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P78412

- IRX6_HUMAN

UniProt

P78412 - IRX6_HUMAN

Protein

Iroquois-class homeodomain protein IRX-6

Gene

IRX6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi144 – 20764Homeobox; TALE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iroquois-class homeodomain protein IRX-6
    Alternative name(s):
    Homeodomain protein IRXB3
    Iroquois homeobox protein 6
    Gene namesi
    Name:IRX6
    Synonyms:IRX7, IRXB3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:14675. IRX6.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29929.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Iroquois-class homeodomain protein IRX-6PRO_0000049162Add
    BLAST

    Proteomic databases

    PaxDbiP78412.
    PRIDEiP78412.

    PTM databases

    PhosphoSiteiP78412.

    Expressioni

    Gene expression databases

    BgeeiP78412.
    CleanExiHS_IRX6.
    GenevestigatoriP78412.

    Organism-specific databases

    HPAiHPA018332.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000290552.

    Structurei

    3D structure databases

    ProteinModelPortaliP78412.
    SMRiP78412. Positions 155-204.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TALE/IRO homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG310996.
    HOGENOMiHOG000234546.
    HOVERGENiHBG006180.
    InParanoidiP78412.
    OMAiLCCAPYD.
    OrthoDBiEOG7JDQXW.
    PhylomeDBiP78412.
    TreeFamiTF319371.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    IPR003893. Iroquois_homeo.
    [Graphical view]
    PfamiPF05920. Homeobox_KN. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    SM00548. IRO. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P78412-1 [UniParc]FASTAAdd to Basket

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    MSFPHFGHPY RGASQFLASA SSSTTCCEST QRSVSDVASG STPAPALCCA    50
    PYDSRLLGSA RPELGAALGI YGAPYAAAAA AQSYPGYLPY SPEPPSLYGA 100
    LNPQYEFKEA AGSFTSSLAQ PGAYYPYERT LGQYQYERYG AVELSGAGRR 150
    KNATRETTST LKAWLNEHRK NPYPTKGEKI MLAIITKMTL TQVSTWFANA 200
    RRRLKKENKM TWAPKNKGGE ERKAEGGEED SLGCLTADTK EVTASQEARG 250
    LRLSDLEDLE EEEEEEEEAE DEEVVATAGD RLTEFRKGAQ SLPGPCAAAR 300
    EGRLERRECG LAAPRFSFND PSGSEEADFL SAETGSPRLT MHYPCLEKPR 350
    IWSLAHTATA SAVEGAPPAR PRPRSPECRM IPGQPPASAR RLSVPRDSAC 400
    DESSCIPKAF GNPKFALQGL PLNCAPCPRR SEPVVQCQYP SGAEAG 446
    Length:446
    Mass (Da):48,240
    Last modified:October 17, 2006 - v3
    Checksum:i4E542FEDD5D06912
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti117 – 1171S → G in AAB50003. 1 PublicationCurated
    Sequence conflicti444 – 4441Missing1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY335937 mRNA. Translation: AAQ16543.1.
    AY335946 Genomic DNA. Translation: AAQ16552.1.
    AK125053 mRNA. Translation: BAC86033.1.
    CH471092 Genomic DNA. Translation: EAW82823.1.
    BC136573 mRNA. Translation: AAI36574.1.
    BC136576 mRNA. Translation: AAI36577.1.
    U90305 mRNA. Translation: AAB50003.1.
    CCDSiCCDS32449.1.
    RefSeqiNP_077311.2. NM_024335.2.
    XP_005256194.1. XM_005256137.1.
    UniGeneiHs.369907.

    Genome annotation databases

    EnsembliENST00000290552; ENSP00000290552; ENSG00000159387.
    GeneIDi79190.
    KEGGihsa:79190.
    UCSCiuc002ehx.3. human.

    Polymorphism databases

    DMDMi116242594.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY335937 mRNA. Translation: AAQ16543.1 .
    AY335946 Genomic DNA. Translation: AAQ16552.1 .
    AK125053 mRNA. Translation: BAC86033.1 .
    CH471092 Genomic DNA. Translation: EAW82823.1 .
    BC136573 mRNA. Translation: AAI36574.1 .
    BC136576 mRNA. Translation: AAI36577.1 .
    U90305 mRNA. Translation: AAB50003.1 .
    CCDSi CCDS32449.1.
    RefSeqi NP_077311.2. NM_024335.2.
    XP_005256194.1. XM_005256137.1.
    UniGenei Hs.369907.

    3D structure databases

    ProteinModelPortali P78412.
    SMRi P78412. Positions 155-204.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000290552.

    PTM databases

    PhosphoSitei P78412.

    Polymorphism databases

    DMDMi 116242594.

    Proteomic databases

    PaxDbi P78412.
    PRIDEi P78412.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000290552 ; ENSP00000290552 ; ENSG00000159387 .
    GeneIDi 79190.
    KEGGi hsa:79190.
    UCSCi uc002ehx.3. human.

    Organism-specific databases

    CTDi 79190.
    GeneCardsi GC16P055357.
    HGNCi HGNC:14675. IRX6.
    HPAi HPA018332.
    MIMi 606196. gene.
    neXtProti NX_P78412.
    PharmGKBi PA29929.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG310996.
    HOGENOMi HOG000234546.
    HOVERGENi HBG006180.
    InParanoidi P78412.
    OMAi LCCAPYD.
    OrthoDBi EOG7JDQXW.
    PhylomeDBi P78412.
    TreeFami TF319371.

    Miscellaneous databases

    GeneWikii IRX6.
    GenomeRNAii 79190.
    NextBioi 68192.
    PROi P78412.
    SOURCEi Search...

    Gene expression databases

    Bgeei P78412.
    CleanExi HS_IRX6.
    Genevestigatori P78412.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    IPR003893. Iroquois_homeo.
    [Graphical view ]
    Pfami PF05920. Homeobox_KN. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    SM00548. IRO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the human homeobox two-cluster Iroquois gene family."
      Hansen L., Wu Q., Tommerup N.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thalamus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "IRX: a new family of human homeobox genes from the breast."
      Lewis M.T., Strickland P.A., Ross S., Snyder C.J., Daniel C.W.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-195.

    Entry informationi

    Entry nameiIRX6_HUMAN
    AccessioniPrimary (citable) accession number: P78412
    Secondary accession number(s): B2RN06, Q7Z2K0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3