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Protein

Claudin-10

Gene

CLDN10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. May form permselective paracellular pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. Plays a key role in controlling cation selectivity and transport in the thick ascending limb (TAL) of Henle's loop in kidney.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-10
Alternative name(s):
OSP-like protein
Gene namesi
Name:CLDN10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:2033. CLDN10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence AnalysisAdd
BLAST
Topological domaini22 – 8059ExtracellularSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Topological domaini102 – 11514CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence AnalysisAdd
BLAST
Topological domaini137 – 16024ExtracellularSequence AnalysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence AnalysisAdd
BLAST
Topological domaini182 – 22847CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26558.

Polymorphism and mutation databases

BioMutaiCLDN10.
DMDMi6685311.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Claudin-10PRO_0000144757Add
BLAST

Proteomic databases

PaxDbiP78369.
PRIDEiP78369.

PTM databases

PhosphoSiteiP78369.

Expressioni

Gene expression databases

BgeeiP78369.
CleanExiHS_CLDN10.
ExpressionAtlasiP78369. baseline and differential.
GenevisibleiP78369. HS.

Organism-specific databases

HPAiCAB012969.
HPA042348.

Interactioni

Protein-protein interaction databases

BioGridi114529. 4 interactions.
STRINGi9606.ENSP00000299339.

Structurei

3D structure databases

ProteinModelPortaliP78369.
SMRiP78369. Positions 3-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The fourth transmembrane region (161-181) is necessary for integration into tight junctions.By similarity

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42372.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiP78369.
KOiK06087.
OMAiTTATYWS.
OrthoDBiEOG76HQ2T.
PhylomeDBiP78369.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003554. Claudin10.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01383. CLAUDIN10.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P78369-1) [UniParc]FASTAAdd to basket

Also known as: Cldn10b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTASEIIA FMVSISGWVL VSSTLPTDYW KVSTIDGTVI TTATYWANLW
60 70 80 90 100
KACVTDSTGV SNCKDFPSML ALDGYIQACR GLMIAAVSLG FFGSIFALFG
110 120 130 140 150
MKCTKVGGSD KAKAKIACLA GIVFILSGLC SMTGCSLYAN KITTEFFDPL
160 170 180 190 200
FVEQKYELGA ALFIGWAGAS LCIIGGVIFC FSISDNNKTP RYTYNGATSV
210 220
MSSRTKYHGG EDFKTTNPSK QFDKNAYV
Length:228
Mass (Da):24,488
Last modified:August 1, 1998 - v2
Checksum:i11E66F9F10BCC87B
GO
Isoform 2 (identifier: P78369-2) [UniParc]FASTAAdd to basket

Also known as: Cldn10a

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MASTASEIIA...KDFPSMLALD → MSRAQIWALV...RPHFTIFKVA

Show »
Length:226
Mass (Da):24,251
Checksum:iC0AE190D115A1E01
GO
Isoform 3 (identifier: P78369-3) [UniParc]FASTAAdd to basket

Also known as: Cldn10a_i1

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MASTASEIIA...KDFPSMLALD → MSRAQIWALV...VYQGLWMNCA

Note: Produced by alternative splicing of isoform 2.
Show »
Length:207
Mass (Da):22,167
Checksum:i86D1BC78F6515B29
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7373MASTA…MLALD → MSRAQIWALVSGVGGFGALV AATTSNEWKVTTRASSVITA TWVYQGLWMNCAGNALGSFH CRPHFTIFKVA in isoform 2. 2 PublicationsVSP_042898Add
BLAST
Alternative sequencei1 – 7373MASTA…MLALD → MSRAQIWALVSGVGGFGALV AATTSNEWKVTTRASSVITA TWVYQGLWMNCA in isoform 3. 1 PublicationVSP_053550Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89916 mRNA. Translation: AAC79506.1.
AK055855 mRNA. Translation: BAB71030.1.
AK315737 mRNA. Translation: BAG38092.1.
CR456845 mRNA. Translation: CAG33126.1.
AL139376, AL357061 Genomic DNA. Translation: CAH71596.1.
AL357061, AL139376 Genomic DNA. Translation: CAI16403.1.
AL627382 Genomic DNA. No translation available.
CH471085 Genomic DNA. Translation: EAX08955.1.
BC010920 mRNA. Translation: AAH10920.1.
CCDSiCCDS9475.1. [P78369-2]
CCDS9476.1. [P78369-1]
RefSeqiNP_001153572.1. NM_001160100.1. [P78369-3]
NP_008915.1. NM_006984.4. [P78369-1]
NP_878268.1. NM_182848.3. [P78369-2]
UniGeneiHs.534377.

Genome annotation databases

EnsembliENST00000299339; ENSP00000299339; ENSG00000134873. [P78369-1]
ENST00000376873; ENSP00000366069; ENSG00000134873. [P78369-2]
GeneIDi9071.
KEGGihsa:9071.
UCSCiuc001vmg.2. human. [P78369-2]
uc001vmh.2. human. [P78369-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89916 mRNA. Translation: AAC79506.1.
AK055855 mRNA. Translation: BAB71030.1.
AK315737 mRNA. Translation: BAG38092.1.
CR456845 mRNA. Translation: CAG33126.1.
AL139376, AL357061 Genomic DNA. Translation: CAH71596.1.
AL357061, AL139376 Genomic DNA. Translation: CAI16403.1.
AL627382 Genomic DNA. No translation available.
CH471085 Genomic DNA. Translation: EAX08955.1.
BC010920 mRNA. Translation: AAH10920.1.
CCDSiCCDS9475.1. [P78369-2]
CCDS9476.1. [P78369-1]
RefSeqiNP_001153572.1. NM_001160100.1. [P78369-3]
NP_008915.1. NM_006984.4. [P78369-1]
NP_878268.1. NM_182848.3. [P78369-2]
UniGeneiHs.534377.

3D structure databases

ProteinModelPortaliP78369.
SMRiP78369. Positions 3-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114529. 4 interactions.
STRINGi9606.ENSP00000299339.

PTM databases

PhosphoSiteiP78369.

Polymorphism and mutation databases

BioMutaiCLDN10.
DMDMi6685311.

Proteomic databases

PaxDbiP78369.
PRIDEiP78369.

Protocols and materials databases

DNASUi9071.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299339; ENSP00000299339; ENSG00000134873. [P78369-1]
ENST00000376873; ENSP00000366069; ENSG00000134873. [P78369-2]
GeneIDi9071.
KEGGihsa:9071.
UCSCiuc001vmg.2. human. [P78369-2]
uc001vmh.2. human. [P78369-1]

Organism-specific databases

CTDi9071.
GeneCardsiGC13P096085.
HGNCiHGNC:2033. CLDN10.
HPAiCAB012969.
HPA042348.
neXtProtiNX_P78369.
PharmGKBiPA26558.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42372.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiP78369.
KOiK06087.
OMAiTTATYWS.
OrthoDBiEOG76HQ2T.
PhylomeDBiP78369.
TreeFamiTF331936.

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Miscellaneous databases

ChiTaRSiCLDN10. human.
GeneWikiiCLDN10.
GenomeRNAii9071.
NextBioi33991.
PROiP78369.

Gene expression databases

BgeeiP78369.
CleanExiHS_CLDN10.
ExpressionAtlasiP78369. baseline and differential.
GenevisibleiP78369. HS.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003554. Claudin10.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01383. CLAUDIN10.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function."
    Gunzel D., Stuiver M., Kausalya P.J., Haisch L., Krug S.M., Rosenthal R., Meij I.C., Hunziker W., Fromm M., Muller D.
    J. Cell Sci. 122:1507-1517(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
    Tissue: Kidney.
  2. Keen T.J.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiCLD10_HUMAN
AccessioniPrimary (citable) accession number: P78369
Secondary accession number(s): Q6IBF9, Q96N78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: June 24, 2015
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.