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Protein

Solute carrier family 35 member B1

Gene

SLC35B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable sugar transporter.By similarity

GO - Molecular functioni

  • UDP-galactose transmembrane transporter activity Source: ProtInc

GO - Biological processi

  • transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121073-MONOMER.

Protein family/group databases

TCDBi2.A.7.11.1. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member B1
Alternative name(s):
UDP-galactose transporter-related protein 1
Short name:
UGTrel1
Short name:
hUGTrel1
Gene namesi
Name:SLC35B1
Synonyms:UGTREL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:20798. SLC35B1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121073.
PharmGKBiPA134864001.

Polymorphism and mutation databases

DMDMi74735602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002133661 – 322Solute carrier family 35 member B1Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: P78383-2)
Modified residuei15PhosphoserineCombined sourcesCurated1
Modified residuei29PhosphoserineCombined sourcesCurated1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP78383.
PaxDbiP78383.
PeptideAtlasiP78383.
PRIDEiP78383.

Expressioni

Gene expression databases

BgeeiENSG00000121073.
CleanExiHS_SLC35B1.
ExpressionAtlasiP78383. baseline and differential.
GenevisibleiP78383. HS.

Organism-specific databases

HPAiHPA057418.

Interactioni

Protein-protein interaction databases

BioGridi115531. 3 interactors.
IntActiP78383. 2 interactors.
STRINGi9606.ENSP00000240333.

Structurei

3D structure databases

ProteinModelPortaliP78383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi318 – 322Di-lysine motif5

Domaini

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEAU. Eukaryota.
ENOG4111PY2. LUCA.
GeneTreeiENSGT00530000063090.
HOGENOMiHOG000091197.
HOVERGENiHBG083706.
InParanoidiP78383.
KOiK15275.
OMAiFVCYFYF.
OrthoDBiEOG091G0LP3.
PhylomeDBiP78383.
TreeFamiTF105967.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P78383-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSSSLVPD RLRLPLCFLG VFVCYFYYGI LQEKITRGKY GEGAKQETFT
60 70 80 90 100
FALTLVFIQC VINAVFAKIL IQFFDTARVD RTRSWLYAAC SISYLGAMVS
110 120 130 140 150
SNSALQFVNY PTQVLGKSCK PIPVMLLGVT LLKKKYPLAK YLCVLLIVAG
160 170 180 190 200
VALFMYKPKK VVGIEEHTVG YGELLLLLSL TLDGLTGVSQ DHMRAHYQTG
210 220 230 240 250
SNHMMLNINL WSTLLLGMGI LFTGELWEFL SFAERYPAII YNILLFGLTS
260 270 280 290 300
ALGQSFIFMT VVYFGPLTCS IITTTRKFFT ILASVILFAN PISPMQWVGT
310 320
VLVFLGLGLD AKFGKGAKKT SH
Length:322
Mass (Da):35,760
Last modified:May 1, 1997 - v1
Checksum:i7B5124A4DEC23598
GO
Isoform 2 (identifier: P78383-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRPLPPVGDVRLELSPPPPLLPVPVVSGSPVGSSGRLM

Note: No experimental confirmation available.Combined sourcesCurated
Show »
Length:359
Mass (Da):39,512
Checksum:i0E54FA5289E2F4F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160K → N in BAG57035 (PubMed:14702039).Curated1
Sequence conflicti211W → R in BAG57035 (PubMed:14702039).Curated1
Isoform 2 (identifier: P78383-2)
Sequence conflicti33S → P in BAG57035 (PubMed:14702039).Combined sourcesCurated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02377881R → H.1 PublicationCorresponds to variant rs1135034dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0542341M → MRPLPPVGDVRLELSPPPPL LPVPVVSGSPVGSSGRLM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87989 mRNA. Translation: BAA13525.1.
AK293563 mRNA. Translation: BAG57035.1.
AC015795 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94666.1.
BC011888 mRNA. Translation: AAH11888.1.
CCDSiCCDS11552.2. [P78383-2]
PIRiJC5024.
RefSeqiNP_005818.2. NM_005827.2. [P78383-2]
UniGeneiHs.154073.

Genome annotation databases

EnsembliENST00000240333; ENSP00000240333; ENSG00000121073. [P78383-2]
GeneIDi10237.
KEGGihsa:10237.
UCSCiuc002iph.3. human. [P78383-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87989 mRNA. Translation: BAA13525.1.
AK293563 mRNA. Translation: BAG57035.1.
AC015795 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94666.1.
BC011888 mRNA. Translation: AAH11888.1.
CCDSiCCDS11552.2. [P78383-2]
PIRiJC5024.
RefSeqiNP_005818.2. NM_005827.2. [P78383-2]
UniGeneiHs.154073.

3D structure databases

ProteinModelPortaliP78383.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115531. 3 interactors.
IntActiP78383. 2 interactors.
STRINGi9606.ENSP00000240333.

Protein family/group databases

TCDBi2.A.7.11.1. the drug/metabolite transporter (dmt) superfamily.

Polymorphism and mutation databases

DMDMi74735602.

Proteomic databases

MaxQBiP78383.
PaxDbiP78383.
PeptideAtlasiP78383.
PRIDEiP78383.

Protocols and materials databases

DNASUi10237.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240333; ENSP00000240333; ENSG00000121073. [P78383-2]
GeneIDi10237.
KEGGihsa:10237.
UCSCiuc002iph.3. human. [P78383-1]

Organism-specific databases

CTDi10237.
GeneCardsiSLC35B1.
HGNCiHGNC:20798. SLC35B1.
HPAiHPA057418.
MIMi610790. gene.
neXtProtiNX_P78383.
OpenTargetsiENSG00000121073.
PharmGKBiPA134864001.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEAU. Eukaryota.
ENOG4111PY2. LUCA.
GeneTreeiENSGT00530000063090.
HOGENOMiHOG000091197.
HOVERGENiHBG083706.
InParanoidiP78383.
KOiK15275.
OMAiFVCYFYF.
OrthoDBiEOG091G0LP3.
PhylomeDBiP78383.
TreeFamiTF105967.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121073-MONOMER.

Miscellaneous databases

GenomeRNAii10237.
PROiP78383.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121073.
CleanExiHS_SLC35B1.
ExpressionAtlasiP78383. baseline and differential.
GenevisibleiP78383. HS.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS35B1_HUMAN
AccessioniPrimary (citable) accession number: P78383
Secondary accession number(s): B4DEC4, J3KQV4, Q96EW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.