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P78410

- BT3A2_HUMAN

UniProt

P78410 - BT3A2_HUMAN

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Protein

Butyrophilin subfamily 3 member A2

Gene

BTN3A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.2 Publications

GO - Biological processi

  1. interferon-gamma secretion Source: UniProtKB
  2. T cell mediated immunity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrophilin subfamily 3 member A2
Gene namesi
Name:BTN3A2
Synonyms:BT3.2, BTF3, BTF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:1139. BTN3A2.

Subcellular locationi

Cell membrane 2 Publications; Single-pass type I membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 248219ExtracellularSequence AnalysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence AnalysisAdd
BLAST
Topological domaini270 – 33465CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: UniProtKB
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 334305Butyrophilin subfamily 3 member A2PRO_0000014533Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 ↔ 1261 PublicationPROSITE-ProRule annotation
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi166 ↔ 2201 PublicationPROSITE-ProRule annotation
Modified residuei282 – 2821Phosphoserine1 Publication
Modified residuei286 – 2861Phosphoserine1 Publication

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP78410.
PaxDbiP78410.
PRIDEiP78410.

PTM databases

PhosphoSiteiP78410.

Miscellaneous databases

PMAP-CutDBP78410.

Expressioni

Tissue specificityi

Detected in T-cells and natural killer cells.1 Publication

Gene expression databases

BgeeiP78410.
CleanExiHS_BTF3.
HS_BTN3A2.
ExpressionAtlasiP78410. baseline and differential.
GenevestigatoriP78410.

Organism-specific databases

HPAiCAB019392.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi116293. 5 interactions.
STRINGi9606.ENSP00000348751.

Structurei

Secondary structure

1
334
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi32 – 343Combined sources
Beta strandi40 – 434Combined sources
Beta strandi48 – 569Combined sources
Beta strandi63 – 697Combined sources
Turni70 – 734Combined sources
Beta strandi74 – 807Combined sources
Helixi86 – 883Combined sources
Helixi91 – 933Combined sources
Turni94 – 963Combined sources
Beta strandi97 – 1004Combined sources
Helixi104 – 1063Combined sources
Beta strandi108 – 1158Combined sources
Helixi118 – 1203Combined sources
Beta strandi122 – 1309Combined sources
Beta strandi133 – 14513Combined sources
Beta strandi151 – 1588Combined sources
Beta strandi161 – 17313Combined sources
Beta strandi176 – 1805Combined sources
Beta strandi202 – 2109Combined sources
Beta strandi217 – 2248Combined sources
Turni225 – 2284Combined sources
Beta strandi229 – 2368Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4F8QX-ray2.38A30-239[»]
ProteinModelPortaliP78410.
SMRiP78410. Positions 30-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 139110Ig-like V-typeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili272 – 31948Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG314774.
GeneTreeiENSGT00760000118933.
HOGENOMiHOG000230860.
HOVERGENiHBG050747.
InParanoidiP78410.
KOiK06712.
OMAiKESTIHI.
PhylomeDBiP78410.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P78410-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMASSLAFL LLNFHVSLLL VQLLTPCSAQ FSVLGPSGPI LAMVGEDADL
60 70 80 90 100
PCHLFPTMSA ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL
110 120 130 140 150
RDGITAGKAA LRIHNVTASD SGKYLCYFQD GDFYEKALVE LKVAALGSNL
160 170 180 190 200
HVEVKGYEDG GIHLECRSTG WYPQPQIQWS NAKGENIPAV EAPVVADGVG
210 220 230 240 250
LYEVAASVIM RGGSGEGVSC IIRNSLLGLE KTASISIADP FFRSAQPWIA
260 270 280 290 300
ALAGTLPILL LLLAGASYFL WRQQKEITAL SSEIESEQEM KEMGYAATER
310 320 330
EISLRESLQE ELKRKKIQYL TRGEESSSDT NKSA
Length:334
Mass (Da):36,428
Last modified:February 1, 2005 - v2
Checksum:i940519D57F95EEE4
GO
Isoform 2 (identifier: P78410-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MKMASSLAFLLLNFHVSLLLVQLLTPCS → MGIPR

Note: No experimental confirmation available.

Show »
Length:311
Mass (Da):33,910
Checksum:iBCF5177F02F440F4
GO
Isoform 3 (identifier: P78410-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.

Show »
Length:292
Mass (Da):32,016
Checksum:i85C66916BF5A9195
GO

Sequence cautioni

The sequence AAB53424.1 differs from that shown. Reason: Frameshift at position 317. Curated
The sequence AAC02652.1 differs from that shown. Reason: Frameshift at position 334. Curated
The sequence AAC02655.1 differs from that shown. Reason: Frameshift at position 334. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631M → L in BAG64615. (PubMed:14702039)Curated
Sequence conflicti180 – 1801S → G in AAF76140. (PubMed:11170752)Curated
Sequence conflicti211 – 2122RG → KS in AAF76140. (PubMed:11170752)Curated
Sequence conflicti327 – 3271S → L in AAC02655. (PubMed:9382921)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti167 – 1671R → T.
Corresponds to variant rs9379861 [ dbSNP | Ensembl ].
VAR_049833
Natural varianti181 – 1811N → D.1 Publication
Corresponds to variant rs9358936 [ dbSNP | Ensembl ].
VAR_026211
Natural varianti182 – 1821A → T.1 Publication
Corresponds to variant rs12205731 [ dbSNP | Ensembl ].
VAR_049834
Natural varianti211 – 2111R → K.
Corresponds to variant rs35183513 [ dbSNP | Ensembl ].
VAR_049835
Natural varianti307 – 3071S → N.1 Publication
Corresponds to variant rs13216828 [ dbSNP | Ensembl ].
VAR_049836

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4242Missing in isoform 3. CuratedVSP_045906Add
BLAST
Alternative sequencei1 – 2828MKMAS…LTPCS → MGIPR in isoform 2. 1 PublicationVSP_045907Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90546 mRNA. Translation: AAB53424.1. Frameshift.
U90144 mRNA. Translation: AAC02652.1. Frameshift.
U97499, U97498 Genomic DNA. Translation: AAC02655.1. Frameshift.
AF257505 mRNA. Translation: AAF76140.1.
AK299417 mRNA. Translation: BAG61399.1.
AK303600 mRNA. Translation: BAG64615.1.
AL021917 Genomic DNA. Translation: CAA17277.2.
BC002832 mRNA. Translation: AAH02832.3.
BC020214 mRNA. Translation: AAH20214.3.
CCDSiCCDS4605.1. [P78410-1]
CCDS56399.1. [P78410-2]
CCDS56400.1. [P78410-3]
RefSeqiNP_001184175.1. NM_001197246.2. [P78410-1]
NP_001184176.1. NM_001197247.2. [P78410-1]
NP_001184177.1. NM_001197248.2. [P78410-2]
NP_001184178.1. NM_001197249.2. [P78410-3]
NP_008978.2. NM_007047.4. [P78410-1]
XP_005248884.1. XM_005248827.1. [P78410-1]
UniGeneiHs.376046.

Genome annotation databases

EnsembliENST00000356386; ENSP00000348751; ENSG00000186470. [P78410-1]
ENST00000377708; ENSP00000366937; ENSG00000186470. [P78410-1]
ENST00000396934; ENSP00000380140; ENSG00000186470. [P78410-2]
ENST00000396948; ENSP00000380152; ENSG00000186470. [P78410-1]
ENST00000508906; ENSP00000442687; ENSG00000186470. [P78410-3]
ENST00000527422; ENSP00000432138; ENSG00000186470. [P78410-1]
GeneIDi11118.
KEGGihsa:11118.
UCSCiuc003nhp.3. human. [P78410-1]

Polymorphism databases

DMDMi67462189.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90546 mRNA. Translation: AAB53424.1 . Frameshift.
U90144 mRNA. Translation: AAC02652.1 . Frameshift.
U97499 , U97498 Genomic DNA. Translation: AAC02655.1 . Frameshift.
AF257505 mRNA. Translation: AAF76140.1 .
AK299417 mRNA. Translation: BAG61399.1 .
AK303600 mRNA. Translation: BAG64615.1 .
AL021917 Genomic DNA. Translation: CAA17277.2 .
BC002832 mRNA. Translation: AAH02832.3 .
BC020214 mRNA. Translation: AAH20214.3 .
CCDSi CCDS4605.1. [P78410-1 ]
CCDS56399.1. [P78410-2 ]
CCDS56400.1. [P78410-3 ]
RefSeqi NP_001184175.1. NM_001197246.2. [P78410-1 ]
NP_001184176.1. NM_001197247.2. [P78410-1 ]
NP_001184177.1. NM_001197248.2. [P78410-2 ]
NP_001184178.1. NM_001197249.2. [P78410-3 ]
NP_008978.2. NM_007047.4. [P78410-1 ]
XP_005248884.1. XM_005248827.1. [P78410-1 ]
UniGenei Hs.376046.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4F8Q X-ray 2.38 A 30-239 [» ]
ProteinModelPortali P78410.
SMRi P78410. Positions 30-239.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116293. 5 interactions.
STRINGi 9606.ENSP00000348751.

