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P78369

- CLD10_HUMAN

UniProt

P78369 - CLD10_HUMAN

Protein

Claudin-10

Gene

CLDN10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. May form permselective paracellular pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. Plays a key role in controlling cation selectivity and transport in the thick ascending limb (TAL) of Henle's loop in kidney.1 Publication

    GO - Molecular functioni

    1. identical protein binding Source: UniProtKB
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. calcium-independent cell-cell adhesion Source: UniProtKB
    2. cell adhesion Source: ProtInc
    3. ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_19373. Tight junction interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Claudin-10
    Alternative name(s):
    OSP-like protein
    Gene namesi
    Name:CLDN10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:2033. CLDN10.

    Subcellular locationi

    Cell junctiontight junction 1 Publication. Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26558.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 228228Claudin-10PRO_0000144757Add
    BLAST

    Proteomic databases

    PaxDbiP78369.
    PRIDEiP78369.

    PTM databases

    PhosphoSiteiP78369.

    Expressioni

    Gene expression databases

    ArrayExpressiP78369.
    BgeeiP78369.
    CleanExiHS_CLDN10.
    GenevestigatoriP78369.

    Organism-specific databases

    HPAiCAB012969.

    Interactioni

    Protein-protein interaction databases

    BioGridi114529. 2 interactions.
    STRINGi9606.ENSP00000299339.

    Structurei

    3D structure databases

    ProteinModelPortaliP78369.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 8059ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini102 – 11514CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini137 – 16024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini182 – 22847CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    The fourth transmembrane region (161-181) is necessary for integration into tight junctions.By similarity

    Sequence similaritiesi

    Belongs to the claudin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42372.
    HOGENOMiHOG000220937.
    HOVERGENiHBG000643.
    InParanoidiP78369.
    KOiK06087.
    OMAiPRMGYAY.
    OrthoDBiEOG76HQ2T.
    PhylomeDBiP78369.
    TreeFamiTF331936.

    Family and domain databases

    InterProiIPR006187. Claudin.
    IPR003554. Claudin10.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PANTHERiPTHR12002. PTHR12002. 1 hit.
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01077. CLAUDIN.
    PR01383. CLAUDIN10.
    PROSITEiPS01346. CLAUDIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P78369-1) [UniParc]FASTAAdd to Basket

    Also known as: Cldn10b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASTASEIIA FMVSISGWVL VSSTLPTDYW KVSTIDGTVI TTATYWANLW    50
    KACVTDSTGV SNCKDFPSML ALDGYIQACR GLMIAAVSLG FFGSIFALFG 100
    MKCTKVGGSD KAKAKIACLA GIVFILSGLC SMTGCSLYAN KITTEFFDPL 150
    FVEQKYELGA ALFIGWAGAS LCIIGGVIFC FSISDNNKTP RYTYNGATSV 200
    MSSRTKYHGG EDFKTTNPSK QFDKNAYV 228
    Length:228
    Mass (Da):24,488
    Last modified:August 1, 1998 - v2
    Checksum:i11E66F9F10BCC87B
    GO
    Isoform 2 (identifier: P78369-2) [UniParc]FASTAAdd to Basket

    Also known as: Cldn10a

    The sequence of this isoform differs from the canonical sequence as follows:
         1-73: MASTASEIIA...KDFPSMLALD → MSRAQIWALV...RPHFTIFKVA

    Show »
    Length:226
    Mass (Da):24,251
    Checksum:iC0AE190D115A1E01
    GO
    Isoform 3 (identifier: P78369-3) [UniParc]FASTAAdd to Basket

    Also known as: Cldn10a_i1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-73: MASTASEIIA...KDFPSMLALD → MSRAQIWALV...VYQGLWMNCA

    Note: Produced by alternative splicing of isoform 2.

    Show »
    Length:207
    Mass (Da):22,167
    Checksum:i86D1BC78F6515B29
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7373MASTA…MLALD → MSRAQIWALVSGVGGFGALV AATTSNEWKVTTRASSVITA TWVYQGLWMNCAGNALGSFH CRPHFTIFKVA in isoform 2. 2 PublicationsVSP_042898Add
    BLAST
    Alternative sequencei1 – 7373MASTA…MLALD → MSRAQIWALVSGVGGFGALV AATTSNEWKVTTRASSVITA TWVYQGLWMNCA in isoform 3. 1 PublicationVSP_053550Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89916 mRNA. Translation: AAC79506.1.
    AK055855 mRNA. Translation: BAB71030.1.
    AK315737 mRNA. Translation: BAG38092.1.
    CR456845 mRNA. Translation: CAG33126.1.
    AL139376, AL357061 Genomic DNA. Translation: CAH71596.1.
    AL357061, AL139376 Genomic DNA. Translation: CAI16403.1.
    AL627382 Genomic DNA. No translation available.
    CH471085 Genomic DNA. Translation: EAX08955.1.
    BC010920 mRNA. Translation: AAH10920.1.
    CCDSiCCDS9475.1. [P78369-2]
    CCDS9476.1. [P78369-1]
    RefSeqiNP_001153572.1. NM_001160100.1. [P78369-3]
    NP_008915.1. NM_006984.4. [P78369-1]
    NP_878268.1. NM_182848.3. [P78369-2]
    UniGeneiHs.534377.

