KRT85

Functionⁱ

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

GO - Molecular functionⁱ

structural molecule activity
Source: ProtInc
Traceable author statementⁱ
- 9084137

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cornification Source: Reactome
epidermis development
Source: ProtInc
Traceable author statementⁱ
- 9084137
keratinization Source: Reactome

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6805567. Keratinization. R-HSA-6809371. Formation of the cornified envelope.

Reactomeⁱ

R-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Keratin, type II cuticular Hb5 Alternative name(s): Hair keratin K2.12 Keratin-85 Short name: K85 Type II hair keratin Hb5 Type-II keratin Kb25
Gene namesⁱ	Name:KRT85 Synonyms:KRTHB5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135443.8.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6462. KRT85.
MIMⁱ	602767. gene.
neXtProtⁱ	NX_P78386.

Subcellular locationⁱ

GO - Cellular component

Keywords - Cellular componentⁱ

Intermediate filament, Keratin

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ectodermal dysplasia 4, hair/nail type (ECTD4)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. ECTD4 is characterized by complete alopecia, hypotricosis and nail dystrophy in all digits. There is no evidence of any other abnormality. Inheritance can be autosomal dominant or recessive.

Keywords - Diseaseⁱ

Disease mutation, Ectodermal dysplasia, Hypotrichosis

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3891.
MalaCards human disease database More...MalaCardsⁱ	KRT85.
MIMⁱ	602032. phenotype.
Open Targets More...OpenTargetsⁱ	ENSG00000135443.
Orphanetⁱ	69084. Pure hair and nail ectodermal dysplasia.
PharmGKBⁱ	PA30251.

Polymorphism and mutation databases

BioMutaⁱ	KRT85.
DMDMⁱ	48474780.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000063702	1 – 507	Keratin, type II cuticular Hb5Add BLAST		507

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	229	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbⁱ	P78386.
PeptideAtlas More...PeptideAtlasⁱ	P78386.
PRIDEⁱ	P78386.

PTM databases

iPTMnetⁱ	P78386.
PhosphoSitePlusⁱ	P78386.
SwissPalmⁱ	P78386.

Expressionⁱ

Tissue specificityⁱ

Synthesis occurs immediately above a small population of matrix cells at the base of the hair bulb and the trichocytes lining the dermal papilla and extends upward through the matrix and ends in the lower part of the cortex of the hair shaft.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000135443.
CleanExⁱ	HS_KRT85.
ExpressionAtlasⁱ	P78386. baseline and differential.
Genevisibleⁱ	P78386. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049778.

HPAⁱ

HPA049778.

Interactionⁱ

Subunit structureⁱ

Heterotetramer of two type I and two type II keratins.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
KRT15	P19012	4	EBI-1049371,EBI-739566
KRT26	Q7Z3Y9	4	EBI-1049371,EBI-12084444
OTX1	P32242	4	EBI-1049371,EBI-740446

Show more details

Protein-protein interaction databases

BioGridⁱ	110089. 18 interactors.
IntActⁱ	P78386. 44 interactors.
STRINGⁱ	9606.ENSP00000257901.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P78386.
SMRⁱ	P78386.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	123 – 434	IF rodPROSITE-ProRule annotationAdd BLAST		312

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 123	HeadAdd BLAST	123
Regionⁱ	124 – 158	Coil 1AAdd BLAST	35
Regionⁱ	159 – 168	Linker 1	10
Regionⁱ	169 – 269	Coil 1BAdd BLAST	101
Regionⁱ	270 – 286	Linker 12Add BLAST	17
Regionⁱ	287 – 430	Coil 2Add BLAST	144
Regionⁱ	431 – 507	TailAdd BLAST	77

Sequence similaritiesⁱ

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IH1H. Eukaryota. ENOG41113GZ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144006.
HOGENOMⁱ	HOG000230976.
HOVERGENⁱ	HBG013015.
InParanoidⁱ	P78386.
KEGG Orthology (KO) More...KOⁱ	K07605.
OMAⁱ	SCGPRMA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06FG.
PhylomeDBⁱ	P78386.
TreeFamⁱ	TF332742.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR032444. Keratin_2_head. IPR003054. Keratin_II.
PANTHERⁱ	PTHR23239. PTHR23239. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00038. Filament. 1 hit. PF16208. Keratin_2_head. 1 hit.
PRINTSⁱ	PR01276. TYPE2KERATIN.
SMARTⁱ	View protein in SMART SM01391. Filament. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00226. IF_ROD_1. 1 hit. PS51842. IF_ROD_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P78386-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSCRSYRISS GCGVTRNFSS CSAVAPKTGN RCCISAAPYR GVSCYRGLTG 
        60         70         80         90        100
FGSRSLCNLG SCGPRIAVGG FRAGSCGRSF GYRSGGVCGP SPPCITTVSV 
       110        120        130        140        150
NESLLTPLNL EIDPNAQCVK QEEKEQIKSL NSRFAAFIDK VRFLEQQNKL 
       160        170        180        190        200
LETKWQFYQN QRCCESNLEP LFSGYIETLR REAECVEADS GRLASELNHV 
       210        220        230        240        250
QEVLEGYKKK YEEEVALRAT AENEFVVLKK DVDCAYLRKS DLEANVEALV 
       260        270        280        290        300
EESSFLRRLY EEEIRVLQAH ISDTSVIVKM DNSRDLNMDC IIAEIKAQYD 
       310        320        330        340        350
DVASRSRAEA ESWYRSKCEE MKATVIRHGE TLRRTKEEIN ELNRMIQRLT 
       360        370        380        390        400
AEIENAKCQR AKLEAAVAEA EQQGEAALSD ARCKLAELEG ALQKAKQDMA 
       410        420        430        440        450
CLLKEYQEVM NSKLGLDIEI ATYRRLLEGE EHRLCEGVGS VNVCVSSSRG 
       460        470        480        490        500
GVSCGGLSYS TTPGRQITSG PSAIGGSITV VAPDSCAPCQ PRSSSFSCGS 

SRSVRFA

Length:507

Mass (Da):55,802

Last modified:May 1, 1997 - v1

Checksum:ⁱ0A3E5ABEAAF4C04D

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	155	W → V in CAB76830 (PubMed:10692104).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_029657	78	R → H in ECTD4. 1 PublicationCorresponds to variant dbSNP:rs61630004Ensembl.		1
Natural variantⁱVAR_049804	155	W → L. Corresponds to variant dbSNP:rs2852471Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X99140 mRNA. Translation: CAA67577.1. Y19210 Genomic DNA. Translation: CAB76830.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8824.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001287739.1. NM_001300810.1. NP_002274.1. NM_002283.3.
UniGeneⁱ	Hs.182507.

Genome annotation databases

Ensemblⁱ	ENST00000257901; ENSP00000257901; ENSG00000135443.
GeneIDⁱ	3891.
KEGGⁱ	hsa:3891.
UCSC genome browser More...UCSCⁱ	uc001sag.4. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P78386	UPI0004BDBE33 UPI0008137A44 UPI0003EC2B93 A0A2K6UWK0 UPI00033167B9 D2I737 UPI00032B1737 UPI0003BB88F4 UPI00046BE671 UPI0002C660E8 +117	Equus przewalskii (Przewalski's horse) (Equus caballus przewalskii) Manis javanica (Malayan pangolin) (Sunda pangolin) Myotis davidii (David's myotis) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Sorex araneus (Eurasian common shrew) (European shrew) Ailuropoda melanoleuca (Giant panda) Ochotona princeps (Southern American pika) Myotis brandtii (Brandt's bat) Eptesicus fuscus (Big brown bat) (Vespertilio fuscus) Ceratotherium simum simum (southern white rhinoceros) And more	507	UniRef90_P78386	Cluster: Keratin, type II cuticular Hb5	128

