true2000-05-302024-03-27203CCNA1_HUMANCharacterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines.Yang R.Morosetti R.Koeffler H.P.1997Cancer Res.57913-920NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)MyeloidCloning of human full-length CDSs in BD Creator(TM) system donor vector.Kalnine N.Chen X.Rolfs A.Halleck A.Hines L.Eisenstein S.Koundinya M.Raphael J.Moreira D.Kelley T.LaBaer J.Lin Y.Phelan M.Farmer A.2004-10EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T.Suzuki Y.Nishikawa T.Otsuki T.Sugiyama T.Irie R.Wakamatsu A.Hayashi K.Sato H.Nagai K.Kimura K.Makita H.Sekine M.Obayashi M.Nishi T.Shibahara T.Tanaka T.Ishii S.Yamamoto J.Saito K.Kawai Y.Isono Y.Nakamura Y.Nagahari K.Murakami K.Yasuda T.Iwayanagi T.Wagatsuma M.Shiratori A.Sudo H.Hosoiri T.Kaku Y.Kodaira H.Kondo H.Sugawara M.Takahashi M.Kanda K.Yokoi T.Furuya T.Kikkawa E.Omura Y.Abe K.Kamihara K.Katsuta N.Sato K.Tanikawa M.Yamazaki M.Ninomiya K.Ishibashi T.Yamashita H.Murakawa K.Fujimori K.Tanai H.Kimata M.Watanabe M.Hiraoka S.Chiba Y.Ishida S.Ono Y.Takiguchi S.Watanabe S.Yosida M.Hotuta T.Kusano J.Kanehori K.Takahashi-Fujii A.Hara H.Tanase T.-O.Nomura Y.Togiya S.Komai F.Hara R.Takeuchi K.Arita M.Imose N.Musashino K.Yuuki H.Oshima A.Sasaki N.Aotsuka S.Yoshikawa Y.Matsunawa H.Ichihara T.Shiohata N.Sano S.Moriya S.Momiyama H.Satoh N.Takami S.Terashima Y.Suzuki O.Nakagawa S.Senoh A.Mizoguchi H.Goto Y.Shimizu F.Wakebe H.Hishigaki H.Watanabe T.Sugiyama A.Takemoto M.Kawakami B.Yamazaki M.'Watanabe K.Kumagai A.Itakura S.Fukuzumi Y.Fujimori Y.Komiyama M.Tashiro H.Tanigami A.Fujiwara T.Ono T.Yamada K.Fujii Y.Ozaki K.Hirao M.Ohmori Y.Kawabata A.Hikiji T.Kobatake N.Inagaki H.Ikema Y.Okamoto S.Okitani R.Kawakami T.Noguchi S.Itoh T.Shigeta K.Senba T.Matsumura K.Nakajima Y.Mizuno T.Morinaga M.Sasaki M.Togashi T.Oyama M.Hata H.Watanabe M.'Komatsu T.Mizushima-Sugano J.Satoh T.Shirai Y.Takahashi Y.Nakagawa K.Okumura K.Nagase T.Nomura N.Kikuchi H.Masuho Y.Yamashita R.Nakai K.Yada T.Nakamura Y.'Ohara O.Isogai T.Sugano S.doi:10.1038/ng12852004Nat. Genet.3640-45NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)TestisThe DNA sequence and analysis of human chromosome 13.Dunham A.Matthews L.H.Burton J.Ashurst J.L.Howe K.L.Ashcroft K.J.Beare D.M.Burford D.C.Hunt S.E.Griffiths-Jones S.Jones M.C.Keenan S.J.Oliver K.Scott C.E.Ainscough R.Almeida J.P.Ambrose K.D.Andrews D.T.Ashwell R.I.S.Babbage A.K.Bagguley C.L.Bailey J.Bannerjee R.Barlow K.F.Bates K.Beasley H.Bird C.P.Bray-Allen S.Brown A.J.Brown J.Y.Burrill W.Carder C.Carter N.P.Chapman J.C.Clamp M.E.Clark S.Y.Clarke G.Clee C.M.Clegg S.C.Cobley V.Collins J.E.Corby N.Coville G.J.Deloukas P.Dhami P.Dunham I.Dunn M.Earthrowl M.E.Ellington A.G.Faulkner L.Frankish A.G.Frankland J.French L.Garner P.Garnett J.Gilbert J.G.R.Gilson C.J.Ghori J.Grafham D.V.Gribble S.M.Griffiths C.Hall R.E.Hammond S.Harley J.L.Hart E.A.Heath P.D.Howden P.J.Huckle E.J.Hunt P.J.Hunt A.R.Johnson C.Johnson D.Kay M.Kimberley A.M.King A.Laird G.K.Langford C.J.Lawlor S.Leongamornlert D.A.Lloyd D.M.Lloyd C.Loveland J.E.Lovell J.Martin S.Mashreghi-Mohammadi M.McLaren S.J.McMurray A.Milne S.Moore M.J.F.Nickerson T.Palmer S.A.Pearce A.V.Peck A.I.Pelan S.Phillimore B.Porter K.M.Rice C.M.Searle S.Sehra H.K.Shownkeen R.Skuce C.D.Smith M.Steward C.A.Sycamore N.Tester J.Thomas D.W.Tracey A.Tromans A.Tubby B.Wall M.Wallis J.M.West A.P.Whitehead S.L.Willey D.L.Wilming L.Wray P.W.Wright M.W.Young L.Coulson A.Durbin R.M.Hubbard T.Sulston J.E.Beck S.Bentley D.R.Rogers J.Ross M.T.doi:10.1038/nature023792004Nature428522-528NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Mural R.J.Istrail S.Sutton G.G.Florea L.Halpern A.L.Mobarry C.M.Lippert R.Walenz B.Shatkay H.Dew I.Miller J.R.Flanigan M.J.Edwards N.J.Bolanos R.Fasulo D.Halldorsson B.V.Hannenhalli S.Turner R.Yooseph S.Lu F.Nusskern D.R.Shue B.C.Zheng X.H.Zhong F.Delcher A.L.Huson D.H.Kravitz S.A.Mouchard L.Reinert K.Remington K.A.Clark A.G.Waterman M.S.Eichler E.E.Adams M.D.Hunkapiller M.W.Myers E.W.Venter J.C.2005-07EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project Teamdoi:10.1101/gr.25965042004Genome Res.142121-2127NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)BrainThe human testes cyclin A1 disrupts growth and DNA damage response of a yeast replication mutant.Perkins E.L.Wood V.J.Sterling J.F.Hashem V.I.Resnick M.A.1997-06EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [MRNA] OF 55-465Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins.Yang R.Mueller C.Huynh V.Fung Y.K.Yee A.S.Koeffler H.P.doi:10.1128/mcb.19.3.24001999Mol. Cell. Biol.192400-2407FUNCTIONIdentification of interaction partners and substrates of the cyclin A1-CDK2 complex.Diederichs S.Baeumer N.Ji P.Metzelder S.K.Idos G.E.Cauvet T.Wang W.Moeller M.Pierschalski S.Gromoll J.Schrader M.G.Koeffler H.P.Berdel W.E.Serve H.Mueller-Tidow C.doi:10.1074/jbc.m4017082002004J. Biol. Chem.27933727-33741INTERACTION WITH INCA1 AND KLHDC9Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.Baeumer N.Tickenbrock L.Tschanter P.Lohmeyer L.Diederichs S.Baeumer S.Skryabin B.V.Zhang F.Agrawal-Singh S.Koehler G.Berdel W.E.Serve H.Koschmieder S.Mueller-Tidow C.doi:10.1074/jbc.m110.2034712011J. Biol. Chem.28628210-28222INTERACTION WITH INCA1Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.Huang X.Summers M.K.Pham V.Lill J.R.Liu J.Lee G.Kirkpatrick D.S.Jackson P.K.Fang G.Dixit V.M.doi:10.1016/j.molcel.2011.03.0272011Mol. Cell42511-523UBIQUITINATIONDEUBIQUITINATION BY USP37Atlas of Genetics and Cytogenetics in Oncology and Haematology61Cyclin A1-CDK1 complexCyclin A1-CDK2 complex16607 antibodies from 37 providershumanCCNA1Tissue enhanced (parathyroid gland, testis)geneEukaryotaG0 and Early G1Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesTelomere Extension By TelomeraseCdc20:Phospho-APC/C mediated degradation of Cyclin ARegulation of APC/C activators between G1/S and early anaphaseSCF(Skp2)-mediated degradation of p27/p21Senescence-Associated Secretory Phenotype (SASP)DNA Damage/Telomere Stress Induced SenescenceUb-specific processing proteasesProcessing of DNA double-strand break endsTP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestRegulation of TP53 Activity through PhosphorylationRegulation of TP53 DegradationG2 PhaseOrc1 removal from chromatinCDK-mediated phosphorylation and removal of Cdc6G1/S-Specific TranscriptionCyclin A/B1/B2 associated events during G2/M transitionp53-Dependent G1 DNA Damage ResponseCyclin A:Cdk2-associated events at S phase entry11 hits in 1156 CRISPR screenshumanTbioProteinExpressed in sperm and 119 other cell types or tissuesbaseline and differentialCYCLIN_CCNA1_rpt1CYCLIN_CCNA1_rpt2Cyclin-likeCyclinCyclin-A_NCyclin-like_domCyclin-like_sfCyclin_C-domCyclin_NCyclins_cyclin-boxCYCLIN-A1CYCLINSCyclin_CCyclin_NCyclin_N2CYCLINCyclin_CCyclin-likeCYCLINSHSCyclin-A1CCNA1May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 (PubMed:15159402, PubMed:21540187). Interacts with KLHDC9 (PubMed:15159402).Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases.Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.Belongs to the cyclin family. Cyclin AB subfamily.Cyclin-A1523581465In isoform 3.44In isoform 2.38SS4347false8false6false3CDKN1ACDKN1BPRKN1997-05-011523583e18cfb6db1691bae0239060da11b8ef1METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQQPVESEAMHCSNPKSGVVLATVARGPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ2METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQPVESEAMHCSNPKSGVVLATVARGPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ3MHCSNPKSGVVLATVARGPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQtruetruetruetruetruetruetruetruetruetruetruetruetrue