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Protein

Glypican-5

Gene

GPC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate.By similarity

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. chondroitin sulfate metabolic process Source: Reactome
  3. glycosaminoglycan biosynthetic process Source: Reactome
  4. glycosaminoglycan catabolic process Source: Reactome
  5. glycosaminoglycan metabolic process Source: Reactome
  6. pathogenesis Source: Reactome
  7. phototransduction, visible light Source: Reactome
  8. retinoid metabolic process Source: Reactome
  9. small molecule metabolic process Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_120752. HS-GAG degradation.
REACT_121248. HS-GAG biosynthesis.
REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_24968. Retinoid metabolism and transport.
REACT_264256. Release of Hh-Np from the secreting cell.
REACT_267741. Defective EXT2 causes exostoses 2.
REACT_267942. Defective EXT1 causes exostoses 1, TRPS2 and CHDS.
REACT_268678. Defective B3GAT3 causes JDSSDHD.
REACT_268749. Defective B4GALT7 causes EDS, progeroid type.

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-5
Cleaved into the following chain:
Gene namesi
Name:GPC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:4453. GPC5.

Subcellular locationi

Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity; Extracellular side By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. extracellular region Source: Reactome
  3. extracellular space Source: UniProtKB-SubCell
  4. Golgi lumen Source: Reactome
  5. integral component of plasma membrane Source: ProtInc
  6. lysosomal lumen Source: Reactome
  7. plasma membrane Source: Reactome
  8. proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28834.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 572Removed in mature formSequence AnalysisPRO_0000012320
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – ?Glypican-5PRO_0000012319
Chaini25 – ?Secreted glypican-5PRO_0000333849

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi441 – 4411O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
Glycosylationi486 – 4861O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
Glycosylationi495 – 4951O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
Glycosylationi507 – 5071O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
Glycosylationi509 – 5091O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
Glycosylationi527 – 5271N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Proteoglycan

Proteomic databases

MaxQBiP78333.
PaxDbiP78333.
PRIDEiP78333.

PTM databases

PhosphoSiteiP78333.

Expressioni

Tissue specificityi

In adult, primarily expressed in the brain. Also detected in fetal brain, lung and liver.2 Publications

Gene expression databases

BgeeiP78333.
CleanExiHS_GPC5.
GenevestigatoriP78333.

Organism-specific databases

HPAiCAB025506.
HPA044081.

Interactioni

Protein-protein interaction databases

BioGridi108553. 2 interactions.
IntActiP78333. 2 interactions.
STRINGi9606.ENSP00000366267.

Structurei

3D structure databases

SMRiP78333. Positions 28-470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG246767.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000049177.
HOVERGENiHBG005896.
InParanoidiP78333.
KOiK08111.
OMAiSPKPDKW.
OrthoDBiEOG761BTG.
PhylomeDBiP78333.
TreeFamiTF105317.

Family and domain databases

InterProiIPR001863. Glypican.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P78333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAQTWPVGF RCLLLLALVG SARSEGVQTC EEVRKLFQWR LLGAVRGLPD
60 70 80 90 100
SPRAGPDLQV CISKKPTCCT RKMEERYQIA ARQDMQQFLQ TSSSTLKFLI
110 120 130 140 150
SRNAAAFQET LETLIKQAEN YTSILFCSTY RNMALEAAAS VQEFFTDVGL
160 170 180 190 200
YLFGADVNPE EFVNRFFDSL FPLVYNHLIN PGVTDSSLEY SECIRMARRD
210 220 230 240 250
VSPFGNIPQR VMGQMGRSLL PSRTFLQALN LGIEVINTTD YLHFSKECSR
260 270 280 290 300
ALLKMQYCPH CQGLALTKPC MGYCLNVMRG CLAHMAELNP HWHAYIRSLE
310 320 330 340 350
ELSDAMHGTY DIGHVLLNFH LLVNDAVLQA HLNGQKLLEQ VNRICGRPVR
360 370 380 390 400
TPTQSPRCSF DQSKEKHGMK TTTRNSEETL ANRRKEFINS LRLYRSFYGG
410 420 430 440 450
LADQLCANEL AAADGLPCWN GEDIVKSYTQ RVVGNGIKAQ SGNPEVKVKG
460 470 480 490 500
IDPVINQIID KLKHVVQLLQ GRSPKPDKWE LLQLGSGGGM VEQVSGDCDD
510 520 530 540 550
EDGCGGSGSG EVKRTLKITD WMPDDMNFSD VKQIHQTDTG STLDTTGAGC
560 570
AVATESMTFT LISVVMLLPG IW
Length:572
Mass (Da):63,707
Last modified:May 1, 1997 - v1
Checksum:iA17969FE0DD0D308
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 2051G → C in AAC12261 (PubMed:9331333).Curated
Sequence conflicti245 – 2451S → F in AAC12261 (PubMed:9331333).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti155 – 1551A → V.
Corresponds to variant rs553717 [ dbSNP | Ensembl ].
VAR_024228

