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- P78460_HUMAN


P78460 - P78460_HUMAN

Submitted name:

P21 protein



Homo sapiens (Human)
Unreviewed - Annotation score: 4 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. GDP binding Source: Ensembl
    2. GMP binding Source: Ensembl
    3. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. actin cytoskeleton organization Source: Ensembl
    2. cell aging Source: Ensembl
    3. cell proliferation Source: Ensembl
    4. cytokine-mediated signaling pathway Source: Ensembl
    5. endocytosis Source: Ensembl
    6. GTP catabolic process Source: InterPro
    7. intrinsic apoptotic signaling pathway Source: Ensembl
    8. negative regulation of neuron apoptotic process Source: Ensembl
    9. positive regulation of cell proliferation Source: Ensembl
    10. positive regulation of DNA replication Source: Ensembl
    11. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    12. positive regulation of gene expression Source: Ensembl
    13. positive regulation of MAP kinase activity Source: Ensembl
    14. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    15. positive regulation of nitric-oxide synthase activity Source: Ensembl
    16. positive regulation of Rac protein signal transduction Source: Ensembl
    17. protein heterooligomerization Source: Ensembl
    18. Ras protein signal transduction Source: Ensembl
    19. regulation of long-term neuronal synaptic plasticity Source: Ensembl
    20. regulation of synaptic transmission, GABAergic Source: Ensembl
    21. response to glucocorticoid Source: Ensembl
    22. response to mineralocorticoid Source: Ensembl
    23. social behavior Source: Ensembl
    24. striated muscle cell differentiation Source: Ensembl
    25. visual learning Source: Ensembl

    Keywords - Ligandi

    GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    P21 proteinImported
    Gene namesi
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. membrane raft Source: Ensembl
    2. mitochondrion Source: Ensembl
    3. plasma membrane Source: Ensembl

    PTM / Processingi

    Proteomic databases



    Gene expression databases


    Family & Domainsi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    [Graphical view]


    Sequence statusi: Fragment.

    P78460-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEYKLVVVG AGGVGKSALT IQLIQNHFVD                         30
    Mass (Da):3,189
    Last modified:May 1, 1997 - v1

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei30 – 301Imported

    Sequence databases

    Select the link destinations:
    Links Updated
    M19990 Genomic DNA. Translation: AAA52693.1.


    Sequence databases

    Select the link destinations:
    Links Updated
    M19990 Genomic DNA. Translation: AAA52693.1 .
    UniGenei Hs.37003.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P78460.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi P78460.
    Bgeei P78460.

    Family and domain databases

    Gene3Di 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...


    1. "Characterization of mutagen-activated cellular oncogenes that confer anchorage independence to human fibroblasts and tumorigenicity to NIH 3T3 cells: sequence analysis of an enzymatically amplified mutant HRAS allele."
      Stevens C.W., Manoharan T.H., Fahl W.E.
      Proc. Natl. Acad. Sci. U.S.A. 85:3875-3879(1988) [PubMed] [Europe PMC] [Abstract]
      Tissue: ForeskinImported.

    Entry informationi

    Entry nameiP78460_HUMAN
    AccessioniPrimary (citable) accession number: P78460
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.