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P78386	P78385 A0A096ML94 UPI000C29E667 A0A2K5WWK9 A0A2K5N3F0 A0A2K6BKN4 A0A2K5I8K4 A0A2I3RCR2 A0A2I2YSB4 Q14533 +273	Homo sapiens (Human) Papio anubis (Olive baboon) Piliocolobus tephrosceles (Ugandan red Colobus) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Macaca nemestrina (Pig-tailed macaque) Colobus angolensis palliatus (Peters' Angolan colobus) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) And more	493	UniRef50_P78385	Cluster: Keratin, type II cuticular Hb3	284

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X99140 mRNA. Translation: CAA67577.1. Y19210 Genomic DNA. Translation: CAB76830.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8824.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001287739.1. NM_001300810.1. NP_002274.1. NM_002283.3.
UniGeneⁱ	Hs.182507.

3D structure databases

ProteinModelPortalⁱ	P78386.
SMRⁱ	P78386.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110089. 18 interactors.
IntActⁱ	P78386. 44 interactors.
STRINGⁱ	9606.ENSP00000257901.

PTM databases

iPTMnetⁱ	P78386.
PhosphoSitePlusⁱ	P78386.
SwissPalmⁱ	P78386.

Polymorphism and mutation databases

BioMutaⁱ	KRT85.
DMDMⁱ	48474780.

Proteomic databases

PaxDbⁱ	P78386.
PeptideAtlas More...PeptideAtlasⁱ	P78386.
PRIDEⁱ	P78386.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3891.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000257901; ENSP00000257901; ENSG00000135443.
GeneIDⁱ	3891.
KEGGⁱ	hsa:3891.
UCSC genome browser More...UCSCⁱ	uc001sag.4. human.

Organism-specific databases

CTDⁱ	3891.
DisGeNET More...DisGeNETⁱ	3891.
EuPathDBⁱ	HostDB:ENSG00000135443.8.
GeneCardsⁱ	KRT85.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6462. KRT85.
Human Protein Atlas More...HPAⁱ	HPA049778.
MalaCards human disease database More...MalaCardsⁱ	KRT85.
MIMⁱ	602032. phenotype. 602767. gene.
neXtProtⁱ	NX_P78386.
Open Targets More...OpenTargetsⁱ	ENSG00000135443.
Orphanetⁱ	69084. Pure hair and nail ectodermal dysplasia.
PharmGKBⁱ	PA30251.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IH1H. Eukaryota. ENOG41113GZ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144006.
HOGENOMⁱ	HOG000230976.
HOVERGENⁱ	HBG013015.
InParanoidⁱ	P78386.
KEGG Orthology (KO) More...KOⁱ	K07605.
OMAⁱ	SCGPRMA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06FG.
PhylomeDBⁱ	P78386.
TreeFamⁱ	TF332742.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6805567. Keratinization. R-HSA-6809371. Formation of the cornified envelope.

Reactomeⁱ

R-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GeneWikiⁱ	KRT85.
GenomeRNAiⁱ	3891.
Protein Ontology More...PROⁱ	PR:P78386.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135443.
CleanExⁱ	HS_KRT85.
ExpressionAtlasⁱ	P78386. baseline and differential.
Genevisibleⁱ	P78386. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR032444. Keratin_2_head. IPR003054. Keratin_II.
PANTHERⁱ	PTHR23239. PTHR23239. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00038. Filament. 1 hit. PF16208. Keratin_2_head. 1 hit.
PRINTSⁱ	PR01276. TYPE2KERATIN.
SMARTⁱ	View protein in SMART SM01391. Filament. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00226. IF_ROD_1. 1 hit. PS51842. IF_ROD_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KRT85_HUMAN
Accessionⁱ	P78386Primary (citable) accession number: P78386 Secondary accession number(s): Q9NSB1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
	Last sequence update:	May 1, 1997
	Last modified:	March 28, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P78386 (KRT85_HUMAN)

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Keratin, type II cuticular Hb5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