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Entry version 181 (27 Sep 2017)
Sequence version 2 (13 Dec 2001)
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Protein

General transcription factor II-I

Gene

GTF2I

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.3 Publications

GO - Molecular functionⁱ

DNA binding Source: GO_Central
mitogen-activated protein kinase binding Source: Ensembl
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central
transcription factor activity, sequence-specific DNA binding
Source: ProtInc
Non-traceable author statementⁱ
- 9334314

Complete GO annotation...

GO - Biological processⁱ

negative regulation of angiogenesis
Source: MGI
Inferred from direct assayⁱ
- 19242469
negative regulation of cytosolic calcium ion concentration Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 9012831
transcription from RNA polymerase II promoter
Source: ProtInc
Traceable author statementⁱ
- 9334314
transcription initiation from RNA polymerase II promoter
Source: ProtInc
Traceable author statementⁱ
- 9334314
transition between slow and fast fiber Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	P78347.

SIGNORⁱ

P78347.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: General transcription factor II-I Short name: GTFII-I Short name: TFII-I Alternative name(s): Bruton tyrosine kinase-associated protein 135 Short name: BAP-135 Short name: BTK-associated protein 135 SRF-Phox1-interacting protein Short name: SPIN Williams-Beuren syndrome chromosomal region 6 protein
Gene namesⁱ	Name:GTF2I Synonyms:BAP135, WBSCR6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000263001.5.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4659. GTF2I.

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

GTF2I is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of GTF2I may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	248	Y → F: Abolishes BTK-mediated transcriptional activation. Abolishes BTK-mediated phosphorylation and impairs BTK-mediated transcriptional activation; when associated with F-398 and F-503. 1 Publication	1
Mutagenesisⁱ	398	Y → F: Abolishes BTK-mediated transcriptional activation. Abolishes BTK-mediated phosphorylation and impairs BTK-mediated transcriptional activation; when associated with F-248 and F-503. 1 Publication	1
Mutagenesisⁱ	460	Y → F: No change on BTK-mediated transcriptional activation. 1 Publication	1
Mutagenesisⁱ	503	Y → F: Impairs BTK-mediated transcriptional activation. Abolishes BTK-mediated phosphorylation and impairs BTK-mediated transcriptional activation; when associated with F-248 and F-398. 1 Publication	1

Keywords - Diseaseⁱ

Williams-Beuren syndrome

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2969.
MalaCards human disease database More...MalaCardsⁱ	GTF2I.
Open Targets More...OpenTargetsⁱ	ENSG00000263001.
Orphanetⁱ	904. Williams syndrome.
PharmGKBⁱ	PA29045.

Polymorphism and mutation databases

BioMutaⁱ	GTF2I.
DMDMⁱ	17865459.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000083872	2 – 998	General transcription factor II-IAdd BLAST		997

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Modified residueⁱ	19	PhosphoserineCombined sources	1
Cross-linkⁱ	35	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	86	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	92	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	94	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	103	PhosphoserineCombined sources	1
Modified residueⁱ	130	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	130	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	140	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	185	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	207	PhosphoserineCombined sources	1
Modified residueⁱ	210	PhosphoserineCombined sources	1
Modified residueⁱ	214	PhosphoserineCombined sources	1
Cross-linkⁱ	219	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	221	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linkⁱ	221	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	248	Phosphotyrosine; by BTK2 Publications	1
Modified residueⁱ	318	Phosphotyrosine; by BTK1 Publication	1
Cross-linkⁱ	326	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	343	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	353	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	353	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	380	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	398	Phosphotyrosine; by BTK1 Publication	1
Modified residueⁱ	412	Phosphoserine; by PKG/PRKG1Combined sources1 Publication	1
Cross-linkⁱ	435	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	450	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	450	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	456	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	488	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	494	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	503	Phosphotyrosine; by BTK1 Publication	1
Modified residueⁱ	517	PhosphoserineCombined sources	1
Cross-linkⁱ	526	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	556	PhosphothreonineBy similarity	1
Modified residueⁱ	558	PhosphothreonineCombined sources	1
Cross-linkⁱ	561	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	660	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	664	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	668	PhosphoserineCombined sources	1
Cross-linkⁱ	670	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	674	PhosphoserineCombined sources	1
Cross-linkⁱ	680	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	715	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	715	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	722	PhosphoserineCombined sources	1
Modified residueⁱ	784	Phosphoserine; by PKG/PRKG1Combined sources1 Publication	1
Cross-linkⁱ	816	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	823	PhosphoserineCombined sources	1
Cross-linkⁱ	827	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	861	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	864	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	879	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	891	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	991	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linkⁱ	991	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 2 (identifier: P78347-2)
Modified residueⁱ	278	PhosphoserineCombined sources	1
Isoform 4 (identifier: P78347-4)
Modified residueⁱ	298	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation.4 Publications

Sumoylated.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P78347.
PaxDbⁱ	P78347.
PeptideAtlas More...PeptideAtlasⁱ	P78347.
PRIDEⁱ	P78347.

PTM databases

iPTMnetⁱ	P78347.
PhosphoSitePlusⁱ	P78347.
SwissPalmⁱ	P78347.

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues.

Gene expression databases

Bgeeⁱ	ENSG00000263001.
CleanExⁱ	HS_GTF2I.
ExpressionAtlasⁱ	P78347. baseline and differential.
Genevisibleⁱ	P78347. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004595. HPA026638.

HPAⁱ

CAB004595.
HPA026638.

Interactionⁱ

Subunit structureⁱ

Homodimer (Potential). Interacts with SRF and PHOX1. Binds a pyrimidine-rich initiator (Inr) and a recognition site (E-box) for upstream stimulatory factor 1 (USF1). Associates with the PH domain of Bruton's tyrosine kinase (BTK). May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with BTK and ARID3A. Interacts with isoform beta of PRKG1.Curated4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BRCA1	P38398	5	EBI-359622,EBI-349905
BTK	Q06187	6	EBI-359622,EBI-624835
DPY30	Q9C005	4	EBI-12033200,EBI-744973

Show more details

GO - Molecular functionⁱ

mitogen-activated protein kinase binding Source: Ensembl

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	109224. 117 interactors.
CORUMⁱ	P78347.
Database of interacting proteins More...DIPⁱ	DIP-24252N.
IntActⁱ	P78347. 49 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1138992.
STRINGⁱ	9606.ENSP00000322542.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	106 – 128	Combined sources	23
Helixⁱ	138 – 143	Combined sources	6
Beta strandⁱ	146 – 152	Combined sources	7
Helixⁱ	167 – 175	Combined sources	9
Turnⁱ	176 – 179	Combined sources	4
Beta strandⁱ	181 – 185	Combined sources	5
Helixⁱ	361 – 376	Combined sources	16
Helixⁱ	387 – 392	Combined sources	6
Turnⁱ	393 – 396	Combined sources	4
Beta strandⁱ	397 – 401	Combined sources	5
Turnⁱ	411 – 413	Combined sources	3
Helixⁱ	416 – 424	Combined sources	9
Turnⁱ	426 – 428	Combined sources	3
Beta strandⁱ	430 – 434	Combined sources	5
Turnⁱ	437 – 439	Combined sources	3
Helixⁱ	466 – 482	Combined sources	17
Helixⁱ	492 – 497	Combined sources	6
Turnⁱ	499 – 501	Combined sources	3
Beta strandⁱ	502 – 506	Combined sources	5
Turnⁱ	516 – 518	Combined sources	3
Helixⁱ	521 – 529	Combined sources	9
Turnⁱ	530 – 533	Combined sources	4
Beta strandⁱ	535 – 539	Combined sources	5
Helixⁱ	541 – 544	Combined sources	4
Turnⁱ	856 – 858	Combined sources	3
Helixⁱ	861 – 883	Combined sources	23
Helixⁱ	894 – 899	Combined sources	6
Beta strandⁱ	901 – 907	Combined sources	7
Turnⁱ	918 – 920	Combined sources	3
Helixⁱ	923 – 931	Combined sources	9
Turnⁱ	932 – 935	Combined sources	4
Beta strandⁱ	937 – 942	Combined sources	6

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2D9B	NMR	-	A	102-197	[»]
	2DN4	NMR	-	A	361-446	[»]
	2ED2	NMR	-	A	466-551	[»]
	2EJE	NMR	-	A	854-954	[»]
ProteinModelPortalⁱ	P78347.
SMRⁱ	P78347.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P78347.

EvolutionaryTraceⁱ

P78347.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	103 – 197	GTF2I-like 1Add BLAST	95
Repeatⁱ	352 – 446	GTF2I-like 2Add BLAST	95
Repeatⁱ	457 – 551	GTF2I-like 3Add BLAST	95
Repeatⁱ	562 – 656	GTF2I-like 4Add BLAST	95
Repeatⁱ	724 – 818	GTF2I-like 5Add BLAST	95
Repeatⁱ	859 – 953	GTF2I-like 6Add BLAST	95

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	320 – 327	Nuclear localization signalSequence analysis		8

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	692 – 695	Poly-Asn		4

Sequence similaritiesⁱ

Belongs to the TFII-I family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IEPZ. Eukaryota. ENOG41100H8. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063863.
HOGENOMⁱ	HOG000147161.
HOVERGENⁱ	HBG051856.
InParanoidⁱ	P78347.
KEGG Orthology (KO) More...KOⁱ	K03121.
OMAⁱ	MPPGVAF.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01ZC.
PhylomeDBⁱ	P78347.
TreeFamⁱ	TF352524.

Family and domain databases

Gene3Dⁱ	3.90.1460.10. 6 hits.
InterProⁱ	View protein in InterPro IPR004212. GTF2I. IPR016659. TF_II-I.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02946. GTF2I. 6 hits.
PIRSFⁱ	PIRSF016441. TF_II-I. 1 hit.
SUPFAMⁱ	SSF117773. SSF117773. 6 hits.
PROSITEⁱ	View protein in PROSITE PS51139. GTF2I. 6 hits.

Sequences (5)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: P78347-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY 
        60         70         80         90        100
ETDVFVVGTE RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN 
       110        120        130        140        150
RMSVDAVEIE TLRKTVEDYF CFCYGKALGK STVVPVPYEK MLRDQSAVVV 
       160        170        180        190        200
QGLPEGVAFK HPENYDLATL KWILENKAGI SFIIKRPFLE PKKHVGGRVM 
       210        220        230        240        250
VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK EESEDPDYYQ 
       260        270        280        290        300
YNIQAGPSET DDVDEKQPLS KPLQGSHHSS EGNEGTEMEV PAEDSTQHVP 
       310        320        330        340        350
SETSEDPEVE VTIEDDDYSP PSKRPKANEL PQPPVPEPAN AGKRKVREFN 
       360        370        380        390        400
FEKWNARITD LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE 
       410        420        430        440        450
GLPEGIPFRR PSTYGIPRLE RILLAKERIR FVIKKHELLN STREDLQLDK 
       460        470        480        490        500
PASGVKEEWY ARITKLRKMV DQLFCKKFAE ALGSTEAKAV PYQKFEAHPN 
       510        520        530        540        550
DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR PELLTHSTTE 
       560        570        580        590        600
VTQPRTNTPV KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF 
       610        620        630        640        650
ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK FVVKKPELVI 
       660        670        680        690        700
SYLPPGMASK INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNNNPQTSA 
       710        720        730        740        750
VRTPTQTNGS NVPFKPRGRE FSFEAWNAKI TDLKQKVENL FNEKCGEALG 
       760        770        780        790        800
LKQAVKVPFA LFESFPEDFY VEGLPEGVPF RRPSTFGIPR LEKILRNKAK 
       810        820        830        840        850
IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG VEDLNIIQVT 
       860        870        880        890        900
IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN 
       910        920        930        940        950
PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN 
       960        970        980        990 
NQLVDQSESE GPVIQESAEP SQLEVPATEE IKETDGSSQI KQEPDPTW

Length:998

Mass (Da):112,416

Last modified:December 13, 2001 - v2

Checksum:ⁱ4CFA2C19002869B9

Isoform 2 (identifier: P78347-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
255-274: Missing.
294-314: Missing.

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        10         20         30         40         50
MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY 
        60         70         80         90        100
ETDVFVVGTE RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN 
       110        120        130        140        150
RMSVDAVEIE TLRKTVEDYF CFCYGKALGK STVVPVPYEK MLRDQSAVVV 
       160        170        180        190        200
QGLPEGVAFK HPENYDLATL KWILENKAGI SFIIKRPFLE PKKHVGGRVM 
       210        220        230        240        250
VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK EESEDPDYYQ 
       260        270        280        290        300
YNIQGSHHSS EGNEGTEMEV PAEDDDYSPP SKRPKANELP QPPVPEPANA 
       310        320        330        340        350
GKRKVREFNF EKWNARITDL RKQVEELFER KYAQAIKAKG PVTIPYPLFQ 
       360        370        380        390        400
SHVEDLYVEG LPEGIPFRRP STYGIPRLER ILLAKERIRF VIKKHELLNS 
       410        420        430        440        450
TREDLQLDKP ASGVKEEWYA RITKLRKMVD QLFCKKFAEA LGSTEAKAVP 
       460        470        480        490        500
YQKFEAHPND LYVEGLPENI PFRSPSWYGI PRLEKIIQVG NRIKFVIKRP 
       510        520        530        540        550
ELLTHSTTEV TQPRTNTPVK EDWNVRITKL RKQVEEIFNL KFAQALGLTE 
       560        570        580        590        600
AVKVPYPVFE SNPEFLYVEG LPEGIPFRSP TWFGIPRLER IVRGSNKIKF 
       610        620        630        640        650
VVKKPELVIS YLPPGMASKI NTKALQSPKR PRSPGSNSKV PEIEVTVEGP 
       660        670        680        690        700
NNNNPQTSAV RTPTQTNGSN VPFKPRGREF SFEAWNAKIT DLKQKVENLF 
       710        720        730        740        750
NEKCGEALGL KQAVKVPFAL FESFPEDFYV EGLPEGVPFR RPSTFGIPRL 
       760        770        780        790        800
EKILRNKAKI KFIIKKPEMF ETAIKESTSS KSPPRKINSS PNVNTTASGV 
       810        820        830        840        850
EDLNIIQVTI PDDDNERLSK VEKARQLREQ VNDLFSRKFG EAIGMGFPVK 
       860        870        880        890        900
VPYRKITINP GCVVVDGMPP GVSFKAPSYL EISSMRRILD SAEFIKFTVI 
       910        920        930        940        950
RPFPGLVINN QLVDQSESEG PVIQESAEPS QLEVPATEEI KETDGSSQIK 

QEPDPTW

Show »

Length:957

Mass (Da):107,970

Checksum:ⁱE091B620FF633AC8

Isoform 3 (identifier: P78347-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
255-274: Missing.

