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Protein

T-complex protein 1 subunit beta

Gene

CCT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.1 Publication

Caution

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein binding involved in protein folding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
  • unfolded protein binding Source: GO_Central

GO - Biological processi

  • binding of sperm to zona pellucida Source: Ensembl
  • chaperone-mediated protein complex assembly Source: MGI
  • chaperone mediated protein folding independent of cofactor Source: BHF-UCL
  • neutrophil degranulation Source: Reactome
  • positive regulation of establishment of protein localization to telomere Source: BHF-UCL
  • positive regulation of protein localization to Cajal body Source: BHF-UCL
  • positive regulation of telomerase activity Source: BHF-UCL
  • positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
  • positive regulation of telomere maintenance via telomerase Source: BHF-UCL
  • protein folding Source: Reactome
  • protein stabilization Source: BHF-UCL
  • scaRNA localization to Cajal body Source: BHF-UCL
  • toxin transport Source: Ensembl

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450 Folding of actin by CCT/TriC
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
R-HSA-6798695 Neutrophil degranulation
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
SIGNORiP78371

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit beta
Short name:
TCP-1-beta
Alternative name(s):
CCT-beta
Gene namesi
Name:CCT2
Synonyms:99D8.1, CCTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000166226.12
HGNCiHGNC:1615 CCT2
MIMi605139 gene
neXtProtiNX_P78371

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10576
OpenTargetsiENSG00000166226
PharmGKBiPA26179

Polymorphism and mutation databases

BioMutaiCCT2
DMDMi6094436

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00001283162 – 535T-complex protein 1 subunit betaAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei3PhosphoserineCombined sources1
Modified residuei13N6-acetyllysineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei154N6-acetyllysineCombined sources1
Modified residuei181N6-acetyllysineCombined sources1
Cross-linki248Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei260PhosphoserineCombined sources1
Modified residuei261PhosphothreonineCombined sources1
Isoform 2 (identifier: P78371-2)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP78371
PaxDbiP78371
PeptideAtlasiP78371
PRIDEiP78371
TopDownProteomicsiP78371-1 [P78371-1]

2D gel databases

OGPiP78371
REPRODUCTION-2DPAGEiIPI00297779
SWISS-2DPAGEiP78371
UCD-2DPAGEiP78371

PTM databases

iPTMnetiP78371
PhosphoSitePlusiP78371
SwissPalmiP78371

Expressioni

Gene expression databases

BgeeiENSG00000166226
CleanExiHS_CCT2
ExpressionAtlasiP78371 baseline and differential
GenevisibleiP78371 HS

Organism-specific databases

HPAiHPA003197
HPA003198

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with FLCN (PubMed:27353360).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein binding involved in protein folding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
  • unfolded protein binding Source: GO_Central

Protein-protein interaction databases

BioGridi115827334 interactors.
CORUMiP78371
DIPiDIP-38123N
IntActiP78371 132 interactors.
MINTiP78371
STRINGi9606.ENSP00000299300

Structurei

3D structure databases

ProteinModelPortaliP78371
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0363 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074930
HOGENOMiHOG000226736
HOVERGENiHBG001052
InParanoidiP78371
KOiK09494
OMAiPGVHQPQ
OrthoDBiEOG091G07BP
PhylomeDBiP78371
TreeFamiTF105645

Family and domain databases

CDDicd03336 TCP1_beta, 1 hit
Gene3Di1.10.560.102 hits
3.30.260.102 hits
3.50.7.101 hit
InterProiView protein in InterPro
IPR012716 Chap_CCT_beta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353 PTHR11353, 1 hit
PTHR11353:SF23 PTHR11353:SF23, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02341 chap_CCT_beta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P78371-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLSLAPVN IFKAGADEER AETARLTSFI GAIAIGDLVK STLGPKGMDK
60 70 80 90 100
ILLSSGRDAS LMVTNDGATI LKNIGVDNPA AKVLVDMSRV QDDEVGDGTT
110 120 130 140 150
SVTVLAAELL REAESLIAKK IHPQTIIAGW REATKAAREA LLSSAVDHGS
160 170 180 190 200
DEVKFRQDLM NIAGTTLSSK LLTHHKDHFT KLAVEAVLRL KGSGNLEAIH
210 220 230 240 250
IIKKLGGSLA DSYLDEGFLL DKKIGVNQPK RIENAKILIA NTGMDTDKIK
260 270 280 290 300
IFGSRVRVDS TAKVAEIEHA EKEKMKEKVE RILKHGINCF INRQLIYNYP
310 320 330 340 350
EQLFGAAGVM AIEHADFAGV ERLALVTGGE IASTFDHPEL VKLGSCKLIE
360 370 380 390 400
EVMIGEDKLI HFSGVALGEA CTIVLRGATQ QILDEAERSL HDALCVLAQT
410 420 430 440 450
VKDSRTVYGG GCSEMLMAHA VTQLANRTPG KEAVAMESYA KALRMLPTII
460 470 480 490 500
ADNAGYDSAD LVAQLRAAHS EGNTTAGLDM REGTIGDMAI LGITESFQVK
510 520 530
RQVLLSAAEA AEVILRVDNI IKAAPRKRVP DHHPC
Length:535
Mass (Da):57,488
Last modified:January 23, 2007 - v4
Checksum:i57F9E1720D84A31F
GO
Isoform 2 (identifier: P78371-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:488
Mass (Da):52,718
Checksum:i5947D87827A365E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51I → T in BAH11729 (PubMed:14702039).Curated1
Sequence conflicti126I → T in CAG33352 (Ref. 5) Curated1
Sequence conflicti354I → T in BAF83456 (PubMed:14702039).Curated1
Sequence conflicti438S → P in BAH13640 (PubMed:14702039).Curated1
Sequence conflicti444R → K in BAG70037 (PubMed:19054851).Curated1
Sequence conflicti444R → K in BAG70160 (PubMed:19054851).Curated1
Sequence conflicti504L → P in CAG33352 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0426481 – 47Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026293 mRNA Translation: AAC96012.1
AF026166 mRNA Translation: AAC98906.1
BT019966 mRNA Translation: AAV38769.1
AK290767 mRNA Translation: BAF83456.1
AK294307 mRNA Translation: BAH11729.1
AK302157 mRNA Translation: BAH13640.1
AK316397 mRNA Translation: BAH14768.1
AK316408 mRNA Translation: BAH14779.1
CR457071 mRNA Translation: CAG33352.1
AB451223 mRNA Translation: BAG70037.1
AB451346 mRNA Translation: BAG70160.1
AC018921 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97230.1
BC113514 mRNA Translation: AAI13515.1
BC113516 mRNA Translation: AAI13517.1
U91327 Genomic DNA Translation: AAB67249.1
CCDSiCCDS55843.1 [P78371-2]
CCDS8991.1 [P78371-1]
RefSeqiNP_001185771.1, NM_001198842.1 [P78371-2]
NP_006422.1, NM_006431.2 [P78371-1]
UniGeneiHs.189772

Genome annotation databases

EnsembliENST00000299300; ENSP00000299300; ENSG00000166226 [P78371-1]
ENST00000543146; ENSP00000445471; ENSG00000166226 [P78371-2]
GeneIDi10576
KEGGihsa:10576
UCSCiuc010stl.2 human [P78371-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTCPB_HUMAN
AccessioniPrimary (citable) accession number: P78371
Secondary accession number(s): A8K402
, B5BTY7, B7Z243, B7Z7K4, B7ZAT2, Q14D36, Q6IAT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 179 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome