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Protein
Submitted name:

P21 protein

Gene

HRAS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. GDP binding Source: Ensembl
  2. GMP binding Source: Ensembl
  3. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. actin cytoskeleton organization Source: Ensembl
  2. cell aging Source: Ensembl
  3. cell proliferation Source: Ensembl
  4. cytokine-mediated signaling pathway Source: Ensembl
  5. endocytosis Source: Ensembl
  6. epithelial tube branching involved in lung morphogenesis Source: Ensembl
  7. GTP catabolic process Source: InterPro
  8. intrinsic apoptotic signaling pathway Source: Ensembl
  9. negative regulation of cell differentiation Source: Ensembl
  10. negative regulation of neuron apoptotic process Source: Ensembl
  11. negative regulation of skeletal muscle tissue development Source: Ensembl
  12. positive regulation of cell proliferation Source: Ensembl
  13. positive regulation of DNA replication Source: Ensembl
  14. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  15. positive regulation of gene expression Source: Ensembl
  16. positive regulation of MAP kinase activity Source: Ensembl
  17. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  18. positive regulation of nitric-oxide synthase activity Source: Ensembl
  19. positive regulation of Rac protein signal transduction Source: Ensembl
  20. protein heterooligomerization Source: Ensembl
  21. Ras protein signal transduction Source: Ensembl
  22. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  23. regulation of synaptic transmission, GABAergic Source: Ensembl
  24. response to glucocorticoid Source: Ensembl
  25. response to mineralocorticoid Source: Ensembl
  26. social behavior Source: Ensembl
  27. striated muscle cell differentiation Source: Ensembl
  28. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
P21 proteinImported
Gene namesi
Name:HRASImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. membrane raft Source: Ensembl
  2. mitochondrion Source: Ensembl
  3. plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiP78460.

Expressioni

Gene expression databases

BgeeiP78460.
ExpressionAtlasiP78460. baseline and differential.

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P78460-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD
Length:30
Mass (Da):3,189
Last modified:May 1, 1997 - v1
Checksum:i6A934F4F20CF18C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei30 – 301Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19990 Genomic DNA. Translation: AAA52693.1.
UniGeneiHs.37003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19990 Genomic DNA. Translation: AAA52693.1.
UniGeneiHs.37003.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP78460.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Gene expression databases

BgeeiP78460.
ExpressionAtlasiP78460. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of mutagen-activated cellular oncogenes that confer anchorage independence to human fibroblasts and tumorigenicity to NIH 3T3 cells: sequence analysis of an enzymatically amplified mutant HRAS allele."
    Stevens C.W., Manoharan T.H., Fahl W.E.
    Proc. Natl. Acad. Sci. U.S.A. 85:3875-3879(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ForeskinImported.

Entry informationi

Entry nameiP78460_HUMAN
AccessioniPrimary (citable) accession number: P78460
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.