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P78333

- GPC5_HUMAN

UniProt

P78333 - GPC5_HUMAN

Protein

Glypican-5

Gene

GPC5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Cell surface proteoglycan that bears heparan sulfate.By similarity

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. chondroitin sulfate metabolic process Source: Reactome
    3. glycosaminoglycan biosynthetic process Source: Reactome
    4. glycosaminoglycan catabolic process Source: Reactome
    5. glycosaminoglycan metabolic process Source: Reactome
    6. phototransduction, visible light Source: Reactome
    7. retinoid metabolic process Source: Reactome
    8. small molecule metabolic process Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_120752. HS-GAG degradation.
    REACT_121248. HS-GAG biosynthesis.
    REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_24968. Retinoid metabolism and transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glypican-5
    Cleaved into the following chain:
    Gene namesi
    Name:GPC5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:4453. GPC5.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity; Extracellular side By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. extracellular space Source: UniProtKB-SubCell
    3. Golgi lumen Source: Reactome
    4. integral component of plasma membrane Source: ProtInc
    5. lysosomal lumen Source: Reactome
    6. plasma membrane Source: Reactome
    7. proteinaceous extracellular matrix Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28834.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei? – 572Removed in mature formSequence AnalysisPRO_0000012320
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – ?Glypican-5PRO_0000012319
    Chaini25 – ?Secreted glypican-5PRO_0000333849

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi441 – 4411O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi486 – 4861O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi495 – 4951O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi507 – 5071O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi509 – 5091O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi527 – 5271N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Proteoglycan

    Proteomic databases

    MaxQBiP78333.
    PaxDbiP78333.
    PRIDEiP78333.

    PTM databases

    PhosphoSiteiP78333.

    Expressioni

    Tissue specificityi

    In adult, primarily expressed in the brain. Also detected in fetal brain, lung and liver.2 Publications

    Gene expression databases

    BgeeiP78333.
    CleanExiHS_GPC5.
    GenevestigatoriP78333.

    Organism-specific databases

    HPAiCAB025506.
    HPA040152.
    HPA057418.

    Interactioni

    Protein-protein interaction databases

    BioGridi108553. 2 interactions.
    IntActiP78333. 2 interactions.
    STRINGi9606.ENSP00000366267.

    Structurei

    3D structure databases

    ProteinModelPortaliP78333.
    SMRiP78333. Positions 28-470.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glypican family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG246767.
    HOGENOMiHOG000049177.
    HOVERGENiHBG005896.
    InParanoidiP78333.
    KOiK08111.
    OMAiSPKPDKW.
    OrthoDBiEOG761BTG.
    PhylomeDBiP78333.
    TreeFamiTF105317.

    Family and domain databases

    InterProiIPR001863. Glypican.
    IPR019803. Glypican_CS.
    [Graphical view]
    PANTHERiPTHR10822. PTHR10822. 1 hit.
    PfamiPF01153. Glypican. 1 hit.
    [Graphical view]
    PROSITEiPS01207. GLYPICAN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P78333-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAQTWPVGF RCLLLLALVG SARSEGVQTC EEVRKLFQWR LLGAVRGLPD    50
    SPRAGPDLQV CISKKPTCCT RKMEERYQIA ARQDMQQFLQ TSSSTLKFLI 100
    SRNAAAFQET LETLIKQAEN YTSILFCSTY RNMALEAAAS VQEFFTDVGL 150
    YLFGADVNPE EFVNRFFDSL FPLVYNHLIN PGVTDSSLEY SECIRMARRD 200
    VSPFGNIPQR VMGQMGRSLL PSRTFLQALN LGIEVINTTD YLHFSKECSR 250
    ALLKMQYCPH CQGLALTKPC MGYCLNVMRG CLAHMAELNP HWHAYIRSLE 300
    ELSDAMHGTY DIGHVLLNFH LLVNDAVLQA HLNGQKLLEQ VNRICGRPVR 350
    TPTQSPRCSF DQSKEKHGMK TTTRNSEETL ANRRKEFINS LRLYRSFYGG 400
    LADQLCANEL AAADGLPCWN GEDIVKSYTQ RVVGNGIKAQ SGNPEVKVKG 450
    IDPVINQIID KLKHVVQLLQ GRSPKPDKWE LLQLGSGGGM VEQVSGDCDD 500
    EDGCGGSGSG EVKRTLKITD WMPDDMNFSD VKQIHQTDTG STLDTTGAGC 550
    AVATESMTFT LISVVMLLPG IW 572
    Length:572
    Mass (Da):63,707
    Last modified:May 1, 1997 - v1
    Checksum:iA17969FE0DD0D308
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti205 – 2051G → C in AAC12261. (PubMed:9331333)Curated
    Sequence conflicti245 – 2451S → F in AAC12261. (PubMed:9331333)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti155 – 1551A → V.
    Corresponds to variant rs553717 [ dbSNP | Ensembl ].
    VAR_024228

