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Protein

mRNA export factor

Gene

RAE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • RNA binding Source: GO_Central
  • ubiquitin binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101146-MONOMER.
ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-159227. Transport of the SLBP independent Mature mRNA.
R-HSA-159230. Transport of the SLBP Dependant Mature mRNA.
R-HSA-159231. Transport of Mature mRNA Derived from an Intronless Transcript.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-165054. Rev-mediated nuclear export of HIV RNA.
R-HSA-168271. Transport of Ribonucleoproteins into the Host Nucleus.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
R-HSA-168325. Viral Messenger RNA Synthesis.
R-HSA-168333. NEP/NS2 Interacts with the Cellular Export Machinery.
R-HSA-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-HSA-180746. Nuclear import of Rev protein.
R-HSA-180910. Vpr-mediated nuclear import of PICs.
R-HSA-191859. snRNP Assembly.
R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.
R-HSA-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-HSA-3371453. Regulation of HSF1-mediated heat shock response.
R-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-4615885. SUMOylation of DNA replication proteins.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-6784531. tRNA processing in the nucleus.
SignaLinkiP78406.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor
Alternative name(s):
Rae1 protein homolog
mRNA-associated protein mrnp 41
Gene namesi
Name:RAE1
Synonyms:MRNP41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:9828. RAE1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • nuclear envelope Source: GO_Central
  • nuclear pore Source: GO_Central
  • nucleolus Source: HPA
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8480.
OpenTargetsiENSG00000101146.
PharmGKBiPA34182.

Polymorphism and mutation databases

BioMutaiRAE1.
DMDMi3122666.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511811 – 368mRNA export factorAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP78406.
MaxQBiP78406.
PaxDbiP78406.
PeptideAtlasiP78406.
PRIDEiP78406.
TopDownProteomicsiP78406.

PTM databases

iPTMnetiP78406.
PhosphoSitePlusiP78406.
SwissPalmiP78406.

Expressioni

Gene expression databases

BgeeiENSG00000101146.
CleanExiHS_RAE1.
ExpressionAtlasiP78406. baseline and differential.
GenevisibleiP78406. HS.

Organism-specific databases

HPAiHPA018242.
HPA048795.

Interactioni

Subunit structurei

Interacts with NUP98 (PubMed:20498086). Interacts with MYCBP2 (PubMed:22357847).2 Publications

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • ubiquitin binding Source: GO_Central

Protein-protein interaction databases

BioGridi114054. 133 interactors.
DIPiDIP-41063N.
IntActiP78406. 38 interactors.
MINTiMINT-121447.
STRINGi9606.ENSP00000360286.

Structurei

Secondary structure

1368
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 47Combined sources6
Beta strandi52 – 61Combined sources10
Beta strandi64 – 71Combined sources8
Beta strandi77 – 84Combined sources8
Beta strandi89 – 94Combined sources6
Beta strandi98 – 105Combined sources8
Beta strandi108 – 114Combined sources7
Turni115 – 118Combined sources4
Beta strandi119 – 125Combined sources7
Beta strandi130 – 137Combined sources8
Beta strandi142 – 148Combined sources7
Beta strandi151 – 156Combined sources6
Beta strandi164 – 168Combined sources5
Beta strandi173 – 179Combined sources7
Beta strandi182 – 187Combined sources6
Helixi188 – 190Combined sources3
Beta strandi192 – 196Combined sources5
Beta strandi198 – 200Combined sources3
Beta strandi202 – 206Combined sources5
Beta strandi215 – 222Combined sources8
Beta strandi228 – 235Combined sources8
Beta strandi238 – 246Combined sources9
Helixi250 – 253Combined sources4
Beta strandi254 – 258Combined sources5
Beta strandi260 – 262Combined sources3
Beta strandi264 – 266Combined sources3
Beta strandi271 – 273Combined sources3
Beta strandi276 – 281Combined sources6
Turni283 – 285Combined sources3
Beta strandi288 – 292Combined sources5
Beta strandi297 – 301Combined sources5
Turni302 – 305Combined sources4
Beta strandi306 – 310Combined sources5
Beta strandi318 – 323Combined sources6
Beta strandi330 – 334Combined sources5
Helixi342 – 344Combined sources3
Beta strandi352 – 356Combined sources5
Turni359 – 362Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MMYX-ray1.65A/C/E/G1-368[»]
4OWRX-ray3.15A31-368[»]
ProteinModelPortaliP78406.
SMRiP78406.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78406.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 79WD 1PROSITE-ProRule annotation1 PublicationAdd BLAST43
Repeati84 – 114WD 2PROSITE-ProRule annotation1 PublicationAdd BLAST31
Repeati125 – 157WD 3PROSITE-ProRule annotation1 PublicationAdd BLAST33
Repeati168 – 206WD 4PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati215 – 255WD 5PROSITE-ProRule annotation1 PublicationAdd BLAST41
Repeati271 – 301WD 6PROSITE-ProRule annotation1 PublicationAdd BLAST31
Repeati310 – 346WD 7PROSITE-ProRule annotation1 PublicationAdd BLAST37

Sequence similaritiesi

Belongs to the WD repeat rae1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0647. Eukaryota.
ENOG410XQ1M. LUCA.
GeneTreeiENSGT00530000063440.
HOVERGENiHBG002942.
InParanoidiP78406.
KOiK14298.
PhylomeDBiP78406.
TreeFamiTF105481.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFGTTSGF GTSGTSMFGS ATTDNHNPMK DIEVTSSPDD SIGCLSFSPP
60 70 80 90 100
TLPGNFLIAG SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK
110 120 130 140 150
VFTASCDKTA KMWDLSSNQA IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD
160 170 180 190 200
KTLKFWDTRS SNPMMVLQLP ERCYCADVIY PMAVVATAER GLIVYQLENQ
210 220 230 240 250
PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV AIHYINPPNP
260 270 280 290 300
AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW
310 320 330 340 350
DKDARTKLKT SEQLDQPISA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK
360
NYIFLRNAAE ELKPRNKK
Length:368
Mass (Da):40,968
Last modified:May 1, 1997 - v1
Checksum:i89A99C34BA668A97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10F → L in AAC28127 (PubMed:9256445).Curated1
Sequence conflicti31D → G in AAC28127 (PubMed:9256445).Curated1
Sequence conflicti56F → S in AAC28127 (PubMed:9256445).Curated1
Sequence conflicti120A → V in AAR04856 (Ref. 3) Curated1
Sequence conflicti158T → N in AAC28127 (PubMed:9256445).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84720 mRNA. Translation: AAC28126.1.
U85943 mRNA. Translation: AAC28127.1.
AY349350 mRNA. Translation: AAR04856.1.
AK292247 mRNA. Translation: BAF84936.1.
AL135939 Genomic DNA. Translation: CAI21524.1.
AL109955, AL135939 Genomic DNA. Translation: CAX15041.1.
CH471077 Genomic DNA. Translation: EAW75523.1.
CH471077 Genomic DNA. Translation: EAW75524.1.
CH471077 Genomic DNA. Translation: EAW75525.1.
BC103754 mRNA. Translation: AAI03755.1.
BC106924 mRNA. Translation: AAI06925.1.
BC106923 mRNA. Translation: AAI06924.1.
CCDSiCCDS13458.1.
RefSeqiNP_001015885.1. NM_001015885.1.
NP_003601.1. NM_003610.3.
XP_005260639.2. XM_005260582.2.
XP_011527390.1. XM_011529088.2.
XP_011527391.1. XM_011529089.1.
UniGeneiHs.371698.

Genome annotation databases

EnsembliENST00000371242; ENSP00000360286; ENSG00000101146.
ENST00000395840; ENSP00000379181; ENSG00000101146.
ENST00000395841; ENSP00000379182; ENSG00000101146.
GeneIDi8480.
KEGGihsa:8480.
UCSCiuc002xyg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84720 mRNA. Translation: AAC28126.1.
U85943 mRNA. Translation: AAC28127.1.
AY349350 mRNA. Translation: AAR04856.1.
AK292247 mRNA. Translation: BAF84936.1.
AL135939 Genomic DNA. Translation: CAI21524.1.
AL109955, AL135939 Genomic DNA. Translation: CAX15041.1.
CH471077 Genomic DNA. Translation: EAW75523.1.
CH471077 Genomic DNA. Translation: EAW75524.1.
CH471077 Genomic DNA. Translation: EAW75525.1.
BC103754 mRNA. Translation: AAI03755.1.
BC106924 mRNA. Translation: AAI06925.1.
BC106923 mRNA. Translation: AAI06924.1.
CCDSiCCDS13458.1.
RefSeqiNP_001015885.1. NM_001015885.1.
NP_003601.1. NM_003610.3.
XP_005260639.2. XM_005260582.2.
XP_011527390.1. XM_011529088.2.
XP_011527391.1. XM_011529089.1.
UniGeneiHs.371698.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MMYX-ray1.65A/C/E/G1-368[»]
4OWRX-ray3.15A31-368[»]
ProteinModelPortaliP78406.
SMRiP78406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114054. 133 interactors.
DIPiDIP-41063N.
IntActiP78406. 38 interactors.
MINTiMINT-121447.
STRINGi9606.ENSP00000360286.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiP78406.
PhosphoSitePlusiP78406.
SwissPalmiP78406.

Polymorphism and mutation databases

BioMutaiRAE1.
DMDMi3122666.

Proteomic databases

EPDiP78406.
MaxQBiP78406.
PaxDbiP78406.
PeptideAtlasiP78406.
PRIDEiP78406.
TopDownProteomicsiP78406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371242; ENSP00000360286; ENSG00000101146.
ENST00000395840; ENSP00000379181; ENSG00000101146.
ENST00000395841; ENSP00000379182; ENSG00000101146.
GeneIDi8480.
KEGGihsa:8480.
UCSCiuc002xyg.4. human.

Organism-specific databases

CTDi8480.
DisGeNETi8480.
GeneCardsiRAE1.
HGNCiHGNC:9828. RAE1.
HPAiHPA018242.
HPA048795.
MIMi603343. gene.
neXtProtiNX_P78406.
OpenTargetsiENSG00000101146.
PharmGKBiPA34182.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0647. Eukaryota.
ENOG410XQ1M. LUCA.
GeneTreeiENSGT00530000063440.
HOVERGENiHBG002942.
InParanoidiP78406.
KOiK14298.
PhylomeDBiP78406.
TreeFamiTF105481.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101146-MONOMER.
ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-159227. Transport of the SLBP independent Mature mRNA.
R-HSA-159230. Transport of the SLBP Dependant Mature mRNA.
R-HSA-159231. Transport of Mature mRNA Derived from an Intronless Transcript.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-165054. Rev-mediated nuclear export of HIV RNA.
R-HSA-168271. Transport of Ribonucleoproteins into the Host Nucleus.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
R-HSA-168325. Viral Messenger RNA Synthesis.
R-HSA-168333. NEP/NS2 Interacts with the Cellular Export Machinery.
R-HSA-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-HSA-180746. Nuclear import of Rev protein.
R-HSA-180910. Vpr-mediated nuclear import of PICs.
R-HSA-191859. snRNP Assembly.
R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.
R-HSA-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-HSA-3371453. Regulation of HSF1-mediated heat shock response.
R-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-4615885. SUMOylation of DNA replication proteins.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-6784531. tRNA processing in the nucleus.
SignaLinkiP78406.

Miscellaneous databases

EvolutionaryTraceiP78406.
GeneWikiiRAE1.
GenomeRNAii8480.
PROiP78406.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101146.
CleanExiHS_RAE1.
ExpressionAtlasiP78406. baseline and differential.
GenevisibleiP78406. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAE1L_HUMAN
AccessioniPrimary (citable) accession number: P78406
Secondary accession number(s): A8K882
, O15306, Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 163 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.