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P78415

- IRX3_HUMAN

UniProt

P78415 - IRX3_HUMAN

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Protein

Iroquois-class homeodomain protein IRX-3

Gene
IRX3, IRXB1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi125 – 18864Homeobox; TALE-typeAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. mesoderm development Source: Ensembl
  2. metanephros development Source: Ensembl
  3. negative regulation of neuron differentiation Source: Ensembl
  4. positive regulation of neuron differentiation Source: Ensembl
  5. specification of loop of Henle identity Source: Ensembl
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-3
Alternative name(s):
Homeodomain protein IRXB1
Iroquois homeobox protein 3
Gene namesi
Name:IRX3
Synonyms:IRXB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:14360. IRX3.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29926.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Iroquois-class homeodomain protein IRX-3PRO_0000049155Add
BLAST

Proteomic databases

PaxDbiP78415.
PRIDEiP78415.

PTM databases

PhosphoSiteiP78415.

Expressioni

Gene expression databases

ArrayExpressiP78415.
BgeeiP78415.
CleanExiHS_IRX3.
GenevestigatoriP78415.

Organism-specific databases

HPAiHPA062522.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331608.

Structurei

3D structure databases

ProteinModelPortaliP78415.
SMRiP78415. Positions 136-185.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi62 – 709Poly-Ala
Compositional biasi201 – 26767Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi229 – 2324Poly-Glu
Compositional biasi304 – 433130Pro-richAdd
BLAST
Compositional biasi388 – 3947Poly-Ala
Compositional biasi446 – 4505Poly-Ala

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG315186.
HOGENOMiHOG000234546.
HOVERGENiHBG006180.
InParanoidiP78415.
OMAiGPISDSK.
OrthoDBiEOG7RV9HC.
PhylomeDBiP78415.
TreeFamiTF319371.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78415-1 [UniParc]FASTAAdd to Basket

« Hide

MSFPQLGYQY IRPLYPSERP GAAGGSGGSA GARGGLGAGA SELNASGSLS    50
NVLSSVYGAP YAAAAAAAAA QGYGAFLPYA AELPIFPQLG AQYELKDSPG 100
VQHPAAAAAF PHPHPAFYPY GQYQFGDPSR PKNATRESTS TLKAWLNEHR 150
KNPYPTKGEK IMLAIITKMT LTQVSTWFAN ARRRLKKENK MTWAPRSRTD 200
EEGNAYGSER EEEDEEEDEE DGKRELELEE EELGGEEEDT GGEGLADDDE 250
DEEIDLENLD GAATEPELSL AGAARRDGDL GLGPISDSKN SDSEDSSEGL 300
EDRPLPVLSL APAPPPVAVA SPSLPSPPVS LDPCAPAPAP ASALQKPKIW 350
SLAETATSPD NPRRSPPGAG GSPPGAAVAP SALQLSPAAA AAAAHRLVSA 400
PLGKFPAWTN RPFPGPPPGP RLHPLSLLGS APPHLLGLPG AAGHPAAAAA 450
FARPAEPEGG TDRCSALEVE KKLLKTAFQP VPRRPQNHLD AALVLSALSS 500
S 501
Length:501
Mass (Da):52,119
Last modified:May 10, 2004 - v3
Checksum:i638D984ED0BEF6C9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti422 – 4221L → P.1 Publication
Corresponds to variant rs1450355 [ dbSNP | Ensembl ].
VAR_061267
Natural varianti479 – 4791Q → H.
Corresponds to variant rs1126960 [ dbSNP | Ensembl ].
VAR_055957

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti222 – 2221G → C in AAQ16549. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY335942 Genomic DNA. Translation: AAQ16548.1.
AY335943 mRNA. Translation: AAQ16549.1.
BC023667 mRNA. Translation: AAH23667.1.
U90308 mRNA. Translation: AAB50006.1.
CCDSiCCDS10750.1.
RefSeqiNP_077312.2. NM_024336.2.
UniGeneiHs.499205.

Genome annotation databases

EnsembliENST00000329734; ENSP00000331608; ENSG00000177508.
GeneIDi79191.
KEGGihsa:79191.
UCSCiuc002eht.1. human.

Polymorphism databases

DMDMi47117874.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY335942 Genomic DNA. Translation: AAQ16548.1 .
AY335943 mRNA. Translation: AAQ16549.1 .
BC023667 mRNA. Translation: AAH23667.1 .
U90308 mRNA. Translation: AAB50006.1 .
CCDSi CCDS10750.1.
RefSeqi NP_077312.2. NM_024336.2.
UniGenei Hs.499205.

3D structure databases

ProteinModelPortali P78415.
SMRi P78415. Positions 136-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000331608.

PTM databases

PhosphoSitei P78415.

Polymorphism databases

DMDMi 47117874.

Proteomic databases

PaxDbi P78415.
PRIDEi P78415.

Protocols and materials databases

DNASUi 79191.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329734 ; ENSP00000331608 ; ENSG00000177508 .
GeneIDi 79191.
KEGGi hsa:79191.
UCSCi uc002eht.1. human.

Organism-specific databases

CTDi 79191.
GeneCardsi GC16M054372.
HGNCi HGNC:14360. IRX3.
HPAi HPA062522.
MIMi 612985. gene.
neXtProti NX_P78415.
PharmGKBi PA29926.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG315186.
HOGENOMi HOG000234546.
HOVERGENi HBG006180.
InParanoidi P78415.
OMAi GPISDSK.
OrthoDBi EOG7RV9HC.
PhylomeDBi P78415.
TreeFami TF319371.

Miscellaneous databases

ChiTaRSi IRX3. human.
GeneWikii IRX3.
GenomeRNAii 79191.
NextBioi 68196.
PROi P78415.
SOURCEi Search...

Gene expression databases

ArrayExpressi P78415.
Bgeei P78415.
CleanExi HS_IRX3.
Genevestigatori P78415.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view ]
Pfami PF05920. Homeobox_KN. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human homeobox two-cluster Iroquois gene family."
    Hansen L., Wu Q., Tommerup N.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-422.
    Tissue: Muscle.
  3. "IRX: a new family of human homeobox genes from the breast."
    Lewis M.T., Strickland P.A., Ross S., Snyder C.J., Daniel C.W.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 91-176.

Entry informationi

Entry nameiIRX3_HUMAN
AccessioniPrimary (citable) accession number: P78415
Secondary accession number(s): Q7Z4A4, Q7Z4A5, Q8IVC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: July 9, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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