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P78383

- S35B1_HUMAN

UniProt

P78383 - S35B1_HUMAN

Protein

Solute carrier family 35 member B1

Gene

SLC35B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Probable sugar transporter.By similarity

    GO - Molecular functioni

    1. UDP-galactose transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. transport Source: ProtInc
    2. UDP-galactose transmembrane transport Source: GOC

    Keywords - Biological processi

    Sugar transport, Transport

    Protein family/group databases

    TCDBi2.A.7.11.1. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 35 member B1
    Alternative name(s):
    UDP-galactose transporter-related protein 1
    Short name:
    UGTrel1
    Short name:
    hUGTrel1
    Gene namesi
    Name:SLC35B1
    Synonyms:UGTREL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:20798. SLC35B1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular membrane-bounded organelle Source: ProtInc

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134864001.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Solute carrier family 35 member B1PRO_0000213366Add
    BLAST

    Proteomic databases

    MaxQBiP78383.
    PaxDbiP78383.
    PRIDEiP78383.

    Expressioni

    Gene expression databases

    ArrayExpressiP78383.
    BgeeiP78383.
    CleanExiHS_SLC35B1.
    GenevestigatoriP78383.

    Interactioni

    Protein-protein interaction databases

    BioGridi115531. 1 interaction.
    STRINGi9606.ENSP00000240333.

    Structurei

    3D structure databases

    ProteinModelPortaliP78383.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei51 – 7121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei210 – 23021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi318 – 3225Di-lysine motif

    Domaini

    The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0697.
    HOGENOMiHOG000091197.
    HOVERGENiHBG083706.
    InParanoidiP78383.
    KOiK15275.
    OMAiANHMMLN.
    OrthoDBiEOG7FV3QW.
    PhylomeDBiP78383.
    TreeFamiTF105967.

    Family and domain databases

    InterProiIPR013657. UAA.
    [Graphical view]
    PfamiPF08449. UAA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P78383-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASSSSLVPD RLRLPLCFLG VFVCYFYYGI LQEKITRGKY GEGAKQETFT    50
    FALTLVFIQC VINAVFAKIL IQFFDTARVD RTRSWLYAAC SISYLGAMVS 100
    SNSALQFVNY PTQVLGKSCK PIPVMLLGVT LLKKKYPLAK YLCVLLIVAG 150
    VALFMYKPKK VVGIEEHTVG YGELLLLLSL TLDGLTGVSQ DHMRAHYQTG 200
    SNHMMLNINL WSTLLLGMGI LFTGELWEFL SFAERYPAII YNILLFGLTS 250
    ALGQSFIFMT VVYFGPLTCS IITTTRKFFT ILASVILFAN PISPMQWVGT 300
    VLVFLGLGLD AKFGKGAKKT SH 322
    Length:322
    Mass (Da):35,760
    Last modified:May 1, 1997 - v1
    Checksum:i7B5124A4DEC23598
    GO
    Isoform 2 (identifier: P78383-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MRPLPPVGDVRLELSPPPPLLPVPVVSGSPVGSSGRLM

    Note: No experimental confirmation available.Curated

    Show »
    Length:359
    Mass (Da):39,512
    Checksum:i0E54FA5289E2F4F2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti160 – 1601K → N in BAG57035. (PubMed:14702039)Curated
    Sequence conflicti211 – 2111W → R in BAG57035. (PubMed:14702039)Curated
    Isoform 2 (identifier: P78383-2)
    Sequence conflicti33 – 331S → P in BAG57035. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti81 – 811R → H.1 Publication
    Corresponds to variant rs1135034 [ dbSNP | Ensembl ].
    VAR_023778

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MRPLPPVGDVRLELSPPPPL LPVPVVSGSPVGSSGRLM in isoform 2. 1 PublicationVSP_054234

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87989 mRNA. Translation: BAA13525.1.
    AK293563 mRNA. Translation: BAG57035.1.
    AC015795 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94666.1.
    BC011888 mRNA. Translation: AAH11888.1.
    CCDSiCCDS11552.2. [P78383-2]
    PIRiJC5024.
    RefSeqiNP_005818.2. NM_005827.2. [P78383-2]
    UniGeneiHs.154073.

    Genome annotation databases

    EnsembliENST00000240333; ENSP00000240333; ENSG00000121073. [P78383-1]
    GeneIDi10237.
    KEGGihsa:10237.
    UCSCiuc002iph.1. human. [P78383-1]

    Polymorphism databases

    DMDMi74735602.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87989 mRNA. Translation: BAA13525.1 .
    AK293563 mRNA. Translation: BAG57035.1 .
    AC015795 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94666.1 .
    BC011888 mRNA. Translation: AAH11888.1 .
    CCDSi CCDS11552.2. [P78383-2 ]
    PIRi JC5024.
    RefSeqi NP_005818.2. NM_005827.2. [P78383-2 ]
    UniGenei Hs.154073.

    3D structure databases

    ProteinModelPortali P78383.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115531. 1 interaction.
    STRINGi 9606.ENSP00000240333.

    Protein family/group databases

    TCDBi 2.A.7.11.1. the drug/metabolite transporter (dmt) superfamily.

    Polymorphism databases

    DMDMi 74735602.

    Proteomic databases

    MaxQBi P78383.
    PaxDbi P78383.
    PRIDEi P78383.

    Protocols and materials databases

    DNASUi 10237.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000240333 ; ENSP00000240333 ; ENSG00000121073 . [P78383-1 ]
    GeneIDi 10237.
    KEGGi hsa:10237.
    UCSCi uc002iph.1. human. [P78383-1 ]

    Organism-specific databases

    CTDi 10237.
    GeneCardsi GC17M047779.
    HGNCi HGNC:20798. SLC35B1.
    MIMi 610790. gene.
    neXtProti NX_P78383.
    PharmGKBi PA134864001.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0697.
    HOGENOMi HOG000091197.
    HOVERGENi HBG083706.
    InParanoidi P78383.
    KOi K15275.
    OMAi ANHMMLN.
    OrthoDBi EOG7FV3QW.
    PhylomeDBi P78383.
    TreeFami TF105967.

    Miscellaneous databases

    GenomeRNAii 10237.
    NextBioi 35471179.
    PROi P78383.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P78383.
    Bgeei P78383.
    CleanExi HS_SLC35B1.
    Genevestigatori P78383.

    Family and domain databases

    InterProi IPR013657. UAA.
    [Graphical view ]
    Pfami PF08449. UAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family."
      Ishida N., Miura N., Yoshioka S., Kawakita M.
      J. Biochem. 120:1074-1078(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Cerebellum.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-81.
      Tissue: Skin.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS35B1_HUMAN
    AccessioniPrimary (citable) accession number: P78383
    Secondary accession number(s): B4DEC4, J3KQV4, Q96EW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3