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Protein

UDP-galactose translocator

Gene

SLC35A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function.

GO - Molecular functioni

GO - Biological processi

  • galactose metabolic process Source: ProtInc
  • UDP-galactose transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102100-MONOMER.
ReactomeiR-HSA-727802. Transport of nucleotide sugars.

Protein family/group databases

TCDBi2.A.7.12.6. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-galactose translocator
Alternative name(s):
Solute carrier family 35 member A2
UDP-galactose transporter
Short name:
UDP-Gal-Tr
Short name:
UGT
Gene namesi
Name:SLC35A2
Synonyms:UGALT, UGT, UGTL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:11022. SLC35A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: CACAO
  • Golgi apparatus Source: CACAO
  • Golgi membrane Source: Reactome
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital disorder of glycosylation 2M (CDG2M)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by developmental delay, hypotonia, ocular anomalies, and brain malformations. Othere more variable clinical features included seizures, hypsarrhythmia, poor feeding, microcephaly, recurrent infections, dysmorphic features, shortened limbs, and coagulation defects. Congenital disorders of glycosylation are caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins and a wide variety of clinical features. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
See also OMIM:300896
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071699213S → F in CDG2M. 1 PublicationCorresponds to variant rs587777436dbSNPEnsembl.1
Natural variantiVAR_069773331V → I in CDG2M. 1 PublicationCorresponds to variant rs587776961dbSNPEnsembl.1

Keywords - Diseasei

Congenital disorder of glycosylation, Disease mutation, Epilepsy

Organism-specific databases

DisGeNETi7355.
MalaCardsiSLC35A2.
MIMi300896. phenotype.
OpenTargetsiENSG00000102100.
Orphaneti356961. SLC35A2-CDG.
PharmGKBiPA35890.

Chemistry databases

ChEMBLiCHEMBL3430867.

Polymorphism and mutation databases

BioMutaiSLC35A2.
DMDMi2499228.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002133531 – 396UDP-galactose translocatorAdd BLAST396

Proteomic databases

MaxQBiP78381.
PaxDbiP78381.
PeptideAtlasiP78381.
PRIDEiP78381.

PTM databases

iPTMnetiP78381.
PhosphoSitePlusiP78381.

Expressioni

Gene expression databases

BgeeiENSG00000102100.
CleanExiHS_SLC35A2.
ExpressionAtlasiP78381. baseline and differential.
GenevisibleiP78381. HS.

Organism-specific databases

HPAiHPA036087.

Interactioni

Subunit structurei

Interacts with SLC35A3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC35A3Q9Y2D23EBI-8101118,EBI-3917581

Protein-protein interaction databases

BioGridi113202. 5 interactors.
IntActiP78381. 5 interactors.
STRINGi9606.ENSP00000247138.

Structurei

3D structure databases

ProteinModelPortaliP78381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2234. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000231358.
HOVERGENiHBG071267.
InParanoidiP78381.
KOiK15272.
OMAiFAKLITC.
OrthoDBiEOG091G0CHS.
PhylomeDBiP78381.
TreeFamiTF315345.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P78381-1) [UniParc]FASTAAdd to basket
Also known as: UGT2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVGAGGST AAPGPGAVSA GALEPGTASA AHRRLKYISL AVLVVQNASL
60 70 80 90 100
ILSIRYARTL PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLVLF
110 120 130 140 150
LHEAVLVQYV DTLKLAVPSL IYTLQNNLQY VAISNLPAAT FQVTYQLKIL
160 170 180 190 200
TTALFSVLML NRSLSRLQWA SLLLLFTGVA IVQAQQAGGG GPRPLDQNPG
210 220 230 240 250
AGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL FGTALGLVGL
260 270 280 290 300
WWAEGTAVAT RGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA
310 320 330 340 350
TSLSIVLSTV ASIRLFGFHV DPLFALGAGL VIGAVYLYSL PRGAAKAIAS
360 370 380 390
ASASASGPCV HQQPPGQPPP PQLSSHRGDL ITEPFLPKLL TKVKGS
Length:396
Mass (Da):41,307
Last modified:May 1, 1997 - v1
Checksum:i6EC1DC9532FE9221
GO
Isoform 2 (identifier: P78381-2) [UniParc]FASTAAdd to basket
Also known as: UGT1

The sequence of this isoform differs from the canonical sequence as follows:
     389-396: LLTKVKGS → SVLVK

Show »
Length:393
Mass (Da):41,007
Checksum:i34D31807D3805A7A
GO
Isoform 3 (identifier: P78381-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-396: VTYQLKILTT...PKLLTKVKGS → PSPRCSQSHS...FGRWSFLPGH

Show »
Length:242
Mass (Da):25,184
Checksum:i7AB122B6343CC9EC
GO
Isoform 4 (identifier: P78381-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-30: A → AELLLTWEEAEARGQGLPQPLPDTSVRIP
     389-396: LLTKVKGS → SVLVK

Note: No experimental confirmation available.
Show »
Length:421
Mass (Da):44,106
Checksum:i11D42242F410B56C
GO
Isoform 5 (identifier: P78381-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-91: Missing.
     389-396: LLTKVKGS → SVLVK

Note: No experimental confirmation available.
Show »
Length:332
Mass (Da):34,194
Checksum:i7FC8A3C442E4C31B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85L → P in BAF82973 (PubMed:14702039).Curated1
Sequence conflicti110V → A in BAG60694 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071699213S → F in CDG2M. 1 PublicationCorresponds to variant rs587777436dbSNPEnsembl.1
Natural variantiVAR_036579252W → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_069773331V → I in CDG2M. 1 PublicationCorresponds to variant rs587776961dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05433530A → AELLLTWEEAEARGQGLPQP LPDTSVRIP in isoform 4. 1 Publication1
Alternative sequenceiVSP_05519731 – 91Missing in isoform 5. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_042029143 – 396VTYQL…KVKGS → PSPRCSQSHSLCLCLRLRAL RSPAASRAATTTAAVFPPWR PHHGALSAKVSAGEVRAGSN GGTQGRGTGVEGVGHLQDPS RHPPGPGSSGFGRWSFLPGH in isoform 3. 2 PublicationsAdd BLAST254
Alternative sequenceiVSP_003728389 – 396LLTKVKGS → SVLVK in isoform 2, isoform 4 and isoform 5. 2 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88146 mRNA. Translation: BAA13545.1.
D84454 mRNA. Translation: BAA12673.1.
AB042425 Genomic DNA. Translation: BAA95614.1.
AB042425 Genomic DNA. Translation: BAA95615.1.
AK290284 mRNA. Translation: BAF82973.1.
AK292816 mRNA. Translation: BAF85505.1.
AK293415 mRNA. Translation: BAG56922.1.
AK298484 mRNA. Translation: BAG60694.1.
AF207550 Genomic DNA. No translation available.
CH471224 Genomic DNA. Translation: EAW50733.1.
CH471224 Genomic DNA. Translation: EAW50734.1.
BC035747 mRNA. Translation: AAH35747.1.
CCDSiCCDS14311.1. [P78381-1]
CCDS35247.1. [P78381-3]
CCDS43937.1. [P78381-2]
CCDS65253.1. [P78381-5]
CCDS65254.1. [P78381-4]
PIRiJC5022.
RefSeqiNP_001027460.1. NM_001032289.2. [P78381-3]
NP_001035963.1. NM_001042498.2. [P78381-2]
NP_001269576.1. NM_001282647.1.
NP_001269577.1. NM_001282648.1.
NP_001269578.1. NM_001282649.1. [P78381-5]
NP_001269579.1. NM_001282650.1.
NP_001269580.1. NM_001282651.1. [P78381-4]
NP_005651.1. NM_005660.2. [P78381-1]
UniGeneiHs.21899.

Genome annotation databases

EnsembliENST00000247138; ENSP00000247138; ENSG00000102100. [P78381-1]
ENST00000376521; ENSP00000365704; ENSG00000102100. [P78381-2]
ENST00000445167; ENSP00000402726; ENSG00000102100. [P78381-3]
ENST00000452555; ENSP00000416002; ENSG00000102100. [P78381-4]
ENST00000635285; ENSP00000489484; ENSG00000102100. [P78381-2]
ENST00000635589; ENSP00000489197; ENSG00000102100. [P78381-5]
GeneIDi7355.
KEGGihsa:7355.
UCSCiuc004dlo.3. human. [P78381-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88146 mRNA. Translation: BAA13545.1.
D84454 mRNA. Translation: BAA12673.1.
AB042425 Genomic DNA. Translation: BAA95614.1.
AB042425 Genomic DNA. Translation: BAA95615.1.
AK290284 mRNA. Translation: BAF82973.1.
AK292816 mRNA. Translation: BAF85505.1.
AK293415 mRNA. Translation: BAG56922.1.
AK298484 mRNA. Translation: BAG60694.1.
AF207550 Genomic DNA. No translation available.
CH471224 Genomic DNA. Translation: EAW50733.1.
CH471224 Genomic DNA. Translation: EAW50734.1.
BC035747 mRNA. Translation: AAH35747.1.
CCDSiCCDS14311.1. [P78381-1]
CCDS35247.1. [P78381-3]
CCDS43937.1. [P78381-2]
CCDS65253.1. [P78381-5]
CCDS65254.1. [P78381-4]
PIRiJC5022.
RefSeqiNP_001027460.1. NM_001032289.2. [P78381-3]
NP_001035963.1. NM_001042498.2. [P78381-2]
NP_001269576.1. NM_001282647.1.
NP_001269577.1. NM_001282648.1.
NP_001269578.1. NM_001282649.1. [P78381-5]
NP_001269579.1. NM_001282650.1.
NP_001269580.1. NM_001282651.1. [P78381-4]
NP_005651.1. NM_005660.2. [P78381-1]
UniGeneiHs.21899.

3D structure databases

ProteinModelPortaliP78381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113202. 5 interactors.
IntActiP78381. 5 interactors.
STRINGi9606.ENSP00000247138.

Chemistry databases

ChEMBLiCHEMBL3430867.

Protein family/group databases

TCDBi2.A.7.12.6. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiP78381.
PhosphoSitePlusiP78381.

Polymorphism and mutation databases

BioMutaiSLC35A2.
DMDMi2499228.

Proteomic databases

MaxQBiP78381.
PaxDbiP78381.
PeptideAtlasiP78381.
PRIDEiP78381.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247138; ENSP00000247138; ENSG00000102100. [P78381-1]
ENST00000376521; ENSP00000365704; ENSG00000102100. [P78381-2]
ENST00000445167; ENSP00000402726; ENSG00000102100. [P78381-3]
ENST00000452555; ENSP00000416002; ENSG00000102100. [P78381-4]
ENST00000635285; ENSP00000489484; ENSG00000102100. [P78381-2]
ENST00000635589; ENSP00000489197; ENSG00000102100. [P78381-5]
GeneIDi7355.
KEGGihsa:7355.
UCSCiuc004dlo.3. human. [P78381-1]

Organism-specific databases

CTDi7355.
DisGeNETi7355.
GeneCardsiSLC35A2.
HGNCiHGNC:11022. SLC35A2.
HPAiHPA036087.
MalaCardsiSLC35A2.
MIMi300896. phenotype.
314375. gene.
neXtProtiNX_P78381.
OpenTargetsiENSG00000102100.
Orphaneti356961. SLC35A2-CDG.
PharmGKBiPA35890.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2234. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000231358.
HOVERGENiHBG071267.
InParanoidiP78381.
KOiK15272.
OMAiFAKLITC.
OrthoDBiEOG091G0CHS.
PhylomeDBiP78381.
TreeFamiTF315345.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102100-MONOMER.
ReactomeiR-HSA-727802. Transport of nucleotide sugars.

Miscellaneous databases

ChiTaRSiSLC35A2. human.
GeneWikiiSLC35A2.
GenomeRNAii7355.
PROiP78381.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102100.
CleanExiHS_SLC35A2.
ExpressionAtlasiP78381. baseline and differential.
GenevisibleiP78381. HS.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS35A2_HUMAN
AccessioniPrimary (citable) accession number: P78381
Secondary accession number(s): A8K2L9
, A8K9V1, B4DE11, B4DPT2, E7EW45, Q8IV21, Q92553
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.