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Reviewed, UniProtKB/Swiss-Prot P78406 (RAE1L_HUMAN)

Last modified January 19, 2010. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    mRNA export factor
Alternative name(s):
    mRNA-associated protein mrnp 41
    Rae1 protein homolog
Gene names
Name: RAE1
Synonyms: MRNP41
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.

Subunit structure

Interacts with NUP98 By similarity.

Subcellular location

Cytoplasm. Nucleus Ref.2.

Sequence similarities

Belongs to the WD repeat rae1 family.

Contains 4 WD repeats.

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Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   DomainRepeat
WD repeat
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmRNA export from nucleus

Traceable author statement. Source: ProtInc

   Cellular componentcytoplasm

Traceable author statement. Source: ProtInc

cytoskeleton Ref.2

Traceable author statement. Source: ProtInc

nuclear outer membrane Ref.2

Traceable author statement. Source: ProtInc

nuclear pore Ref.2

Traceable author statement. Source: ProtInc

   Molecular functionRNA binding Ref.2

Traceable author statement. Source: ProtInc

microtubule binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368mRNA export factor
PRO_0000051181

Regions

Repeat84 – 11431WD 1
Repeat125 – 15733WD 2
Repeat168 – 19629WD 3
Repeat271 – 30131WD 4

Experimental info

Sequence conflict101F → L in AAC28127. Ref.2
Sequence conflict311D → G in AAC28127. Ref.2
Sequence conflict561F → S in AAC28127. Ref.2
Sequence conflict1201A → V in AAR04856. Ref.3
Sequence conflict1581T → N in AAC28127. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P78406-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 89A99C34BA668A97

FASTA36840,968
        10         20         30         40         50         60 
MSLFGTTSGF GTSGTSMFGS ATTDNHNPMK DIEVTSSPDD SIGCLSFSPP TLPGNFLIAG 

        70         80         90        100        110        120 
SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK VFTASCDKTA KMWDLSSNQA 

       130        140        150        160        170        180 
IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD KTLKFWDTRS SNPMMVLQLP ERCYCADVIY 

       190        200        210        220        230        240 
PMAVVATAER GLIVYQLENQ PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV 

       250        260        270        280        290        300 
AIHYINPPNP AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW 

       310        320        330        340        350        360 
DKDARTKLKT SEQLDQPISA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK NYIFLRNAAE 


ELKPRNKK

« Hide

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References

« Hide 'large scale' references
[1]"The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of poly(A)+ RNA."
Bharathi A., Ghosh A., Whalen W.A., Yoon J.H., Pu R., Dasso M., Dhar R.
Gene 198:251-258(1997) [PubMed: 9370289] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Mammary carcinoma.
[2]"mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm."
Kraemer D.M., Blobel G.
Proc. Natl. Acad. Sci. U.S.A. 94:9119-9124(1997) [PubMed: 9256445] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
[3]Lu L., Huang X.Y., Xu M., Yin L.L., Li J.M., Zhou Z.M., Sha J.H.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[4]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[6]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U84720 mRNA. Translation: AAC28126.1.
U85943 mRNA. Translation: AAC28127.1.
AY349350 mRNA. Translation: AAR04856.1.
AL135939 Genomic DNA. Translation: CAI21524.1.
BC103754 mRNA. Translation: AAI03755.1.
BC106924 mRNA. Translation: AAI06925.1.
BC106923 mRNA. Translation: AAI06924.1.
IPIIPI00019733.
RefSeqNP_001015885.1.
NP_003601.1.
UniGeneHs.371698

3D structure databases

SMRP78406. Positions 29-357.
ModBaseSearch...

Protein-protein interaction databases

IntActP78406. 1 interaction.
STRINGP78406.

PTM databases

PhosphoSiteP78406.

Proteomic databases

PRIDEP78406.

Genome annotation databases

EnsemblENST00000371242; ENSP00000360286; ENSG00000101146; Homo sapiens. [Genome view]
ENST00000395840; ENSP00000379181; ENSG00000101146; Homo sapiens. [Genome view]
ENST00000395841; ENSP00000379182; ENSG00000101146; Homo sapiens. [Genome view]
GeneID8480.
KEGGhsa:8480.
UCSCuc002xyg.1. human.

Organism-specific databases

CTD8480.
GeneCardsGC20P055359.
H-InvDBHIX0015938.
HGNCHGNC:9828. RAE1.
HPAHPA018242.
MIM603343. gene.
PharmGKBPA34182.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG09392.
HOVERGENP78406.
InParanoidP78406.
OMAWEVQDNG.
PhylomeDBP78406.

Enzyme and pathway databases

ReactomeREACT_6185. HIV Infection.

Gene expression databases

ArrayExpressP78406.
BgeeP78406.
CleanExHS_RAE1.
GenevestigatorP78406.
GermOnlineENSG00000101146. Homo sapiens.

Family and domain databases

InterProIPR020472. G-protein_beta_WD-40_rep_reg.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR019782. WD40_repeat_2.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR019781. WD40_repeat_sg.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PfamPF00400. WD40. 4 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00320. WD40. 4 hits.
[Graphical view]
PROSITEPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio31729.
SOURCESearch...

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Entry information

Entry nameRAE1L_HUMAN
AccessionPrimary (citable) accession number: P78406
Secondary accession number(s): O15306 expand/collapse secondary AC list , Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: January 19, 2010
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents