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Protein

Casein kinase I isoform gamma-2

Gene

CSNK1G2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.5 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Stimulated by estrogen. Repressed by 5-iodotubercidin (DB04604).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei75ATPPROSITE-ProRule annotation1
Active sitei165Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi52 – 60ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • endocytosis Source: GO_Central
  • peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
  • protein autophosphorylation Source: Ensembl
  • protein phosphorylation Source: ProtInc
  • regulation of cell shape Source: GO_Central
  • signal transduction Source: ProtInc
  • sphingolipid biosynthetic process Source: Reactome
  • Wnt signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS05754-MONOMER.
BRENDAi2.7.11.1. 2681.
ReactomeiR-HSA-1660661. Sphingolipid de novo biosynthesis.
R-HSA-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.
SignaLinkiP78368.
SIGNORiP78368.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform gamma-2 (EC:2.7.11.1)
Short name:
CKI-gamma 2
Gene namesi
Name:CSNK1G2
Synonyms:CK1G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:2455. CSNK1G2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: Reactome
  • membrane Source: UniProtKB
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi1455.
OpenTargetsiENSG00000133275.
PharmGKBiPA26955.

Chemistry databases

ChEMBLiCHEMBL2543.
GuidetoPHARMACOLOGYi2000.

Polymorphism and mutation databases

BioMutaiCSNK1G2.
DMDMi3024060.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928421 – 415Casein kinase I isoform gamma-2Add BLAST415

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP78368.
MaxQBiP78368.
PaxDbiP78368.
PeptideAtlasiP78368.
PRIDEiP78368.

PTM databases

iPTMnetiP78368.
PhosphoSitePlusiP78368.
SwissPalmiP78368.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSG00000133275.
CleanExiHS_CSNK1G2.
ExpressionAtlasiP78368. baseline and differential.
GenevisibleiP78368. HS.

Organism-specific databases

HPAiHPA034868.
HPA056572.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with MTA1 (short isoform) in the cytoplasm. Interacts with SMAD3.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-748380,EBI-743771
COL4A3BPQ9Y5P44EBI-748380,EBI-739994
KRTAP10-7P604093EBI-748380,EBI-10172290

Protein-protein interaction databases

BioGridi107839. 30 interactors.
IntActiP78368. 12 interactors.
MINTiMINT-1473562.
STRINGi9606.ENSP00000255641.

Chemistry databases

BindingDBiP78368.

Structurei

Secondary structure

1415
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi46 – 51Combined sources6
Beta strandi60 – 65Combined sources6
Turni66 – 68Combined sources3
Beta strandi71 – 78Combined sources8
Helixi86 – 95Combined sources10
Turni96 – 98Combined sources3
Beta strandi105 – 111Combined sources7
Beta strandi114 – 120Combined sources7
Helixi126 – 132Combined sources7
Turni133 – 135Combined sources3
Helixi139 – 158Combined sources20
Helixi168 – 170Combined sources3
Beta strandi171 – 173Combined sources3
Turni179 – 182Combined sources4
Beta strandi183 – 186Combined sources4
Beta strandi193 – 196Combined sources4
Turni198 – 200Combined sources3
Turni216 – 218Combined sources3
Helixi221 – 224Combined sources4
Helixi231 – 247Combined sources17
Turni251 – 254Combined sources4
Beta strandi257 – 259Combined sources3
Helixi260 – 272Combined sources13
Helixi276 – 279Combined sources4
Turni280 – 282Combined sources3
Helixi285 – 295Combined sources11
Helixi305 – 318Combined sources14
Turni328 – 331Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C47X-ray2.40A/B/C/D43-353[»]
ProteinModelPortaliP78368.
SMRiP78368.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78368.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 316Protein kinasePROSITE-ProRule annotationAdd BLAST271

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1165. Eukaryota.
ENOG410XNXP. LUCA.
GeneTreeiENSGT00760000119040.
HOGENOMiHOG000182054.
HOVERGENiHBG000176.
InParanoidiP78368.
KOiK08958.
OMAiSINRYID.
OrthoDBiEOG091G0F3Z.
PhylomeDBiP78368.
TreeFamiTF313349.

Family and domain databases

InterProiIPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFDKKGGKG ETEEGRRMSK AGGGRSSHGI RSSGTSSGVL MVGPNFRVGK
60 70 80 90 100
KIGCGNFGEL RLGKNLYTNE YVAIKLEPIK SRAPQLHLEY RFYKQLSATE
110 120 130 140 150
GVPQVYYFGP CGKYNAMVLE LLGPSLEDLF DLCDRTFTLK TVLMIAIQLI
160 170 180 190 200
TRMEYVHTKS LIYRDVKPEN FLVGRPGTKR QHAIHIIDFG LAKEYIDPET
210 220 230 240 250
KKHIPYREHK SLTGTARYMS INTHLGKEQS RRDDLEALGH MFMYFLRGSL
260 270 280 290 300
PWQGLKADTL KERYQKIGDT KRATPIEVLC ENFPEEMATY LRYVRRLDFF
310 320 330 340 350
EKPDYDYLRK LFTDLFDRSG FVFDYEYDWA GKPLPTPIGT VHTDLPSQPQ
360 370 380 390 400
LRDKTQPHSK NQALNSTNGE LNADDPTAGH SNAPITAPAE VEVADETKCC
410
CFFKRRKRKS LQRHK
Length:415
Mass (Da):47,457
Last modified:May 1, 1997 - v1
Checksum:i036A39148A1DA038
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113K → N in AAP88924 (Ref. 2) Curated1
Sequence conflicti113K → N in AAH20972 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042086189F → L.1 PublicationCorresponds to variant rs55702630dbSNPEnsembl.1
Natural variantiVAR_042087194E → G.1 PublicationCorresponds to variant rs55780547dbSNPEnsembl.1
Natural variantiVAR_042088196I → T.1 PublicationCorresponds to variant rs55923222dbSNPEnsembl.1
Natural variantiVAR_042089206Y → C.1 PublicationCorresponds to variant rs56264133dbSNPEnsembl.1
Natural variantiVAR_042090206Y → H.1 PublicationCorresponds to variant rs56108438dbSNPEnsembl.1
Natural variantiVAR_042091207R → S.1 PublicationCorresponds to variant rs56340103dbSNPEnsembl.1
Natural variantiVAR_042092208E → Q.1 PublicationCorresponds to variant rs55818316dbSNPEnsembl.1
Natural variantiVAR_042093217R → C.1 PublicationCorresponds to variant rs55754218dbSNPEnsembl.1
Natural variantiVAR_042094223T → M.1 PublicationCorresponds to variant rs56038081dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89896 mRNA. Translation: AAB88627.1.
BT009922 mRNA. Translation: AAP88924.1.
AF001177 Transcribed RNA. Translation: AAC00212.1.
AB451278 mRNA. Translation: BAG70092.1.
AB451410 mRNA. Translation: BAG70224.1.
AC005306 Genomic DNA. Translation: AAC26983.1.
CH471139 Genomic DNA. Translation: EAW69430.1.
BC018693 mRNA. Translation: AAH18693.1.
BC018699 mRNA. Translation: AAH18699.1.
BC020972 mRNA. Translation: AAH20972.1.
CCDSiCCDS12077.1.
RefSeqiNP_001310.3. NM_001319.6.
UniGeneiHs.651905.

Genome annotation databases

EnsembliENST00000255641; ENSP00000255641; ENSG00000133275.
GeneIDi1455.
KEGGihsa:1455.
UCSCiuc002lul.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89896 mRNA. Translation: AAB88627.1.
BT009922 mRNA. Translation: AAP88924.1.
AF001177 Transcribed RNA. Translation: AAC00212.1.
AB451278 mRNA. Translation: BAG70092.1.
AB451410 mRNA. Translation: BAG70224.1.
AC005306 Genomic DNA. Translation: AAC26983.1.
CH471139 Genomic DNA. Translation: EAW69430.1.
BC018693 mRNA. Translation: AAH18693.1.
BC018699 mRNA. Translation: AAH18699.1.
BC020972 mRNA. Translation: AAH20972.1.
CCDSiCCDS12077.1.
RefSeqiNP_001310.3. NM_001319.6.
UniGeneiHs.651905.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C47X-ray2.40A/B/C/D43-353[»]
ProteinModelPortaliP78368.
SMRiP78368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107839. 30 interactors.
IntActiP78368. 12 interactors.
MINTiMINT-1473562.
STRINGi9606.ENSP00000255641.

Chemistry databases

BindingDBiP78368.
ChEMBLiCHEMBL2543.
GuidetoPHARMACOLOGYi2000.

PTM databases

iPTMnetiP78368.
PhosphoSitePlusiP78368.
SwissPalmiP78368.

Polymorphism and mutation databases

BioMutaiCSNK1G2.
DMDMi3024060.

Proteomic databases

EPDiP78368.
MaxQBiP78368.
PaxDbiP78368.
PeptideAtlasiP78368.
PRIDEiP78368.

Protocols and materials databases

DNASUi1455.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255641; ENSP00000255641; ENSG00000133275.
GeneIDi1455.
KEGGihsa:1455.
UCSCiuc002lul.5. human.

Organism-specific databases

CTDi1455.
DisGeNETi1455.
GeneCardsiCSNK1G2.
HGNCiHGNC:2455. CSNK1G2.
HPAiHPA034868.
HPA056572.
MIMi602214. gene.
neXtProtiNX_P78368.
OpenTargetsiENSG00000133275.
PharmGKBiPA26955.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1165. Eukaryota.
ENOG410XNXP. LUCA.
GeneTreeiENSGT00760000119040.
HOGENOMiHOG000182054.
HOVERGENiHBG000176.
InParanoidiP78368.
KOiK08958.
OMAiSINRYID.
OrthoDBiEOG091G0F3Z.
PhylomeDBiP78368.
TreeFamiTF313349.

Enzyme and pathway databases

BioCyciZFISH:HS05754-MONOMER.
BRENDAi2.7.11.1. 2681.
ReactomeiR-HSA-1660661. Sphingolipid de novo biosynthesis.
R-HSA-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.
SignaLinkiP78368.
SIGNORiP78368.

Miscellaneous databases

ChiTaRSiCSNK1G2. human.
EvolutionaryTraceiP78368.
GenomeRNAii1455.
PROiP78368.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133275.
CleanExiHS_CSNK1G2.
ExpressionAtlasiP78368. baseline and differential.
GenevisibleiP78368. HS.

Family and domain databases

InterProiIPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKC1G2_HUMAN
AccessioniPrimary (citable) accession number: P78368
Secondary accession number(s): B5BU42, O00704, Q8WUB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 170 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.