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Protein

Iroquois-class homeodomain protein IRX-6

Gene

IRX6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi144 – 20764Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-6
Alternative name(s):
Homeodomain protein IRXB3
Iroquois homeobox protein 6
Gene namesi
Name:IRX6
Synonyms:IRX7, IRXB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:14675. IRX6.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Iroquois-class homeodomain protein IRX-6PRO_0000049162Add
BLAST

Proteomic databases

PaxDbiP78412.
PRIDEiP78412.

PTM databases

PhosphoSiteiP78412.

Expressioni

Gene expression databases

BgeeiP78412.
CleanExiHS_IRX6.
ExpressionAtlasiP78412. baseline.
GenevestigatoriP78412.

Organism-specific databases

HPAiHPA018332.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000290552.

Structurei

3D structure databases

ProteinModelPortaliP78412.
SMRiP78412. Positions 155-204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG310996.
GeneTreeiENSGT00750000117365.
HOGENOMiHOG000234546.
HOVERGENiHBG006180.
InParanoidiP78412.
OMAiLCCAPYD.
OrthoDBiEOG7JDQXW.
PhylomeDBiP78412.
TreeFamiTF319371.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78412-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFPHFGHPY RGASQFLASA SSSTTCCEST QRSVSDVASG STPAPALCCA
60 70 80 90 100
PYDSRLLGSA RPELGAALGI YGAPYAAAAA AQSYPGYLPY SPEPPSLYGA
110 120 130 140 150
LNPQYEFKEA AGSFTSSLAQ PGAYYPYERT LGQYQYERYG AVELSGAGRR
160 170 180 190 200
KNATRETTST LKAWLNEHRK NPYPTKGEKI MLAIITKMTL TQVSTWFANA
210 220 230 240 250
RRRLKKENKM TWAPKNKGGE ERKAEGGEED SLGCLTADTK EVTASQEARG
260 270 280 290 300
LRLSDLEDLE EEEEEEEEAE DEEVVATAGD RLTEFRKGAQ SLPGPCAAAR
310 320 330 340 350
EGRLERRECG LAAPRFSFND PSGSEEADFL SAETGSPRLT MHYPCLEKPR
360 370 380 390 400
IWSLAHTATA SAVEGAPPAR PRPRSPECRM IPGQPPASAR RLSVPRDSAC
410 420 430 440
DESSCIPKAF GNPKFALQGL PLNCAPCPRR SEPVVQCQYP SGAEAG
Length:446
Mass (Da):48,240
Last modified:October 17, 2006 - v3
Checksum:i4E542FEDD5D06912
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1171S → G in AAB50003. 1 PublicationCurated
Sequence conflicti444 – 4441Missing1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335937 mRNA. Translation: AAQ16543.1.
AY335946 Genomic DNA. Translation: AAQ16552.1.
AK125053 mRNA. Translation: BAC86033.1.
CH471092 Genomic DNA. Translation: EAW82823.1.
BC136573 mRNA. Translation: AAI36574.1.
BC136576 mRNA. Translation: AAI36577.1.
U90305 mRNA. Translation: AAB50003.1.
CCDSiCCDS32449.1.
RefSeqiNP_077311.2. NM_024335.2.
XP_005256194.1. XM_005256137.1.
UniGeneiHs.369907.

Genome annotation databases

EnsembliENST00000290552; ENSP00000290552; ENSG00000159387.
GeneIDi79190.
KEGGihsa:79190.
UCSCiuc002ehx.3. human.

Polymorphism databases

DMDMi116242594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335937 mRNA. Translation: AAQ16543.1.
AY335946 Genomic DNA. Translation: AAQ16552.1.
AK125053 mRNA. Translation: BAC86033.1.
CH471092 Genomic DNA. Translation: EAW82823.1.
BC136573 mRNA. Translation: AAI36574.1.
BC136576 mRNA. Translation: AAI36577.1.
U90305 mRNA. Translation: AAB50003.1.
CCDSiCCDS32449.1.
RefSeqiNP_077311.2. NM_024335.2.
XP_005256194.1. XM_005256137.1.
UniGeneiHs.369907.

3D structure databases

ProteinModelPortaliP78412.
SMRiP78412. Positions 155-204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000290552.

PTM databases

PhosphoSiteiP78412.

Polymorphism databases

DMDMi116242594.

Proteomic databases

PaxDbiP78412.
PRIDEiP78412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290552; ENSP00000290552; ENSG00000159387.
GeneIDi79190.
KEGGihsa:79190.
UCSCiuc002ehx.3. human.

Organism-specific databases

CTDi79190.
GeneCardsiGC16P055357.
HGNCiHGNC:14675. IRX6.
HPAiHPA018332.
MIMi606196. gene.
neXtProtiNX_P78412.
PharmGKBiPA29929.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG310996.
GeneTreeiENSGT00750000117365.
HOGENOMiHOG000234546.
HOVERGENiHBG006180.
InParanoidiP78412.
OMAiLCCAPYD.
OrthoDBiEOG7JDQXW.
PhylomeDBiP78412.
TreeFamiTF319371.

Miscellaneous databases

GeneWikiiIRX6.
GenomeRNAii79190.
NextBioi68192.
PROiP78412.
SOURCEiSearch...

Gene expression databases

BgeeiP78412.
CleanExiHS_IRX6.
ExpressionAtlasiP78412. baseline.
GenevestigatoriP78412.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR003893. Iroquois_homeo.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human homeobox two-cluster Iroquois gene family."
    Hansen L., Wu Q., Tommerup N.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "IRX: a new family of human homeobox genes from the breast."
    Lewis M.T., Strickland P.A., Ross S., Snyder C.J., Daniel C.W.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-195.

Entry informationi

Entry nameiIRX6_HUMAN
AccessioniPrimary (citable) accession number: P78412
Secondary accession number(s): B2RN06, Q7Z2K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 17, 2006
Last modified: January 7, 2015
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.