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66033 mRNA. Translation: AAC51118.1.
AF001462 mRNA. Translation: AAC12261.1.
AK312815 mRNA. Translation: BAG35673.1.
AL157363
, AL162456, AL163537, AL157821, AL138714 Genomic DNA. Translation: CAH71865.1.
AL138714
, AL157821, AL163537, AL162456, AL157363 Genomic DNA. Translation: CAH70260.1.
AL157821
, AL157363, AL163537, AL162456, AL138714 Genomic DNA. Translation: CAC34558.2.
AL163537
, AL138714, AL162456, AL157821, AL157363 Genomic DNA. Translation: CAI13232.1.
AL162456
, AL163537, AL157821, AL157363, AL138714 Genomic DNA. Translation: CAI17090.1.
BC039730 mRNA. Translation: AAH39730.1.
CCDSiCCDS9468.1.
RefSeqiNP_004457.1. NM_004466.5.
UniGeneiHs.655675.

Genome annotation databases

EnsembliENST00000377067; ENSP00000366267; ENSG00000179399.
GeneIDi2262.
KEGGihsa:2262.
UCSCiuc010tif.2. human.

Polymorphism databases

DMDMi2829667.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66033 mRNA. Translation: AAC51118.1.
AF001462 mRNA. Translation: AAC12261.1.
AK312815 mRNA. Translation: BAG35673.1.
AL157363
, AL162456, AL163537, AL157821, AL138714 Genomic DNA. Translation: CAH71865.1.
AL138714
, AL157821, AL163537, AL162456, AL157363 Genomic DNA. Translation: CAH70260.1.
AL157821
, AL157363, AL163537, AL162456, AL138714 Genomic DNA. Translation: CAC34558.2.
AL163537
, AL138714, AL162456, AL157821, AL157363 Genomic DNA. Translation: CAI13232.1.
AL162456
, AL163537, AL157821, AL157363, AL138714 Genomic DNA. Translation: CAI17090.1.
BC039730 mRNA. Translation: AAH39730.1.
CCDSiCCDS9468.1.
RefSeqiNP_004457.1. NM_004466.5.
UniGeneiHs.655675.

3D structure databases

SMRiP78333. Positions 28-470.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108553. 2 interactions.
IntActiP78333. 2 interactions.
STRINGi9606.ENSP00000366267.

PTM databases

PhosphoSiteiP78333.

Polymorphism databases

DMDMi2829667.

Proteomic databases

MaxQBiP78333.
PaxDbiP78333.
PRIDEiP78333.

Protocols and materials databases

DNASUi2262.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377067; ENSP00000366267; ENSG00000179399.
GeneIDi2262.
KEGGihsa:2262.
UCSCiuc010tif.2. human.

Organism-specific databases

CTDi2262.
GeneCardsiGC13P092050.
HGNCiHGNC:4453. GPC5.
HPAiCAB025506.
HPA044081.
MIMi602446. gene.
neXtProtiNX_P78333.
PharmGKBiPA28834.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG246767.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000049177.
HOVERGENiHBG005896.
InParanoidiP78333.
KOiK08111.
OMAiSPKPDKW.
OrthoDBiEOG761BTG.
PhylomeDBiP78333.
TreeFamiTF105317.

Enzyme and pathway databases

ReactomeiREACT_120752. HS-GAG degradation.
REACT_121248. HS-GAG biosynthesis.
REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_24968. Retinoid metabolism and transport.
REACT_264256. Release of Hh-Np from the secreting cell.
REACT_267741. Defective EXT2 causes exostoses 2.
REACT_267942. Defective EXT1 causes exostoses 1, TRPS2 and CHDS.
REACT_268678. Defective B3GAT3 causes JDSSDHD.
REACT_268749. Defective B4GALT7 causes EDS, progeroid type.

Miscellaneous databases

ChiTaRSiGPC5. human.
GeneWikiiGlypican_5.
GenomeRNAii2262.
NextBioi9185.
PROiP78333.
SOURCEiSearch...

Gene expression databases

BgeeiP78333.
CleanExiHS_GPC5.
GenevestigatoriP78333.

Family and domain databases

InterProiIPR001863. Glypican.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family."
    Veugelers M., Vermeesch J., Reekmans G., Steinfeld R., Marynen P., David G.
    Genomics 40:24-30(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain."
    Saunders S., Paine-Saunders S., Lander A.D.
    Dev. Biol. 190:78-93(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGPC5_HUMAN
AccessioniPrimary (citable) accession number: P78333
Secondary accession number(s): B2R726, O60436, Q9BX27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: April 1, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.