CCNA1

Functionⁱ

May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.1 Publication

GO - Biological processⁱ

cell division Source: UniProtKB-KW
male meiosis I
Source: ProtInc
Traceable author statementⁱ
- 9843212
protein deubiquitination Source: Reactome
regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Reactome
spermatogenesis
Source: ProtInc
Traceable author statementⁱ
- 9843212

Complete GO annotation...

Keywordsⁱ

Molecular function	Cyclin
Biological process	Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1538133. G0 and Early G1. R-HSA-170145. Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes. R-HSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. R-HSA-176408. Regulation of APC/C activators between G1/S and early anaphase. R-HSA-187577. SCF(Skp2)-mediated degradation of p27/p21. R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP). R-HSA-2559586. DNA Damage/Telomere Stress Induced Senescence. R-HSA-539107. Activation of E2F1 target genes at G1/S. R-HSA-5689880. Ub-specific processing proteases. R-HSA-5693607. Processing of DNA double-strand break ends. R-HSA-6804116. TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest. R-HSA-6804756. Regulation of TP53 Activity through Phosphorylation. R-HSA-6804757. Regulation of TP53 Degradation. R-HSA-68911. G2 Phase. R-HSA-68949. Orc1 removal from chromatin. R-HSA-69273. Cyclin A/B1 associated events during G2/M transition. R-HSA-69563. p53-Dependent G1 DNA Damage Response. R-HSA-69656. Cyclin A:Cdk2-associated events at S phase entry.
SignaLinkⁱ	P78396.
SIGNORⁱ	P78396.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-A1
Gene namesⁱ	Name:CCNA1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1577. CCNA1.

HGNCⁱ

HGNC:1577. CCNA1.

Subcellular locationⁱ

Nucleus By similarity

GO - Cellular componentⁱ

cyclin A1-CDK2 complex Source: Ensembl
cytosol
Source: ProtInc
Traceable author statementⁱ
- 9041194
microtubule cytoskeleton Source: LIFEdb
nucleoplasm Source: Reactome

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8900.
Open Targets More...OpenTargetsⁱ	ENSG00000133101.
PharmGKBⁱ	PA26147.

Chemistry databases

ChEMBLⁱ	CHEMBL3038470.

ChEMBLⁱ

CHEMBL3038470.

Polymorphism and mutation databases

BioMutaⁱ	CCNA1.
DMDMⁱ	8134359.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080333	1 – 465	Cyclin-A1Add BLAST		465

Post-translational modificationⁱ

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.1 Publication

Keywords - PTMⁱ

Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P78396.
PaxDbⁱ	P78396.
PeptideAtlas More...PeptideAtlasⁱ	P78396.
PRIDEⁱ	P78396.

PTM databases

iPTMnetⁱ	P78396.
PhosphoSitePlusⁱ	P78396.

Expressionⁱ

Tissue specificityⁱ

Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.

Developmental stageⁱ

Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases.

Gene expression databases

Bgeeⁱ	ENSG00000133101.
CleanExⁱ	HS_CCNA1.
ExpressionAtlasⁱ	P78396. baseline and differential.
Genevisibleⁱ	P78396. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA060646.

HPAⁱ

HPA060646.

Interactionⁱ

Subunit structureⁱ

Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 and KLHDC9.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CDKN1A	P38936	3	EBI-375065,EBI-375077

With

Entry

#Exp.

IntAct

Notes

CDKN1A

P38936

3

EBI-375065,EBI-375077

Protein-protein interaction databases

BioGridⁱ	114417. 50 interactors.
IntActⁱ	P78396. 10 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-104479.
STRINGⁱ	9606.ENSP00000255465.

Chemistry databases

BindingDBⁱ

P78396.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P78396.
SMRⁱ	P78396.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	388 – 391	Poly-Ala		4

Sequence similaritiesⁱ

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0654. Eukaryota. COG5024. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118939.
HOGENOMⁱ	HOG000167672.
HOVERGENⁱ	HBG106244.
InParanoidⁱ	P78396.
KEGG Orthology (KO) More...KOⁱ	K06627.
OMAⁱ	AEIRHRP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G090I.
PhylomeDBⁱ	P78396.
TreeFamⁱ	TF101002.

Family and domain databases

Gene3Dⁱ	1.10.472.10. 2 hits.
InterProⁱ	View protein in InterPro IPR013763. Cyclin-like. IPR004367. Cyclin_C-dom. IPR006671. Cyclin_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02984. Cyclin_C. 1 hit. PF00134. Cyclin_N. 1 hit.
SMARTⁱ	View protein in SMART SM00385. CYCLIN. 2 hits. SM01332. Cyclin_C. 1 hit.
SUPFAMⁱ	SSF47954. SSF47954. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00292. CYCLINS. 1 hit.

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: P78396-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METGFPAIMY PGSFIGGWGE EYLSWEGPGL PDFVFQQQPV ESEAMHCSNP 
        60         70         80         90        100
KSGVVLATVA RGPDACQILT RAPLGQDPPQ RTVLGLLTAN GQYRRTCGQG 
       110        120        130        140        150
ITRIRCYSGS ENAFPPAGKK ALPDCGVQEP PKQGFDIYMD ELEQGDRDSC 
       160        170        180        190        200
SVREGMAFED VYEVDTGTLK SDLHFLLDFN TVSPMLVDSS LLSQSEDISS 
       210        220        230        240        250
LGTDVINVTE YAEEIYQYLR EAEIRHRPKA HYMKKQPDIT EGMRTILVDW 
       260        270        280        290        300
LVEVGEEYKL RAETLYLAVN FLDRFLSCMS VLRGKLQLVG TAAMLLASKY 
       310        320        330        340        350
EEIYPPEVDE FVYITDDTYT KRQLLKMEHL LLKVLAFDLT VPTTNQFLLQ 
       360        370        380        390        400
YLRRQGVCVR TENLAKYVAE LSLLEADPFL KYLPSLIAAA AFCLANYTVN 
       410        420        430        440        450
KHFWPETLAA FTGYSLSEIV PCLSELHKAY LDIPHRPQQA IREKYKASKY 
       460 
LCVSLMEPPA VLLLQ

Length:465

Mass (Da):52,358

Last modified:May 1, 1997 - v1

Checksum:ⁱC9C023EEA1CF036D

GO

Isoform 2 (identifier: P78396-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
38-38: Missing.

« Hide

        10         20         30         40         50
METGFPAIMY PGSFIGGWGE EYLSWEGPGL PDFVFQQPVE SEAMHCSNPK 
        60         70         80         90        100
SGVVLATVAR GPDACQILTR APLGQDPPQR TVLGLLTANG QYRRTCGQGI 
       110        120        130        140        150
TRIRCYSGSE NAFPPAGKKA LPDCGVQEPP KQGFDIYMDE LEQGDRDSCS 
       160        170        180        190        200
VREGMAFEDV YEVDTGTLKS DLHFLLDFNT VSPMLVDSSL LSQSEDISSL 
       210        220        230        240        250
GTDVINVTEY AEEIYQYLRE AEIRHRPKAH YMKKQPDITE GMRTILVDWL 
       260        270        280        290        300
VEVGEEYKLR AETLYLAVNF LDRFLSCMSV LRGKLQLVGT AAMLLASKYE 
       310        320        330        340        350
EIYPPEVDEF VYITDDTYTK RQLLKMEHLL LKVLAFDLTV PTTNQFLLQY 
       360        370        380        390        400
LRRQGVCVRT ENLAKYVAEL SLLEADPFLK YLPSLIAAAA FCLANYTVNK 
       410        420        430        440        450
HFWPETLAAF TGYSLSEIVP CLSELHKAYL DIPHRPQQAI REKYKASKYL 
       460 
CVSLMEPPAV LLLQ

Show »

Length:464

Mass (Da):52,230

Checksum:ⁱE67C6E6D741B7D73

GO

Isoform 3 (identifier: P78396-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-44: Missing.

« Hide

        10         20         30         40         50
MHCSNPKSGV VLATVARGPD ACQILTRAPL GQDPPQRTVL GLLTANGQYR 
        60         70         80         90        100
RTCGQGITRI RCYSGSENAF PPAGKKALPD CGVQEPPKQG FDIYMDELEQ 
       110        120        130        140        150
GDRDSCSVRE GMAFEDVYEV DTGTLKSDLH FLLDFNTVSP MLVDSSLLSQ 
       160        170        180        190        200
SEDISSLGTD VINVTEYAEE IYQYLREAEI RHRPKAHYMK KQPDITEGMR 
       210        220        230        240        250
TILVDWLVEV GEEYKLRAET LYLAVNFLDR FLSCMSVLRG KLQLVGTAAM 
       260        270        280        290        300
LLASKYEEIY PPEVDEFVYI TDDTYTKRQL LKMEHLLLKV LAFDLTVPTT 
       310        320        330        340        350
NQFLLQYLRR QGVCVRTENL AKYVAELSLL EADPFLKYLP SLIAAAAFCL 
       360        370        380        390        400
ANYTVNKHFW PETLAAFTGY SLSEIVPCLS ELHKAYLDIP HRPQQAIREK 
       410        420 
YKASKYLCVS LMEPPAVLLL Q

Show »

Length:421

Mass (Da):47,494

Checksum:ⁱ33F2BA565699105C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	43 – 47	EAMHC → SS in AAV38384 (Ref. 2) Curated		5

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044257	1 – 44	Missing in isoform 3. 1 PublicationAdd BLAST		44
Alternative sequenceⁱVSP_034392	38	Missing in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U66838 mRNA. Translation: AAB49754.1. BT019577 mRNA. Translation: AAV38384.1. AK301897 mRNA. Translation: BAH13579.1. AK316392 mRNA. Translation: BAH14763.1. AL359767 Genomic DNA. Translation: CAI12728.1. CH471075 Genomic DNA. Translation: EAX08565.1. CH471075 Genomic DNA. Translation: EAX08566.1. BC036346 mRNA. Translation: AAH36346.1. U97680 mRNA. Translation: AAB60863.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45030.1. [P78396-2] CCDS45031.1. [P78396-3] CCDS9357.1. [P78396-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001104515.1. NM_001111045.1. [P78396-2] NP_001104516.1. NM_001111046.1. [P78396-3] NP_001104517.1. NM_001111047.1. [P78396-3] NP_003905.1. NM_003914.3. [P78396-1] XP_011533596.1. XM_011535294.2. [P78396-3] XP_011533597.1. XM_011535295.2. [P78396-3] XP_011533598.1. XM_011535296.2. [P78396-3]
UniGeneⁱ	Hs.417050.

Genome annotation databases

Ensemblⁱ	ENST00000255465; ENSP00000255465; ENSG00000133101. [P78396-1] ENST00000440264; ENSP00000400666; ENSG00000133101. [P78396-3] ENST00000625767; ENSP00000486017; ENSG00000133101. [P78396-2] ENST00000630422; ENSP00000486482; ENSG00000133101. [P78396-3]
GeneIDⁱ	8900.
KEGGⁱ	hsa:8900.
UCSC genome browser More...UCSCⁱ	uc001uvr.5. human. [P78396-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U66838 mRNA. Translation: AAB49754.1. BT019577 mRNA. Translation: AAV38384.1. AK301897 mRNA. Translation: BAH13579.1. AK316392 mRNA. Translation: BAH14763.1. AL359767 Genomic DNA. Translation: CAI12728.1. CH471075 Genomic DNA. Translation: EAX08565.1. CH471075 Genomic DNA. Translation: EAX08566.1. BC036346 mRNA. Translation: AAH36346.1. U97680 mRNA. Translation: AAB60863.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45030.1. [P78396-2] CCDS45031.1. [P78396-3] CCDS9357.1. [P78396-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001104515.1. NM_001111045.1. [P78396-2] NP_001104516.1. NM_001111046.1. [P78396-3] NP_001104517.1. NM_001111047.1. [P78396-3] NP_003905.1. NM_003914.3. [P78396-1] XP_011533596.1. XM_011535294.2. [P78396-3] XP_011533597.1. XM_011535295.2. [P78396-3] XP_011533598.1. XM_011535296.2. [P78396-3]
UniGeneⁱ	Hs.417050.

3D structure databases

ProteinModelPortalⁱ	P78396.
SMRⁱ	P78396.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114417. 50 interactors.
IntActⁱ	P78396. 10 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-104479.
STRINGⁱ	9606.ENSP00000255465.

