYWGRIGSEN NMTSCHRPIC RKEGVLLDYS TDGGITWTLL HEMDYQKYIS 3010 3020 3030 3040 3050 3060 VRHDYILLPE DALTNTTRLR WWQPFVISNG IVVSGVERAQ WALDNILIGG AEINPSQLVD 3070 3080 3090 3100 3110 3120 TFDDEGTSHE ENWSFYPNAV RTAGFCGNPS FHLYWPNKKK DKTHNALSSR ELIIQPGYMM 3130 3140 3150 3160 3170 3180 QFKIVVGCEA TSCGDLHSVM LEYTKDARSD SWQLVQTQCL PSSSNSIGCS PFQFHEATIY 3190 3200 3210 3220 3230 3240 NSVNSSSWKR ITIQLPDHVS SSATQFRWIQ KGEETEKQSW AIDHVYIGEA CPKLCSGHGY 3250 3260 3270 3280 3290 3300 CTTGAICICD ESFQGDDCSV FSHDLPSYIK DNFESARVTE ANWETIQGGV IGSGCGQLAP 3310 3320 3330 3340 3350 3360 YAHGDSLYFN GCQIRQAATK PLDLTRASKI MFVLQIGSMS QTDSCNSDLS GPHAVDKAVL 3370 3380 3390 3400 3410 3420 LQYSVNNGIT WHVIAQHQPK DFTQAQRVSY NVPLEARMKG VLLRWWQPRH NGTGHDQWAL 3430 3440 3450 DHVEVVLTRK QNYMMNFSRQ HGLRHFYNRR RRSLRRYP
	Isoform 3 [UniParc]. Checksum: E9DF2AE0AC29DB8C	FASTA	3,427	384,093
	10 20 30 40 50 60 MERSGWARQT FLLALLLGAT LRARAAAGYY PRFSPFFFLC THHGELEGDG EQGEVLISLH 70 80 90 100 110 120 IAGNPTYYVP GQEYHVTIST STFFDGLLVT GLYTSTSVQA SQSIGGSSAF GFGIMSDHQF 130 140 150 160 170 180 GNQFMCSVVA SHVSHLPTTN LSFIWIAPPA GTGCVNFMAT ATHRGQVIFK DALAQQLCEQ 190 200 210 220 230 240 GAPTDVTVHP HLAEIHSDSI ILRDDFDSYH QLQLNPNIWV ECNNCETGEQ CGAIMHGNAV 250 260 270 280 290 300 TFCEPYGPRE LITTGLNTTT ASVLQFSIGS GSCRFSYSDP SIIVLYAKNN SADWIQLEKI 310 320 330 340 350 360 RAPSNVSTII HILYLPEDAK GENVQFQWKQ ENLRVGEVYE ACWALDNILI INSAHRQVVL 370 380 390 400 410 420 EDSLDPVDTG NWLFFPGATV KHSCQSDGNS IYFHGNEGSE FNFATTRDVD LSTEDIQEQW 430 440 450 460 470 480 SEEFESQPTG WDVLGAVIGT ECGTIESGLS MVFLKDGERK LCTPSMDTTG YGNLRFYFVM 490 500 510 520 530 540 GGICDPGNSH ENDIILYAKI EGRKEHITLD TLSYSSYKVP SLVSVVINPE LQTPATKFCL 550 560 570 580 590 600 RQKNHQGHNR NVWAVDFFHV LPVLPSTMSH MIQFSINLGC GTHQPGNSVS LEFSTNHGRS 610 620 630 640 650 660 WSLLHTECLP EICAGPHLPH STVYSSENYS GWNRITIPLP NAALTRNTRI RWRQTGPILG 670 680 690 700 710 720 NMWAIDNVYI GPSCLKFCSG RGQCTRHGCK CDPGFSGPAC EMASQTFPMF ISESFGSSRL 730 740 750 760 770 780 SSYHNFYSIR GAEVSFGCGV LASGKALVFN KDGRRQLITS FLDSSQSRFL QFTLRLGSKS 790 800 810 820 830 840 VLSTCRAPDQ PGEGVLLHYS YDNGITWKLL EHYSYLSYHE PRIISVELPG DAKQFGIQFR 850 860 870 880 890 900 WWQPYHSSQR EDVWAIDEII MTSVLFNSIS LDFTNLVEVT QSLGFYLGNV QPYCGHDWTL 910 920 930 940 950 960 CFTGDSKLAS SMRYVETQSM QIGASYMIQF SLVMGCGQKY TPHMDNQVKL EYSTNHGLTW 970 980 990 1000 1010 1020 HLVQEECLPS MPSCQEFTSA SIYHASEFTQ WRRVIVLLPQ KTWSSATRFR WSQSYYTAQD 1030 1040 1050 1060 1070 1080 EWALDSIYIG QQCPNMCSGH GSCDHGICRC DQGYQGTECH PEAALPSTIM SDFENQNGWE 1090 1100 1110 1120 1130 1140 SDWQEVIGGE IVKPEQGCGV ISSGSSLYFS KAGKRQLVSW DLDTSWVDFV QFYIQIGGES 1150 1160 1170 1180 1190 1200 ASCNKPDSRE EGVLLQYSNN GGIQWHLLAE MYFSDFSKPR FVYLELPAAA KTPCTRFRWW 1210 1220 1230 1240 1250 1260 QPVFSGEDYD QWAVDDIIIL SEKQKQIIPV INPTLPQNFY EKPAFDYPMN QMSVWLMLAN 1270 1280 1290 1300 1310 1320 EGMVKNETFC AATPSAMIFG KSDGDRFAVT RDLTLKPGYV LQFKLNIGCA NQFSSTAPVL 1330 1340 1350 1360 1370 1380 LQYSHDAGMS WFLVKEGCYP ASAGKGCEGN SRELSEPTMY HTGDFEEWTR ITIVIPRSLA 1390 1400 1410 1420 1430 1440 SSKTRFRWIQ ESSSQKNVPP FGLDGVYISE PCPSYCSGHG DCISGVCFCD LGYTAAQGTC 1450 1460 1470 1480 1490 1500 VSNVPNHNEM FDRFEGKLSP LWYKITGAQV GTGCGTLNDG KSLYFNGPGK REARTVPLDT 1510 1520 1530 1540 1550 1560 RNIRLVQFYI QIGSKTSGIT CIKPRTRNEG LIVQYSNDNG ILWHLLRELD FMSFLEPQII 1570 1580 1590 1600 1610 1620 SIDLPQDAKT PATAFRWWQP QHGKHSAQWA LDDVLIGMND SSQTGFQDKF DGSIDLQANW 1630 1640 1650 1660 1670 1680 YRIQGGQVDI DCLSMDTALI FTENIGKPRY AETWDFHVSA STFLQFEMSM GCSKPFSNSH 1690 1700 1710 1720 1730 1740 SVQLQYSLNN GKDWHLVTEE CVPPTIGCLH YTESSIYTSE RFQNWKRITV YLPLSTISPR 1750 1760 1770 1780 1790 1800 TRFRWIQANY TVGADSWAID NVVLASGCPW MCSGRGICDA GRCVCDRGFG GPYCVPVVPL 1810 1820 1830 1840 1850 1860 PSILKDDFNG NLHPDLWPEV YGAERGNLNG ETIKSGTSLI FKGEGLRMLI SRDLDCTNTM 1870 1880 1890 1900 1910 1920 YVQFSLRFIA KSTPERSHSI LLQFSISGGI TWHLMDEFYF PQTTNILFIN VPLPYTAQTN 1930 1940 1950 1960 1970 1980 ATRFRLWQPY NNGKKEEIWI VDDFIIDGNN VNNPVMLLDT FDFGPREDNW FFYPGGNIGL 1990 2000 2010 2020 2030 2040 YCPYSSKGAP EEDSAMVFVS NEVGEHSITT RDLNVNENTI IQFEINVGCS TDSSSADPVR 2050 2060 2070 2080 2090 2100 LEFSRDFGAT WHLLLPLCYH SSSHVSSLCS TEHHPSSTYY AGTMQGWRRE VVHFGKLHLC 2110 2120 2130 2140 2150 2160 GSVRFRWYQG FYPAGSQPVT WAIDNVYIGP QCEEMCNGQG SCINGTKCIC DPGYSGPTCK 2170 2180 2190 2200 2210 2220 ISTKNPDFLK DDFEGQLESD RFLLMSGGKP SRKCGILSSG NNLFFNEDGL RMLMTRDLDL 2230 2240 2250 2260 2270 2280 SHARFVQFFM RLGCGKGVPD PRSQPVLLQY SLNGGLSWSL LQEFLFSNSS NVGRYIALEI 2290 2300 2310 2320 2330 2340 PLKARSGSTR LRWWQPSENG HFYSPWVIDQ ILIGGNISGN TVLEDDFTTL DSRKWLLHPG 2350 2360 2370 2380 2390 2400 GTKMPVCGST GDALVFIEKA STRYVVSTDV AVNEDSFLQI DFAASCSVTD SCYAIELEYS 2410 2420 2430 2440 2450 2460 VDLGLSWHPL VRDCLPTNVE CSRYHLQRIL VSDTFNKWTR ITLPLPPYTR SQATRFRWHQ 2470 2480 2490 2500 2510 2520 PAPFDKQQTW AIDNVYIGDG CIDMCSGHGR CIQGNCVCDE QWGGLYCDDP ETSLPTQLKD 2530 2540 2550 2560 2570 2580 NFNRAPSSQN WLTVNGGKLS TVCGAVASGM ALHFSGGCSR LLVTVDLNLT NAEFIQFYFM 2590 2600 2610 2620 2630 2640 YGCLITPNNR NQGVLLEYSV NGGITWNLLM EIFYDQYSKP GFVNILLPPD AKEIATRFRW 2650 2660 2670 2680 2690 2700 WQPRHDGLDQ NDWAIDNVLI SGSADQRTVM LDTFSSAPVP QHERSPADAG PVGRIAFDMF 2710 2720 2730 2740 2750 2760 MEDKTSVNEH WLFHDDCTVE RFCDSPDGVM LCGSHDGREV YAVTHDLTPT EGWIMQFKIS 2770 2780 2790 2800 2810 2820 VGCKVSEKIA QNQIHVQYST DFGVSWNYLV PQCLPADPKC SGSVSQPSVF FPTKGWKRIT 2830 2840 2850 2860 2870 2880 YPLPESLVGN PVRFRFYQKY SDMQWAIDNF YLGPGCLDNC RGHGDCLREQ CICDPGYSGP 2890 2900 2910 2920 2930 2940 NCYLTHTLKT FLKERFDSEE IKPDLWMSLE GGSTCTECGI LAEDTALYFG GSTVRQAVTQ 2950 2960 2970 2980 2990 3000 DLDLRGAKFL QYWGRIGSEN NMTSCHRPIC RKEGVLLDYS TDGGITWTLL HEMDYQKYIS 3010 3020 3030 3040 3050 3060 VRHDYILLPE DALTNTTRLR WWQPFVISNG IVVSGVERAQ WALDNILIGG AEINPSQLVD 3070 3080 3090 3100 3110 3120 TFDDEGTSHE ENWSFYPNAV RTAGFCGNPS FHLYWPNKKK DKTHNALSSR ELIIQPGYMM 3130 3140 3150 3160 3170 3180 QFKIVVGCEA TSCGDLHSVM LEYTKDARSD SWQLVQTQCL PSSSNSIGCS PFQFHEATIY 3190 3200 3210 3220 3230 3240 NSVNSSSWKR ITIQLPDHVS SSATQFRWIQ KGEETEKQSW AIDHVYIGEA CPKLCSGHGY 3250 3260 3270 3280 3290 3300 CTTGAICICD ESFQGDDCSV FSHDLPSYIK DNFESARVTE ANWETIQGGV IGSGCGQLAP 3310 3320 3330 3340 3350 3360 YAHGDSLYFN GCQIRQAATK PLDLTRASKI MFVLQIGSMS QTDSCNSDLS GPHAVDKAVL 3370 3380 3390 3400 3410 3420 LQYSVNNGIT WHVIAQHQPK DFTQAQRVSY NVPLEARMKG VLLRWWQPRH NGTGHDQWAL DHVEVVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human reelin gene: isolation, sequencing, and mapping on chromosome 7." DeSilva U., D'Arcangelo G., Braden V.V., Chen J., Miao G.G., Curran T., Green E.D. Genome Res. 7:157-164(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Evolutionarily conserved, alternative splicing of reelin during brain development." Lambert de Rouvroit C., Bernier B., Royaux I., de Bergeyck V., Goffinet A.M. Exp. Neurol. 156:229-238(1999) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING.
[5]	"A decrease of reelin expression as a putative vulnerability factor in schizophrenia." Impagnatiello F., Guidotti A.R., Pesold C., Dwivedi Y., Caruncho H., Pisu M.G., Uzunov D.P., Smalheiser N.R., Davis J.M., Pandey G.N., Pappas G.D., Tueting P., Sharma R.P., Costa E. Proc. Natl. Acad. Sci. U.S.A. 95:15718-15723(1998) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[6]	"Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations." Hong S.E., Shugart Y.Y., Huang D.T., Shahwan S.A., Grant P.E., Hourihane J.O.B., Martin N.D.T., Walsh C.A. Nat. Genet. 26:93-96(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN LIS2.
[7]	Erratum Hong S.E., Shugart Y.Y., Huang D.T., Shahwan S.A., Grant P.E., Hourihane J.O.B., Martin N.D.T., Walsh C.A. Nat. Genet. 27:225-225(2001)
[8]	"Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder." Persico A.M., D'Agruma L., Maiorano N., Totaro A., Militerni R., Bravaccio C., Wassink T.H., Schneider C., Melmed R., Trillo S., Montecchi F., Palermo M., Pascucci T., Puglisi-Allegra S., Reichelt K.-L., Conciatori M., Marino R., Quattrocchi C.C. , Baldi A., Zelante L., Gasparini P., Keller F. Mol. Psychiatry 6:150-159(2001) [PubMed] [Europe PMC] [Abstract] Cited for: POLYMORPHISM.
[9]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-305; ASN-1920 AND ASN-3015, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Web resources