« Hide

        10         20         30         40         50
MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY 
        60         70         80         90        100
ETDVFVVGTE RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN 
       110        120        130        140        150
RMSVDAVEIE TLRKTVEDYF CFCYGKALGK STVVPVPYEK MLRDQSAVVV 
       160        170        180        190        200
QGLPEGVAFK HPENYDLATL KWILENKAGI SFIIKRPFLE PKKHVGGRVM 
       210        220        230        240        250
VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK EESEDPDYYQ 
       260        270        280        290        300
YNIQGSHHSS EGNEGTEMEV PAEDSTQHVP SETSEDPEVE VTIEDDDYSP 
       310        320        330        340        350
PSKRPKANEL PQPPVPEPAN AGKRKVREFN FEKWNARITD LRKQVEELFE 
       360        370        380        390        400
RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE 
       410        420        430        440        450
RILLAKERIR FVIKKHELLN STREDLQLDK PASGVKEEWY ARITKLRKMV 
       460        470        480        490        500
DQLFCKKFAE ALGSTEAKAV PYQKFEAHPN DLYVEGLPEN IPFRSPSWYG 
       510        520        530        540        550
IPRLEKIIQV GNRIKFVIKR PELLTHSTTE VTQPRTNTPV KEDWNVRITK 
       560        570        580        590        600
LRKQVEEIFN LKFAQALGLT EAVKVPYPVF ESNPEFLYVE GLPEGIPFRS 
       610        620        630        640        650
PTWFGIPRLE RIVRGSNKIK FVVKKPELVI SYLPPGMASK INTKALQSPK 
       660        670        680        690        700
RPRSPGSNSK VPEIEVTVEG PNNNNPQTSA VRTPTQTNGS NVPFKPRGRE 
       710        720        730        740        750
FSFEAWNAKI TDLKQKVENL FNEKCGEALG LKQAVKVPFA LFESFPEDFY 
       760        770        780        790        800
VEGLPEGVPF RRPSTFGIPR LEKILRNKAK IKFIIKKPEM FETAIKESTS 
       810        820        830        840        850
SKSPPRKINS SPNVNTTASG VEDLNIIQVT IPDDDNERLS KVEKARQLRE 
       860        870        880        890        900
QVNDLFSRKF GEAIGMGFPV KVPYRKITIN PGCVVVDGMP PGVSFKAPSY 
       910        920        930        940        950
LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQSESE GPVIQESAEP 
       960        970 
SQLEVPATEE IKETDGSSQI KQEPDPTW

Show »

Length:978

Mass (Da):110,280

Checksum:ⁱ1F006D480F0BE702

Isoform 4 (identifier: P78347-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
294-314: Missing.

« Hide

        10         20         30         40         50
MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY 
        60         70         80         90        100
ETDVFVVGTE RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN 
       110        120        130        140        150
RMSVDAVEIE TLRKTVEDYF CFCYGKALGK STVVPVPYEK MLRDQSAVVV 
       160        170        180        190        200
QGLPEGVAFK HPENYDLATL KWILENKAGI SFIIKRPFLE PKKHVGGRVM 
       210        220        230        240        250
VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK EESEDPDYYQ 
       260        270        280        290        300
YNIQAGPSET DDVDEKQPLS KPLQGSHHSS EGNEGTEMEV PAEDDDYSPP 
       310        320        330        340        350
SKRPKANELP QPPVPEPANA GKRKVREFNF EKWNARITDL RKQVEELFER 
       360        370        380        390        400
KYAQAIKAKG PVTIPYPLFQ SHVEDLYVEG LPEGIPFRRP STYGIPRLER 
       410        420        430        440        450
ILLAKERIRF VIKKHELLNS TREDLQLDKP ASGVKEEWYA RITKLRKMVD 
       460        470        480        490        500
QLFCKKFAEA LGSTEAKAVP YQKFEAHPND LYVEGLPENI PFRSPSWYGI 
       510        520        530        540        550
PRLEKIIQVG NRIKFVIKRP ELLTHSTTEV TQPRTNTPVK EDWNVRITKL 
       560        570        580        590        600
RKQVEEIFNL KFAQALGLTE AVKVPYPVFE SNPEFLYVEG LPEGIPFRSP 
       610        620        630        640        650
TWFGIPRLER IVRGSNKIKF VVKKPELVIS YLPPGMASKI NTKALQSPKR 
       660        670        680        690        700
PRSPGSNSKV PEIEVTVEGP NNNNPQTSAV RTPTQTNGSN VPFKPRGREF 
       710        720        730        740        750
SFEAWNAKIT DLKQKVENLF NEKCGEALGL KQAVKVPFAL FESFPEDFYV 
       760        770        780        790        800
EGLPEGVPFR RPSTFGIPRL EKILRNKAKI KFIIKKPEMF ETAIKESTSS 
       810        820        830        840        850
KSPPRKINSS PNVNTTASGV EDLNIIQVTI PDDDNERLSK VEKARQLREQ 
       860        870        880        890        900
VNDLFSRKFG EAIGMGFPVK VPYRKITINP GCVVVDGMPP GVSFKAPSYL 
       910        920        930        940        950
EISSMRRILD SAEFIKFTVI RPFPGLVINN QLVDQSESEG PVIQESAEPS 
       960        970 
QLEVPATEEI KETDGSSQIK QEPDPTW

Show »

Length:977

Mass (Da):110,106

Checksum:ⁱ418D59EC623E6141

Isoform 5 (identifier: P78347-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-274: Missing.
     294-294: D → G
     295-998: Missing.

« Hide

        10         20         30         40         50
MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY 
        60         70         80         90        100
ETDVFVVGTE RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN 
       110        120        130        140        150
RMSVDAVEIE TLRKTVEDYF CFCYGKALGK STVVPVPYEK MLRDQSAVVV 
       160        170        180        190        200
QGLPEGVAFK HPENYDLATL KWILENKAGI SFIIKRPFLE PKKHVGGRVM 
       210        220        230        240        250
VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK EESEDPDYYQ 
       260        270 
YNIQGSHHSS EGNEGTEMEV PAEG

Note: No experimental confirmation available.

Show »

Length:274

Mass (Da):30,409

Checksum:ⁱC693096D47E9CDC7

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	174	L → G in AAB48826 (PubMed:9012831).Curated	1
Sequence conflictⁱ	178	A → G in AAB48826 (PubMed:9012831).Curated	1
Sequence conflictⁱ	481	A → R in AAB70791 (PubMed:9384587).Curated	1
Sequence conflictⁱ	634	R → H in AAB48826 (PubMed:9012831).Curated	1
Sequence conflictⁱ	960	E → K in AAB48826 (PubMed:9012831).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051026	174	L → V. Corresponds to variant dbSNP:rs1057896Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_003867	255 – 274	Missing in isoform 2, isoform 3 and isoform 5. 6 PublicationsAdd BLAST	20
Alternative sequenceⁱVSP_003868	294 – 314	Missing in isoform 2 and isoform 4. 5 PublicationsAdd BLAST	21
Alternative sequenceⁱVSP_055195	294	D → G in isoform 5. 2 Publications	1
Alternative sequenceⁱVSP_055196	295 – 998	Missing in isoform 5. 2 PublicationsAdd BLAST	704

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF015553 mRNA. Translation: AAB70791.1. Y14946 mRNA. Translation: CAA75163.1. U77948 mRNA. Translation: AAB48826.1. AF035737 mRNA. Translation: AAC08312.1. AF038967 mRNA. Translation: AAC08313.1. AF038968 mRNA. Translation: AAC08314.1. AF038969 mRNA. Translation: AAC08315.1. BT007450 mRNA. Translation: AAP36118.1. AC005231 Genomic DNA. No translation available. AC083884 Genomic DNA. Translation: AAS07460.1. AC083884 Genomic DNA. Translation: AAS07461.1. AC083884 Genomic DNA. Translation: AAS07462.1. AC083884 Genomic DNA. Translation: AAS07463.1. AC083884 Genomic DNA. Translation: AAS07464.1. AC004883 Genomic DNA. Translation: AAL93085.1. CH471200 Genomic DNA. Translation: EAW69598.1. BC004472 mRNA. Translation: AAH04472.1. BC070484 mRNA. Translation: AAH70484.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47614.1. [P78347-2] CCDS5573.1. [P78347-1] CCDS5574.1. [P78347-3] CCDS5575.1. [P78347-4] CCDS64680.1. [P78347-5]
PIRⁱ	T03829. T09492.
NCBI Reference Sequences More...RefSeqⁱ	NP_001157108.1. NM_001163636.2. NP_001267729.1. NM_001280800.1. [P78347-5] NP_001509.3. NM_001518.4. [P78347-2] NP_127492.1. NM_032999.3. [P78347-1] NP_127493.1. NM_033000.3. [P78347-3] NP_127494.1. NM_033001.3. [P78347-4]
UniGeneⁱ	Hs.647041. Hs.654705. Hs.743231.

Genome annotation databases

Ensemblⁱ	ENST00000443166; ENSP00000404240; ENSG00000263001. [P78347-5] ENST00000573035; ENSP00000460070; ENSG00000263001. [P78347-1] ENST00000614986; ENSP00000484526; ENSG00000263001. [P78347-3] ENST00000620879; ENSP00000477837; ENSG00000263001. [P78347-2] ENST00000621734; ENSP00000482476; ENSG00000263001. [P78347-4]
GeneIDⁱ	2969.
KEGGⁱ	hsa:2969.
UCSC genome browser More...UCSCⁱ	uc003uat.5. human. [P78347-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P78347	X5DR09 H2QUR5 UPI0004F0133C G1RBS1 B4DH52	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Pan paniscus (Pygmy chimpanzee) (Bonobo) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)	998	UniRef100_P78347	Cluster: General transcription factor II-I	6
P78347-2	K7B7I3 X5D2J9	Pan troglodytes (Chimpanzee) Homo sapiens (Human)	957	UniRef100_K7B7I3	Cluster: General transcription factor IIi	3
P78347-3	K7CPW9 X5DNP5	Pan troglodytes (Chimpanzee) Homo sapiens (Human)	978	UniRef100_K7CPW9	Cluster: General transcription factor IIi	3
P78347-4	K7BBK4 X5D939	Pan troglodytes (Chimpanzee) Homo sapiens (Human)	977	UniRef100_K7BBK4	Cluster: General transcription factor IIi	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P78347	Q9ESZ8 UPI0009819781 UPI00098158FF UPI000981E3A2 UPI00034F51C4 UPI00034F5992 UPI00034F294F UPI000A33A058 UPI00094329DC UPI000944DCFC +190	Mus musculus (Mouse) Castor canadensis (Beaver) Heterocephalus glaber (Naked mole rat) Rhinolophus sinicus (Chinese rufous horseshoe bat) Myotis brandtii (Brandt's bat) Papio anubis (Olive baboon) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Tarsius syrichta (Philippine tarsier) Colobus angolensis palliatus (Peters' Angolan colobus) Myotis davidii (David's myotis) And more	998	UniRef90_Q9ESZ8	Cluster: General transcription factor II-I	201
P78347-2	Q9ESZ8-3 UPI0009809A88 UPI00098175E9 UPI000981A3C6 UPI00034FF3F9 UPI0009442EFE UPI000945999A UPI00083EEDEC UPI0003AB6C1C UPI00083EB197 +92	Castor canadensis (Beaver) Heterocephalus glaber (Naked mole rat) Rhinolophus sinicus (Chinese rufous horseshoe bat) Papio anubis (Olive baboon) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Jaculus jaculus (Lesser Egyptian jerboa) Loxodonta africana (African elephant) Sus scrofa (Pig) Mus caroli (Ryukyu mouse) (Ricefield mouse) And more	960	UniRef90_Q9ESZ8-3	Cluster: Isoform 3 of General transcription factor II-I	103
P78347-3	Q9ESZ8-2 UPI0009817444 UPI0009812A68 UPI000980D736 UPI0009819FF1 UPI00034F3772 UPI00034F739E UPI00034FD19C UPI0009422874 UPI00094534C0 +201	Castor canadensis (Beaver) Heterocephalus glaber (Naked mole rat) Rhinolophus sinicus (Chinese rufous horseshoe bat) Papio anubis (Olive baboon) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Jaculus jaculus (Lesser Egyptian jerboa) Ailuropoda melanoleuca (Giant panda) Mus musculus (Mouse) Dipodomys ordii (Ord's kangaroo rat) And more	979	UniRef90_Q9ESZ8-2	Cluster: Isoform 2 of General transcription factor II-I	212
P78347-4	Q9ESZ8-2 UPI0009817444 UPI0009812A68 UPI000980D736 UPI0009819FF1 UPI00034F3772 UPI00034F739E UPI00034FD19C UPI0009422874 UPI00094534C0 +201	Castor canadensis (Beaver) Heterocephalus glaber (Naked mole rat) Rhinolophus sinicus (Chinese rufous horseshoe bat) Papio anubis (Olive baboon) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Jaculus jaculus (Lesser Egyptian jerboa) Ailuropoda melanoleuca (Giant panda) Mus musculus (Mouse) Dipodomys ordii (Ord's kangaroo rat) And more	979	UniRef90_Q9ESZ8-2	Cluster: Isoform 2 of General transcription factor II-I	212

