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P78357

- CNTP1_HUMAN

UniProt

P78357 - CNTP1_HUMAN

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Protein

Contactin-associated protein 1

Gene

CNTNAP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.

GO - Molecular functioni

  1. receptor activity Source: ProtInc
  2. SH3/SH2 adaptor activity Source: ProtInc
  3. SH3 domain binding Source: BHF-UCL

GO - Biological processi

  1. axon cargo transport Source: BHF-UCL
  2. axon guidance Source: Reactome
  3. cell adhesion Source: UniProtKB-KW
  4. cytoskeleton organization Source: BHF-UCL
  5. neuromuscular process controlling balance Source: Ensembl
  6. neuromuscular process controlling posture Source: Ensembl
  7. neuronal action potential propagation Source: BHF-UCL
  8. neuron projection morphogenesis Source: BHF-UCL
  9. paranodal junction assembly Source: BHF-UCL
  10. positive regulation of signal transduction Source: GOC
  11. protein localization to paranode region of axon Source: BHF-UCL
  12. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_22312. Neurofascin interactions.
SignaLinkiP78357.

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-associated protein 1
Short name:
Caspr
Short name:
Caspr1
Alternative name(s):
Neurexin IV
Neurexin-4
p190
Gene namesi
Name:CNTNAP1
Synonyms:CASPR, NRXN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:8011. CNTNAP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 12831264ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1284 – 130421HelicalSequence AnalysisAdd
BLAST
Topological domaini1305 – 138480CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: BHF-UCL
  2. integral component of plasma membrane Source: ProtInc
  3. paranode region of axon Source: BHF-UCL
  4. voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti2680. Hypomyelination neuropathy - arthrogryposis.
PharmGKBiPA26691.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 13841365Contactin-associated protein 1PRO_0000019503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 168By similarity
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi323 ↔ 355By similarity
Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi506 ↔ 538By similarity
Glycosylationi518 – 5181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi544 ↔ 555By similarity
Disulfide bondi549 ↔ 564By similarity
Disulfide bondi566 ↔ 576By similarity
Glycosylationi597 – 5971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi653 – 6531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi664 – 6641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi763 – 7631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi804 – 8041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi843 – 8431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi860 – 8601N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi930 ↔ 957By similarity
Glycosylationi948 – 9481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi956 – 9561N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi961 ↔ 974By similarity
Disulfide bondi968 ↔ 983By similarity
Disulfide bondi985 ↔ 995By similarity
Glycosylationi1078 – 10781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1147 – 11471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1209 ↔ 1250By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP78357.
PaxDbiP78357.
PRIDEiP78357.

PTM databases

PhosphoSiteiP78357.

Expressioni

Tissue specificityi

Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.

Gene expression databases

BgeeiP78357.
CleanExiHS_CNTNAP1.
ExpressionAtlasiP78357. baseline and differential.
GenevestigatoriP78357.

Organism-specific databases

HPAiHPA011772.

Interactioni

Subunit structurei

Interacts with contactin in cis form.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1751903,EBI-389883

Protein-protein interaction databases

BioGridi114078. 10 interactions.
IntActiP78357. 6 interactions.
STRINGi9606.ENSP00000264638.

Structurei

3D structure databases

ProteinModelPortaliP78357.
SMRiP78357. Positions 40-168, 172-576, 779-1261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 168144F5/8 type CPROSITE-ProRule annotationAdd
BLAST
Domaini203 – 355153Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini389 – 538150Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini540 – 57738EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini576 – 795220Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini813 – 956144Laminin G-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini957 – 99640EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini1088 – 1250163Laminin G-like 4PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1328 – 136942SH3-bindingSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation
Contains 4 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, SH3-binding, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291100.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230964.
HOVERGENiHBG057718.
InParanoidiP78357.
KOiK07379.
OMAiEPKATHD.
OrthoDBiEOG7GXP9N.
PhylomeDBiP78357.
TreeFamiTF321823.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
3.90.215.10. 1 hit.
InterProiIPR028872. Caspr1.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
[Graphical view]
PANTHERiPTHR10127:SF584. PTHR10127:SF584. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 1 hit.
SM00231. FA58C. 1 hit.
SM00186. FBG. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P78357-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMHLRLFCIL LAAVSGAEGW GYYGCDEELV GPLYARSLGA SSYYSLLTAP
60 70 80 90 100
RFARLHGISG WSPRIGDPNP WLQIDLMKKH RIRAVATQGS FNSWDWVTRY
110 120 130 140 150
MLLYGDRVDS WTPFYQRGHN STFFGNVNES AVVRHDLHFH FTARYIRIVP
160 170 180 190 200
LAWNPRGKIG LRLGLYGCPY KADILYFDGD DAISYRFPRG VSRSLWDVFA
210 220 230 240 250
FSFKTEEKDG LLLHAEGAQG DYVTLELEGA HLLLHMSLGS SPIQPRPGHT
260 270 280 290 300
TVSAGGVLND QHWHYVRVDR FGRDVNFTLD GYVQRFILNG DFERLNLDTE
310 320 330 340 350
MFIGGLVGAA RKNLAYRHNF RGCIENVIFN RVNIADLAVR RHSRITFEGK
360 370 380 390 400
VAFRCLDPVP HPINFGGPHN FVQVPGFPRR GRLAVSFRFR TWDLTGLLLF
410 420 430 440 450
SRLGDGLGHV ELTLSEGQVN VSIAQSGRKK LQFAAGYRLN DGFWHEVNFV
460 470 480 490 500
AQENHAVISI DDVEGAEVRV SYPLLIRTGT SYFFGGCPKP ASRWDCHSNQ
510 520 530 540 550
TAFHGCMELL KVDGQLVNLT LVEGRRLGFY AEVLFDTCGI TDRCSPNMCE
560 570 580 590 600
HDGRCYQSWD DFICYCELTG YKGETCHTPL YKESCEAYRL SGKTSGNFTI
610 620 630 640 650
DPDGSGPLKP FVVYCDIREN RAWTVVRHDR LWTTRVTGSS MERPFLGAIQ
660 670 680 690 700
YWNASWEEVS ALANASQHCE QWIEFSCYNS RLLNTAGGYP YSFWIGRNEE
710 720 730 740 750
QHFYWGGSQP GIQRCACGLD RSCVDPALYC NCDADQPQWR TDKGLLTFVD
760 770 780 790 800
HLPVTQVVIG DTNRSTSEAQ FFLRPLRCYG DRNSWNTISF HTGAALRFPP
810 820 830 840 850
IRANHSLDVS FYFRTSAPSG VFLENMGGPY CQWRRPYVRV ELNTSRDVVF
860 870 880 890 900
AFDVGNGDEN LTVHSDDFEF NDDEWHLVRA EINVKQARLR VDHRPWVLRP
910 920 930 940 950
MPLQTYIWME YDQPLYVGSA ELKRRPFVGC LRAMRLNGVT LNLEGRANAS
960 970 980 990 1000
EGTSPNCTGH CAHPRLPCFH GGRCVERYSY YTCDCDLTAF DGPYCNHDIG
1010 1020 1030 1040 1050
GFFEPGTWMR YNLQSALRSA AREFSHMLSR PVPGYEPGYI PGYDTPGYVP
1060 1070 1080 1090 1100
GYHGPGYRLP DYPRPGRPVP GYRGPVYNVT GEEVSFSFST SSAPAVLLYV
1110 1120 1130 1140 1150
SSFVRDYMAV LIKDDGTLQL RYQLGTSPYV YQLTTRPVTD GQPHSINITR
1160 1170 1180 1190 1200
VYRNLFIQVD YFPLTEQKFS LLVDSQLDSP KALYLGRVME TGVIDPEIQR
1210 1220 1230 1240 1250
YNTPGFSGCL SGVRFNNVAP LKTHFRTPRP MTAELAEALR VQGELSESNC
1260 1270 1280 1290 1300
GAMPRLVSEV PPELDPWYLP PDFPYYHDEG WVAILLGFLV AFLLLGLVGM
1310 1320 1330 1340 1350
LVLFYLQNHR YKGSYHTNEP KAAHEYHPGS KPPLPTSGPA QVPTPTAAPN
1360 1370 1380
QAPASAPAPA PTPAPAPGPR DQNLPQILEE SRSE
Length:1,384
Mass (Da):156,267
Last modified:May 1, 1997 - v1
Checksum:i7727A13DF626DDCA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti522 – 5221V → L.
Corresponds to variant rs35437096 [ dbSNP | Ensembl ].
VAR_050267

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87223 mRNA. Translation: AAB48481.1.
CCDSiCCDS11436.1.
RefSeqiNP_003623.1. NM_003632.2.
XP_006722204.1. XM_006722141.1.
XP_006722205.1. XM_006722142.1.
UniGeneiHs.408730.

Genome annotation databases

EnsembliENST00000264638; ENSP00000264638; ENSG00000108797.
GeneIDi8506.
KEGGihsa:8506.
UCSCiuc002iay.3. human.

Polymorphism databases

DMDMi17433016.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87223 mRNA. Translation: AAB48481.1 .
CCDSi CCDS11436.1.
RefSeqi NP_003623.1. NM_003632.2.
XP_006722204.1. XM_006722141.1.
XP_006722205.1. XM_006722142.1.
UniGenei Hs.408730.

3D structure databases

ProteinModelPortali P78357.
SMRi P78357. Positions 40-168, 172-576, 779-1261.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114078. 10 interactions.
IntActi P78357. 6 interactions.
STRINGi 9606.ENSP00000264638.

PTM databases

PhosphoSitei P78357.

Polymorphism databases

DMDMi 17433016.

Proteomic databases

MaxQBi P78357.
PaxDbi P78357.
PRIDEi P78357.

Protocols and materials databases

DNASUi 8506.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264638 ; ENSP00000264638 ; ENSG00000108797 .
GeneIDi 8506.
KEGGi hsa:8506.
UCSCi uc002iay.3. human.

Organism-specific databases

CTDi 8506.
GeneCardsi GC17P040835.
HGNCi HGNC:8011. CNTNAP1.
HPAi HPA011772.
MIMi 602346. gene.
neXtProti NX_P78357.
Orphaneti 2680. Hypomyelination neuropathy - arthrogryposis.
PharmGKBi PA26691.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG291100.
GeneTreei ENSGT00760000118991.
HOGENOMi HOG000230964.
HOVERGENi HBG057718.
InParanoidi P78357.
KOi K07379.
OMAi EPKATHD.
OrthoDBi EOG7GXP9N.
PhylomeDBi P78357.
TreeFami TF321823.

Enzyme and pathway databases

Reactomei REACT_22312. Neurofascin interactions.
SignaLinki P78357.

Miscellaneous databases

ChiTaRSi CNTNAP1. human.
GenomeRNAii 8506.
NextBioi 31835.
PROi P78357.
SOURCEi Search...

Gene expression databases

Bgeei P78357.
CleanExi HS_CNTNAP1.
ExpressionAtlasi P78357. baseline and differential.
Genevestigatori P78357.

Family and domain databases

Gene3Di 2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
3.90.215.10. 1 hit.
InterProi IPR028872. Caspr1.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
[Graphical view ]
PANTHERi PTHR10127:SF584. PTHR10127:SF584. 1 hit.
Pfami PF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
SM00181. EGF. 1 hit.
SM00231. FA58C. 1 hit.
SM00186. FBG. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEi PS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions."
    Peles E., Nativ M., Lustig M., Grumet M., Schilling J., Martinez R., Plowman G.D., Schlessinger J.
    EMBO J. 16:978-988(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CONTACTIN.
    Tissue: Neuroblastoma.

Entry informationi

Entry nameiCNTP1_HUMAN
AccessioniPrimary (citable) accession number: P78357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3