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Protein

Iroquois-class homeodomain protein IRX-1

Gene

IRX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi125 – 18864Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. proximal/distal pattern formation involved in metanephric nephron development Source: Ensembl
  2. regulation of transcription, DNA-templated Source: InterPro
  3. specification of loop of Henle identity Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-1
Alternative name(s):
Homeodomain protein IRXA1
Iroquois homeobox protein 1
Gene namesi
Name:IRX1
Synonyms:IRXA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:14358. IRX1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29924.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Iroquois-class homeodomain protein IRX-1PRO_0000049151Add
BLAST

Proteomic databases

PaxDbiP78414.
PeptideAtlasiP78414.
PRIDEiP78414.

PTM databases

PhosphoSiteiP78414.

Expressioni

Gene expression databases

BgeeiP78414.
CleanExiHS_IRX1.
GenevestigatoriP78414.

Organism-specific databases

HPAiHPA043160.

Interactioni

Protein-protein interaction databases

BioGridi122604. 1 interaction.
STRINGi9606.ENSP00000305244.

Structurei

3D structure databases

ProteinModelPortaliP78414.
SMRiP78414. Positions 136-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi334 – 3374Poly-Pro
Compositional biasi407 – 4159Poly-Pro

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG279452.
GeneTreeiENSGT00750000117365.
HOGENOMiHOG000234546.
HOVERGENiHBG006180.
InParanoidiP78414.
OMAiKVTWGSR.
OrthoDBiEOG7H1JM1.
PhylomeDBiP78414.
TreeFamiTF319371.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78414-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPQLGYPQ YLSAAGPGAY GGERPGVLAA AAAAAAAASS GRPGAAELGG
60 70 80 90 100
GAGAAAVTSV LGMYAAAGPY AGAPNYSAFL PYAADLSLFS QMGSQYELKD
110 120 130 140 150
NPGVHPATFA AHTAPAYYPY GQFQYGDPGR PKNATRESTS TLKAWLNEHR
160 170 180 190 200
KNPYPTKGEK IMLAIITKMT LTQVSTWFAN ARRRLKKENK VTWGARSKDQ
210 220 230 240 250
EDGALFGSDT EGDPEKAEDD EEIDLESIDI DKIDEHDGDQ SNEDDEDKAE
260 270 280 290 300
APHAPAAPSA LARDQGSPLA AADVLKPQDS PLGLAKEAPE PGSTRLLSPG
310 320 330 340 350
AAAGGLQGAP HGKPKIWSLA ETATSPDGAP KASPPPPAGH PGAHGPSAGA
360 370 380 390 400
PLQHPAFLPS HGLYTCHIGK FSNWTNSAFL AQGSLLNMRS FLGVGAPHAA
410 420 430 440 450
PHGPHLPAPP PPQPPVAIAP GALNGDKASV RSSPTLPERD LVPRPDSPAQ
460 470 480
QLKSPFQPVR DNSLAPQEGT PRILAALPSA
Length:480
Mass (Da):49,621
Last modified:May 10, 2004 - v3
Checksum:iABC3A7069593E0E1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381S → N in AAB50005 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335938 mRNA. Translation: AAQ16544.1.
AY335947 Genomic DNA. Translation: AAQ16553.1.
BC029160 mRNA. Translation: AAH29160.1.
U90307 mRNA. Translation: AAB50005.1.
CCDSiCCDS34132.1.
RefSeqiNP_077313.3. NM_024337.3.
UniGeneiHs.424156.

Genome annotation databases

EnsembliENST00000302006; ENSP00000305244; ENSG00000170549.
GeneIDi79192.
KEGGihsa:79192.
UCSCiuc003jde.3. human.

Polymorphism databases

DMDMi47117873.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335938 mRNA. Translation: AAQ16544.1.
AY335947 Genomic DNA. Translation: AAQ16553.1.
BC029160 mRNA. Translation: AAH29160.1.
U90307 mRNA. Translation: AAB50005.1.
CCDSiCCDS34132.1.
RefSeqiNP_077313.3. NM_024337.3.
UniGeneiHs.424156.

3D structure databases

ProteinModelPortaliP78414.
SMRiP78414. Positions 136-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122604. 1 interaction.
STRINGi9606.ENSP00000305244.

PTM databases

PhosphoSiteiP78414.

Polymorphism databases

DMDMi47117873.

Proteomic databases

PaxDbiP78414.
PeptideAtlasiP78414.
PRIDEiP78414.

Protocols and materials databases

DNASUi79192.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302006; ENSP00000305244; ENSG00000170549.
GeneIDi79192.
KEGGihsa:79192.
UCSCiuc003jde.3. human.

Organism-specific databases

CTDi79192.
GeneCardsiGC05P003596.
HGNCiHGNC:14358. IRX1.
HPAiHPA043160.
MIMi606197. gene.
neXtProtiNX_P78414.
PharmGKBiPA29924.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG279452.
GeneTreeiENSGT00750000117365.
HOGENOMiHOG000234546.
HOVERGENiHBG006180.
InParanoidiP78414.
OMAiKVTWGSR.
OrthoDBiEOG7H1JM1.
PhylomeDBiP78414.
TreeFamiTF319371.

Miscellaneous databases

GeneWikiiIRX1.
GenomeRNAii79192.
NextBioi68200.
PROiP78414.
SOURCEiSearch...

Gene expression databases

BgeeiP78414.
CleanExiHS_IRX1.
GenevestigatoriP78414.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human homeobox two-cluster Iroquois gene family."
    Hansen L., Wu Q., Tommerup N.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-480.
    Tissue: Brain and Lung.
  3. "IRX: a new family of human homeobox genes from the breast."
    Lewis M.T., Strickland P.A., Ross S., Snyder C.J., Daniel C.W.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 84-176.

Entry informationi

Entry nameiIRX1_HUMAN
AccessioniPrimary (citable) accession number: P78414
Secondary accession number(s): Q7Z2F8, Q8N312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: January 7, 2015
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.