    Genome annotation databases

    EnsembliENST00000299339; ENSP00000299339; ENSG00000134873. [P78369-1]
    ENST00000376873; ENSP00000366069; ENSG00000134873. [P78369-2]
    GeneIDi9071.
    KEGGihsa:9071.
    UCSCiuc001vmg.2. human. [P78369-2]
    uc001vmh.2. human. [P78369-1]

    Polymorphism databases

    DMDMi6685311.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89916 mRNA. Translation: AAC79506.1 .
    AK055855 mRNA. Translation: BAB71030.1 .
    AK315737 mRNA. Translation: BAG38092.1 .
    CR456845 mRNA. Translation: CAG33126.1 .
    AL139376 , AL357061 Genomic DNA. Translation: CAH71596.1 .
    AL357061 , AL139376 Genomic DNA. Translation: CAI16403.1 .
    AL627382 Genomic DNA. No translation available.
    CH471085 Genomic DNA. Translation: EAX08955.1 .
    BC010920 mRNA. Translation: AAH10920.1 .
    CCDSi CCDS9475.1. [P78369-2 ]
    CCDS9476.1. [P78369-1 ]
    RefSeqi NP_001153572.1. NM_001160100.1. [P78369-3 ]
    NP_008915.1. NM_006984.4. [P78369-1 ]
    NP_878268.1. NM_182848.3. [P78369-2 ]
    UniGenei Hs.534377.

    3D structure databases

    ProteinModelPortali P78369.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114529. 2 interactions.
    STRINGi 9606.ENSP00000299339.

    PTM databases

    PhosphoSitei P78369.

    Polymorphism databases

    DMDMi 6685311.

    Proteomic databases

    PaxDbi P78369.
    PRIDEi P78369.

    Protocols and materials databases

    DNASUi 9071.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299339 ; ENSP00000299339 ; ENSG00000134873 . [P78369-1 ]
    ENST00000376873 ; ENSP00000366069 ; ENSG00000134873 . [P78369-2 ]
    GeneIDi 9071.
    KEGGi hsa:9071.
    UCSCi uc001vmg.2. human. [P78369-2 ]
    uc001vmh.2. human. [P78369-1 ]

    Organism-specific databases

    CTDi 9071.
    GeneCardsi GC13P096085.
    HGNCi HGNC:2033. CLDN10.
    HPAi CAB012969.
    neXtProti NX_P78369.
    PharmGKBi PA26558.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42372.
    HOGENOMi HOG000220937.
    HOVERGENi HBG000643.
    InParanoidi P78369.
    KOi K06087.
    OMAi PRMGYAY.
    OrthoDBi EOG76HQ2T.
    PhylomeDBi P78369.
    TreeFami TF331936.

    Enzyme and pathway databases

    Reactomei REACT_19373. Tight junction interactions.

    Miscellaneous databases

    ChiTaRSi CLDN10. human.
    GeneWikii CLDN10.
    GenomeRNAii 9071.
    NextBioi 33991.
    PROi P78369.

    Gene expression databases

    ArrayExpressi P78369.
    Bgeei P78369.
    CleanExi HS_CLDN10.
    Genevestigatori P78369.

    Family and domain databases

    InterProi IPR006187. Claudin.
    IPR003554. Claudin10.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    PANTHERi PTHR12002. PTHR12002. 1 hit.
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01077. CLAUDIN.
    PR01383. CLAUDIN10.
    PROSITEi PS01346. CLAUDIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function."
      Gunzel D., Stuiver M., Kausalya P.J., Haisch L., Krug S.M., Rosenthal R., Meij I.C., Hunziker W., Fromm M., Muller D.
      J. Cell Sci. 122:1507-1517(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
      Tissue: Kidney.
    2. Keen T.J.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Kidney.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiCLD10_HUMAN
    AccessioniPrimary (citable) accession number: P78369
    Secondary accession number(s): Q6IBF9, Q96N78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3