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P78357

- CNTP1_HUMAN

UniProt

P78357 - CNTP1_HUMAN

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Protein
Contactin-associated protein 1
Gene
CNTNAP1, CASPR, NRXN4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.

GO - Molecular functioni

  1. SH3 domain binding Source: BHF-UCL
  2. SH3/SH2 adaptor activity Source: ProtInc
  3. protein binding Source: IntAct
  4. receptor activity Source: ProtInc

GO - Biological processi

  1. axon cargo transport Source: BHF-UCL
  2. axon guidance Source: Reactome
  3. cell adhesion Source: UniProtKB-KW
  4. cytoskeleton organization Source: BHF-UCL
  5. neuromuscular process controlling balance Source: Ensembl
  6. neuromuscular process controlling posture Source: Ensembl
  7. neuron projection morphogenesis Source: BHF-UCL
  8. neuronal action potential propagation Source: BHF-UCL
  9. paranodal junction assembly Source: BHF-UCL
  10. positive regulation of signal transduction Source: GOC
  11. protein localization to paranode region of axon Source: BHF-UCL
  12. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_22312. Neurofascin interactions.
SignaLinkiP78357.

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-associated protein 1
Short name:
Caspr
Short name:
Caspr1
Alternative name(s):
Neurexin IV
Neurexin-4
p190
Gene namesi
Name:CNTNAP1
Synonyms:CASPR, NRXN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:8011. CNTNAP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 12831264Extracellular Reviewed prediction
Add
BLAST
Transmembranei1284 – 130421Helical; Reviewed prediction
Add
BLAST
Topological domaini1305 – 138480Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: BHF-UCL
  2. integral component of plasma membrane Source: ProtInc
  3. paranode region of axon Source: BHF-UCL
  4. voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26691.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 13841365Contactin-associated protein 1
PRO_0000019503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 168 By similarity
Glycosylationi120 – 1201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi128 – 1281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi276 – 2761N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi323 ↔ 355 By similarity
Glycosylationi420 – 4201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi499 – 4991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi506 ↔ 538 By similarity
Glycosylationi518 – 5181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi544 ↔ 555 By similarity
Disulfide bondi549 ↔ 564 By similarity
Disulfide bondi566 ↔ 576 By similarity
Glycosylationi597 – 5971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi653 – 6531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi664 – 6641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi763 – 7631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi804 – 8041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi843 – 8431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi860 – 8601N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi930 ↔ 957 By similarity
Glycosylationi948 – 9481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi956 – 9561N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi961 ↔ 974 By similarity
Disulfide bondi968 ↔ 983 By similarity
Disulfide bondi985 ↔ 995 By similarity
Glycosylationi1078 – 10781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1147 – 11471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1209 ↔ 1250 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP78357.
PaxDbiP78357.
PRIDEiP78357.

PTM databases

PhosphoSiteiP78357.

Expressioni

Tissue specificityi

Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.

Gene expression databases

ArrayExpressiP78357.
BgeeiP78357.
CleanExiHS_CNTNAP1.
GenevestigatoriP78357.

Organism-specific databases

HPAiHPA011772.

Interactioni

Subunit structurei

Interacts with contactin in cis form.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1751903,EBI-389883

Protein-protein interaction databases

BioGridi114078. 9 interactions.
IntActiP78357. 6 interactions.
STRINGi9606.ENSP00000264638.

Structurei

3D structure databases

ProteinModelPortaliP78357.
SMRiP78357. Positions 40-168, 172-578, 779-1261.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 168144F5/8 type C
Add
BLAST
Domaini203 – 355153Laminin G-like 1
Add
BLAST
Domaini389 – 538150Laminin G-like 2
Add
BLAST
Domaini540 – 57738EGF-like 1
Add
BLAST
Domaini576 – 795220Fibrinogen C-terminal
Add
BLAST
Domaini813 – 956144Laminin G-like 3
Add
BLAST
Domaini957 – 99640EGF-like 2
Add
BLAST
Domaini1088 – 1250163Laminin G-like 4
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1328 – 136942SH3-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the neurexin family.
Contains 2 EGF-like domains.
Contains 1 F5/8 type C domain.

Keywords - Domaini

EGF-like domain, Repeat, SH3-binding, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291100.
HOGENOMiHOG000230964.
HOVERGENiHBG057718.
InParanoidiP78357.
KOiK07379.
OMAiEPKATHD.
OrthoDBiEOG7GXP9N.
PhylomeDBiP78357.
TreeFamiTF321823.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
3.90.215.10. 1 hit.
InterProiIPR028872. Caspr1.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
[Graphical view]
PANTHERiPTHR10127:SF584. PTHR10127:SF584. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 1 hit.
SM00231. FA58C. 1 hit.
SM00186. FBG. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P78357-1 [UniParc]FASTAAdd to Basket

« Hide

MMHLRLFCIL LAAVSGAEGW GYYGCDEELV GPLYARSLGA SSYYSLLTAP     50
RFARLHGISG WSPRIGDPNP WLQIDLMKKH RIRAVATQGS FNSWDWVTRY 100
MLLYGDRVDS WTPFYQRGHN STFFGNVNES AVVRHDLHFH FTARYIRIVP 150
LAWNPRGKIG LRLGLYGCPY KADILYFDGD DAISYRFPRG VSRSLWDVFA 200
FSFKTEEKDG LLLHAEGAQG DYVTLELEGA HLLLHMSLGS SPIQPRPGHT 250
TVSAGGVLND QHWHYVRVDR FGRDVNFTLD GYVQRFILNG DFERLNLDTE 300
MFIGGLVGAA RKNLAYRHNF RGCIENVIFN RVNIADLAVR RHSRITFEGK 350
VAFRCLDPVP HPINFGGPHN FVQVPGFPRR GRLAVSFRFR TWDLTGLLLF 400
SRLGDGLGHV ELTLSEGQVN VSIAQSGRKK LQFAAGYRLN DGFWHEVNFV 450
AQENHAVISI DDVEGAEVRV SYPLLIRTGT SYFFGGCPKP ASRWDCHSNQ 500
TAFHGCMELL KVDGQLVNLT LVEGRRLGFY AEVLFDTCGI TDRCSPNMCE 550
HDGRCYQSWD DFICYCELTG YKGETCHTPL YKESCEAYRL SGKTSGNFTI 600
DPDGSGPLKP FVVYCDIREN RAWTVVRHDR LWTTRVTGSS MERPFLGAIQ 650
YWNASWEEVS ALANASQHCE QWIEFSCYNS RLLNTAGGYP YSFWIGRNEE 700
QHFYWGGSQP GIQRCACGLD RSCVDPALYC NCDADQPQWR TDKGLLTFVD 750
HLPVTQVVIG DTNRSTSEAQ FFLRPLRCYG DRNSWNTISF HTGAALRFPP 800
IRANHSLDVS FYFRTSAPSG VFLENMGGPY CQWRRPYVRV ELNTSRDVVF 850
AFDVGNGDEN LTVHSDDFEF NDDEWHLVRA EINVKQARLR VDHRPWVLRP 900
MPLQTYIWME YDQPLYVGSA ELKRRPFVGC LRAMRLNGVT LNLEGRANAS 950
EGTSPNCTGH CAHPRLPCFH GGRCVERYSY YTCDCDLTAF DGPYCNHDIG 1000
GFFEPGTWMR YNLQSALRSA AREFSHMLSR PVPGYEPGYI PGYDTPGYVP 1050
GYHGPGYRLP DYPRPGRPVP GYRGPVYNVT GEEVSFSFST SSAPAVLLYV 1100
SSFVRDYMAV LIKDDGTLQL RYQLGTSPYV YQLTTRPVTD GQPHSINITR 1150
VYRNLFIQVD YFPLTEQKFS LLVDSQLDSP KALYLGRVME TGVIDPEIQR 1200
YNTPGFSGCL SGVRFNNVAP LKTHFRTPRP MTAELAEALR VQGELSESNC 1250
GAMPRLVSEV PPELDPWYLP PDFPYYHDEG WVAILLGFLV AFLLLGLVGM 1300
LVLFYLQNHR YKGSYHTNEP KAAHEYHPGS KPPLPTSGPA QVPTPTAAPN 1350
QAPASAPAPA PTPAPAPGPR DQNLPQILEE SRSE 1384
Length:1,384
Mass (Da):156,267
Last modified:May 1, 1997 - v1
Checksum:i7727A13DF626DDCA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti522 – 5221V → L.
Corresponds to variant rs35437096 [ dbSNP | Ensembl ].
VAR_050267

