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P78415

- IRX3_HUMAN

UniProt

P78415 - IRX3_HUMAN

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Protein

Iroquois-class homeodomain protein IRX-3

Gene

IRX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi125 – 18864Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. mesoderm development Source: Ensembl
  2. metanephros development Source: Ensembl
  3. negative regulation of neuron differentiation Source: Ensembl
  4. positive regulation of neuron differentiation Source: Ensembl
  5. regulation of transcription, DNA-templated Source: UniProtKB-KW
  6. specification of loop of Henle identity Source: Ensembl
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-3
Alternative name(s):
Homeodomain protein IRXB1
Iroquois homeobox protein 3
Gene namesi
Name:IRX3
Synonyms:IRXB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:14360. IRX3.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29926.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Iroquois-class homeodomain protein IRX-3PRO_0000049155Add
BLAST

Proteomic databases

PaxDbiP78415.
PRIDEiP78415.

PTM databases

PhosphoSiteiP78415.

Expressioni

Gene expression databases

BgeeiP78415.
CleanExiHS_IRX3.
ExpressionAtlasiP78415. baseline and differential.
GenevestigatoriP78415.

Organism-specific databases

HPAiHPA062522.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331608.

Structurei

3D structure databases

ProteinModelPortaliP78415.
SMRiP78415. Positions 136-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi62 – 709Poly-Ala
Compositional biasi201 – 26767Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi229 – 2324Poly-Glu
Compositional biasi304 – 433130Pro-richAdd
BLAST
Compositional biasi388 – 3947Poly-Ala
Compositional biasi446 – 4505Poly-Ala

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG315186.
GeneTreeiENSGT00750000117365.
HOGENOMiHOG000234546.
HOVERGENiHBG006180.
InParanoidiP78415.
OMAiGPISDSK.
OrthoDBiEOG7RV9HC.
PhylomeDBiP78415.
TreeFamiTF319371.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78415-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFPQLGYQY IRPLYPSERP GAAGGSGGSA GARGGLGAGA SELNASGSLS
60 70 80 90 100
NVLSSVYGAP YAAAAAAAAA QGYGAFLPYA AELPIFPQLG AQYELKDSPG
110 120 130 140 150
VQHPAAAAAF PHPHPAFYPY GQYQFGDPSR PKNATRESTS TLKAWLNEHR
160 170 180 190 200
KNPYPTKGEK IMLAIITKMT LTQVSTWFAN ARRRLKKENK MTWAPRSRTD
210 220 230 240 250
EEGNAYGSER EEEDEEEDEE DGKRELELEE EELGGEEEDT GGEGLADDDE
260 270 280 290 300
DEEIDLENLD GAATEPELSL AGAARRDGDL GLGPISDSKN SDSEDSSEGL
310 320 330 340 350
EDRPLPVLSL APAPPPVAVA SPSLPSPPVS LDPCAPAPAP ASALQKPKIW
360 370 380 390 400
SLAETATSPD NPRRSPPGAG GSPPGAAVAP SALQLSPAAA AAAAHRLVSA
410 420 430 440 450
PLGKFPAWTN RPFPGPPPGP RLHPLSLLGS APPHLLGLPG AAGHPAAAAA
460 470 480 490 500
FARPAEPEGG TDRCSALEVE KKLLKTAFQP VPRRPQNHLD AALVLSALSS

S
Length:501
Mass (Da):52,119
Last modified:May 10, 2004 - v3
Checksum:i638D984ED0BEF6C9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti222 – 2221G → C in AAQ16549. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti422 – 4221L → P.1 Publication
Corresponds to variant rs1450355 [ dbSNP | Ensembl ].
VAR_061267
Natural varianti479 – 4791Q → H.
Corresponds to variant rs1126960 [ dbSNP | Ensembl ].
VAR_055957

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY335942 Genomic DNA. Translation: AAQ16548.1.
AY335943 mRNA. Translation: AAQ16549.1.
BC023667 mRNA. Translation: AAH23667.1.
U90308 mRNA. Translation: AAB50006.1.
CCDSiCCDS10750.1.
RefSeqiNP_077312.2. NM_024336.2.
UniGeneiHs.499205.

Genome annotation databases

EnsembliENST00000329734; ENSP00000331608; ENSG00000177508.
GeneIDi79191.
KEGGihsa:79191.
UCSCiuc002eht.1. human.

Polymorphism databases

DMDMi47117874.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY335942 Genomic DNA. Translation: AAQ16548.1 .
AY335943 mRNA. Translation: AAQ16549.1 .
BC023667 mRNA. Translation: AAH23667.1 .
U90308 mRNA. Translation: AAB50006.1 .
CCDSi CCDS10750.1.
RefSeqi NP_077312.2. NM_024336.2.
UniGenei Hs.499205.

3D structure databases

ProteinModelPortali P78415.
SMRi P78415. Positions 136-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000331608.

PTM databases

PhosphoSitei P78415.

Polymorphism databases

DMDMi 47117874.

Proteomic databases

PaxDbi P78415.
PRIDEi P78415.

Protocols and materials databases

DNASUi 79191.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329734 ; ENSP00000331608 ; ENSG00000177508 .
GeneIDi 79191.
KEGGi hsa:79191.
UCSCi uc002eht.1. human.

Organism-specific databases

CTDi 79191.
GeneCardsi GC16M054372.
HGNCi HGNC:14360. IRX3.
HPAi HPA062522.
MIMi 612985. gene.
neXtProti NX_P78415.
PharmGKBi PA29926.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG315186.
GeneTreei ENSGT00750000117365.
HOGENOMi HOG000234546.
HOVERGENi HBG006180.
InParanoidi P78415.
OMAi GPISDSK.
OrthoDBi EOG7RV9HC.
PhylomeDBi P78415.
TreeFami TF319371.

Miscellaneous databases

ChiTaRSi IRX3. human.
GeneWikii IRX3.
GenomeRNAii 79191.
NextBioi 68196.
PROi P78415.
SOURCEi Search...

Gene expression databases

Bgeei P78415.
CleanExi HS_IRX3.
ExpressionAtlasi P78415. baseline and differential.
Genevestigatori P78415.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view ]
Pfami PF05920. Homeobox_KN. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human homeobox two-cluster Iroquois gene family."
    Hansen L., Wu Q., Tommerup N.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-422.
    Tissue: Muscle.
  3. "IRX: a new family of human homeobox genes from the breast."
    Lewis M.T., Strickland P.A., Ross S., Snyder C.J., Daniel C.W.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 91-176.

Entry informationi

Entry nameiIRX3_HUMAN
AccessioniPrimary (citable) accession number: P78415
Secondary accession number(s): Q7Z4A4, Q7Z4A5, Q8IVC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: October 29, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3