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P78357

- CNTP1_HUMAN

UniProt

P78357 - CNTP1_HUMAN

Protein

Contactin-associated protein 1

Gene

CNTNAP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. receptor activity Source: ProtInc
    3. SH3/SH2 adaptor activity Source: ProtInc
    4. SH3 domain binding Source: BHF-UCL

    GO - Biological processi

    1. axon cargo transport Source: BHF-UCL
    2. axon guidance Source: Reactome
    3. cell adhesion Source: UniProtKB-KW
    4. cytoskeleton organization Source: BHF-UCL
    5. neuromuscular process controlling balance Source: Ensembl
    6. neuromuscular process controlling posture Source: Ensembl
    7. neuronal action potential propagation Source: BHF-UCL
    8. neuron projection morphogenesis Source: BHF-UCL
    9. paranodal junction assembly Source: BHF-UCL
    10. positive regulation of signal transduction Source: GOC
    11. protein localization to paranode region of axon Source: BHF-UCL
    12. signal transduction Source: ProtInc

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_22312. Neurofascin interactions.
    SignaLinkiP78357.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Contactin-associated protein 1
    Short name:
    Caspr
    Short name:
    Caspr1
    Alternative name(s):
    Neurexin IV
    Neurexin-4
    p190
    Gene namesi
    Name:CNTNAP1
    Synonyms:CASPR, NRXN4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:8011. CNTNAP1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: BHF-UCL
    2. integral component of plasma membrane Source: ProtInc
    3. paranode region of axon Source: BHF-UCL
    4. voltage-gated potassium channel complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26691.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 13841365Contactin-associated protein 1PRO_0000019503Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 168By similarity
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi323 ↔ 355By similarity
    Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi506 ↔ 538By similarity
    Glycosylationi518 – 5181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi544 ↔ 555By similarity
    Disulfide bondi549 ↔ 564By similarity
    Disulfide bondi566 ↔ 576By similarity
    Glycosylationi597 – 5971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi653 – 6531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi664 – 6641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi763 – 7631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi804 – 8041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi843 – 8431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi860 – 8601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi930 ↔ 957By similarity
    Glycosylationi948 – 9481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi956 – 9561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi961 ↔ 974By similarity
    Disulfide bondi968 ↔ 983By similarity
    Disulfide bondi985 ↔ 995By similarity
    Glycosylationi1078 – 10781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1147 – 11471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1209 ↔ 1250By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP78357.
    PaxDbiP78357.
    PRIDEiP78357.

    PTM databases

    PhosphoSiteiP78357.

    Expressioni

    Tissue specificityi

    Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.

    Gene expression databases

    ArrayExpressiP78357.
    BgeeiP78357.
    CleanExiHS_CNTNAP1.
    GenevestigatoriP78357.

    Organism-specific databases

    HPAiHPA011772.

    Interactioni

    Subunit structurei

    Interacts with contactin in cis form.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NCK1P163332EBI-1751903,EBI-389883

    Protein-protein interaction databases

    BioGridi114078. 9 interactions.
    IntActiP78357. 6 interactions.
    STRINGi9606.ENSP00000264638.

    Structurei

    3D structure databases

    ProteinModelPortaliP78357.
    SMRiP78357. Positions 40-168, 172-578, 779-1261.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 12831264ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1305 – 138480CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1284 – 130421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 168144F5/8 type CPROSITE-ProRule annotationAdd
    BLAST
    Domaini203 – 355153Laminin G-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini389 – 538150Laminin G-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini540 – 57738EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini576 – 795220Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini813 – 956144Laminin G-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini957 – 99640EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1088 – 1250163Laminin G-like 4PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1328 – 136942SH3-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the neurexin family.Curated
    Contains 2 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation
    Contains 4 laminin G-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, SH3-binding, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG291100.
    HOGENOMiHOG000230964.
    HOVERGENiHBG057718.
    InParanoidiP78357.
    KOiK07379.
    OMAiEPKATHD.
    OrthoDBiEOG7GXP9N.
    PhylomeDBiP78357.
    TreeFamiTF321823.

    Family and domain databases

    Gene3Di2.60.120.200. 5 hits.
    2.60.120.260. 1 hit.
    3.90.215.10. 1 hit.
    InterProiIPR028872. Caspr1.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR008979. Galactose-bd-like.
    IPR001791. Laminin_G.
    IPR003585. Neurexin-like.
    [Graphical view]
    PANTHERiPTHR10127:SF584. PTHR10127:SF584. 1 hit.
    PfamiPF00754. F5_F8_type_C. 1 hit.
    PF02210. Laminin_G_2. 4 hits.
    [Graphical view]
    SMARTiSM00294. 4.1m. 1 hit.
    SM00181. EGF. 1 hit.
    SM00231. FA58C. 1 hit.
    SM00186. FBG. 1 hit.
    SM00282. LamG. 4 hits.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF49899. SSF49899. 5 hits.
    SSF56496. SSF56496. 1 hit.
    PROSITEiPS50026. EGF_3. 2 hits.
    PS01285. FA58C_1. 1 hit.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    PS50025. LAM_G_DOMAIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P78357-1 [UniParc]FASTAAdd to Basket

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    MMHLRLFCIL LAAVSGAEGW GYYGCDEELV GPLYARSLGA SSYYSLLTAP     50
    RFARLHGISG WSPRIGDPNP WLQIDLMKKH RIRAVATQGS FNSWDWVTRY 100
    MLLYGDRVDS WTPFYQRGHN STFFGNVNES AVVRHDLHFH FTARYIRIVP 150
    LAWNPRGKIG LRLGLYGCPY KADILYFDGD DAISYRFPRG VSRSLWDVFA 200
    FSFKTEEKDG LLLHAEGAQG DYVTLELEGA HLLLHMSLGS SPIQPRPGHT 250
    TVSAGGVLND QHWHYVRVDR FGRDVNFTLD GYVQRFILNG DFERLNLDTE 300
    MFIGGLVGAA RKNLAYRHNF RGCIENVIFN RVNIADLAVR RHSRITFEGK 350
    VAFRCLDPVP HPINFGGPHN FVQVPGFPRR GRLAVSFRFR TWDLTGLLLF 400
    SRLGDGLGHV ELTLSEGQVN VSIAQSGRKK LQFAAGYRLN DGFWHEVNFV 450
    AQENHAVISI DDVEGAEVRV SYPLLIRTGT SYFFGGCPKP ASRWDCHSNQ 500
    TAFHGCMELL KVDGQLVNLT LVEGRRLGFY AEVLFDTCGI TDRCSPNMCE 550
    HDGRCYQSWD DFICYCELTG YKGETCHTPL YKESCEAYRL SGKTSGNFTI 600
    DPDGSGPLKP FVVYCDIREN RAWTVVRHDR LWTTRVTGSS MERPFLGAIQ 650
    YWNASWEEVS ALANASQHCE QWIEFSCYNS RLLNTAGGYP YSFWIGRNEE 700
    QHFYWGGSQP GIQRCACGLD RSCVDPALYC NCDADQPQWR TDKGLLTFVD 750
    HLPVTQVVIG DTNRSTSEAQ FFLRPLRCYG DRNSWNTISF HTGAALRFPP 800
    IRANHSLDVS FYFRTSAPSG VFLENMGGPY CQWRRPYVRV ELNTSRDVVF 850
    AFDVGNGDEN LTVHSDDFEF NDDEWHLVRA EINVKQARLR VDHRPWVLRP 900
    MPLQTYIWME YDQPLYVGSA ELKRRPFVGC LRAMRLNGVT LNLEGRANAS 950
    EGTSPNCTGH CAHPRLPCFH GGRCVERYSY YTCDCDLTAF DGPYCNHDIG 1000
    GFFEPGTWMR YNLQSALRSA AREFSHMLSR PVPGYEPGYI PGYDTPGYVP 1050
    GYHGPGYRLP DYPRPGRPVP GYRGPVYNVT GEEVSFSFST SSAPAVLLYV 1100
    SSFVRDYMAV LIKDDGTLQL RYQLGTSPYV YQLTTRPVTD GQPHSINITR 1150
    VYRNLFIQVD YFPLTEQKFS LLVDSQLDSP KALYLGRVME TGVIDPEIQR 1200
    YNTPGFSGCL SGVRFNNVAP LKTHFRTPRP MTAELAEALR VQGELSESNC 1250
    GAMPRLVSEV PPELDPWYLP PDFPYYHDEG WVAILLGFLV AFLLLGLVGM 1300
    LVLFYLQNHR YKGSYHTNEP KAAHEYHPGS KPPLPTSGPA QVPTPTAAPN 1350
    QAPASAPAPA PTPAPAPGPR DQNLPQILEE SRSE 1384
    Length:1,384
    Mass (Da):156,267
    Last modified:May 1, 1997 - v1
    Checksum:i7727A13DF626DDCA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti522 – 5221V → L.
    Corresponds to variant rs35437096 [ dbSNP | Ensembl ].
    VAR_050267

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U87223 mRNA. Translation: AAB48481.1.
    CCDSiCCDS11436.1.
    RefSeqiNP_003623.1. NM_003632.2.
    XP_006722204.1. XM_006722141.1.
    XP_006722205.1. XM_006722142.1.
    UniGeneiHs.408730.

    Genome annotation databases

    EnsembliENST00000264638; ENSP00000264638; ENSG00000108797.
    GeneIDi8506.
    KEGGihsa:8506.
    UCSCiuc002iay.3. human.

    Polymorphism databases

    DMDMi17433016.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U87223 mRNA. Translation: AAB48481.1 .
    CCDSi CCDS11436.1.
    RefSeqi NP_003623.1. NM_003632.2.
    XP_006722204.1. XM_006722141.1.
    XP_006722205.1. XM_006722142.1.
    UniGenei Hs.408730.

    3D structure databases

    ProteinModelPortali P78357.
    SMRi P78357. Positions 40-168, 172-578, 779-1261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114078. 9 interactions.
    IntActi P78357. 6 interactions.
    STRINGi 9606.ENSP00000264638.

    PTM databases

    PhosphoSitei P78357.

    Polymorphism databases

    DMDMi 17433016.

    Proteomic databases

    MaxQBi P78357.
    PaxDbi P78357.
    PRIDEi P78357.

    Protocols and materials databases

    DNASUi 8506.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264638 ; ENSP00000264638 ; ENSG00000108797 .
    GeneIDi 8506.
    KEGGi hsa:8506.
    UCSCi uc002iay.3. human.

    Organism-specific databases

    CTDi 8506.
    GeneCardsi GC17P040835.
    HGNCi HGNC:8011. CNTNAP1.
    HPAi HPA011772.
    MIMi 602346. gene.
    neXtProti NX_P78357.
    PharmGKBi PA26691.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291100.
    HOGENOMi HOG000230964.
    HOVERGENi HBG057718.
    InParanoidi P78357.
    KOi K07379.
    OMAi EPKATHD.
    OrthoDBi EOG7GXP9N.
    PhylomeDBi P78357.
    TreeFami TF321823.

    Enzyme and pathway databases

    Reactomei REACT_22312. Neurofascin interactions.
    SignaLinki P78357.

    Miscellaneous databases

    ChiTaRSi CNTNAP1. human.
    GenomeRNAii 8506.
    NextBioi 31835.
    PROi P78357.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P78357.
    Bgeei P78357.
    CleanExi HS_CNTNAP1.
    Genevestigatori P78357.

    Family and domain databases

    Gene3Di 2.60.120.200. 5 hits.
    2.60.120.260. 1 hit.
    3.90.215.10. 1 hit.
    InterProi IPR028872. Caspr1.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR008979. Galactose-bd-like.
    IPR001791. Laminin_G.
    IPR003585. Neurexin-like.
    [Graphical view ]
    PANTHERi PTHR10127:SF584. PTHR10127:SF584. 1 hit.
    Pfami PF00754. F5_F8_type_C. 1 hit.
    PF02210. Laminin_G_2. 4 hits.
    [Graphical view ]
    SMARTi SM00294. 4.1m. 1 hit.
    SM00181. EGF. 1 hit.
    SM00231. FA58C. 1 hit.
    SM00186. FBG. 1 hit.
    SM00282. LamG. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF49899. SSF49899. 5 hits.
    SSF56496. SSF56496. 1 hit.
    PROSITEi PS50026. EGF_3. 2 hits.
    PS01285. FA58C_1. 1 hit.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    PS50025. LAM_G_DOMAIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions."
      Peles E., Nativ M., Lustig M., Grumet M., Schilling J., Martinez R., Plowman G.D., Schlessinger J.
      EMBO J. 16:978-988(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CONTACTIN.
      Tissue: Neuroblastoma.

    Entry informationi

    Entry nameiCNTP1_HUMAN
    AccessioniPrimary (citable) accession number: P78357
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 136 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3