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- P78460_HUMAN


P78460 - P78460_HUMAN

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Submitted name:

P21 protein



Homo sapiens (Human)
Unreviewed - Annotation score: 4 out of 5- Protein predictedi


GO - Molecular functioni

  1. GDP binding Source: Ensembl
  2. GMP binding Source: Ensembl
  3. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. actin cytoskeleton organization Source: Ensembl
  2. cell aging Source: Ensembl
  3. cell proliferation Source: Ensembl
  4. cytokine-mediated signaling pathway Source: Ensembl
  5. endocytosis Source: Ensembl
  6. epithelial tube branching involved in lung morphogenesis Source: Ensembl
  7. GTP catabolic process Source: InterPro
  8. intrinsic apoptotic signaling pathway Source: Ensembl
  9. negative regulation of cell differentiation Source: Ensembl
  10. negative regulation of neuron apoptotic process Source: Ensembl
  11. negative regulation of skeletal muscle tissue development Source: Ensembl
  12. positive regulation of cell proliferation Source: Ensembl
  13. positive regulation of DNA replication Source: Ensembl
  14. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  15. positive regulation of gene expression Source: Ensembl
  16. positive regulation of MAP kinase activity Source: Ensembl
  17. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  18. positive regulation of nitric-oxide synthase activity Source: Ensembl
  19. positive regulation of Rac protein signal transduction Source: Ensembl
  20. protein heterooligomerization Source: Ensembl
  21. Ras protein signal transduction Source: Ensembl
  22. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  23. regulation of synaptic transmission, GABAergic Source: Ensembl
  24. response to glucocorticoid Source: Ensembl
  25. response to mineralocorticoid Source: Ensembl
  26. social behavior Source: Ensembl
  27. striated muscle cell differentiation Source: Ensembl
  28. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
P21 proteinImported
Gene namesi
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. membrane raft Source: Ensembl
  2. mitochondrion Source: Ensembl
  3. plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases



Gene expression databases

ExpressionAtlasiP78460. baseline and differential.

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]


Sequence statusi: Fragment.

P78460-1 [UniParc]FASTAAdd to Basket

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        10         20         30
Mass (Da):3,189
Last modified:May 1, 1997 - v1

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei30 – 301Imported

Sequence databases

Select the link destinations:
Links Updated
M19990 Genomic DNA. Translation: AAA52693.1.


Sequence databases

Select the link destinations:
Links Updated
M19990 Genomic DNA. Translation: AAA52693.1 .
UniGenei Hs.37003.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P78460.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

Bgeei P78460.
ExpressionAtlasi P78460. baseline and differential.

Family and domain databases

Gene3Di 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...


  1. "Characterization of mutagen-activated cellular oncogenes that confer anchorage independence to human fibroblasts and tumorigenicity to NIH 3T3 cells: sequence analysis of an enzymatically amplified mutant HRAS allele."
    Stevens C.W., Manoharan T.H., Fahl W.E.
    Proc. Natl. Acad. Sci. U.S.A. 85:3875-3879(1988) [PubMed] [Europe PMC] [Abstract]
    Tissue: ForeskinImported.

Entry informationi

Entry nameiP78460_HUMAN
AccessioniPrimary (citable) accession number: P78460
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.