Chemistry databases

BindingDBⁱ	P78396.
ChEMBLⁱ	CHEMBL3038470.

PTM databases

iPTMnetⁱ	P78396.
PhosphoSitePlusⁱ	P78396.

Polymorphism and mutation databases

BioMutaⁱ	CCNA1.
DMDMⁱ	8134359.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P78396.
PaxDbⁱ	P78396.
PeptideAtlas More...PeptideAtlasⁱ	P78396.
PRIDEⁱ	P78396.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8900.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000255465; ENSP00000255465; ENSG00000133101. [P78396-1] ENST00000440264; ENSP00000400666; ENSG00000133101. [P78396-3] ENST00000625767; ENSP00000486017; ENSG00000133101. [P78396-2] ENST00000630422; ENSP00000486482; ENSG00000133101. [P78396-3]
GeneIDⁱ	8900.
KEGGⁱ	hsa:8900.
UCSC genome browser More...UCSCⁱ	uc001uvr.5. human. [P78396-1]

Organism-specific databases

CTDⁱ	8900.
DisGeNET More...DisGeNETⁱ	8900.
GeneCardsⁱ	CCNA1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1577. CCNA1.
Human Protein Atlas More...HPAⁱ	HPA060646.
MIMⁱ	604036. gene.
neXtProtⁱ	NX_P78396.
Open Targets More...OpenTargetsⁱ	ENSG00000133101.
PharmGKBⁱ	PA26147.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0654. Eukaryota. COG5024. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118939.
HOGENOMⁱ	HOG000167672.
HOVERGENⁱ	HBG106244.
InParanoidⁱ	P78396.
KEGG Orthology (KO) More...KOⁱ	K06627.
OMAⁱ	AEIRHRP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G090I.
PhylomeDBⁱ	P78396.
TreeFamⁱ	TF101002.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1538133. G0 and Early G1. R-HSA-170145. Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes. R-HSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. R-HSA-176408. Regulation of APC/C activators between G1/S and early anaphase. R-HSA-187577. SCF(Skp2)-mediated degradation of p27/p21. R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP). R-HSA-2559586. DNA Damage/Telomere Stress Induced Senescence. R-HSA-539107. Activation of E2F1 target genes at G1/S. R-HSA-5689880. Ub-specific processing proteases. R-HSA-5693607. Processing of DNA double-strand break ends. R-HSA-6804116. TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest. R-HSA-6804756. Regulation of TP53 Activity through Phosphorylation. R-HSA-6804757. Regulation of TP53 Degradation. R-HSA-68911. G2 Phase. R-HSA-68949. Orc1 removal from chromatin. R-HSA-69273. Cyclin A/B1 associated events during G2/M transition. R-HSA-69563. p53-Dependent G1 DNA Damage Response. R-HSA-69656. Cyclin A:Cdk2-associated events at S phase entry.
SignaLinkⁱ	P78396.
SIGNORⁱ	P78396.

Miscellaneous databases

GeneWikiⁱ	Cyclin_A1.
GenomeRNAiⁱ	8900.
Protein Ontology More...PROⁱ	PR:P78396.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000133101.
CleanExⁱ	HS_CCNA1.
ExpressionAtlasⁱ	P78396. baseline and differential.
Genevisibleⁱ	P78396. HS.

Family and domain databases

Gene3Dⁱ	1.10.472.10. 2 hits.
InterProⁱ	View protein in InterPro IPR013763. Cyclin-like. IPR004367. Cyclin_C-dom. IPR006671. Cyclin_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02984. Cyclin_C. 1 hit. PF00134. Cyclin_N. 1 hit.
SMARTⁱ	View protein in SMART SM00385. CYCLIN. 2 hits. SM01332. Cyclin_C. 1 hit.
SUPFAMⁱ	SSF47954. SSF47954. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00292. CYCLINS. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCNA1_HUMAN
Accessionⁱ	P78396Primary (citable) accession number: P78396 Secondary accession number(s): B7Z7E3 , Q5T3V0, Q5U0G2, Q8IY91
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	May 1, 1997
	Last modified:	July 5, 2017
	This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P78396 (CCNA1_HUMAN)

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Cyclin-A1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (3)ⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