Wikipedia

Reelin entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	U79716 mRNA. Translation: AAC51105.1. AC002067 Genomic DNA. Translation: AAM49151.1. AC006981 Genomic DNA. No translation available. AC073208 Genomic DNA. Translation: AAP22355.1. AC005101 Genomic DNA. Translation: AAP22330.1. AC000121 Genomic DNA. Translation: AAB46357.2. AC006316 Genomic DNA. Translation: AAD29127.1. AC005064 Genomic DNA. No translation available. CH236947 Genomic DNA. Translation: EAL24410.1. CH236947 Genomic DNA. Translation: EAL24411.1.
IPI	IPI00241562. IPI00294776. IPI00847589.
RefSeq	NP_005036.2. NM_005045.3. NP_774959.1. NM_173054.2.
UniGene	Hs.655654.
3D structure databases
ProteinModelPortal	P78509.
SMR	P78509. Positions 1293-1596, 1955-2661.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000392423.
PTM databases
PhosphoSite	P78509.
Polymorphism databases
DMDM	296452988.
Proteomic databases
PaxDb	P78509.
PRIDE	P78509.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343529; ENSP00000345694; ENSG00000189056. ENST00000428762; ENSP00000392423; ENSG00000189056.
GeneID	5649.
KEGG	hsa:5649.
UCSC	uc010liz.3. human. uc022ajq.1. human.
Organism-specific databases
CTD	5649.
GeneCards	GC07M103112.
H-InvDB	HIX0033998. HIX0201200.
HGNC	HGNC:9957. RELN.
HPA	CAB004556.
MIM	257320. phenotype. 600514. gene.
neXtProt	NX_P78509.
Orphanet	89844. Lissencephaly syndrome, Norman-Roberts type.
PharmGKB	PA34323.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45680.
HOVERGEN	HBG023117.
InParanoid	P78509.
KO	K06249.
OMA	RDFGATW.
OrthoDB	EOG4GB757.
Enzyme and pathway databases
Pathway_Interaction_DB	lis1pathway. Lissencephaly gene (LIS1) in neuronal migration and development. reelinpathway. Reelin signaling pathway.
Gene expression databases
ArrayExpress	P78509.
Bgee	P78509.
CleanEx	HS_RELN.
Genevestigator	P78509.
GermOnline	ENSG00000189056. Homo sapiens.
Family and domain databases
Gene3D	2.120.10.10. 2 hits.
InterPro	IPR000742. EG-like_dom. IPR013032. EGF-like_CS. IPR002861. Reeler_dom. IPR011040. Sialidases. [Graphical view]
Pfam	PF02014. Reeler. 1 hit. [Graphical view]
SMART	SM00181. EGF. 5 hits. [Graphical view]
SUPFAM	SSF50939. Sialidase. 3 hits.
PROSITE	PS00022. EGF_1. 7 hits. PS01186. EGF_2. 6 hits. PS50026. EGF_3. 5 hits. PS51019. REELIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5649.
NextBio	21946.
SOURCE	Search...

Entry information

Entry name

RELN_HUMAN

Accession

Primary (citable) accession number: P78509
Secondary accession number(s): A4D0P9 , A4D0Q0, Q86UJ0, Q86UJ8, Q8NDV0, Q9UDQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 130 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.