P78412 (IRX6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Iroquois-class homeodomain protein IRX-6

Alternative name(s):
Homeodomain protein IRXB3
Iroquois homeobox protein 6

Gene names

Name:	IRX6
Synonyms:	IRX7, IRXB3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the TALE/IRO homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Iroquois-class homeodomain protein IRX-6		PRO_0000049162
Regions
	DNA binding	144 – 207	64	Homeobox; TALE-type
Experimental info
	Sequence conflict	117	1	S → G in AAB50003. Ref.5
	Sequence conflict	444	1	Missing Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P78412 [UniParc]. Last modified October 17, 2006. Version 3. Checksum: 4E542FEDD5D06912	FASTA	446	48,240
	10 20 30 40 50 60 MSFPHFGHPY RGASQFLASA SSSTTCCEST QRSVSDVASG STPAPALCCA PYDSRLLGSA 70 80 90 100 110 120 RPELGAALGI YGAPYAAAAA AQSYPGYLPY SPEPPSLYGA LNPQYEFKEA AGSFTSSLAQ 130 140 150 160 170 180 PGAYYPYERT LGQYQYERYG AVELSGAGRR KNATRETTST LKAWLNEHRK NPYPTKGEKI 190 200 210 220 230 240 MLAIITKMTL TQVSTWFANA RRRLKKENKM TWAPKNKGGE ERKAEGGEED SLGCLTADTK 250 260 270 280 290 300 EVTASQEARG LRLSDLEDLE EEEEEEEEAE DEEVVATAGD RLTEFRKGAQ SLPGPCAAAR 310 320 330 340 350 360 EGRLERRECG LAAPRFSFND PSGSEEADFL SAETGSPRLT MHYPCLEKPR IWSLAHTATA 370 380 390 400 410 420 SAVEGAPPAR PRPRSPECRM IPGQPPASAR RLSVPRDSAC DESSCIPKAF GNPKFALQGL 430 440 PLNCAPCPRR SEPVVQCQYP SGAEAG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the human homeobox two-cluster Iroquois gene family." Hansen L., Wu Q., Tommerup N. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"IRX: a new family of human homeobox genes from the breast." Lewis M.T., Strickland P.A., Ross S., Snyder C.J., Daniel C.W. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY335937 mRNA. Translation: AAQ16543.1. AY335946 Genomic DNA. Translation: AAQ16552.1. AK125053 mRNA. Translation: BAC86033.1. CH471092 Genomic DNA. Translation: EAW82823.1. BC136573 mRNA. Translation: AAI36574.1. BC136576 mRNA. Translation: AAI36577.1. U90305 mRNA. Translation: AAB50003.1.
IPI	IPI00400792.
RefSeq	NP_077311.2. NM_024335.2.
UniGene	Hs.369907.
3D structure databases
ProteinModelPortal	P78412.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000290552.
PTM databases
PhosphoSite	P78412.
Polymorphism databases
DMDM	116242594.
Proteomic databases
PaxDb	P78412.
PRIDE	P78412.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000290552; ENSP00000290552; ENSG00000159387.
GeneID	79190.
KEGG	hsa:79190.
UCSC	uc002ehx.3. human.
Organism-specific databases
CTD	79190.
GeneCards	GC16P055357.
HGNC	HGNC:14675. IRX6.
HPA	HPA018332.
MIM	606196. gene.
neXtProt	NX_P78412.
PharmGKB	PA29929.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG310996.
HOGENOM	HOG000234546.
HOVERGEN	HBG006180.
InParanoid	P78412.
OMA	LNCAPCP.
OrthoDB	EOG479F7C.
PhylomeDB	P78412.
Gene expression databases
ArrayExpress	P78412.
Bgee	P78412.
CleanEx	HS_IRX6.
Genevestigator	P78412.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR008422. Homeobox_KN_domain. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR003893. Iroquois_homeo. [Graphical view]
Pfam	PF05920. Homeobox_KN. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. SM00548. IRO. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79190.
NextBio	68192.
SOURCE	Search...

Entry information

Entry name

IRX6_HUMAN

Accession

Primary (citable) accession number: P78412
Secondary accession number(s): B2RN06, Q7Z2K0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 103 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.