Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UDP-galactose translocator

Gene

SLC35A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function.

GO - Molecular functioni

  • sugar:proton symporter activity Source: InterPro
  • UDP-galactose transmembrane transporter activity Source: ProtInc

GO - Biological processi

  • galactose metabolic process Source: ProtInc
  • transmembrane transport Source: Reactome
  • UDP-galactose transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiREACT_22151. Transport of nucleotide sugars.

Protein family/group databases

TCDBi2.A.7.12.6. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-galactose translocator
Alternative name(s):
Solute carrier family 35 member A2
UDP-galactose transporter
Short name:
UDP-Gal-Tr
Short name:
UGT
Gene namesi
Name:SLC35A2
Synonyms:UGALT, UGT, UGTL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:11022. SLC35A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence AnalysisAdd
BLAST
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence AnalysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence AnalysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence AnalysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence AnalysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: CACAO
  • Golgi apparatus Source: CACAO
  • Golgi membrane Source: Reactome
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital disorder of glycosylation 2M (CDG2M)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by developmental delay, hypotonia, ocular anomalies, and brain malformations. Othere more variable clinical features included seizures, hypsarrhythmia, poor feeding, microcephaly, recurrent infections, dysmorphic features, shortened limbs, and coagulation defects. Congenital disorders of glycosylation are caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins and a wide variety of clinical features. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.

See also OMIM:300896
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti213 – 2131S → F in CDG2M. 1 Publication
VAR_071699
Natural varianti331 – 3311V → I in CDG2M. 1 Publication
VAR_069773

Keywords - Diseasei

Congenital disorder of glycosylation, Disease mutation, Epilepsy

Organism-specific databases

MIMi300896. phenotype.
Orphaneti356961. SLC35A2-CDG.
PharmGKBiPA35890.

Polymorphism and mutation databases

BioMutaiSLC35A2.
DMDMi2499228.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396UDP-galactose translocatorPRO_0000213353Add
BLAST

Proteomic databases

MaxQBiP78381.
PaxDbiP78381.
PRIDEiP78381.

PTM databases

PhosphoSiteiP78381.

Expressioni

Gene expression databases

BgeeiP78381.
CleanExiHS_SLC35A2.
ExpressionAtlasiP78381. baseline and differential.
GenevisibleiP78381. HS.

Organism-specific databases

HPAiHPA036087.

Interactioni

Subunit structurei

Interacts with SLC35A3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC35A3Q9Y2D23EBI-8101118,EBI-3917581

Protein-protein interaction databases

BioGridi113202. 3 interactions.
IntActiP78381. 3 interactions.
STRINGi9606.ENSP00000247138.

Structurei

3D structure databases

ProteinModelPortaliP78381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000231358.
HOVERGENiHBG071267.
InParanoidiP78381.
KOiK15272.
OMAiSGPCVHQ.
PhylomeDBiP78381.
TreeFamiTF315345.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsiTIGR00803. nst. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P78381-1) [UniParc]FASTAAdd to basket

Also known as: UGT2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVGAGGST AAPGPGAVSA GALEPGTASA AHRRLKYISL AVLVVQNASL
60 70 80 90 100
ILSIRYARTL PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLVLF
110 120 130 140 150
LHEAVLVQYV DTLKLAVPSL IYTLQNNLQY VAISNLPAAT FQVTYQLKIL
160 170 180 190 200
TTALFSVLML NRSLSRLQWA SLLLLFTGVA IVQAQQAGGG GPRPLDQNPG
210 220 230 240 250
AGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL FGTALGLVGL
260 270 280 290 300
WWAEGTAVAT RGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA
310 320 330 340 350
TSLSIVLSTV ASIRLFGFHV DPLFALGAGL VIGAVYLYSL PRGAAKAIAS
360 370 380 390
ASASASGPCV HQQPPGQPPP PQLSSHRGDL ITEPFLPKLL TKVKGS
Length:396
Mass (Da):41,307
Last modified:May 1, 1997 - v1
Checksum:i6EC1DC9532FE9221
GO
Isoform 2 (identifier: P78381-2) [UniParc]FASTAAdd to basket

Also known as: UGT1

The sequence of this isoform differs from the canonical sequence as follows:
     389-396: LLTKVKGS → SVLVK

Show »
Length:393
Mass (Da):41,007
Checksum:i34D31807D3805A7A
GO
Isoform 3 (identifier: P78381-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-396: VTYQLKILTT...PKLLTKVKGS → PSPRCSQSHS...FGRWSFLPGH

Show »
Length:242
Mass (Da):25,184
Checksum:i7AB122B6343CC9EC
GO
Isoform 4 (identifier: P78381-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-30: A → AELLLTWEEAEARGQGLPQPLPDTSVRIP
     389-396: LLTKVKGS → SVLVK

Note: No experimental confirmation available.
Show »
Length:421
Mass (Da):44,106
Checksum:i11D42242F410B56C
GO
Isoform 5 (identifier: P78381-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-91: Missing.
     389-396: LLTKVKGS → SVLVK

Note: No experimental confirmation available.
Show »
Length:332
Mass (Da):34,194
Checksum:i7FC8A3C442E4C31B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851L → P in BAF82973 (PubMed:14702039).Curated
Sequence conflicti110 – 1101V → A in BAG60694 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti213 – 2131S → F in CDG2M. 1 Publication
VAR_071699
Natural varianti252 – 2521W → C in a breast cancer sample; somatic mutation. 1 Publication
VAR_036579
Natural varianti331 – 3311V → I in CDG2M. 1 Publication
VAR_069773

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei30 – 301A → AELLLTWEEAEARGQGLPQP LPDTSVRIP in isoform 4. 1 PublicationVSP_054335
Alternative sequencei31 – 9161Missing in isoform 5. 1 PublicationVSP_055197Add
BLAST
Alternative sequencei143 – 396254VTYQL…KVKGS → PSPRCSQSHSLCLCLRLRAL RSPAASRAATTTAAVFPPWR PHHGALSAKVSAGEVRAGSN GGTQGRGTGVEGVGHLQDPS RHPPGPGSSGFGRWSFLPGH in isoform 3. 2 PublicationsVSP_042029Add
BLAST
Alternative sequencei389 – 3968LLTKVKGS → SVLVK in isoform 2, isoform 4 and isoform 5. 2 PublicationsVSP_003728

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88146 mRNA. Translation: BAA13545.1.
D84454 mRNA. Translation: BAA12673.1.
AB042425 Genomic DNA. Translation: BAA95614.1.
AB042425 Genomic DNA. Translation: BAA95615.1.
AK290284 mRNA. Translation: BAF82973.1.
AK292816 mRNA. Translation: BAF85505.1.
AK293415 mRNA. Translation: BAG56922.1.
AK298484 mRNA. Translation: BAG60694.1.
AF207550 Genomic DNA. No translation available.
CH471224 Genomic DNA. Translation: EAW50733.1.
CH471224 Genomic DNA. Translation: EAW50734.1.
BC035747 mRNA. Translation: AAH35747.1.
CCDSiCCDS14311.1. [P78381-1]
CCDS35247.1. [P78381-3]
CCDS43937.1. [P78381-2]
CCDS65253.1. [P78381-5]
CCDS65254.1. [P78381-4]
PIRiJC5022.
RefSeqiNP_001027460.1. NM_001032289.2. [P78381-3]
NP_001035963.1. NM_001042498.2. [P78381-2]
NP_001269576.1. NM_001282647.1.
NP_001269577.1. NM_001282648.1.
NP_001269578.1. NM_001282649.1. [P78381-5]
NP_001269579.1. NM_001282650.1.
NP_001269580.1. NM_001282651.1. [P78381-4]
NP_005651.1. NM_005660.2. [P78381-1]
UniGeneiHs.21899.

Genome annotation databases

EnsembliENST00000247138; ENSP00000247138; ENSG00000102100. [P78381-1]
ENST00000376521; ENSP00000365704; ENSG00000102100. [P78381-2]
ENST00000413561; ENSP00000393233; ENSG00000102100. [P78381-5]
ENST00000445167; ENSP00000402726; ENSG00000102100. [P78381-3]
ENST00000452555; ENSP00000416002; ENSG00000102100. [P78381-4]
GeneIDi7355.
KEGGihsa:7355.
UCSCiuc004dlo.1. human. [P78381-1]
uc004dlp.1. human. [P78381-2]
uc004dlq.3. human. [P78381-3]
uc011mmn.1. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88146 mRNA. Translation: BAA13545.1.
D84454 mRNA. Translation: BAA12673.1.
AB042425 Genomic DNA. Translation: BAA95614.1.
AB042425 Genomic DNA. Translation: BAA95615.1.
AK290284 mRNA. Translation: BAF82973.1.
AK292816 mRNA. Translation: BAF85505.1.
AK293415 mRNA. Translation: BAG56922.1.
AK298484 mRNA. Translation: BAG60694.1.
AF207550 Genomic DNA. No translation available.
CH471224 Genomic DNA. Translation: EAW50733.1.
CH471224 Genomic DNA. Translation: EAW50734.1.
BC035747 mRNA. Translation: AAH35747.1.
CCDSiCCDS14311.1. [P78381-1]
CCDS35247.1. [P78381-3]
CCDS43937.1. [P78381-2]
CCDS65253.1. [P78381-5]
CCDS65254.1. [P78381-4]
PIRiJC5022.
RefSeqiNP_001027460.1. NM_001032289.2. [P78381-3]
NP_001035963.1. NM_001042498.2. [P78381-2]
NP_001269576.1. NM_001282647.1.
NP_001269577.1. NM_001282648.1.
NP_001269578.1. NM_001282649.1. [P78381-5]
NP_001269579.1. NM_001282650.1.
NP_001269580.1. NM_001282651.1. [P78381-4]
NP_005651.1. NM_005660.2. [P78381-1]
UniGeneiHs.21899.

3D structure databases

ProteinModelPortaliP78381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113202. 3 interactions.
IntActiP78381. 3 interactions.
STRINGi9606.ENSP00000247138.

Protein family/group databases

TCDBi2.A.7.12.6. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteiP78381.

Polymorphism and mutation databases

BioMutaiSLC35A2.
DMDMi2499228.

Proteomic databases

MaxQBiP78381.
PaxDbiP78381.
PRIDEiP78381.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247138; ENSP00000247138; ENSG00000102100. [P78381-1]
ENST00000376521; ENSP00000365704; ENSG00000102100. [P78381-2]
ENST00000413561; ENSP00000393233; ENSG00000102100. [P78381-5]
ENST00000445167; ENSP00000402726; ENSG00000102100. [P78381-3]
ENST00000452555; ENSP00000416002; ENSG00000102100. [P78381-4]
GeneIDi7355.
KEGGihsa:7355.
UCSCiuc004dlo.1. human. [P78381-1]
uc004dlp.1. human. [P78381-2]
uc004dlq.3. human. [P78381-3]
uc011mmn.1. human.

Organism-specific databases

CTDi7355.
GeneCardsiGC0XM048760.
HGNCiHGNC:11022. SLC35A2.
HPAiHPA036087.
MIMi300896. phenotype.
314375. gene.
neXtProtiNX_P78381.
Orphaneti356961. SLC35A2-CDG.
PharmGKBiPA35890.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000231358.
HOVERGENiHBG071267.
InParanoidiP78381.
KOiK15272.
OMAiSGPCVHQ.
PhylomeDBiP78381.
TreeFamiTF315345.

Enzyme and pathway databases

ReactomeiREACT_22151. Transport of nucleotide sugars.

Miscellaneous databases

ChiTaRSiSLC35A2. human.
GeneWikiiSLC35A2.
GenomeRNAii7355.
NextBioi28796.
PROiP78381.
SOURCEiSearch...

Gene expression databases

BgeeiP78381.
CleanExiHS_SLC35A2.
ExpressionAtlasiP78381. baseline and differential.
GenevisibleiP78381. HS.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsiTIGR00803. nst. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator."
    Miura N., Ishida N., Hoshino M., Yamauchi M., Hara T., Ayusawa D., Kawakita M.
    J. Biochem. 120:236-241(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family."
    Ishida N., Miura N., Yoshioka S., Kawakita M.
    J. Biochem. 120:1074-1078(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Fibroblast.
  3. "The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus."
    Hara T., Yamauchi M., Takahashi E., Hoshino M., Aoki K., Ayusawa D., Kawakita M.
    Somat. Cell Mol. Genet. 19:571-575(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Genomic organization of the human UDP-galactose transporter gene."
    Ishida N., Miura N., Yamauchi M., Kawakita M.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4 AND 5).
    Tissue: Colon, Lymphoblast and Trachea.
  6. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Pancreas.
  9. "UDP-N-acetylglucosamine transporter and UDP-galactose transporter form heterologous complexes in the Golgi membrane."
    Maszczak-Seneczko D., Sosicka P., Majkowski M., Olczak T., Olczak M.
    FEBS Lett. 586:4082-4087(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SLC35A3.
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-252.
  11. Cited for: VARIANT CDG2M ILE-331.
  12. Cited for: INVOLVEMENT IN CDG2M, VARIANT CDG2M PHE-213.

Entry informationi

Entry nameiS35A2_HUMAN
AccessioniPrimary (citable) accession number: P78381
Secondary accession number(s): A8K2L9
, A8K9V1, B4DE11, B4DPT2, E7EW45, Q8IV21, Q92553
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 24, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.