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P78347	Q9ESZ8 UPI0009819781 UPI00098158FF UPI000981E3A2 UPI00034F51C4 UPI00034F5992 UPI00034F294F UPI000A33A058 UPI00094329DC UPI000944DCFC +657	Mus musculus (Mouse) Castor canadensis (Beaver) Heterocephalus glaber (Naked mole rat) Rhinolophus sinicus (Chinese rufous horseshoe bat) Myotis brandtii (Brandt's bat) Papio anubis (Olive baboon) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Colobus angolensis palliatus (Peters' Angolan colobus) Tarsius syrichta (Philippine tarsier) Myotis davidii (David's myotis) And more	998	UniRef50_Q9ESZ8	Cluster: General transcription factor II-I	668
P78347-5	UPI0008F502F1 UPI000732A6C3 UPI00062558C2 A0A091Q4B0 UPI00052266E9 A0A087VDJ6 UPI0005323AF7 UPI000522C073 UPI0005228D44 A0A091LFS8 +2	Gorilla gorilla gorilla (Western lowland gorilla) Macaca mulatta (Rhesus macaque) Aotus nancymaae (Ma's night monkey) Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor) Balearica regulorum gibbericeps (East African grey crowned-crane) Haliaeetus albicilla (White-tailed sea-eagle) Chlamydotis macqueenii (Macqueen's bustard) Python bivittatus (Burmese python) (Python molurus bivittatus)	274	UniRef50_P78347-5	Cluster: Isoform 5 of General transcription factor II-I	13

The DNASU plasmid repository More...DNASUⁱ	2969.
Structural Biology Knowledgebase	Search...

CTDⁱ	2969.
DisGeNET More...DisGeNETⁱ	2969.
EuPathDBⁱ	HostDB:ENSG00000263001.5.
GeneCardsⁱ	GTF2I.
H-InvDBⁱ	HIX0023260.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4659. GTF2I.
Human Protein Atlas More...HPAⁱ	CAB004595. HPA026638.
MalaCards human disease database More...MalaCardsⁱ	GTF2I.
MIMⁱ	601679. gene.
neXtProtⁱ	NX_P78347.
Open Targets More...OpenTargetsⁱ	ENSG00000263001.
Orphanetⁱ	904. Williams syndrome.
PharmGKBⁱ	PA29045.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

SIGNORⁱ	P78347.

ChiTaRSⁱ	GTF2I. human.
EvolutionaryTraceⁱ	P78347.
GeneWikiⁱ	GTF2I.
GenomeRNAiⁱ	2969.
Protein Ontology More...PROⁱ	PR:P78347.
SOURCEⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GTF2I_HUMAN
Accessionⁱ	P78347Primary (citable) accession number: P78347 Secondary accession number(s): O14743 Q9BSZ4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 13, 2001
	Last sequence update:	December 13, 2001
	Last modified:	September 27, 2017
	This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P78347 (GTF2I_HUMAN)

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General transcription factor II-I

GTF2I

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Nucleus

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<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Proteomic databases

Protocols and materials databases

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Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (5)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