PTM databases

PhosphoSitei P78410.

Polymorphism databases

DMDMi 67462189.

Proteomic databases

MaxQBi P78410.
PaxDbi P78410.
PRIDEi P78410.

Protocols and materials databases

DNASUi 11118.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356386 ; ENSP00000348751 ; ENSG00000186470 . [P78410-1 ]
ENST00000377708 ; ENSP00000366937 ; ENSG00000186470 . [P78410-1 ]
ENST00000396934 ; ENSP00000380140 ; ENSG00000186470 . [P78410-2 ]
ENST00000396948 ; ENSP00000380152 ; ENSG00000186470 . [P78410-1 ]
ENST00000508906 ; ENSP00000442687 ; ENSG00000186470 . [P78410-3 ]
ENST00000527422 ; ENSP00000432138 ; ENSG00000186470 . [P78410-1 ]
GeneIDi 11118.
KEGGi hsa:11118.
UCSCi uc003nhp.3. human. [P78410-1 ]

Organism-specific databases

CTDi 11118.
GeneCardsi GC06P026365.
HGNCi HGNC:1139. BTN3A2.
HPAi CAB019392.
MIMi 613594. gene.
neXtProti NX_P78410.
PharmGKBi PA25460.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314774.
GeneTreei ENSGT00760000118933.
HOGENOMi HOG000230860.
HOVERGENi HBG050747.
InParanoidi P78410.
KOi K06712.
OMAi KESTIHI.
PhylomeDBi P78410.
TreeFami TF331083.

Miscellaneous databases

ChiTaRSi BTN3A2. human.
GenomeRNAii 11118.
NextBioi 42256.
PMAP-CutDB P78410.
PROi P78410.
SOURCEi Search...

Gene expression databases

Bgeei P78410.
CleanExi HS_BTF3.
HS_BTN3A2.
ExpressionAtlasi P78410. baseline and differential.
Genevestigatori P78410.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex."
    Tazi-Ahnini R., Henry J., Offer C., Bouissou-Bouchouata C., Mather I.H., Pontarotti P.
    Immunogenetics 47:55-63(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  3. "The cluster of BTN genes in the extended major histocompatibility complex."
    Rhodes D.A., Stammers M., Malcherek G., Beck S., Trowsdale J.
    Genomics 71:351-362(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ASP-181; THR-182 AND ASN-307.
    Tissue: Thymus and Tongue.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta and Skin.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282 AND SER-286, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Stimulation of human butyrophilin 3 molecules results in negative regulation of cellular immunity."
    Yamashiro H., Yoshizaki S., Tadaki T., Egawa K., Seo N.
    J. Leukoc. Biol. 88:757-767(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION.
  9. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  10. "Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset."
    Harly C., Guillaume Y., Nedellec S., Peigne C.M., Monkkonen H., Monkkonen J., Li J., Kuball J., Adams E.J., Netzer S., Dechanet-Merville J., Leger A., Herrmann T., Breathnach R., Olive D., Bonneville M., Scotet E.
    Blood 120:2269-2279(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. "The molecular basis for modulation of human Vgamma9Vdelta2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies."
    Palakodeti A., Sandstrom A., Sundaresan L., Harly C., Nedellec S., Olive D., Scotet E., Bonneville M., Adams E.J.
    J. Biol. Chem. 287:32780-32790(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.38 ANGSTROMS) OF 30-239, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiBT3A2_HUMAN
AccessioniPrimary (citable) accession number: P78410
Secondary accession number(s): B4DRT7
, B4E103, F5H791, F8W6E0, O00477, O15338, O75658, Q76PA0, Q9BU81, Q9NR44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 26, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3