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66033 mRNA. Translation: AAC51118.1.
    AF001462 mRNA. Translation: AAC12261.1.
    AK312815 mRNA. Translation: BAG35673.1.
    AL157363
    , AL162456, AL163537, AL157821, AL138714 Genomic DNA. Translation: CAH71865.1.
    AL138714
    , AL157821, AL163537, AL162456, AL157363 Genomic DNA. Translation: CAH70260.1.
    AL157821
    , AL157363, AL163537, AL162456, AL138714 Genomic DNA. Translation: CAC34558.2.
    AL163537
    , AL138714, AL162456, AL157821, AL157363 Genomic DNA. Translation: CAI13232.1.
    AL162456
    , AL163537, AL157821, AL157363, AL138714 Genomic DNA. Translation: CAI17090.1.
    BC039730 mRNA. Translation: AAH39730.1.
    CCDSiCCDS9468.1.
    RefSeqiNP_004457.1. NM_004466.5.
    UniGeneiHs.655675.

    Genome annotation databases

    EnsembliENST00000377067; ENSP00000366267; ENSG00000179399.
    GeneIDi2262.
    KEGGihsa:2262.
    UCSCiuc010tif.2. human.

    Polymorphism databases

    DMDMi2829667.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66033 mRNA. Translation: AAC51118.1 .
    AF001462 mRNA. Translation: AAC12261.1 .
    AK312815 mRNA. Translation: BAG35673.1 .
    AL157363
    , AL162456 , AL163537 , AL157821 , AL138714 Genomic DNA. Translation: CAH71865.1 .
    AL138714
    , AL157821 , AL163537 , AL162456 , AL157363 Genomic DNA. Translation: CAH70260.1 .
    AL157821
    , AL157363 , AL163537 , AL162456 , AL138714 Genomic DNA. Translation: CAC34558.2 .
    AL163537
    , AL138714 , AL162456 , AL157821 , AL157363 Genomic DNA. Translation: CAI13232.1 .
    AL162456
    , AL163537 , AL157821 , AL157363 , AL138714 Genomic DNA. Translation: CAI17090.1 .
    BC039730 mRNA. Translation: AAH39730.1 .
    CCDSi CCDS9468.1.
    RefSeqi NP_004457.1. NM_004466.5.
    UniGenei Hs.655675.

    3D structure databases

    ProteinModelPortali P78333.
    SMRi P78333. Positions 28-470.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108553. 2 interactions.
    IntActi P78333. 2 interactions.
    STRINGi 9606.ENSP00000366267.

    PTM databases

    PhosphoSitei P78333.

    Polymorphism databases

    DMDMi 2829667.

    Proteomic databases

    MaxQBi P78333.
    PaxDbi P78333.
    PRIDEi P78333.

    Protocols and materials databases

    DNASUi 2262.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377067 ; ENSP00000366267 ; ENSG00000179399 .
    GeneIDi 2262.
    KEGGi hsa:2262.
    UCSCi uc010tif.2. human.

    Organism-specific databases

    CTDi 2262.
    GeneCardsi GC13P092050.
    HGNCi HGNC:4453. GPC5.
    HPAi CAB025506.
    HPA040152.
    HPA057418.
    MIMi 602446. gene.
    neXtProti NX_P78333.
    PharmGKBi PA28834.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG246767.
    HOGENOMi HOG000049177.
    HOVERGENi HBG005896.
    InParanoidi P78333.
    KOi K08111.
    OMAi SPKPDKW.
    OrthoDBi EOG761BTG.
    PhylomeDBi P78333.
    TreeFami TF105317.

    Enzyme and pathway databases

    Reactomei REACT_120752. HS-GAG degradation.
    REACT_121248. HS-GAG biosynthesis.
    REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_24968. Retinoid metabolism and transport.

    Miscellaneous databases

    GeneWikii Glypican_5.
    GenomeRNAii 2262.
    NextBioi 9185.
    PROi P78333.
    SOURCEi Search...

    Gene expression databases

    Bgeei P78333.
    CleanExi HS_GPC5.
    Genevestigatori P78333.

    Family and domain databases

    InterProi IPR001863. Glypican.
    IPR019803. Glypican_CS.
    [Graphical view ]
    PANTHERi PTHR10822. PTHR10822. 1 hit.
    Pfami PF01153. Glypican. 1 hit.
    [Graphical view ]
    PROSITEi PS01207. GLYPICAN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family."
      Veugelers M., Vermeesch J., Reekmans G., Steinfeld R., Marynen P., David G.
      Genomics 40:24-30(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain."
      Saunders S., Paine-Saunders S., Lander A.D.
      Dev. Biol. 190:78-93(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGPC5_HUMAN
    AccessioniPrimary (citable) accession number: P78333
    Secondary accession number(s): B2R726, O60436, Q9BX27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3