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Protein

Iroquois-class homeodomain protein IRX-6

Gene

IRX6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi144 – 207Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-6
Alternative name(s):
Homeodomain protein IRXB3
Iroquois homeobox protein 6
Gene namesi
Name:IRX6
Synonyms:IRX7, IRXB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000159387.7.
HGNCiHGNC:14675. IRX6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159387.
PharmGKBiPA29929.

Polymorphism and mutation databases

BioMutaiIRX6.
DMDMi116242594.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491621 – 446Iroquois-class homeodomain protein IRX-6Add BLAST446

Proteomic databases

MaxQBiP78412.
PaxDbiP78412.
PeptideAtlasiP78412.
PRIDEiP78412.

PTM databases

iPTMnetiP78412.
PhosphoSitePlusiP78412.

Expressioni

Gene expression databases

BgeeiENSG00000159387.
CleanExiHS_IRX6.

Organism-specific databases

HPAiHPA018332.

Interactioni

Protein-protein interaction databases

IntActiP78412. 6 interactors.
STRINGi9606.ENSP00000290552.

Structurei

3D structure databases

ProteinModelPortaliP78412.
SMRiP78412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
GeneTreeiENSGT00750000117365.
HOGENOMiHOG000234546.
HOVERGENiHBG006180.
InParanoidiP78412.
OMAiLCCAPYD.
OrthoDBiEOG091G0N9R.
PhylomeDBiP78412.
TreeFamiTF319371.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR003893. Iroquois_homeo.
PfamiView protein in Pfam
PF05920. Homeobox_KN. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00548. IRO. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P78412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPHFGHPY RGASQFLASA SSSTTCCEST QRSVSDVASG STPAPALCCA
60 70 80 90 100
PYDSRLLGSA RPELGAALGI YGAPYAAAAA AQSYPGYLPY SPEPPSLYGA
110 120 130 140 150
LNPQYEFKEA AGSFTSSLAQ PGAYYPYERT LGQYQYERYG AVELSGAGRR
160 170 180 190 200
KNATRETTST LKAWLNEHRK NPYPTKGEKI MLAIITKMTL TQVSTWFANA
210 220 230 240 250
RRRLKKENKM TWAPKNKGGE ERKAEGGEED SLGCLTADTK EVTASQEARG
260 270 280 290 300
LRLSDLEDLE EEEEEEEEAE DEEVVATAGD RLTEFRKGAQ SLPGPCAAAR
310 320 330 340 350
EGRLERRECG LAAPRFSFND PSGSEEADFL SAETGSPRLT MHYPCLEKPR
360 370 380 390 400
IWSLAHTATA SAVEGAPPAR PRPRSPECRM IPGQPPASAR RLSVPRDSAC
410 420 430 440
DESSCIPKAF GNPKFALQGL PLNCAPCPRR SEPVVQCQYP SGAEAG
Length:446
Mass (Da):48,240
Last modified:October 17, 2006 - v3
Checksum:i4E542FEDD5D06912
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117S → G in AAB50003 (Ref. 5) Curated1
Sequence conflicti444Missing (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335937 mRNA. Translation: AAQ16543.1.
AY335946 Genomic DNA. Translation: AAQ16552.1.
AK125053 mRNA. Translation: BAC86033.1.
CH471092 Genomic DNA. Translation: EAW82823.1.
BC136573 mRNA. Translation: AAI36574.1.
BC136576 mRNA. Translation: AAI36577.1.
U90305 mRNA. Translation: AAB50003.1.
CCDSiCCDS32449.1.
RefSeqiNP_077311.2. NM_024335.2.
XP_005256194.1. XM_005256137.2.
UniGeneiHs.369907.

Genome annotation databases

EnsembliENST00000290552; ENSP00000290552; ENSG00000159387.
GeneIDi79190.
KEGGihsa:79190.
UCSCiuc002ehy.4. human.

Similar proteinsi

Entry informationi

Entry nameiIRX6_HUMAN
AccessioniPrimary (citable) accession number: P78412
Secondary accession number(s): B2RN06, Q7Z2K0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 17, 2006
Last modified: September 27, 2017
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families