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P78357 (CNTP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Contactin-associated protein 1

Short name=Caspr
Short name=Caspr1
Alternative name(s):
Neurexin IV
Neurexin-4
p190
Gene names
Name:CNTNAP1
Synonyms:CASPR, NRXN4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1384 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.

Subunit structure

Interacts with contactin in cis form. Ref.1

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.

Sequence similarities

Belongs to the neurexin family.

Contains 2 EGF-like domains.

Contains 1 F5/8 type C domain.

Contains 1 fibrinogen C-terminal domain.

Contains 4 laminin G-like domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainEGF-like domain
Repeat
SH3-binding
Signal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon cargo transport

Inferred from sequence or structural similarity. Source: BHF-UCL

axon guidance

Traceable author statement. Source: Reactome

cell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton organization

Inferred from sequence or structural similarity. Source: BHF-UCL

neuromuscular process controlling balance

Inferred from electronic annotation. Source: Ensembl

neuromuscular process controlling posture

Inferred from electronic annotation. Source: Ensembl

neuron projection morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

neuronal action potential propagation

Inferred from sequence or structural similarity. Source: BHF-UCL

paranodal junction assembly

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of signal transduction

Traceable author statement Ref.1. Source: GOC

protein localization to paranode region of axon

Inferred from sequence or structural similarity. Source: BHF-UCL

signal transduction

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentintegral component of membrane

Inferred from sequence or structural similarity. Source: BHF-UCL

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

paranode region of axon

Inferred from sequence or structural similarity. Source: BHF-UCL

voltage-gated potassium channel complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionSH3 domain binding

Inferred from sequence or structural similarity. Source: BHF-UCL

SH3/SH2 adaptor activity

Traceable author statement Ref.1. Source: ProtInc

receptor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NCK1P163332EBI-1751903,EBI-389883

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 13841365Contactin-associated protein 1
PRO_0000019503

Regions

Topological domain20 – 12831264Extracellular Potential
Transmembrane1284 – 130421Helical; Potential
Topological domain1305 – 138480Cytoplasmic Potential
Domain25 – 168144F5/8 type C
Domain203 – 355153Laminin G-like 1
Domain389 – 538150Laminin G-like 2
Domain540 – 57738EGF-like 1
Domain576 – 795220Fibrinogen C-terminal
Domain813 – 956144Laminin G-like 3
Domain957 – 99640EGF-like 2
Domain1088 – 1250163Laminin G-like 4
Motif1328 – 136942SH3-binding Potential

Amino acid modifications

Glycosylation1201N-linked (GlcNAc...) Potential
Glycosylation1281N-linked (GlcNAc...) Potential
Glycosylation2761N-linked (GlcNAc...) Potential
Glycosylation4201N-linked (GlcNAc...) Potential
Glycosylation4991N-linked (GlcNAc...) Potential
Glycosylation5181N-linked (GlcNAc...) Potential
Glycosylation5971N-linked (GlcNAc...) Potential
Glycosylation6531N-linked (GlcNAc...) Potential
Glycosylation6641N-linked (GlcNAc...) Potential
Glycosylation7631N-linked (GlcNAc...) Potential
Glycosylation8041N-linked (GlcNAc...) Potential
Glycosylation8431N-linked (GlcNAc...) Potential
Glycosylation8601N-linked (GlcNAc...) Potential
Glycosylation9481N-linked (GlcNAc...) Potential
Glycosylation9561N-linked (GlcNAc...) Potential
Glycosylation10781N-linked (GlcNAc...) Potential
Glycosylation11471N-linked (GlcNAc...) Potential
Disulfide bond25 ↔ 168 By similarity
Disulfide bond323 ↔ 355 By similarity
Disulfide bond506 ↔ 538 By similarity
Disulfide bond544 ↔ 555 By similarity
Disulfide bond549 ↔ 564 By similarity
Disulfide bond566 ↔ 576 By similarity
Disulfide bond930 ↔ 957 By similarity
Disulfide bond961 ↔ 974 By similarity
Disulfide bond968 ↔ 983 By similarity
Disulfide bond985 ↔ 995 By similarity
Disulfide bond1209 ↔ 1250 By similarity

Natural variations

Natural variant5221V → L.
Corresponds to variant rs35437096 [ dbSNP | Ensembl ].
VAR_050267

Sequences

Sequence LengthMass (Da)Tools
P78357 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 7727A13DF626DDCA

FASTA1,384156,267
        10         20         30         40         50         60 
MMHLRLFCIL LAAVSGAEGW GYYGCDEELV GPLYARSLGA SSYYSLLTAP RFARLHGISG 

        70         80         90        100        110        120 
WSPRIGDPNP WLQIDLMKKH RIRAVATQGS FNSWDWVTRY MLLYGDRVDS WTPFYQRGHN 

       130        140        150        160        170        180 
STFFGNVNES AVVRHDLHFH FTARYIRIVP LAWNPRGKIG LRLGLYGCPY KADILYFDGD 

       190        200        210        220        230        240 
DAISYRFPRG VSRSLWDVFA FSFKTEEKDG LLLHAEGAQG DYVTLELEGA HLLLHMSLGS 

       250        260        270        280        290        300 
SPIQPRPGHT TVSAGGVLND QHWHYVRVDR FGRDVNFTLD GYVQRFILNG DFERLNLDTE 

       310        320        330        340        350        360 
MFIGGLVGAA RKNLAYRHNF RGCIENVIFN RVNIADLAVR RHSRITFEGK VAFRCLDPVP 

       370        380        390        400        410        420 
HPINFGGPHN FVQVPGFPRR GRLAVSFRFR TWDLTGLLLF SRLGDGLGHV ELTLSEGQVN 

       430        440        450        460        470        480 
VSIAQSGRKK LQFAAGYRLN DGFWHEVNFV AQENHAVISI DDVEGAEVRV SYPLLIRTGT 

       490        500        510        520        530        540 
SYFFGGCPKP ASRWDCHSNQ TAFHGCMELL KVDGQLVNLT LVEGRRLGFY AEVLFDTCGI 

       550        560        570        580        590        600 
TDRCSPNMCE HDGRCYQSWD DFICYCELTG YKGETCHTPL YKESCEAYRL SGKTSGNFTI 

       610        620        630        640        650        660 
DPDGSGPLKP FVVYCDIREN RAWTVVRHDR LWTTRVTGSS MERPFLGAIQ YWNASWEEVS 

       670        680        690        700        710        720 
ALANASQHCE QWIEFSCYNS RLLNTAGGYP YSFWIGRNEE QHFYWGGSQP GIQRCACGLD 

       730        740        750        760        770        780 
RSCVDPALYC NCDADQPQWR TDKGLLTFVD HLPVTQVVIG DTNRSTSEAQ FFLRPLRCYG 

       790        800        810        820        830        840 
DRNSWNTISF HTGAALRFPP IRANHSLDVS FYFRTSAPSG VFLENMGGPY CQWRRPYVRV 

       850        860        870        880        890        900 
ELNTSRDVVF AFDVGNGDEN LTVHSDDFEF NDDEWHLVRA EINVKQARLR VDHRPWVLRP 

       910        920        930        940        950        960 
MPLQTYIWME YDQPLYVGSA ELKRRPFVGC LRAMRLNGVT LNLEGRANAS EGTSPNCTGH 

       970        980        990       1000       1010       1020 
CAHPRLPCFH GGRCVERYSY YTCDCDLTAF DGPYCNHDIG GFFEPGTWMR YNLQSALRSA 

      1030       1040       1050       1060       1070       1080 
AREFSHMLSR PVPGYEPGYI PGYDTPGYVP GYHGPGYRLP DYPRPGRPVP GYRGPVYNVT 

      1090       1100       1110       1120       1130       1140 
GEEVSFSFST SSAPAVLLYV SSFVRDYMAV LIKDDGTLQL RYQLGTSPYV YQLTTRPVTD 

      1150       1160       1170       1180       1190       1200 
GQPHSINITR VYRNLFIQVD YFPLTEQKFS LLVDSQLDSP KALYLGRVME TGVIDPEIQR 

      1210       1220       1230       1240       1250       1260 
YNTPGFSGCL SGVRFNNVAP LKTHFRTPRP MTAELAEALR VQGELSESNC GAMPRLVSEV 

      1270       1280       1290       1300       1310       1320 
PPELDPWYLP PDFPYYHDEG WVAILLGFLV AFLLLGLVGM LVLFYLQNHR YKGSYHTNEP 

      1330       1340       1350       1360       1370       1380 
KAAHEYHPGS KPPLPTSGPA QVPTPTAAPN QAPASAPAPA PTPAPAPGPR DQNLPQILEE 


SRSE 

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References

[1]"Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions."
Peles E., Nativ M., Lustig M., Grumet M., Schilling J., Martinez R., Plowman G.D., Schlessinger J.
EMBO J. 16:978-988(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CONTACTIN.
Tissue: Neuroblastoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U87223 mRNA. Translation: AAB48481.1.
RefSeqNP_003623.1. NM_003632.2.
UniGeneHs.408730.

3D structure databases

ProteinModelPortalP78357.
SMRP78357. Positions 24-582, 779-1261.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114078. 9 interactions.
IntActP78357. 6 interactions.
STRING9606.ENSP00000264638.

PTM databases

PhosphoSiteP78357.

Polymorphism databases

DMDM17433016.

Proteomic databases

PaxDbP78357.
PRIDEP78357.

Protocols and materials databases

DNASU8506.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264638; ENSP00000264638; ENSG00000108797.
GeneID8506.
KEGGhsa:8506.
UCSCuc002iay.3. human.

Organism-specific databases

CTD8506.
GeneCardsGC17P040835.
HGNCHGNC:8011. CNTNAP1.
HPAHPA011772.
MIM602346. gene.
neXtProtNX_P78357.
PharmGKBPA26691.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG291100.
HOGENOMHOG000230964.
HOVERGENHBG057718.
InParanoidP78357.
KOK07379.
OMAEPKATHD.
OrthoDBEOG7GXP9N.
PhylomeDBP78357.
TreeFamTF321823.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
SignaLinkP78357.

Gene expression databases

ArrayExpressP78357.
BgeeP78357.
CleanExHS_CNTNAP1.
GenevestigatorP78357.

Family and domain databases

Gene3D2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
3.90.215.10. 1 hit.
InterProIPR028872. Caspr1.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
[Graphical view]
PANTHERPTHR10127:SF510. PTHR10127:SF510. 1 hit.
PfamPF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTSM00294. 4.1m. 1 hit.
SM00181. EGF. 1 hit.
SM00231. FA58C. 1 hit.
SM00186. FBG. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEPS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCNTNAP1. human.
GenomeRNAi8506.
NextBio31835.
PROP78357.
SOURCESearch...

Entry information

Entry nameCNTP1_HUMAN
AccessionPrimary (citable) accession number: P78357
Entry history
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM