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P78410

- BT3A2_HUMAN

UniProt

P78410 - BT3A2_HUMAN

Protein

Butyrophilin subfamily 3 member A2

Gene

BTN3A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.2 Publications

    GO - Biological processi

    1. interferon-gamma secretion Source: UniProtKB
    2. T cell mediated immunity Source: UniProtKB

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Butyrophilin subfamily 3 member A2
    Gene namesi
    Name:BTN3A2
    Synonyms:BT3.2, BTF3, BTF4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:1139. BTN3A2.

    Subcellular locationi

    Cell membrane 2 Publications; Single-pass type I membrane protein 2 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25460.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 334305Butyrophilin subfamily 3 member A2PRO_0000014533Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi52 ↔ 1261 PublicationPROSITE-ProRule annotation
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi166 ↔ 2201 PublicationPROSITE-ProRule annotation
    Modified residuei282 – 2821Phosphoserine1 Publication
    Modified residuei286 – 2861Phosphoserine1 Publication

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP78410.
    PaxDbiP78410.
    PRIDEiP78410.

    PTM databases

    PhosphoSiteiP78410.

    Miscellaneous databases

    PMAP-CutDBP78410.

    Expressioni

    Tissue specificityi

    Detected in T-cells and natural killer cells.1 Publication

    Gene expression databases

    ArrayExpressiP78410.
    BgeeiP78410.
    CleanExiHS_BTF3.
    HS_BTN3A2.
    GenevestigatoriP78410.

    Organism-specific databases

    HPAiCAB019392.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi116293. 1 interaction.
    STRINGi9606.ENSP00000348751.

    Structurei

    Secondary structure

    1
    334
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi32 – 343
    Beta strandi40 – 434
    Beta strandi48 – 569
    Beta strandi63 – 697
    Turni70 – 734
    Beta strandi74 – 807
    Helixi86 – 883
    Helixi91 – 933
    Turni94 – 963
    Beta strandi97 – 1004
    Helixi104 – 1063
    Beta strandi108 – 1158
    Helixi118 – 1203
    Beta strandi122 – 1309
    Beta strandi133 – 14513
    Beta strandi151 – 1588
    Beta strandi161 – 17313
    Beta strandi176 – 1805
    Beta strandi202 – 2109
    Beta strandi217 – 2248
    Turni225 – 2284
    Beta strandi229 – 2368

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4F8QX-ray2.38A30-239[»]
    ProteinModelPortaliP78410.
    SMRiP78410. Positions 30-239.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 248219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini270 – 33465CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei249 – 26921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 139110Ig-like V-typeAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili272 – 31948Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil, Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG314774.
    HOGENOMiHOG000230860.
    HOVERGENiHBG050747.
    InParanoidiP78410.
    KOiK06712.
    OMAiKESTIHI.
    PhylomeDBiP78410.
    TreeFamiTF331083.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P78410-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKMASSLAFL LLNFHVSLLL VQLLTPCSAQ FSVLGPSGPI LAMVGEDADL    50
    PCHLFPTMSA ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL 100
    RDGITAGKAA LRIHNVTASD SGKYLCYFQD GDFYEKALVE LKVAALGSNL 150
    HVEVKGYEDG GIHLECRSTG WYPQPQIQWS NAKGENIPAV EAPVVADGVG 200
    LYEVAASVIM RGGSGEGVSC IIRNSLLGLE KTASISIADP FFRSAQPWIA 250
    ALAGTLPILL LLLAGASYFL WRQQKEITAL SSEIESEQEM KEMGYAATER 300
    EISLRESLQE ELKRKKIQYL TRGEESSSDT NKSA 334
    Length:334
    Mass (Da):36,428
    Last modified:February 1, 2005 - v2
    Checksum:i940519D57F95EEE4
    GO
    Isoform 2 (identifier: P78410-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-28: MKMASSLAFLLLNFHVSLLLVQLLTPCS → MGIPR

    Note: No experimental confirmation available.

    Show »
    Length:311
    Mass (Da):33,910
    Checksum:iBCF5177F02F440F4
    GO
    Isoform 3 (identifier: P78410-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-42: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:292
    Mass (Da):32,016
    Checksum:i85C66916BF5A9195
    GO

    Sequence cautioni

    The sequence AAB53424.1 differs from that shown. Reason: Frameshift at position 317.
    The sequence AAC02652.1 differs from that shown. Reason: Frameshift at position 334.
    The sequence AAC02655.1 differs from that shown. Reason: Frameshift at position 334.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti63 – 631M → L in BAG64615. (PubMed:14702039)Curated
    Sequence conflicti180 – 1801S → G in AAF76140. (PubMed:11170752)Curated
    Sequence conflicti211 – 2122RG → KS in AAF76140. (PubMed:11170752)Curated
    Sequence conflicti327 – 3271S → L in AAC02655. (PubMed:9382921)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti167 – 1671R → T.
    Corresponds to variant rs9379861 [ dbSNP | Ensembl ].
    VAR_049833
    Natural varianti181 – 1811N → D.1 Publication
    Corresponds to variant rs9358936 [ dbSNP | Ensembl ].
    VAR_026211
    Natural varianti182 – 1821A → T.1 Publication
    Corresponds to variant rs12205731 [ dbSNP | Ensembl ].
    VAR_049834
    Natural varianti211 – 2111R → K.
    Corresponds to variant rs35183513 [ dbSNP | Ensembl ].
    VAR_049835
    Natural varianti307 – 3071S → N.1 Publication
    Corresponds to variant rs13216828 [ dbSNP | Ensembl ].
    VAR_049836

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4242Missing in isoform 3. CuratedVSP_045906Add
    BLAST
    Alternative sequencei1 – 2828MKMAS…LTPCS → MGIPR in isoform 2. 1 PublicationVSP_045907Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90546 mRNA. Translation: AAB53424.1. Frameshift.
    U90144 mRNA. Translation: AAC02652.1. Frameshift.
    U97499, U97498 Genomic DNA. Translation: AAC02655.1. Frameshift.
    AF257505 mRNA. Translation: AAF76140.1.
    AK299417 mRNA. Translation: BAG61399.1.
    AK303600 mRNA. Translation: BAG64615.1.
    AL021917 Genomic DNA. Translation: CAA17277.2.
    BC002832 mRNA. Translation: AAH02832.3.
    BC020214 mRNA. Translation: AAH20214.3.
    CCDSiCCDS4605.1. [P78410-1]
    CCDS56399.1. [P78410-2]
    CCDS56400.1. [P78410-3]
    RefSeqiNP_001184175.1. NM_001197246.2. [P78410-1]
    NP_001184176.1. NM_001197247.2. [P78410-1]
    NP_001184177.1. NM_001197248.2. [P78410-2]
    NP_001184178.1. NM_001197249.2. [P78410-3]
    NP_008978.2. NM_007047.4. [P78410-1]
    XP_005248884.1. XM_005248827.1. [P78410-1]
    UniGeneiHs.376046.

    Genome annotation databases

    EnsembliENST00000356386; ENSP00000348751; ENSG00000186470. [P78410-1]
    ENST00000377708; ENSP00000366937; ENSG00000186470. [P78410-1]
    ENST00000396934; ENSP00000380140; ENSG00000186470. [P78410-2]
    ENST00000396948; ENSP00000380152; ENSG00000186470. [P78410-1]
    ENST00000508906; ENSP00000442687; ENSG00000186470. [P78410-3]
    ENST00000527422; ENSP00000432138; ENSG00000186470. [P78410-1]
    GeneIDi11118.
    KEGGihsa:11118.
    UCSCiuc003nhp.3. human. [P78410-1]

    Polymorphism databases

    DMDMi67462189.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90546 mRNA. Translation: AAB53424.1 . Frameshift.
    U90144 mRNA. Translation: AAC02652.1 . Frameshift.
    U97499 , U97498 Genomic DNA. Translation: AAC02655.1 . Frameshift.
    AF257505 mRNA. Translation: AAF76140.1 .
    AK299417 mRNA. Translation: BAG61399.1 .
    AK303600 mRNA. Translation: BAG64615.1 .
    AL021917 Genomic DNA. Translation: CAA17277.2 .
    BC002832 mRNA. Translation: AAH02832.3 .
    BC020214 mRNA. Translation: AAH20214.3 .
    CCDSi CCDS4605.1. [P78410-1 ]
    CCDS56399.1. [P78410-2 ]
    CCDS56400.1. [P78410-3 ]
    RefSeqi NP_001184175.1. NM_001197246.2. [P78410-1 ]
    NP_001184176.1. NM_001197247.2. [P78410-1 ]
    NP_001184177.1. NM_001197248.2. [P78410-2 ]
    NP_001184178.1. NM_001197249.2. [P78410-3 ]
    NP_008978.2. NM_007047.4. [P78410-1 ]
    XP_005248884.1. XM_005248827.1. [P78410-1 ]
    UniGenei Hs.376046.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4F8Q X-ray 2.38 A 30-239 [» ]
    ProteinModelPortali P78410.
    SMRi P78410. Positions 30-239.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116293. 1 interaction.
    STRINGi 9606.ENSP00000348751.

    PTM databases

    PhosphoSitei P78410.

    Polymorphism databases

    DMDMi 67462189.

    Proteomic databases

    MaxQBi P78410.
    PaxDbi P78410.
    PRIDEi P78410.

    Protocols and materials databases

    DNASUi 11118.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356386 ; ENSP00000348751 ; ENSG00000186470 . [P78410-1 ]
    ENST00000377708 ; ENSP00000366937 ; ENSG00000186470 . [P78410-1 ]
    ENST00000396934 ; ENSP00000380140 ; ENSG00000186470 . [P78410-2 ]
    ENST00000396948 ; ENSP00000380152 ; ENSG00000186470 . [P78410-1 ]
    ENST00000508906 ; ENSP00000442687 ; ENSG00000186470 . [P78410-3 ]
    ENST00000527422 ; ENSP00000432138 ; ENSG00000186470 . [P78410-1 ]
    GeneIDi 11118.
    KEGGi hsa:11118.
    UCSCi uc003nhp.3. human. [P78410-1 ]

    Organism-specific databases

    CTDi 11118.
    GeneCardsi GC06P026365.
    HGNCi HGNC:1139. BTN3A2.
    HPAi CAB019392.
    MIMi 613594. gene.
    neXtProti NX_P78410.
    PharmGKBi PA25460.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314774.
    HOGENOMi HOG000230860.
    HOVERGENi HBG050747.
    InParanoidi P78410.
    KOi K06712.
    OMAi KESTIHI.
    PhylomeDBi P78410.
    TreeFami TF331083.

    Miscellaneous databases

    ChiTaRSi BTN3A2. human.
    GenomeRNAii 11118.
    NextBioi 42256.
    PMAP-CutDB P78410.
    PROi P78410.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P78410.
    Bgeei P78410.
    CleanExi HS_BTF3.
    HS_BTN3A2.
    Genevestigatori P78410.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex."
      Tazi-Ahnini R., Henry J., Offer C., Bouissou-Bouchouata C., Mather I.H., Pontarotti P.
      Immunogenetics 47:55-63(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    3. "The cluster of BTN genes in the extended major histocompatibility complex."
      Rhodes D.A., Stammers M., Malcherek G., Beck S., Trowsdale J.
      Genomics 71:351-362(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ASP-181; THR-182 AND ASN-307.
      Tissue: Thymus and Tongue.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta and Skin.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282 AND SER-286, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Stimulation of human butyrophilin 3 molecules results in negative regulation of cellular immunity."
      Yamashiro H., Yoshizaki S., Tadaki T., Egawa K., Seo N.
      J. Leukoc. Biol. 88:757-767(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION.
    9. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    10. "Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset."
      Harly C., Guillaume Y., Nedellec S., Peigne C.M., Monkkonen H., Monkkonen J., Li J., Kuball J., Adams E.J., Netzer S., Dechanet-Merville J., Leger A., Herrmann T., Breathnach R., Olive D., Bonneville M., Scotet E.
      Blood 120:2269-2279(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    11. "The molecular basis for modulation of human Vgamma9Vdelta2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies."
      Palakodeti A., Sandstrom A., Sundaresan L., Harly C., Nedellec S., Olive D., Scotet E., Bonneville M., Adams E.J.
      J. Biol. Chem. 287:32780-32790(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.38 ANGSTROMS) OF 30-239, SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiBT3A2_HUMAN
    AccessioniPrimary (citable) accession number: P78410
    Secondary accession number(s): B4DRT7
    , B4E103, F5H791, F8W6E0, O00477, O15338, O75658, Q76PA0, Q9BU81, Q9NR44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3