ID   GBRE_HUMAN              Reviewed;         506 AA.
AC   P78334; E7ET93; O15345; O15346; Q6PCD2; Q99520;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2001, sequence version 2.
DT   24-JAN-2024, entry version 193.
DE   RecName: Full=Gamma-aminobutyric acid receptor subunit epsilon;
DE   AltName: Full=GABA(A) receptor subunit epsilon;
DE   Flags: Precursor;
GN   Name=GABRE;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ALA-102.
RX   PubMed=9039914; DOI=10.1038/385820a0;
RA   Davies P.A., Hanna M.C., Hales T.G., Kirkness E.F.;
RT   "Insensitivity to anaesthetic agents conferred by a class of GABA(A)
RT   receptor subunit.";
RL   Nature 385:820-823(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=9339354; DOI=10.1006/geno.1997.4885;
RA   Wilke K., Gaul R., Klauck S.M., Poustka A.;
RT   "A gene in human chromosome band Xq28 (GABRE) defines a putative new
RT   subunit class of the GABAA neurotransmitter receptor.";
RL   Genomics 45:1-10(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ALA-102.
RX   PubMed=9084408; DOI=10.1046/j.1471-4159.1997.68041382.x;
RA   Garret M., Bascles L., Boue-Grabot E., Sartor P., Charron G., Bloch B.,
RA   Margolskee R.F.;
RT   "An mRNA encoding a putative GABA-gated chloride channel is expressed in
RT   the human cardiac conduction system.";
RL   J. Neurochem. 68:1382-1389(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hanna M.C., Hales T.G., Kirkness E.F.;
RT   "Alternative transcripts of a gene encoding the GABA-A receptor epsilon
RT   subunit on chromosome Xq28.";
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS PHE-9 AND
RP   ALA-102.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate
CC       brain, mediates neuronal inhibition by binding to the
CC       GABA/benzodiazepine receptor and opening an integral chloride channel.
CC   -!- SUBUNIT: Generally pentameric. Associates with alpha and beta subunits.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC       protein. Cell membrane; Multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P78334-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P78334-2; Sequence=VSP_055776, VSP_055777;
CC   -!- TISSUE SPECIFICITY: Expressed in many tissues. Highest levels of
CC       expression in adult heart and placenta.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRE sub-
CC       subfamily. {ECO:0000305}.
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DR   EMBL; U66661; AAB49284.1; -; mRNA.
DR   EMBL; Y09763; CAA70903.1; -; Genomic_DNA.
DR   EMBL; Y09764; CAA70903.1; JOINED; Genomic_DNA.
DR   EMBL; Y09765; CAA70904.1; -; mRNA.
DR   EMBL; Y07637; CAA68914.1; -; mRNA.
DR   EMBL; U92283; AAB94645.1; -; Genomic_DNA.
DR   EMBL; U92281; AAB94645.1; JOINED; Genomic_DNA.
DR   EMBL; U92282; AAB94645.1; JOINED; Genomic_DNA.
DR   EMBL; AF274855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC026337; AAH26337.1; -; mRNA.
DR   EMBL; BC047108; AAH47108.1; -; mRNA.
DR   EMBL; BC059376; AAH59376.1; -; mRNA.
DR   CCDS; CCDS14703.1; -. [P78334-1]
DR   RefSeq; NP_004952.2; NM_004961.3. [P78334-1]
DR   AlphaFoldDB; P78334; -.
DR   SMR; P78334; -.
DR   BioGRID; 108838; 50.
DR   IntAct; P78334; 25.
DR   STRING; 9606.ENSP00000359353; -.
DR   ChEMBL; CHEMBL2093872; -.
DR   DrugBank; DB12537; 1,2-Benzodiazepine.
DR   DrugBank; DB00546; Adinazolam.
DR   DrugBank; DB00404; Alprazolam.
DR   DrugBank; DB00543; Amoxapine.
DR   DrugBank; DB11901; Apalutamide.
DR   DrugBank; DB14719; Bentazepam.
DR   DrugBank; DB11859; Brexanolone.
DR   DrugBank; DB01558; Bromazepam.
DR   DrugBank; DB09017; Brotizolam.
DR   DrugBank; DB00237; Butabarbital.
DR   DrugBank; DB00241; Butalbital.
DR   DrugBank; DB01489; Camazepam.
DR   DrugBank; DB00475; Chlordiazepoxide.
DR   DrugBank; DB14715; Cinazepam.
DR   DrugBank; DB01594; Cinolazepam.
DR   DrugBank; DB00349; Clobazam.
DR   DrugBank; DB01068; Clonazepam.
DR   DrugBank; DB00628; Clorazepic acid.
DR   DrugBank; DB01559; Clotiazepam.
DR   DrugBank; DB01553; Cloxazolam.
DR   DrugBank; DB01511; Delorazepam.
DR   DrugBank; DB01189; Desflurane.
DR   DrugBank; DB00829; Diazepam.
DR   DrugBank; DB13837; Doxefazepam.
DR   DrugBank; DB00228; Enflurane.
DR   DrugBank; DB01215; Estazolam.
DR   DrugBank; DB00402; Eszopiclone.
DR   DrugBank; DB00898; Ethanol.
DR   DrugBank; DB00189; Ethchlorvynol.
DR   DrugBank; DB01545; Ethyl loflazepate.
DR   DrugBank; DB09166; Etizolam.
DR   DrugBank; DB00292; Etomidate.
DR   DrugBank; DB01567; Fludiazepam.
DR   DrugBank; DB01205; Flumazenil.
DR   DrugBank; DB01544; Flunitrazepam.
DR   DrugBank; DB00690; Flurazepam.
DR   DrugBank; DB05087; Ganaxolone.
DR   DrugBank; DB01437; Glutethimide.
DR   DrugBank; DB00801; Halazepam.
DR   DrugBank; DB01159; Halothane.
DR   DrugBank; DB00753; Isoflurane.
DR   DrugBank; DB01587; Ketazolam.
DR   DrugBank; DB00555; Lamotrigine.
DR   DrugBank; DB13643; Loprazolam.
DR   DrugBank; DB00186; Lorazepam.
DR   DrugBank; DB13872; Lormetazepam.
DR   DrugBank; DB13437; Medazepam.
DR   DrugBank; DB00603; Medroxyprogesterone acetate.
DR   DrugBank; DB01043; Memantine.
DR   DrugBank; DB00371; Meprobamate.
DR   DrugBank; DB00463; Metharbital.
DR   DrugBank; DB01028; Methoxyflurane.
DR   DrugBank; DB01107; Methyprylon.
DR   DrugBank; DB15489; Mexazolam.
DR   DrugBank; DB00683; Midazolam.
DR   DrugBank; DB01595; Nitrazepam.
DR   DrugBank; DB14028; Nordazepam.
DR   DrugBank; DB00842; Oxazepam.
DR   DrugBank; DB14672; Oxazepam acetate.
DR   DrugBank; DB00312; Pentobarbital.
DR   DrugBank; DB00252; Phenytoin.
DR   DrugBank; DB13335; Pinazepam.
DR   DrugBank; DB01708; Prasterone.
DR   DrugBank; DB01588; Prazepam.
DR   DrugBank; DB00794; Primidone.
DR   DrugBank; DB00818; Propofol.
DR   DrugBank; DB01589; Quazepam.
DR   DrugBank; DB12404; Remimazolam.
DR   DrugBank; DB01236; Sevoflurane.
DR   DrugBank; DB09118; Stiripentol.
DR   DrugBank; DB00306; Talbutal.
DR   DrugBank; DB01956; Taurine.
DR   DrugBank; DB00231; Temazepam.
DR   DrugBank; DB11582; Thiocolchicoside.
DR   DrugBank; DB00897; Triazolam.
DR   DrugCentral; P78334; -.
DR   GlyCosmos; P78334; 2 sites, No reported glycans.
DR   GlyGen; P78334; 2 sites.
DR   iPTMnet; P78334; -.
DR   PhosphoSitePlus; P78334; -.
DR   BioMuta; GABRE; -.
DR   DMDM; 13124728; -.
DR   MassIVE; P78334; -.
DR   PaxDb; 9606-ENSP00000359353; -.
DR   PeptideAtlas; P78334; -.
DR   ProteomicsDB; 18154; -.
DR   ProteomicsDB; 57572; -. [P78334-1]
DR   ABCD; P78334; 1 sequenced antibody.
DR   Antibodypedia; 30712; 269 antibodies from 24 providers.
DR   DNASU; 2564; -.
DR   Ensembl; ENST00000370328.4; ENSP00000359353.3; ENSG00000102287.19. [P78334-1]
DR   GeneID; 2564; -.
DR   KEGG; hsa:2564; -.
DR   MANE-Select; ENST00000370328.4; ENSP00000359353.3; NM_004961.4; NP_004952.2.
DR   UCSC; uc004ffi.3; human. [P78334-1]
DR   AGR; HGNC:4085; -.
DR   CTD; 2564; -.
DR   DisGeNET; 2564; -.
DR   GeneCards; GABRE; -.
DR   HGNC; HGNC:4085; GABRE.
DR   HPA; ENSG00000102287; Tissue enhanced (adipose tissue, brain, heart muscle).
DR   MalaCards; GABRE; -.
DR   MIM; 300093; gene.
DR   neXtProt; NX_P78334; -.
DR   OpenTargets; ENSG00000102287; -.
DR   PharmGKB; PA28499; -.
DR   VEuPathDB; HostDB:ENSG00000102287; -.
DR   eggNOG; KOG3642; Eukaryota.
DR   GeneTree; ENSGT00940000161201; -.
DR   HOGENOM; CLU_010920_2_0_1; -.
DR   InParanoid; P78334; -.
DR   OMA; CFIFCFC; -.
DR   OrthoDB; 4265336at2759; -.
DR   PhylomeDB; P78334; -.
DR   TreeFam; TF315453; -.
DR   PathwayCommons; P78334; -.
DR   SignaLink; P78334; -.
DR   BioGRID-ORCS; 2564; 4 hits in 789 CRISPR screens.
DR   ChiTaRS; GABRE; human.
DR   GeneWiki; GABRE; -.
DR   GenomeRNAi; 2564; -.
DR   Pharos; P78334; Tclin.
DR   PRO; PR:P78334; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; P78334; Protein.
DR   Bgee; ENSG00000102287; Expressed in lower esophagus mucosa and 150 other cell types or tissues.
DR   ExpressionAtlas; P78334; baseline and differential.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0032590; C:dendrite membrane; IBA:GO_Central.
DR   GO; GO:1902711; C:GABA-A receptor complex; IDA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0098794; C:postsynapse; IBA:GO_Central.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR   GO; GO:0022851; F:GABA-gated chloride ion channel activity; IDA:GO_Central.
DR   GO; GO:0005237; F:inhibitory extracellular ligand-gated monoatomic ion channel activity; IBA:GO_Central.
DR   GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR   GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:GO_Central.
DR   GO; GO:2001226; P:negative regulation of chloride transport; IDA:GO_Central.
DR   GO; GO:0060078; P:regulation of postsynaptic membrane potential; IBA:GO_Central.
DR   GO; GO:0051932; P:synaptic transmission, GABAergic; IBA:GO_Central.
DR   CDD; cd19002; LGIC_ECD_GABAAR_E; 1.
DR   CDD; cd19057; LGIC_TM_GABAAR_epsilon; 1.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR008099; GABAAe_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   NCBIfam; TIGR00860; LIC; 1.
DR   PANTHER; PTHR18945:SF397; GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT EPSILON; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR01723; GABAAREPSLON.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
DR   Genevisible; P78334; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Chloride; Chloride channel;
KW   Disulfide bond; Glycoprotein; Ion channel; Ion transport; Membrane;
KW   Postsynaptic cell membrane; Reference proteome; Signal; Synapse;
KW   Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..506
FT                   /note="Gamma-aminobutyric acid receptor subunit epsilon"
FT                   /id="PRO_0000000471"
FT   TOPO_DOM        23..253
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        365..485
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        486..506
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          23..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          413..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        252
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        195..209
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         365
FT                   /note="I -> M (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_055776"
FT   VAR_SEQ         366..506
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_055777"
FT   VARIANT         9
FT                   /note="L -> F (in dbSNP:rs17855708)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_071089"
FT   VARIANT         102
FT                   /note="S -> A (in dbSNP:rs1139916)"
FT                   /evidence="ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|PubMed:9039914, ECO:0000269|PubMed:9084408"
FT                   /id="VAR_048175"
FT   CONFLICT        245
FT                   /note="F -> L (in Ref. 2; CAA70903)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        261
FT                   /note="Missing (in Ref. 3; CAA68914)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        471
FT                   /note="G -> A (in Ref. 2; CAA70903)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        502
FT                   /note="V -> F (in Ref. 2; CAA70903)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   506 AA;  57972 MW;  013EE136EECFCC73 CRC64;
     MLSKVLPVLL GILLILQSRV EGPQTESKNE ASSRDVVYGP QPQPLENQLL SEETKSTETE
     TGSRVGKLPE ASRILNTILS NYDHKLRPGI GEKPTVVTVE ISVNSLGPLS ILDMEYTIDI
     IFSQTWYDER LCYNDTFESL VLNGNVVSQL WIPDTFFRNS KRTHEHEITM PNQMVRIYKD
     GKVLYTIRMT IDAGCSLHML RFPMDSHSCP LSFSSFSYPE NEMIYKWENF KLEINEKNSW
     KLFQFDFTGV SNKTEIITTP VGDFMVMTIF FNVSRRFGYV AFQNYVPSSV TTMLSWVSFW
     IKTESAPART SLGITSVLTM TTLGTFSRKN FPRVSYITAL DFYIAICFVF CFCALLEFAV
     LNFLIYNQTK AHASPKLRHP RINSRAHART RARSRACARQ HQEAFVCQIV TTEGSDGEER
     PSCSAQQPPS PGSPEGPRSL CSKLACCEWC KRFKKYFCMV PDCEGSTWQQ GRLCIHVYRL
     DNYSRVVFPV TFFFFNVLYW LVCLNL
//