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Protein

Butyrophilin subfamily 3 member A2

Gene

BTN3A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.2 Publications

GO - Biological processi

  • interferon-gamma secretion Source: UniProtKB
  • T cell mediated immunity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrophilin subfamily 3 member A2
Gene namesi
Name:BTN3A2
Synonyms:BT3.2, BTF3, BTF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1139. BTN3A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 248ExtracellularSequence analysisAdd BLAST219
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 334CytoplasmicSequence analysisAdd BLAST65

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11118.
OpenTargetsiENSG00000186470.
PharmGKBiPA25460.

Polymorphism and mutation databases

DMDMi67462189.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001453330 – 334Butyrophilin subfamily 3 member A2Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 126PROSITE-ProRule annotation1 Publication
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi166 ↔ 220PROSITE-ProRule annotation1 Publication
Modified residuei282PhosphoserineCombined sources1
Modified residuei286PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP78410.
MaxQBiP78410.
PaxDbiP78410.
PeptideAtlasiP78410.
PRIDEiP78410.

PTM databases

iPTMnetiP78410.
PhosphoSitePlusiP78410.

Miscellaneous databases

PMAP-CutDBP78410.

Expressioni

Tissue specificityi

Detected in T-cells and natural killer cells.1 Publication

Gene expression databases

BgeeiENSG00000186470.
CleanExiHS_BTF3.
HS_BTN3A2.
ExpressionAtlasiP78410. baseline and differential.
GenevisibleiP78410. HS.

Organism-specific databases

HPAiCAB019392.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi116293. 6 interactors.

Structurei

Secondary structure

1334
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 34Combined sources3
Beta strandi40 – 43Combined sources4
Beta strandi48 – 56Combined sources9
Beta strandi63 – 69Combined sources7
Turni70 – 73Combined sources4
Beta strandi74 – 80Combined sources7
Helixi86 – 88Combined sources3
Helixi91 – 93Combined sources3
Turni94 – 96Combined sources3
Beta strandi97 – 100Combined sources4
Helixi104 – 106Combined sources3
Beta strandi108 – 115Combined sources8
Helixi118 – 120Combined sources3
Beta strandi122 – 130Combined sources9
Beta strandi133 – 145Combined sources13
Beta strandi151 – 158Combined sources8
Beta strandi161 – 173Combined sources13
Beta strandi176 – 180Combined sources5
Beta strandi202 – 210Combined sources9
Beta strandi217 – 224Combined sources8
Turni225 – 228Combined sources4
Beta strandi229 – 236Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F8QX-ray2.38A30-239[»]
ProteinModelPortaliP78410.
SMRiP78410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 139Ig-like V-typeAdd BLAST110

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili272 – 319Sequence analysisAdd BLAST48

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118933.
HOGENOMiHOG000230860.
HOVERGENiHBG050747.
InParanoidiP78410.
KOiK06712.
OMAiTGWHPQP.
OrthoDBiEOG091G05N6.
PhylomeDBiP78410.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P78410-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMASSLAFL LLNFHVSLLL VQLLTPCSAQ FSVLGPSGPI LAMVGEDADL
60 70 80 90 100
PCHLFPTMSA ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL
110 120 130 140 150
RDGITAGKAA LRIHNVTASD SGKYLCYFQD GDFYEKALVE LKVAALGSNL
160 170 180 190 200
HVEVKGYEDG GIHLECRSTG WYPQPQIQWS NAKGENIPAV EAPVVADGVG
210 220 230 240 250
LYEVAASVIM RGGSGEGVSC IIRNSLLGLE KTASISIADP FFRSAQPWIA
260 270 280 290 300
ALAGTLPILL LLLAGASYFL WRQQKEITAL SSEIESEQEM KEMGYAATER
310 320 330
EISLRESLQE ELKRKKIQYL TRGEESSSDT NKSA
Length:334
Mass (Da):36,428
Last modified:February 1, 2005 - v2
Checksum:i940519D57F95EEE4
GO
Isoform 2 (identifier: P78410-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MKMASSLAFLLLNFHVSLLLVQLLTPCS → MGIPR

Note: No experimental confirmation available.
Show »
Length:311
Mass (Da):33,910
Checksum:iBCF5177F02F440F4
GO
Isoform 3 (identifier: P78410-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.
Show »
Length:292
Mass (Da):32,016
Checksum:i85C66916BF5A9195
GO

Sequence cautioni

The sequence AAB53424 differs from that shown. Reason: Frameshift at position 317.Curated
The sequence AAC02652 differs from that shown. Reason: Frameshift at position 334.Curated
The sequence AAC02655 differs from that shown. Reason: Frameshift at position 334.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63M → L in BAG64615 (PubMed:14702039).Curated1
Sequence conflicti180S → G in AAF76140 (PubMed:11170752).Curated1
Sequence conflicti211 – 212RG → KS in AAF76140 (PubMed:11170752).Curated2
Sequence conflicti327S → L in AAC02655 (PubMed:9382921).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049833167R → T.Corresponds to variant rs9379861dbSNPEnsembl.1
Natural variantiVAR_026211181N → D.1 PublicationCorresponds to variant rs9358936dbSNPEnsembl.1
Natural variantiVAR_049834182A → T.1 PublicationCorresponds to variant rs12205731dbSNPEnsembl.1
Natural variantiVAR_049835211R → K.Corresponds to variant rs35183513dbSNPEnsembl.1
Natural variantiVAR_049836307S → N.1 PublicationCorresponds to variant rs13216828dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0459061 – 42Missing in isoform 3. CuratedAdd BLAST42
Alternative sequenceiVSP_0459071 – 28MKMAS…LTPCS → MGIPR in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90546 mRNA. Translation: AAB53424.1. Frameshift.
U90144 mRNA. Translation: AAC02652.1. Frameshift.
U97499, U97498 Genomic DNA. Translation: AAC02655.1. Frameshift.
AF257505 mRNA. Translation: AAF76140.1.
AK299417 mRNA. Translation: BAG61399.1.
AK303600 mRNA. Translation: BAG64615.1.
AL021917 Genomic DNA. Translation: CAA17277.2.
BC002832 mRNA. Translation: AAH02832.3.
BC020214 mRNA. Translation: AAH20214.3.
CCDSiCCDS4605.1. [P78410-1]
CCDS56399.1. [P78410-2]
CCDS56400.1. [P78410-3]
RefSeqiNP_001184175.1. NM_001197246.2. [P78410-1]
NP_001184176.1. NM_001197247.2. [P78410-1]
NP_001184177.1. NM_001197248.2. [P78410-2]
NP_001184178.1. NM_001197249.2. [P78410-3]
NP_008978.2. NM_007047.4. [P78410-1]
XP_005248884.1. XM_005248827.3. [P78410-1]
XP_016865700.1. XM_017010211.1. [P78410-1]
XP_016865701.1. XM_017010212.1. [P78410-1]
XP_016865703.1. XM_017010214.1. [P78410-3]
UniGeneiHs.376046.

Genome annotation databases

EnsembliENST00000356386; ENSP00000348751; ENSG00000186470. [P78410-1]
ENST00000377708; ENSP00000366937; ENSG00000186470. [P78410-1]
ENST00000396934; ENSP00000380140; ENSG00000186470. [P78410-2]
ENST00000396948; ENSP00000380152; ENSG00000186470. [P78410-1]
ENST00000508906; ENSP00000442687; ENSG00000186470. [P78410-3]
ENST00000527422; ENSP00000432138; ENSG00000186470. [P78410-1]
GeneIDi11118.
KEGGihsa:11118.
UCSCiuc003nhp.5. human. [P78410-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90546 mRNA. Translation: AAB53424.1. Frameshift.
U90144 mRNA. Translation: AAC02652.1. Frameshift.
U97499, U97498 Genomic DNA. Translation: AAC02655.1. Frameshift.
AF257505 mRNA. Translation: AAF76140.1.
AK299417 mRNA. Translation: BAG61399.1.
AK303600 mRNA. Translation: BAG64615.1.
AL021917 Genomic DNA. Translation: CAA17277.2.
BC002832 mRNA. Translation: AAH02832.3.
BC020214 mRNA. Translation: AAH20214.3.
CCDSiCCDS4605.1. [P78410-1]
CCDS56399.1. [P78410-2]
CCDS56400.1. [P78410-3]
RefSeqiNP_001184175.1. NM_001197246.2. [P78410-1]
NP_001184176.1. NM_001197247.2. [P78410-1]
NP_001184177.1. NM_001197248.2. [P78410-2]
NP_001184178.1. NM_001197249.2. [P78410-3]
NP_008978.2. NM_007047.4. [P78410-1]
XP_005248884.1. XM_005248827.3. [P78410-1]
XP_016865700.1. XM_017010211.1. [P78410-1]
XP_016865701.1. XM_017010212.1. [P78410-1]
XP_016865703.1. XM_017010214.1. [P78410-3]
UniGeneiHs.376046.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F8QX-ray2.38A30-239[»]
ProteinModelPortaliP78410.
SMRiP78410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116293. 6 interactors.

PTM databases

iPTMnetiP78410.
PhosphoSitePlusiP78410.

Polymorphism and mutation databases

DMDMi67462189.

Proteomic databases

EPDiP78410.
MaxQBiP78410.
PaxDbiP78410.
PeptideAtlasiP78410.
PRIDEiP78410.

Protocols and materials databases

DNASUi11118.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356386; ENSP00000348751; ENSG00000186470. [P78410-1]
ENST00000377708; ENSP00000366937; ENSG00000186470. [P78410-1]
ENST00000396934; ENSP00000380140; ENSG00000186470. [P78410-2]
ENST00000396948; ENSP00000380152; ENSG00000186470. [P78410-1]
ENST00000508906; ENSP00000442687; ENSG00000186470. [P78410-3]
ENST00000527422; ENSP00000432138; ENSG00000186470. [P78410-1]
GeneIDi11118.
KEGGihsa:11118.
UCSCiuc003nhp.5. human. [P78410-1]

Organism-specific databases

CTDi11118.
DisGeNETi11118.
GeneCardsiBTN3A2.
HGNCiHGNC:1139. BTN3A2.
HPAiCAB019392.
MIMi613594. gene.
neXtProtiNX_P78410.
OpenTargetsiENSG00000186470.
PharmGKBiPA25460.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118933.
HOGENOMiHOG000230860.
HOVERGENiHBG050747.
InParanoidiP78410.
KOiK06712.
OMAiTGWHPQP.
OrthoDBiEOG091G05N6.
PhylomeDBiP78410.
TreeFamiTF331083.

Miscellaneous databases

ChiTaRSiBTN3A2. human.
GenomeRNAii11118.
PMAP-CutDBP78410.
PROiP78410.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186470.
CleanExiHS_BTF3.
HS_BTN3A2.
ExpressionAtlasiP78410. baseline and differential.
GenevisibleiP78410. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBT3A2_HUMAN
AccessioniPrimary (citable) accession number: P78410
Secondary accession number(s): B4DRT7
, B4E103, F5H791, F8W6E0, O00477, O15338, O75658, Q76PA0, Q9BU81, Q9NR44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.