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P78414 (IRX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Iroquois-class homeodomain protein IRX-1
Alternative name(s):
Homeodomain protein IRXA1
Iroquois homeobox protein 1
Gene names
Name:IRX1
Synonyms:IRXA1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the TALE/IRO homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480Iroquois-class homeodomain protein IRX-1
PRO_0000049151

Regions

DNA binding125 – 18864Homeobox; TALE-type
Compositional bias334 – 3374Poly-Pro
Compositional bias407 – 4159Poly-Pro

Experimental info

Sequence conflict1381S → N in AAB50005. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P78414 [UniParc].

Last modified May 10, 2004. Version 3.
Checksum: ABC3A7069593E0E1

FASTA48049,621
        10         20         30         40         50         60 
MSFPQLGYPQ YLSAAGPGAY GGERPGVLAA AAAAAAAASS GRPGAAELGG GAGAAAVTSV 

        70         80         90        100        110        120 
LGMYAAAGPY AGAPNYSAFL PYAADLSLFS QMGSQYELKD NPGVHPATFA AHTAPAYYPY 

       130        140        150        160        170        180 
GQFQYGDPGR PKNATRESTS TLKAWLNEHR KNPYPTKGEK IMLAIITKMT LTQVSTWFAN 

       190        200        210        220        230        240 
ARRRLKKENK VTWGARSKDQ EDGALFGSDT EGDPEKAEDD EEIDLESIDI DKIDEHDGDQ 

       250        260        270        280        290        300 
SNEDDEDKAE APHAPAAPSA LARDQGSPLA AADVLKPQDS PLGLAKEAPE PGSTRLLSPG 

       310        320        330        340        350        360 
AAAGGLQGAP HGKPKIWSLA ETATSPDGAP KASPPPPAGH PGAHGPSAGA PLQHPAFLPS 

       370        380        390        400        410        420 
HGLYTCHIGK FSNWTNSAFL AQGSLLNMRS FLGVGAPHAA PHGPHLPAPP PPQPPVAIAP 

       430        440        450        460        470        480 
GALNGDKASV RSSPTLPERD LVPRPDSPAQ QLKSPFQPVR DNSLAPQEGT PRILAALPSA 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the human homeobox two-cluster Iroquois gene family."
Hansen L., Wu Q., Tommerup N.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-480.
Tissue: Brain and Lung.
[3]"IRX: a new family of human homeobox genes from the breast."
Lewis M.T., Strickland P.A., Ross S., Snyder C.J., Daniel C.W.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 84-176.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY335938 mRNA. Translation: AAQ16544.1.
AY335947 Genomic DNA. Translation: AAQ16553.1.
BC029160 mRNA. Translation: AAH29160.1.
U90307 mRNA. Translation: AAB50005.1.
CCDSCCDS34132.1.
RefSeqNP_077313.3. NM_024337.3.
UniGeneHs.424156.

3D structure databases

ProteinModelPortalP78414.
SMRP78414. Positions 136-185.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122604. 1 interaction.
STRING9606.ENSP00000305244.

PTM databases

PhosphoSiteP78414.

Polymorphism databases

DMDM47117873.

Proteomic databases

PaxDbP78414.
PeptideAtlasP78414.
PRIDEP78414.

Protocols and materials databases

DNASU79192.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302006; ENSP00000305244; ENSG00000170549.
GeneID79192.
KEGGhsa:79192.
UCSCuc003jde.3. human.

Organism-specific databases

CTD79192.
GeneCardsGC05P003596.
HGNCHGNC:14358. IRX1.
HPAHPA043160.
MIM606197. gene.
neXtProtNX_P78414.
PharmGKBPA29924.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG279452.
HOGENOMHOG000234546.
HOVERGENHBG006180.
InParanoidP78414.
OMAKVTWGSR.
OrthoDBEOG7H1JM1.
PhylomeDBP78414.
TreeFamTF319371.

Gene expression databases

BgeeP78414.
CleanExHS_IRX1.
GenevestigatorP78414.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIRX1.
GenomeRNAi79192.
NextBio68200.
PROP78414.
SOURCESearch...

Entry information

Entry nameIRX1_HUMAN
AccessionPrimary (citable) accession number: P78414
Secondary accession number(s): Q7Z2F8, Q8N312
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: July 9, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM