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P78414

- IRX1_HUMAN

UniProt

P78414 - IRX1_HUMAN

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Protein

Iroquois-class homeodomain protein IRX-1

Gene

IRX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi125 – 18864Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. proximal/distal pattern formation involved in metanephric nephron development Source: Ensembl
  2. regulation of transcription, DNA-templated Source: InterPro
  3. specification of loop of Henle identity Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-1
Alternative name(s):
Homeodomain protein IRXA1
Iroquois homeobox protein 1
Gene namesi
Name:IRX1
Synonyms:IRXA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:14358. IRX1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29924.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Iroquois-class homeodomain protein IRX-1PRO_0000049151Add
BLAST

Proteomic databases

PaxDbiP78414.
PeptideAtlasiP78414.
PRIDEiP78414.

PTM databases

PhosphoSiteiP78414.

Expressioni

Gene expression databases

BgeeiP78414.
CleanExiHS_IRX1.
GenevestigatoriP78414.

Organism-specific databases

HPAiHPA043160.

Interactioni

Protein-protein interaction databases

BioGridi122604. 1 interaction.
STRINGi9606.ENSP00000305244.

Structurei

3D structure databases

ProteinModelPortaliP78414.
SMRiP78414. Positions 136-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi334 – 3374Poly-Pro
Compositional biasi407 – 4159Poly-Pro

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG279452.
GeneTreeiENSGT00750000117365.
HOGENOMiHOG000234546.
HOVERGENiHBG006180.
InParanoidiP78414.
OMAiKVTWGSR.
OrthoDBiEOG7H1JM1.
PhylomeDBiP78414.
TreeFamiTF319371.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78414-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFPQLGYPQ YLSAAGPGAY GGERPGVLAA AAAAAAAASS GRPGAAELGG
60 70 80 90 100
GAGAAAVTSV LGMYAAAGPY AGAPNYSAFL PYAADLSLFS QMGSQYELKD
110 120 130 140 150
NPGVHPATFA AHTAPAYYPY GQFQYGDPGR PKNATRESTS TLKAWLNEHR
160 170 180 190 200
KNPYPTKGEK IMLAIITKMT LTQVSTWFAN ARRRLKKENK VTWGARSKDQ
210 220 230 240 250
EDGALFGSDT EGDPEKAEDD EEIDLESIDI DKIDEHDGDQ SNEDDEDKAE
260 270 280 290 300
APHAPAAPSA LARDQGSPLA AADVLKPQDS PLGLAKEAPE PGSTRLLSPG
310 320 330 340 350
AAAGGLQGAP HGKPKIWSLA ETATSPDGAP KASPPPPAGH PGAHGPSAGA
360 370 380 390 400
PLQHPAFLPS HGLYTCHIGK FSNWTNSAFL AQGSLLNMRS FLGVGAPHAA
410 420 430 440 450
PHGPHLPAPP PPQPPVAIAP GALNGDKASV RSSPTLPERD LVPRPDSPAQ
460 470 480
QLKSPFQPVR DNSLAPQEGT PRILAALPSA
Length:480
Mass (Da):49,621
Last modified:May 10, 2004 - v3
Checksum:iABC3A7069593E0E1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381S → N in AAB50005. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY335938 mRNA. Translation: AAQ16544.1.
AY335947 Genomic DNA. Translation: AAQ16553.1.
BC029160 mRNA. Translation: AAH29160.1.
U90307 mRNA. Translation: AAB50005.1.
CCDSiCCDS34132.1.
RefSeqiNP_077313.3. NM_024337.3.
UniGeneiHs.424156.

Genome annotation databases

EnsembliENST00000302006; ENSP00000305244; ENSG00000170549.
GeneIDi79192.
KEGGihsa:79192.
UCSCiuc003jde.3. human.

Polymorphism databases

DMDMi47117873.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY335938 mRNA. Translation: AAQ16544.1 .
AY335947 Genomic DNA. Translation: AAQ16553.1 .
BC029160 mRNA. Translation: AAH29160.1 .
U90307 mRNA. Translation: AAB50005.1 .
CCDSi CCDS34132.1.
RefSeqi NP_077313.3. NM_024337.3.
UniGenei Hs.424156.

3D structure databases

ProteinModelPortali P78414.
SMRi P78414. Positions 136-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122604. 1 interaction.
STRINGi 9606.ENSP00000305244.

PTM databases

PhosphoSitei P78414.

Polymorphism databases

DMDMi 47117873.

Proteomic databases

PaxDbi P78414.
PeptideAtlasi P78414.
PRIDEi P78414.

Protocols and materials databases

DNASUi 79192.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302006 ; ENSP00000305244 ; ENSG00000170549 .
GeneIDi 79192.
KEGGi hsa:79192.
UCSCi uc003jde.3. human.

Organism-specific databases

CTDi 79192.
GeneCardsi GC05P003596.
HGNCi HGNC:14358. IRX1.
HPAi HPA043160.
MIMi 606197. gene.
neXtProti NX_P78414.
PharmGKBi PA29924.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG279452.
GeneTreei ENSGT00750000117365.
HOGENOMi HOG000234546.
HOVERGENi HBG006180.
InParanoidi P78414.
OMAi KVTWGSR.
OrthoDBi EOG7H1JM1.
PhylomeDBi P78414.
TreeFami TF319371.

Miscellaneous databases

GeneWikii IRX1.
GenomeRNAii 79192.
NextBioi 68200.
PROi P78414.
SOURCEi Search...

Gene expression databases

Bgeei P78414.
CleanExi HS_IRX1.
Genevestigatori P78414.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view ]
Pfami PF05920. Homeobox_KN. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human homeobox two-cluster Iroquois gene family."
    Hansen L., Wu Q., Tommerup N.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-480.
    Tissue: Brain and Lung.
  3. "IRX: a new family of human homeobox genes from the breast."
    Lewis M.T., Strickland P.A., Ross S., Snyder C.J., Daniel C.W.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 84-176.

Entry informationi

Entry nameiIRX1_HUMAN
AccessioniPrimary (citable) accession number: P78414
Secondary accession number(s): Q7Z2F8, Q8N312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: October 29, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3