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Protein
Submitted name:

Alpha-1 thalassemia globin gene

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi31Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Biological processOxygen transportPROSITE-ProRule annotationSAAS annotation, Transport
LigandHemePROSITE-ProRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-1 thalassemia globin geneImported
Submitted name:
Alpha-globin gene (alpha-thalassemia allelic form)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PeptideAtlasiP78461.
PRIDEiP78461.

Expressioni

Gene expression databases

BgeeiENSG00000188536.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322421.

Structurei

3D structure databases

ProteinModelPortaliP78461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 85GLOBINInterPro annotationAdd BLAST85

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Fragment.

P78461-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GHGKKVADAL TNAVAHVDDM PNALSALSDL HAHKLRVDPV NFKLLSHCLL
60 70 80
VTLAAHLPAE FTPAVHASLD KFLASVSTVL TSKYR
Length:85
Mass (Da):9,079
Last modified:May 1, 1997 - v1
Checksum:i0EF0AE4DF96204A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei85Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00157 Genomic DNA. Translation: AAA52632.1.
V00492 Genomic DNA. Translation: CAA23751.1.
UniGeneiHs.449630.
Hs.654744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00157 Genomic DNA. Translation: AAA52632.1.
V00492 Genomic DNA. Translation: CAA23751.1.
UniGeneiHs.449630.
Hs.654744.

3D structure databases

ProteinModelPortaliP78461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322421.

Proteomic databases

PeptideAtlasiP78461.
PRIDEiP78461.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.

Gene expression databases

BgeeiENSG00000188536.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiP78461_HUMAN
AccessioniPrimary (citable) accession number: P78461
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: January 18, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.