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P78414

- IRX1_HUMAN

UniProt

P78414 - IRX1_HUMAN

Protein

Iroquois-class homeodomain protein IRX-1

Gene

IRX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 3 (10 May 2004)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi125 – 18864Homeobox; TALE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. proximal/distal pattern formation involved in metanephric nephron development Source: Ensembl
    2. specification of loop of Henle identity Source: Ensembl

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iroquois-class homeodomain protein IRX-1
    Alternative name(s):
    Homeodomain protein IRXA1
    Iroquois homeobox protein 1
    Gene namesi
    Name:IRX1
    Synonyms:IRXA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:14358. IRX1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29924.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480Iroquois-class homeodomain protein IRX-1PRO_0000049151Add
    BLAST

    Proteomic databases

    PaxDbiP78414.
    PeptideAtlasiP78414.
    PRIDEiP78414.

    PTM databases

    PhosphoSiteiP78414.

    Expressioni

    Gene expression databases

    BgeeiP78414.
    CleanExiHS_IRX1.
    GenevestigatoriP78414.

    Organism-specific databases

    HPAiHPA043160.

    Interactioni

    Protein-protein interaction databases

    BioGridi122604. 1 interaction.
    STRINGi9606.ENSP00000305244.

    Structurei

    3D structure databases

    ProteinModelPortaliP78414.
    SMRiP78414. Positions 136-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi334 – 3374Poly-Pro
    Compositional biasi407 – 4159Poly-Pro

    Sequence similaritiesi

    Belongs to the TALE/IRO homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG279452.
    HOGENOMiHOG000234546.
    HOVERGENiHBG006180.
    InParanoidiP78414.
    OMAiKVTWGSR.
    OrthoDBiEOG7H1JM1.
    PhylomeDBiP78414.
    TreeFamiTF319371.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    IPR003893. Iroquois_homeo.
    [Graphical view]
    PfamiPF05920. Homeobox_KN. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    SM00548. IRO. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P78414-1 [UniParc]FASTAAdd to Basket

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    MSFPQLGYPQ YLSAAGPGAY GGERPGVLAA AAAAAAAASS GRPGAAELGG    50
    GAGAAAVTSV LGMYAAAGPY AGAPNYSAFL PYAADLSLFS QMGSQYELKD 100
    NPGVHPATFA AHTAPAYYPY GQFQYGDPGR PKNATRESTS TLKAWLNEHR 150
    KNPYPTKGEK IMLAIITKMT LTQVSTWFAN ARRRLKKENK VTWGARSKDQ 200
    EDGALFGSDT EGDPEKAEDD EEIDLESIDI DKIDEHDGDQ SNEDDEDKAE 250
    APHAPAAPSA LARDQGSPLA AADVLKPQDS PLGLAKEAPE PGSTRLLSPG 300
    AAAGGLQGAP HGKPKIWSLA ETATSPDGAP KASPPPPAGH PGAHGPSAGA 350
    PLQHPAFLPS HGLYTCHIGK FSNWTNSAFL AQGSLLNMRS FLGVGAPHAA 400
    PHGPHLPAPP PPQPPVAIAP GALNGDKASV RSSPTLPERD LVPRPDSPAQ 450
    QLKSPFQPVR DNSLAPQEGT PRILAALPSA 480
    Length:480
    Mass (Da):49,621
    Last modified:May 10, 2004 - v3
    Checksum:iABC3A7069593E0E1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti138 – 1381S → N in AAB50005. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY335938 mRNA. Translation: AAQ16544.1.
    AY335947 Genomic DNA. Translation: AAQ16553.1.
    BC029160 mRNA. Translation: AAH29160.1.
    U90307 mRNA. Translation: AAB50005.1.
    CCDSiCCDS34132.1.
    RefSeqiNP_077313.3. NM_024337.3.
    UniGeneiHs.424156.

    Genome annotation databases

    EnsembliENST00000302006; ENSP00000305244; ENSG00000170549.
    GeneIDi79192.
    KEGGihsa:79192.
    UCSCiuc003jde.3. human.

    Polymorphism databases

    DMDMi47117873.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY335938 mRNA. Translation: AAQ16544.1 .
    AY335947 Genomic DNA. Translation: AAQ16553.1 .
    BC029160 mRNA. Translation: AAH29160.1 .
    U90307 mRNA. Translation: AAB50005.1 .
    CCDSi CCDS34132.1.
    RefSeqi NP_077313.3. NM_024337.3.
    UniGenei Hs.424156.

    3D structure databases

    ProteinModelPortali P78414.
    SMRi P78414. Positions 136-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122604. 1 interaction.
    STRINGi 9606.ENSP00000305244.

    PTM databases

    PhosphoSitei P78414.

    Polymorphism databases

    DMDMi 47117873.

    Proteomic databases

    PaxDbi P78414.
    PeptideAtlasi P78414.
    PRIDEi P78414.

    Protocols and materials databases

    DNASUi 79192.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302006 ; ENSP00000305244 ; ENSG00000170549 .
    GeneIDi 79192.
    KEGGi hsa:79192.
    UCSCi uc003jde.3. human.

    Organism-specific databases

    CTDi 79192.
    GeneCardsi GC05P003596.
    HGNCi HGNC:14358. IRX1.
    HPAi HPA043160.
    MIMi 606197. gene.
    neXtProti NX_P78414.
    PharmGKBi PA29924.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279452.
    HOGENOMi HOG000234546.
    HOVERGENi HBG006180.
    InParanoidi P78414.
    OMAi KVTWGSR.
    OrthoDBi EOG7H1JM1.
    PhylomeDBi P78414.
    TreeFami TF319371.

    Miscellaneous databases

    GeneWikii IRX1.
    GenomeRNAii 79192.
    NextBioi 68200.
    PROi P78414.
    SOURCEi Search...

    Gene expression databases

    Bgeei P78414.
    CleanExi HS_IRX1.
    Genevestigatori P78414.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    IPR003893. Iroquois_homeo.
    [Graphical view ]
    Pfami PF05920. Homeobox_KN. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    SM00548. IRO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the human homeobox two-cluster Iroquois gene family."
      Hansen L., Wu Q., Tommerup N.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-480.
      Tissue: Brain and Lung.
    3. "IRX: a new family of human homeobox genes from the breast."
      Lewis M.T., Strickland P.A., Ross S., Snyder C.J., Daniel C.W.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 84-176.

    Entry informationi

    Entry nameiIRX1_HUMAN
    AccessioniPrimary (citable) accession number: P78414
    Secondary accession number(s): Q7Z2F8, Q8N312
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 117 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3