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U87223 mRNA. Translation: AAB48481.1.
CCDSiCCDS11436.1.
RefSeqiNP_003623.1. NM_003632.2.
XP_006722204.1. XM_006722141.1.
XP_006722205.1. XM_006722142.1.
UniGeneiHs.408730.

Genome annotation databases

EnsembliENST00000264638; ENSP00000264638; ENSG00000108797.
GeneIDi8506.
KEGGihsa:8506.
UCSCiuc002iay.3. human.

Polymorphism databases

DMDMi17433016.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U87223 mRNA. Translation: AAB48481.1 .
CCDSi CCDS11436.1.
RefSeqi NP_003623.1. NM_003632.2.
XP_006722204.1. XM_006722141.1.
XP_006722205.1. XM_006722142.1.
UniGenei Hs.408730.

3D structure databases

ProteinModelPortali P78357.
SMRi P78357. Positions 40-168, 172-578, 779-1261.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114078. 9 interactions.
IntActi P78357. 6 interactions.
STRINGi 9606.ENSP00000264638.

PTM databases

PhosphoSitei P78357.

Polymorphism databases

DMDMi 17433016.

Proteomic databases

MaxQBi P78357.
PaxDbi P78357.
PRIDEi P78357.

Protocols and materials databases

DNASUi 8506.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264638 ; ENSP00000264638 ; ENSG00000108797 .
GeneIDi 8506.
KEGGi hsa:8506.
UCSCi uc002iay.3. human.

Organism-specific databases

CTDi 8506.
GeneCardsi GC17P040835.
HGNCi HGNC:8011. CNTNAP1.
HPAi HPA011772.
MIMi 602346. gene.
neXtProti NX_P78357.
PharmGKBi PA26691.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG291100.
HOGENOMi HOG000230964.
HOVERGENi HBG057718.
InParanoidi P78357.
KOi K07379.
OMAi EPKATHD.
OrthoDBi EOG7GXP9N.
PhylomeDBi P78357.
TreeFami TF321823.

Enzyme and pathway databases

Reactomei REACT_22312. Neurofascin interactions.
SignaLinki P78357.

Miscellaneous databases

ChiTaRSi CNTNAP1. human.
GenomeRNAii 8506.
NextBioi 31835.
PROi P78357.
SOURCEi Search...

Gene expression databases

ArrayExpressi P78357.
Bgeei P78357.
CleanExi HS_CNTNAP1.
Genevestigatori P78357.

Family and domain databases

Gene3Di 2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
3.90.215.10. 1 hit.
InterProi IPR028872. Caspr1.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
[Graphical view ]
PANTHERi PTHR10127:SF584. PTHR10127:SF584. 1 hit.
Pfami PF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
SM00181. EGF. 1 hit.
SM00231. FA58C. 1 hit.
SM00186. FBG. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEi PS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions."
    Peles E., Nativ M., Lustig M., Grumet M., Schilling J., Martinez R., Plowman G.D., Schlessinger J.
    EMBO J. 16:978-988(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CONTACTIN.
    Tissue: Neuroblastoma.

Entry informationi

Entry nameiCNTP1_HUMAN
AccessioniPrimary (citable) accession number: P78357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: May 1, 1997
Last modified: September 3, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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