P78414 (IRX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Iroquois-class homeodomain protein IRX-1

Alternative name(s):
Homeodomain protein IRXA1
Iroquois homeobox protein 1

Gene names

Name:	IRX1
Synonyms:	IRXA1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the TALE/IRO homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proximal/distal pattern formation involved in metanephric nephron development Inferred from electronic annotation. Source: Compara specification of loop of Henle identity Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 480	480	Iroquois-class homeodomain protein IRX-1		PRO_0000049151
Regions
	DNA binding	125 – 188	64	Homeobox; TALE-type
	Compositional bias	334 – 337	4	Poly-Pro
	Compositional bias	407 – 415	9	Poly-Pro
Experimental info
	Sequence conflict	138	1	S → N in AAB50005. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P78414 [UniParc]. Last modified May 10, 2004. Version 3. Checksum: ABC3A7069593E0E1	FASTA	480	49,621
	10 20 30 40 50 60 MSFPQLGYPQ YLSAAGPGAY GGERPGVLAA AAAAAAAASS GRPGAAELGG GAGAAAVTSV 70 80 90 100 110 120 LGMYAAAGPY AGAPNYSAFL PYAADLSLFS QMGSQYELKD NPGVHPATFA AHTAPAYYPY 130 140 150 160 170 180 GQFQYGDPGR PKNATRESTS TLKAWLNEHR KNPYPTKGEK IMLAIITKMT LTQVSTWFAN 190 200 210 220 230 240 ARRRLKKENK VTWGARSKDQ EDGALFGSDT EGDPEKAEDD EEIDLESIDI DKIDEHDGDQ 250 260 270 280 290 300 SNEDDEDKAE APHAPAAPSA LARDQGSPLA AADVLKPQDS PLGLAKEAPE PGSTRLLSPG 310 320 330 340 350 360 AAAGGLQGAP HGKPKIWSLA ETATSPDGAP KASPPPPAGH PGAHGPSAGA PLQHPAFLPS 370 380 390 400 410 420 HGLYTCHIGK FSNWTNSAFL AQGSLLNMRS FLGVGAPHAA PHGPHLPAPP PPQPPVAIAP 430 440 450 460 470 480 GALNGDKASV RSSPTLPERD LVPRPDSPAQ QLKSPFQPVR DNSLAPQEGT PRILAALPSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the human homeobox two-cluster Iroquois gene family." Hansen L., Wu Q., Tommerup N. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-480. Tissue: Brain and Lung.
[3]	"IRX: a new family of human homeobox genes from the breast." Lewis M.T., Strickland P.A., Ross S., Snyder C.J., Daniel C.W. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 84-176.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY335938 mRNA. Translation: AAQ16544.1. AY335947 Genomic DNA. Translation: AAQ16553.1. BC029160 mRNA. Translation: AAH29160.1. U90307 mRNA. Translation: AAB50005.1.
IPI	IPI00375629.
RefSeq	NP_077313.3. NM_024337.3.
UniGene	Hs.424156.
3D structure databases
ProteinModelPortal	P78414.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000305244.
PTM databases
PhosphoSite	P78414.
Polymorphism databases
DMDM	47117873.
Proteomic databases
PaxDb	P78414.
PeptideAtlas	P78414.
PRIDE	P78414.
Protocols and materials databases
DNASU	79192.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302006; ENSP00000305244; ENSG00000170549.
GeneID	79192.
KEGG	hsa:79192.
UCSC	uc003jde.3. human.
Organism-specific databases
CTD	79192.
GeneCards	GC05P003596.
HGNC	HGNC:14358. IRX1.
HPA	HPA043160.
MIM	606197. gene.
neXtProt	NX_P78414.
PharmGKB	PA29924.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG279452.
HOGENOM	HOG000234546.
HOVERGEN	HBG006180.
InParanoid	P78414.
OMA	VRDNSLA.
OrthoDB	EOG4MGS95.
PhylomeDB	P78414.
Gene expression databases
Bgee	P78414.
CleanEx	HS_IRX1.
Genevestigator	P78414.
GermOnline	ENSG00000170549. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR008422. Homeobox_KN_domain. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR003893. Iroquois_homeo. [Graphical view]
Pfam	PF05920. Homeobox_KN. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. SM00548. IRO. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79192.
NextBio	68200.
SOURCE	Search...

Entry information

Entry name

IRX1_HUMAN

Accession

Primary (citable) accession number: P78414
Secondary accession number(s): Q7Z2F8, Q8N312

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 10, 2004
Last modified:	May 1, 2013
This is version 107 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.