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Protein
Submitted name:

Tyrosine kinase

Gene

c-fgr

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, Transferase

Enzyme and pathway databases

SignaLinkiP78453.

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine kinaseImported
Gene namesi
Name:c-fgrImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28135.

PTM / Processingi

Proteomic databases

PaxDbiP78453.
PeptideAtlasiP78453.

Expressioni

Gene expression databases

BgeeiENSG00000000938.
GenevisibleiP78453. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363115.

Structurei

3D structure databases

ProteinModelPortaliP78453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 138SH3InterPro annotationAdd BLAST62
Domaini144 – 177SH2InterPro annotationAdd BLAST34

Keywords - Domaini

SH3 domainSAAS annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG008761.
KOiK08891.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR000980. SH2.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00326. SH3. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Fragment.

P78453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI
60 70 80 90 100
PNYSNFSSQA INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK
110 120 130 140 150
GEKFHILNNT EGDWWEARSL SSGKTGCIPS NYVAPVDSIQ AEEWYFGKIG
160 170
RKDAERQLLS PGNPQGAFLI RESETTK
Length:177
Mass (Da):19,354
Last modified:May 1, 1997 - v1
Checksum:i11ACD7F3BAF3D43E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei177Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27454 mRNA. Translation: AAA35679.1.
RefSeqiNP_001036194.1. NM_001042729.1.
UniGeneiHs.1422.

Genome annotation databases

GeneIDi2268.
KEGGihsa:2268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27454 mRNA. Translation: AAA35679.1.
RefSeqiNP_001036194.1. NM_001042729.1.
UniGeneiHs.1422.

3D structure databases

ProteinModelPortaliP78453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363115.

Proteomic databases

PaxDbiP78453.
PeptideAtlasiP78453.

Protocols and materials databases

DNASUi2268.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2268.
KEGGihsa:2268.

Organism-specific databases

CTDi2268.
PharmGKBiPA28135.

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG008761.
KOiK08891.

Enzyme and pathway databases

SignaLinkiP78453.

Miscellaneous databases

GenomeRNAii2268.

Gene expression databases

BgeeiENSG00000000938.
GenevisibleiP78453. HS.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR000980. SH2.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00326. SH3. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiP78453_HUMAN
AccessioniPrimary (citable) accession number: P78453
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: February 15, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.