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P78369 (CLD10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Claudin-10
Alternative name(s):
OSP-like protein
Gene names
Name:CLDN10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. May form permselective paracellular pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. Plays a key role in controlling cation selectivity and transport in the thick ascending limb (TAL) of Henle's loop in kidney. Ref.1

Subcellular location

Cell junctiontight junction. Cell membrane; Multi-pass membrane protein Ref.1.

Domain

The fourth transmembrane region (161-181) is necessary for integration into tight junctions By similarity.

Sequence similarities

Belongs to the claudin family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P78369-1)

Also known as: Cldn10b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P78369-2)

Also known as: Cldn10a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MASTASEIIA...KDFPSMLALD → MSRAQIWALV...RPHFTIFKVA
Isoform 3 (identifier: P78369-3)

Also known as: Cldn10a_i1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MASTASEIIA...KDFPSMLALD → MSRAQIWALV...VYQGLWMNCA
Note: Produced by alternative splicing of isoform 2.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 228228Claudin-10
PRO_0000144757

Regions

Transmembrane1 – 2121Helical; Potential
Topological domain22 – 8059Extracellular Potential
Transmembrane81 – 10121Helical; Potential
Topological domain102 – 11514Cytoplasmic Potential
Transmembrane116 – 13621Helical; Potential
Topological domain137 – 16024Extracellular Potential
Transmembrane161 – 18121Helical; Potential
Topological domain182 – 22847Cytoplasmic Potential

Natural variations

Alternative sequence1 – 7373MASTA…MLALD → MSRAQIWALVSGVGGFGALV AATTSNEWKVTTRASSVITA TWVYQGLWMNCAGNALGSFH CRPHFTIFKVA in isoform 2.
VSP_042898
Alternative sequence1 – 7373MASTA…MLALD → MSRAQIWALVSGVGGFGALV AATTSNEWKVTTRASSVITA TWVYQGLWMNCA in isoform 3.
VSP_053550

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Cldn10b) [UniParc].

Last modified August 1, 1998. Version 2.
Checksum: 11E66F9F10BCC87B

FASTA22824,488
        10         20         30         40         50         60 
MASTASEIIA FMVSISGWVL VSSTLPTDYW KVSTIDGTVI TTATYWANLW KACVTDSTGV 

        70         80         90        100        110        120 
SNCKDFPSML ALDGYIQACR GLMIAAVSLG FFGSIFALFG MKCTKVGGSD KAKAKIACLA 

       130        140        150        160        170        180 
GIVFILSGLC SMTGCSLYAN KITTEFFDPL FVEQKYELGA ALFIGWAGAS LCIIGGVIFC 

       190        200        210        220 
FSISDNNKTP RYTYNGATSV MSSRTKYHGG EDFKTTNPSK QFDKNAYV 

« Hide

Isoform 2 (Cldn10a) [UniParc].

Checksum: C0AE190D115A1E01
Show »

FASTA22624,251
Isoform 3 (Cldn10a_i1) [UniParc].

Checksum: 86D1BC78F6515B29
Show »

FASTA20722,167

References

« Hide 'large scale' references
[1]"Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function."
Gunzel D., Stuiver M., Kausalya P.J., Haisch L., Krug S.M., Rosenthal R., Meij I.C., Hunziker W., Fromm M., Muller D.
J. Cell Sci. 122:1507-1517(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
Tissue: Kidney.
[2]Keen T.J.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Liver.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Kidney.
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skeletal muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U89916 mRNA. Translation: AAC79506.1.
AK055855 mRNA. Translation: BAB71030.1.
AK315737 mRNA. Translation: BAG38092.1.
CR456845 mRNA. Translation: CAG33126.1.
AL139376, AL357061 Genomic DNA. Translation: CAH71596.1.
AL357061, AL139376 Genomic DNA. Translation: CAI16403.1.
AL627382 Genomic DNA. No translation available.
CH471085 Genomic DNA. Translation: EAX08955.1.
BC010920 mRNA. Translation: AAH10920.1.
CCDSCCDS9475.1. [P78369-2]
CCDS9476.1. [P78369-1]
RefSeqNP_001153572.1. NM_001160100.1. [P78369-3]
NP_008915.1. NM_006984.4. [P78369-1]
NP_878268.1. NM_182848.3. [P78369-2]
UniGeneHs.534377.

3D structure databases

ProteinModelPortalP78369.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114529. 2 interactions.
STRING9606.ENSP00000299339.

PTM databases

PhosphoSiteP78369.

Polymorphism databases

DMDM6685311.

Proteomic databases

PaxDbP78369.
PRIDEP78369.

Protocols and materials databases

DNASU9071.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000299339; ENSP00000299339; ENSG00000134873. [P78369-1]
ENST00000376873; ENSP00000366069; ENSG00000134873. [P78369-2]
GeneID9071.
KEGGhsa:9071.
UCSCuc001vmg.2. human. [P78369-2]
uc001vmh.2. human. [P78369-1]

Organism-specific databases

CTD9071.
GeneCardsGC13P096085.
HGNCHGNC:2033. CLDN10.
HPACAB012969.
neXtProtNX_P78369.
PharmGKBPA26558.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42372.
HOGENOMHOG000220937.
HOVERGENHBG000643.
InParanoidP78369.
KOK06087.
OMAPRMGYAY.
OrthoDBEOG76HQ2T.
PhylomeDBP78369.
TreeFamTF331936.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpressP78369.
BgeeP78369.
CleanExHS_CLDN10.
GenevestigatorP78369.

Family and domain databases

InterProIPR006187. Claudin.
IPR003554. Claudin10.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERPTHR12002. PTHR12002. 1 hit.
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01077. CLAUDIN.
PR01383. CLAUDIN10.
PROSITEPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCLDN10. human.
GeneWikiCLDN10.
GenomeRNAi9071.
NextBio33991.
PROP78369.

Entry information

Entry nameCLD10_HUMAN
AccessionPrimary (citable) accession number: P78369
Secondary accession number(s): Q6IBF9, Q96N78
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM