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P78333 (GPC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glypican-5

Cleaved into the following chain:

  1. Secreted glypican-5
Gene names
Name:GPC5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell surface proteoglycan that bears heparan sulfate By similarity.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor; Extracellular side By similarity.

Secreted glypican-5: Secretedextracellular space By similarity.

Tissue specificity

In adult, primarily expressed in the brain. Also detected in fetal brain, lung and liver. Ref.1 Ref.2

Sequence similarities

Belongs to the glypican family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – ?Glypican-5PRO_0000012319
Chain25 – ?Secreted glypican-5PRO_0000333849
Propeptide? – 572Removed in mature form PotentialPRO_0000012320

Amino acid modifications

Glycosylation1201N-linked (GlcNAc...) Potential
Glycosylation2371N-linked (GlcNAc...) Potential
Glycosylation4411O-linked (Xyl...) (glycosaminoglycan) Potential
Glycosylation4861O-linked (Xyl...) (glycosaminoglycan) Potential
Glycosylation4951O-linked (Xyl...) (glycosaminoglycan) Potential
Glycosylation5071O-linked (Xyl...) (glycosaminoglycan) Potential
Glycosylation5091O-linked (Xyl...) (glycosaminoglycan) Potential
Glycosylation5271N-linked (GlcNAc...) Potential

Natural variations

Natural variant1551A → V.
Corresponds to variant rs553717 [ dbSNP | Ensembl ].
VAR_024228

Experimental info

Sequence conflict2051G → C in AAC12261. Ref.2
Sequence conflict2451S → F in AAC12261. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P78333 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: A17969FE0DD0D308

FASTA57263,707
        10         20         30         40         50         60 
MDAQTWPVGF RCLLLLALVG SARSEGVQTC EEVRKLFQWR LLGAVRGLPD SPRAGPDLQV 

        70         80         90        100        110        120 
CISKKPTCCT RKMEERYQIA ARQDMQQFLQ TSSSTLKFLI SRNAAAFQET LETLIKQAEN 

       130        140        150        160        170        180 
YTSILFCSTY RNMALEAAAS VQEFFTDVGL YLFGADVNPE EFVNRFFDSL FPLVYNHLIN 

       190        200        210        220        230        240 
PGVTDSSLEY SECIRMARRD VSPFGNIPQR VMGQMGRSLL PSRTFLQALN LGIEVINTTD 

       250        260        270        280        290        300 
YLHFSKECSR ALLKMQYCPH CQGLALTKPC MGYCLNVMRG CLAHMAELNP HWHAYIRSLE 

       310        320        330        340        350        360 
ELSDAMHGTY DIGHVLLNFH LLVNDAVLQA HLNGQKLLEQ VNRICGRPVR TPTQSPRCSF 

       370        380        390        400        410        420 
DQSKEKHGMK TTTRNSEETL ANRRKEFINS LRLYRSFYGG LADQLCANEL AAADGLPCWN 

       430        440        450        460        470        480 
GEDIVKSYTQ RVVGNGIKAQ SGNPEVKVKG IDPVINQIID KLKHVVQLLQ GRSPKPDKWE 

       490        500        510        520        530        540 
LLQLGSGGGM VEQVSGDCDD EDGCGGSGSG EVKRTLKITD WMPDDMNFSD VKQIHQTDTG 

       550        560        570 
STLDTTGAGC AVATESMTFT LISVVMLLPG IW 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family."
Veugelers M., Vermeesch J., Reekmans G., Steinfeld R., Marynen P., David G.
Genomics 40:24-30(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain.
[2]"Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain."
Saunders S., Paine-Saunders S., Lander A.D.
Dev. Biol. 190:78-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U66033 mRNA. Translation: AAC51118.1.
AF001462 mRNA. Translation: AAC12261.1.
AK312815 mRNA. Translation: BAG35673.1.
AL157363 expand/collapse EMBL AC list , AL162456, AL163537, AL157821, AL138714 Genomic DNA. Translation: CAH71865.1.
AL138714 expand/collapse EMBL AC list , AL157821, AL163537, AL162456, AL157363 Genomic DNA. Translation: CAH70260.1.
AL157821 expand/collapse EMBL AC list , AL157363, AL163537, AL162456, AL138714 Genomic DNA. Translation: CAC34558.2.
AL163537 expand/collapse EMBL AC list , AL138714, AL162456, AL157821, AL157363 Genomic DNA. Translation: CAI13232.1.
AL162456 expand/collapse EMBL AC list , AL163537, AL157821, AL157363, AL138714 Genomic DNA. Translation: CAI17090.1.
BC039730 mRNA. Translation: AAH39730.1.
CCDSCCDS9468.1.
RefSeqNP_004457.1. NM_004466.5.
UniGeneHs.655675.

3D structure databases

ProteinModelPortalP78333.
SMRP78333. Positions 28-470.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108553. 2 interactions.
IntActP78333. 2 interactions.
STRING9606.ENSP00000366267.

PTM databases

PhosphoSiteP78333.

Polymorphism databases

DMDM2829667.

Proteomic databases

MaxQBP78333.
PaxDbP78333.
PRIDEP78333.

Protocols and materials databases

DNASU2262.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377067; ENSP00000366267; ENSG00000179399.
GeneID2262.
KEGGhsa:2262.
UCSCuc010tif.2. human.

Organism-specific databases

CTD2262.
GeneCardsGC13P092050.
HGNCHGNC:4453. GPC5.
HPACAB025506.
HPA040152.
HPA057418.
MIM602446. gene.
neXtProtNX_P78333.
PharmGKBPA28834.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG246767.
HOGENOMHOG000049177.
HOVERGENHBG005896.
InParanoidP78333.
KOK08111.
OMASPKPDKW.
OrthoDBEOG761BTG.
PhylomeDBP78333.
TreeFamTF105317.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_111217. Metabolism.
REACT_116125. Disease.

Gene expression databases

BgeeP78333.
CleanExHS_GPC5.
GenevestigatorP78333.

Family and domain databases

InterProIPR001863. Glypican.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERPTHR10822. PTHR10822. 1 hit.
PfamPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEPS01207. GLYPICAN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGlypican_5.
GenomeRNAi2262.
NextBio9185.
PROP78333.
SOURCESearch...

Entry information

Entry nameGPC5_HUMAN
AccessionPrimary (citable) accession number: P78333
Secondary accession number(s): B2R726, O60436, Q9BX27
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM