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P78383

- S35B1_HUMAN

UniProt

P78383 - S35B1_HUMAN

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Protein

Solute carrier family 35 member B1

Gene

SLC35B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probable sugar transporter.By similarity

GO - Molecular functioni

  1. UDP-galactose transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. transport Source: ProtInc
  2. UDP-galactose transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Protein family/group databases

TCDBi2.A.7.11.1. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member B1
Alternative name(s):
UDP-galactose transporter-related protein 1
Short name:
UGTrel1
Short name:
hUGTrel1
Gene namesi
Name:SLC35B1
Synonyms:UGTREL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:20798. SLC35B1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134864001.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Solute carrier family 35 member B1PRO_0000213366Add
BLAST

Proteomic databases

MaxQBiP78383.
PaxDbiP78383.
PRIDEiP78383.

Expressioni

Gene expression databases

BgeeiP78383.
CleanExiHS_SLC35B1.
ExpressionAtlasiP78383. baseline and differential.
GenevestigatoriP78383.

Interactioni

Protein-protein interaction databases

BioGridi115531. 1 interaction.
STRINGi9606.ENSP00000240333.

Structurei

3D structure databases

ProteinModelPortaliP78383.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Transmembranei51 – 7121HelicalSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Transmembranei210 – 23021HelicalSequence AnalysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence AnalysisAdd
BLAST
Transmembranei285 – 30521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi318 – 3225Di-lysine motif

Domaini

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00530000063090.
HOGENOMiHOG000091197.
HOVERGENiHBG083706.
InParanoidiP78383.
KOiK15275.
OMAiANHMMLN.
OrthoDBiEOG7FV3QW.
PhylomeDBiP78383.
TreeFamiTF105967.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P78383) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSSSLVPD RLRLPLCFLG VFVCYFYYGI LQEKITRGKY GEGAKQETFT
60 70 80 90 100
FALTLVFIQC VINAVFAKIL IQFFDTARVD RTRSWLYAAC SISYLGAMVS
110 120 130 140 150
SNSALQFVNY PTQVLGKSCK PIPVMLLGVT LLKKKYPLAK YLCVLLIVAG
160 170 180 190 200
VALFMYKPKK VVGIEEHTVG YGELLLLLSL TLDGLTGVSQ DHMRAHYQTG
210 220 230 240 250
SNHMMLNINL WSTLLLGMGI LFTGELWEFL SFAERYPAII YNILLFGLTS
260 270 280 290 300
ALGQSFIFMT VVYFGPLTCS IITTTRKFFT ILASVILFAN PISPMQWVGT
310 320
VLVFLGLGLD AKFGKGAKKT SH
Length:322
Mass (Da):35,760
Last modified:May 1, 1997 - v1
Checksum:i7B5124A4DEC23598
GO
Isoform 2 (identifier: P78383-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRPLPPVGDVRLELSPPPPLLPVPVVSGSPVGSSGRLM

Note: No experimental confirmation available.Curated

Show »
Length:359
Mass (Da):39,512
Checksum:i0E54FA5289E2F4F2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601K → N in BAG57035. (PubMed:14702039)Curated
Sequence conflicti211 – 2111W → R in BAG57035. (PubMed:14702039)Curated
Isoform 2 (identifier: P78383-2)
Sequence conflicti33 – 331S → P in BAG57035. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811R → H.1 Publication
Corresponds to variant rs1135034 [ dbSNP | Ensembl ].
VAR_023778

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MRPLPPVGDVRLELSPPPPL LPVPVVSGSPVGSSGRLM in isoform 2. 1 PublicationVSP_054234

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87989 mRNA. Translation: BAA13525.1.
AK293563 mRNA. Translation: BAG57035.1.
AC015795 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94666.1.
BC011888 mRNA. Translation: AAH11888.1.
CCDSiCCDS11552.2. [P78383-2]
PIRiJC5024.
RefSeqiNP_005818.2. NM_005827.2. [P78383-2]
UniGeneiHs.154073.

Genome annotation databases

EnsembliENST00000240333; ENSP00000240333; ENSG00000121073. [P78383-2]
GeneIDi10237.
KEGGihsa:10237.
UCSCiuc002iph.1. human. [P78383-1]

Polymorphism databases

DMDMi74735602.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87989 mRNA. Translation: BAA13525.1 .
AK293563 mRNA. Translation: BAG57035.1 .
AC015795 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94666.1 .
BC011888 mRNA. Translation: AAH11888.1 .
CCDSi CCDS11552.2. [P78383-2 ]
PIRi JC5024.
RefSeqi NP_005818.2. NM_005827.2. [P78383-2 ]
UniGenei Hs.154073.

3D structure databases

ProteinModelPortali P78383.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115531. 1 interaction.
STRINGi 9606.ENSP00000240333.

Protein family/group databases

TCDBi 2.A.7.11.1. the drug/metabolite transporter (dmt) superfamily.

Polymorphism databases

DMDMi 74735602.

Proteomic databases

MaxQBi P78383.
PaxDbi P78383.
PRIDEi P78383.

Protocols and materials databases

DNASUi 10237.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000240333 ; ENSP00000240333 ; ENSG00000121073 . [P78383-2 ]
GeneIDi 10237.
KEGGi hsa:10237.
UCSCi uc002iph.1. human. [P78383-1 ]

Organism-specific databases

CTDi 10237.
GeneCardsi GC17M047779.
HGNCi HGNC:20798. SLC35B1.
MIMi 610790. gene.
neXtProti NX_P78383.
PharmGKBi PA134864001.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0697.
GeneTreei ENSGT00530000063090.
HOGENOMi HOG000091197.
HOVERGENi HBG083706.
InParanoidi P78383.
KOi K15275.
OMAi ANHMMLN.
OrthoDBi EOG7FV3QW.
PhylomeDBi P78383.
TreeFami TF105967.

Miscellaneous databases

GenomeRNAii 10237.
NextBioi 35471179.
PROi P78383.
SOURCEi Search...

Gene expression databases

Bgeei P78383.
CleanExi HS_SLC35B1.
ExpressionAtlasi P78383. baseline and differential.
Genevestigatori P78383.

Family and domain databases

InterProi IPR013657. UAA.
[Graphical view ]
Pfami PF08449. UAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family."
    Ishida N., Miura N., Yoshioka S., Kawakita M.
    J. Biochem. 120:1074-1078(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-81.
    Tissue: Skin.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS35B1_HUMAN
AccessioniPrimary (citable) accession number: P78383
Secondary accession number(s): B4DEC4, J3KQV4, Q96EW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3