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P78412 (IRX6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Iroquois-class homeodomain protein IRX-6
Alternative name(s):
Homeodomain protein IRXB3
Iroquois homeobox protein 6
Gene names
Name:IRX6
Synonyms:IRX7, IRXB3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the TALE/IRO homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Iroquois-class homeodomain protein IRX-6
PRO_0000049162

Regions

DNA binding144 – 20764Homeobox; TALE-type

Experimental info

Sequence conflict1171S → G in AAB50003. Ref.5
Sequence conflict4441Missing Ref.1

Sequences

Sequence LengthMass (Da)Tools
P78412 [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: 4E542FEDD5D06912

FASTA44648,240
        10         20         30         40         50         60 
MSFPHFGHPY RGASQFLASA SSSTTCCEST QRSVSDVASG STPAPALCCA PYDSRLLGSA 

        70         80         90        100        110        120 
RPELGAALGI YGAPYAAAAA AQSYPGYLPY SPEPPSLYGA LNPQYEFKEA AGSFTSSLAQ 

       130        140        150        160        170        180 
PGAYYPYERT LGQYQYERYG AVELSGAGRR KNATRETTST LKAWLNEHRK NPYPTKGEKI 

       190        200        210        220        230        240 
MLAIITKMTL TQVSTWFANA RRRLKKENKM TWAPKNKGGE ERKAEGGEED SLGCLTADTK 

       250        260        270        280        290        300 
EVTASQEARG LRLSDLEDLE EEEEEEEEAE DEEVVATAGD RLTEFRKGAQ SLPGPCAAAR 

       310        320        330        340        350        360 
EGRLERRECG LAAPRFSFND PSGSEEADFL SAETGSPRLT MHYPCLEKPR IWSLAHTATA 

       370        380        390        400        410        420 
SAVEGAPPAR PRPRSPECRM IPGQPPASAR RLSVPRDSAC DESSCIPKAF GNPKFALQGL 

       430        440 
PLNCAPCPRR SEPVVQCQYP SGAEAG 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the human homeobox two-cluster Iroquois gene family."
Hansen L., Wu Q., Tommerup N.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thalamus.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"IRX: a new family of human homeobox genes from the breast."
Lewis M.T., Strickland P.A., Ross S., Snyder C.J., Daniel C.W.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-195.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY335937 mRNA. Translation: AAQ16543.1.
AY335946 Genomic DNA. Translation: AAQ16552.1.
AK125053 mRNA. Translation: BAC86033.1.
CH471092 Genomic DNA. Translation: EAW82823.1.
BC136573 mRNA. Translation: AAI36574.1.
BC136576 mRNA. Translation: AAI36577.1.
U90305 mRNA. Translation: AAB50003.1.
RefSeqNP_077311.2. NM_024335.2.
XP_005256194.1. XM_005256137.1.
UniGeneHs.369907.

3D structure databases

ProteinModelPortalP78412.
SMRP78412. Positions 155-204.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000290552.

PTM databases

PhosphoSiteP78412.

Polymorphism databases

DMDM116242594.

Proteomic databases

PaxDbP78412.
PRIDEP78412.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000290552; ENSP00000290552; ENSG00000159387.
GeneID79190.
KEGGhsa:79190.
UCSCuc002ehx.3. human.

Organism-specific databases

CTD79190.
GeneCardsGC16P055357.
HGNCHGNC:14675. IRX6.
HPAHPA018332.
MIM606196. gene.
neXtProtNX_P78412.
PharmGKBPA29929.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG310996.
HOGENOMHOG000234546.
HOVERGENHBG006180.
InParanoidP78412.
OMALCCAPYD.
OrthoDBEOG7JDQXW.
PhylomeDBP78412.
TreeFamTF319371.

Gene expression databases

BgeeP78412.
CleanExHS_IRX6.
GenevestigatorP78412.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIRX6.
GenomeRNAi79190.
NextBio68192.
PROP78412.
SOURCESearch...

Entry information

Entry nameIRX6_HUMAN
AccessionPrimary (citable) accession number: P78412
Secondary accession number(s): B2RN06, Q7Z2K0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM