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P78415

- IRX3_HUMAN

UniProt

P78415 - IRX3_HUMAN

Protein

Iroquois-class homeodomain protein IRX-3

Gene

IRX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 3 (10 May 2004)
      Previous versions | rss
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    Functioni

    Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi125 – 18864Homeobox; TALE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. mesoderm development Source: Ensembl
    2. metanephros development Source: Ensembl
    3. negative regulation of neuron differentiation Source: Ensembl
    4. positive regulation of neuron differentiation Source: Ensembl
    5. specification of loop of Henle identity Source: Ensembl
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iroquois-class homeodomain protein IRX-3
    Alternative name(s):
    Homeodomain protein IRXB1
    Iroquois homeobox protein 3
    Gene namesi
    Name:IRX3
    Synonyms:IRXB1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:14360. IRX3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29926.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Iroquois-class homeodomain protein IRX-3PRO_0000049155Add
    BLAST

    Proteomic databases

    PaxDbiP78415.
    PRIDEiP78415.

    PTM databases

    PhosphoSiteiP78415.

    Expressioni

    Gene expression databases

    ArrayExpressiP78415.
    BgeeiP78415.
    CleanExiHS_IRX3.
    GenevestigatoriP78415.

    Organism-specific databases

    HPAiHPA062522.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000331608.

    Structurei

    3D structure databases

    ProteinModelPortaliP78415.
    SMRiP78415. Positions 136-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi62 – 709Poly-Ala
    Compositional biasi201 – 26767Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi229 – 2324Poly-Glu
    Compositional biasi304 – 433130Pro-richAdd
    BLAST
    Compositional biasi388 – 3947Poly-Ala
    Compositional biasi446 – 4505Poly-Ala

    Sequence similaritiesi

    Belongs to the TALE/IRO homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG315186.
    HOGENOMiHOG000234546.
    HOVERGENiHBG006180.
    InParanoidiP78415.
    OMAiGPISDSK.
    OrthoDBiEOG7RV9HC.
    PhylomeDBiP78415.
    TreeFamiTF319371.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    IPR003893. Iroquois_homeo.
    [Graphical view]
    PfamiPF05920. Homeobox_KN. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    SM00548. IRO. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P78415-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFPQLGYQY IRPLYPSERP GAAGGSGGSA GARGGLGAGA SELNASGSLS    50
    NVLSSVYGAP YAAAAAAAAA QGYGAFLPYA AELPIFPQLG AQYELKDSPG 100
    VQHPAAAAAF PHPHPAFYPY GQYQFGDPSR PKNATRESTS TLKAWLNEHR 150
    KNPYPTKGEK IMLAIITKMT LTQVSTWFAN ARRRLKKENK MTWAPRSRTD 200
    EEGNAYGSER EEEDEEEDEE DGKRELELEE EELGGEEEDT GGEGLADDDE 250
    DEEIDLENLD GAATEPELSL AGAARRDGDL GLGPISDSKN SDSEDSSEGL 300
    EDRPLPVLSL APAPPPVAVA SPSLPSPPVS LDPCAPAPAP ASALQKPKIW 350
    SLAETATSPD NPRRSPPGAG GSPPGAAVAP SALQLSPAAA AAAAHRLVSA 400
    PLGKFPAWTN RPFPGPPPGP RLHPLSLLGS APPHLLGLPG AAGHPAAAAA 450
    FARPAEPEGG TDRCSALEVE KKLLKTAFQP VPRRPQNHLD AALVLSALSS 500
    S 501
    Length:501
    Mass (Da):52,119
    Last modified:May 10, 2004 - v3
    Checksum:i638D984ED0BEF6C9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti222 – 2221G → C in AAQ16549. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti422 – 4221L → P.1 Publication
    Corresponds to variant rs1450355 [ dbSNP | Ensembl ].
    VAR_061267
    Natural varianti479 – 4791Q → H.
    Corresponds to variant rs1126960 [ dbSNP | Ensembl ].
    VAR_055957

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY335942 Genomic DNA. Translation: AAQ16548.1.
    AY335943 mRNA. Translation: AAQ16549.1.
    BC023667 mRNA. Translation: AAH23667.1.
    U90308 mRNA. Translation: AAB50006.1.
    CCDSiCCDS10750.1.
    RefSeqiNP_077312.2. NM_024336.2.
    UniGeneiHs.499205.

    Genome annotation databases

    EnsembliENST00000329734; ENSP00000331608; ENSG00000177508.
    GeneIDi79191.
    KEGGihsa:79191.
    UCSCiuc002eht.1. human.

    Polymorphism databases

    DMDMi47117874.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY335942 Genomic DNA. Translation: AAQ16548.1 .
    AY335943 mRNA. Translation: AAQ16549.1 .
    BC023667 mRNA. Translation: AAH23667.1 .
    U90308 mRNA. Translation: AAB50006.1 .
    CCDSi CCDS10750.1.
    RefSeqi NP_077312.2. NM_024336.2.
    UniGenei Hs.499205.

    3D structure databases

    ProteinModelPortali P78415.
    SMRi P78415. Positions 136-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000331608.

    PTM databases

    PhosphoSitei P78415.

    Polymorphism databases

    DMDMi 47117874.

    Proteomic databases

    PaxDbi P78415.
    PRIDEi P78415.

    Protocols and materials databases

    DNASUi 79191.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329734 ; ENSP00000331608 ; ENSG00000177508 .
    GeneIDi 79191.
    KEGGi hsa:79191.
    UCSCi uc002eht.1. human.

    Organism-specific databases

    CTDi 79191.
    GeneCardsi GC16M054372.
    HGNCi HGNC:14360. IRX3.
    HPAi HPA062522.
    MIMi 612985. gene.
    neXtProti NX_P78415.
    PharmGKBi PA29926.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315186.
    HOGENOMi HOG000234546.
    HOVERGENi HBG006180.
    InParanoidi P78415.
    OMAi GPISDSK.
    OrthoDBi EOG7RV9HC.
    PhylomeDBi P78415.
    TreeFami TF319371.

    Miscellaneous databases

    ChiTaRSi IRX3. human.
    GeneWikii IRX3.
    GenomeRNAii 79191.
    NextBioi 68196.
    PROi P78415.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P78415.
    Bgeei P78415.
    CleanExi HS_IRX3.
    Genevestigatori P78415.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    IPR003893. Iroquois_homeo.
    [Graphical view ]
    Pfami PF05920. Homeobox_KN. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    SM00548. IRO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the human homeobox two-cluster Iroquois gene family."
      Hansen L., Wu Q., Tommerup N.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-422.
      Tissue: Muscle.
    3. "IRX: a new family of human homeobox genes from the breast."
      Lewis M.T., Strickland P.A., Ross S., Snyder C.J., Daniel C.W.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 91-176.

    Entry informationi

    Entry nameiIRX3_HUMAN
    AccessioniPrimary (citable) accession number: P78415
    Secondary accession number(s): Q7Z4A4, Q7Z4A5, Q8IVC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3