P78383 (S35B1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 35 member B1

Alternative name(s):
UDP-galactose transporter-related protein 1
Short name=UGTrel1
Short name=hUGTrel1

Gene names

Name:	SLC35B1
Synonyms:	UGTREL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable sugar transporter By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.
Domain	The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins By similarity.
Sequence similarities	Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular membrane-bounded organelle Traceable author statement Ref.1. Source: ProtInc
Molecular_function	UDP-galactose transmembrane transporter activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Solute carrier family 35 member B1		PRO_0000213366
Regions
	Transmembrane	12 – 32	21	Helical; Potential
	Transmembrane	51 – 71	21	Helical; Potential
	Transmembrane	85 – 105	21	Helical; Potential
	Transmembrane	136 – 156	21	Helical; Potential
	Transmembrane	168 – 188	21	Helical; Potential
	Transmembrane	210 – 230	21	Helical; Potential
	Transmembrane	243 – 263	21	Helical; Potential
	Transmembrane	285 – 305	21	Helical; Potential
	Motif	318 – 322	5	Di-lysine motif
Natural variations
	Natural variant	81	1	R → H. Ref.2 Corresponds to variant rs1135034 [ dbSNP | Ensembl ].		VAR_023778

Sequences

	Sequence		Length	Mass (Da)
	P78383 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 7B5124A4DEC23598	FASTA	322	35,760
	10 20 30 40 50 60 MASSSSLVPD RLRLPLCFLG VFVCYFYYGI LQEKITRGKY GEGAKQETFT FALTLVFIQC 70 80 90 100 110 120 VINAVFAKIL IQFFDTARVD RTRSWLYAAC SISYLGAMVS SNSALQFVNY PTQVLGKSCK 130 140 150 160 170 180 PIPVMLLGVT LLKKKYPLAK YLCVLLIVAG VALFMYKPKK VVGIEEHTVG YGELLLLLSL 190 200 210 220 230 240 TLDGLTGVSQ DHMRAHYQTG SNHMMLNINL WSTLLLGMGI LFTGELWEFL SFAERYPAII 250 260 270 280 290 300 YNILLFGLTS ALGQSFIFMT VVYFGPLTCS IITTTRKFFT ILASVILFAN PISPMQWVGT 310 320 VLVFLGLGLD AKFGKGAKKT SH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family." Ishida N., Miura N., Yoshioka S., Kawakita M. J. Biochem. 120:1074-1078(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-81. Tissue: Skin.

Web resources

GGDB

GlycoGene database

Cross-references

Sequence databases
EMBL GenBank DDBJ	D87989 mRNA. Translation: BAA13525.1. BC011888 mRNA. Translation: AAH11888.1.
IPI	IPI00940994.
PIR	JC5024.
RefSeq	NP_005818.1. NM_005827.1.
UniGene	Hs.154073.
3D structure databases
ProteinModelPortal	P78383.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000240333.
Protein family/group databases
TCDB	2.A.7.11.1. drug/metabolite transporter (DMT) superfamily.
Polymorphism databases
DMDM	74735602.
Proteomic databases
PaxDb	P78383.
PRIDE	P78383.
Protocols and materials databases
DNASU	10237.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000240333; ENSP00000240333; ENSG00000121073.
GeneID	10237.
KEGG	hsa:10237.
UCSC	uc002iph.1. human.
Organism-specific databases
CTD	10237.
GeneCards	GC17M047779.
HGNC	HGNC:20798. SLC35B1.
MIM	610790. gene.
neXtProt	NX_P78383.
PharmGKB	PA134864001.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0697.
HOGENOM	HOG000091197.
HOVERGEN	HBG083706.
InParanoid	P78383.
KO	K15275.
OrthoDB	EOG4SN1P9.
PhylomeDB	P78383.
Gene expression databases
ArrayExpress	P78383.
Bgee	P78383.
CleanEx	HS_SLC35B1.
Genevestigator	P78383.
GermOnline	ENSG00000121073. Homo sapiens.
Family and domain databases
InterPro	IPR013657. UAA. [Graphical view]
Pfam	PF08449. UAA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10237.
NextBio	38780.
SOURCE	Search...

Entry information

Entry name

S35B1_HUMAN

Accession

Primary (citable) accession number: P78383
Secondary accession number(s): Q96EW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.