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Protein

Iroquois-class homeodomain protein IRX-1

Gene

IRX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi125 – 188Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-1
Alternative name(s):
Homeodomain protein IRXA1
Iroquois homeobox protein 1
Gene namesi
Name:IRX1
Synonyms:IRXA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000170549.3
HGNCiHGNC:14358 IRX1
MIMi606197 gene
neXtProtiNX_P78414

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79192
OpenTargetsiENSG00000170549
PharmGKBiPA29924

Polymorphism and mutation databases

BioMutaiIRX1
DMDMi47117873

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491511 – 480Iroquois-class homeodomain protein IRX-1Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei241PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP78414
MaxQBiP78414
PaxDbiP78414
PeptideAtlasiP78414
PRIDEiP78414

PTM databases

iPTMnetiP78414
PhosphoSitePlusiP78414

Expressioni

Gene expression databases

BgeeiENSG00000170549
CleanExiHS_IRX1
GenevisibleiP78414 HS

Organism-specific databases

HPAiHPA043160

Interactioni

Protein-protein interaction databases

BioGridi122604, 2 interactors
STRINGi9606.ENSP00000305244

Structurei

3D structure databases

ProteinModelPortaliP78414
SMRiP78414
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi334 – 337Poly-Pro4
Compositional biasi407 – 415Poly-Pro9

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOGENOMiHOG000234546
HOVERGENiHBG006180
InParanoidiP78414
OMAiLYTCHIG
OrthoDBiEOG091G0BOB
PhylomeDBiP78414
TreeFamiTF319371

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P78414-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPQLGYPQ YLSAAGPGAY GGERPGVLAA AAAAAAAASS GRPGAAELGG
60 70 80 90 100
GAGAAAVTSV LGMYAAAGPY AGAPNYSAFL PYAADLSLFS QMGSQYELKD
110 120 130 140 150
NPGVHPATFA AHTAPAYYPY GQFQYGDPGR PKNATRESTS TLKAWLNEHR
160 170 180 190 200
KNPYPTKGEK IMLAIITKMT LTQVSTWFAN ARRRLKKENK VTWGARSKDQ
210 220 230 240 250
EDGALFGSDT EGDPEKAEDD EEIDLESIDI DKIDEHDGDQ SNEDDEDKAE
260 270 280 290 300
APHAPAAPSA LARDQGSPLA AADVLKPQDS PLGLAKEAPE PGSTRLLSPG
310 320 330 340 350
AAAGGLQGAP HGKPKIWSLA ETATSPDGAP KASPPPPAGH PGAHGPSAGA
360 370 380 390 400
PLQHPAFLPS HGLYTCHIGK FSNWTNSAFL AQGSLLNMRS FLGVGAPHAA
410 420 430 440 450
PHGPHLPAPP PPQPPVAIAP GALNGDKASV RSSPTLPERD LVPRPDSPAQ
460 470 480
QLKSPFQPVR DNSLAPQEGT PRILAALPSA
Length:480
Mass (Da):49,621
Last modified:May 10, 2004 - v3
Checksum:iABC3A7069593E0E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138S → N in AAB50005 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335938 mRNA Translation: AAQ16544.1
AY335947 Genomic DNA Translation: AAQ16553.1
BC029160 mRNA Translation: AAH29160.1
U90307 mRNA Translation: AAB50005.1
CCDSiCCDS34132.1
RefSeqiNP_077313.3, NM_024337.3
UniGeneiHs.424156

Genome annotation databases

EnsembliENST00000302006; ENSP00000305244; ENSG00000170549
GeneIDi79192
KEGGihsa:79192
UCSCiuc003jde.3 human

Similar proteinsi

Entry informationi

Entry nameiIRX1_HUMAN
AccessioniPrimary (citable) accession number: P78414
Secondary accession number(s): Q7Z2F8, Q8N312
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: May 23, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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