P78333 (GPC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glypican-5

Cleaved into the following chain:

1. Secreted glypican-5

Gene names

Name:

GPC5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	572 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cell surface proteoglycan that bears heparan sulfate By similarity.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor; Extracellular side By similarity. Secreted glypican-5: Secreted › extracellular space By similarity.
Tissue specificity	In adult, primarily expressed in the brain. Also detected in fetal brain, lung and liver. Ref.1 Ref.2
Sequence similarities	Belongs to the glypican family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	GPI-anchor Glycoprotein Heparan sulfate Lipoprotein Proteoglycan
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Traceable author statement. Source: Reactome chondroitin sulfate metabolic process Traceable author statement. Source: Reactome glycosaminoglycan biosynthetic process Traceable author statement. Source: Reactome glycosaminoglycan catabolic process Traceable author statement. Source: Reactome phototransduction, visible light Traceable author statement. Source: Reactome retinoid metabolic process Traceable author statement. Source: Reactome
Cellular_component	Golgi lumen Traceable author statement. Source: Reactome anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Traceable author statement PubMed 7657705. Source: ProtInc lysosomal lumen Traceable author statement. Source: Reactome proteinaceous extracellular matrix Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – ?		Glypican-5		PRO_0000012319
	Chain	25 – ?		Secreted glypican-5		PRO_0000333849
	Propeptide	? – 572		Removed in mature form Potential		PRO_0000012320
Amino acid modifications
	Glycosylation	120	1	N-linked (GlcNAc...) Potential
	Glycosylation	237	1	N-linked (GlcNAc...) Potential
	Glycosylation	441	1	O-linked (Xyl...) (glycosaminoglycan) Potential
	Glycosylation	486	1	O-linked (Xyl...) (glycosaminoglycan) Potential
	Glycosylation	495	1	O-linked (Xyl...) (glycosaminoglycan) Potential
	Glycosylation	507	1	O-linked (Xyl...) (glycosaminoglycan) Potential
	Glycosylation	509	1	O-linked (Xyl...) (glycosaminoglycan) Potential
	Glycosylation	527	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	155	1	A → V. Corresponds to variant rs553717 [ dbSNP | Ensembl ].		VAR_024228
Experimental info
	Sequence conflict	205	1	G → C in AAC12261. Ref.2
	Sequence conflict	245	1	S → F in AAC12261. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P78333 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: A17969FE0DD0D308	FASTA	572	63,707
	10 20 30 40 50 60 MDAQTWPVGF RCLLLLALVG SARSEGVQTC EEVRKLFQWR LLGAVRGLPD SPRAGPDLQV 70 80 90 100 110 120 CISKKPTCCT RKMEERYQIA ARQDMQQFLQ TSSSTLKFLI SRNAAAFQET LETLIKQAEN 130 140 150 160 170 180 YTSILFCSTY RNMALEAAAS VQEFFTDVGL YLFGADVNPE EFVNRFFDSL FPLVYNHLIN 190 200 210 220 230 240 PGVTDSSLEY SECIRMARRD VSPFGNIPQR VMGQMGRSLL PSRTFLQALN LGIEVINTTD 250 260 270 280 290 300 YLHFSKECSR ALLKMQYCPH CQGLALTKPC MGYCLNVMRG CLAHMAELNP HWHAYIRSLE 310 320 330 340 350 360 ELSDAMHGTY DIGHVLLNFH LLVNDAVLQA HLNGQKLLEQ VNRICGRPVR TPTQSPRCSF 370 380 390 400 410 420 DQSKEKHGMK TTTRNSEETL ANRRKEFINS LRLYRSFYGG LADQLCANEL AAADGLPCWN 430 440 450 460 470 480 GEDIVKSYTQ RVVGNGIKAQ SGNPEVKVKG IDPVINQIID KLKHVVQLLQ GRSPKPDKWE 490 500 510 520 530 540 LLQLGSGGGM VEQVSGDCDD EDGCGGSGSG EVKRTLKITD WMPDDMNFSD VKQIHQTDTG 550 560 570 STLDTTGAGC AVATESMTFT LISVVMLLPG IW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family." Veugelers M., Vermeesch J., Reekmans G., Steinfeld R., Marynen P., David G. Genomics 40:24-30(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain.
[2]	"Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain." Saunders S., Paine-Saunders S., Lander A.D. Dev. Biol. 190:78-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	U66033 mRNA. Translation: AAC51118.1. AF001462 mRNA. Translation: AAC12261.1. AK312815 mRNA. Translation: BAG35673.1. AL157363 , AL162456, AL163537, AL157821, AL138714 Genomic DNA. Translation: CAH71865.1. AL138714 , AL157821, AL163537, AL162456, AL157363 Genomic DNA. Translation: CAH70260.1. AL157821 , AL157363, AL163537, AL162456, AL138714 Genomic DNA. Translation: CAC34558.2. AL163537 , AL138714, AL162456, AL157821, AL157363 Genomic DNA. Translation: CAI13232.1. AL162456 , AL163537, AL157821, AL157363, AL138714 Genomic DNA. Translation: CAI17090.1. BC039730 mRNA. Translation: AAH39730.1.
IPI	IPI00019180.
RefSeq	NP_004457.1. NM_004466.4.
UniGene	Hs.655675.
3D structure databases
ProteinModelPortal	P78333.
ModBase	Search...
Protein-protein interaction databases
IntAct	P78333. 2 interactions.
STRING	9606.ENSP00000366267.
PTM databases
PhosphoSite	P78333.
Polymorphism databases
DMDM	2829667.
Proteomic databases
PaxDb	P78333.
PRIDE	P78333.
Protocols and materials databases
DNASU	2262.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377067; ENSP00000366267; ENSG00000179399.
GeneID	2262.
KEGG	hsa:2262.
UCSC	uc010tif.2. human.
Organism-specific databases
CTD	2262.
GeneCards	GC13P092050.
HGNC	HGNC:4453. GPC5.
HPA	CAB025506.
MIM	602446. gene.
neXtProt	NX_P78333.
PharmGKB	PA28834.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG246767.
HOGENOM	HOG000049177.
HOVERGEN	HBG005896.
InParanoid	P78333.
KO	K08111.
OMA	PKPDKWE.
OrthoDB	EOG46144N.
PhylomeDB	P78333.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_116125. Disease.
Gene expression databases
Bgee	P78333.
CleanEx	HS_GPC5.
Genevestigator	P78333.
GermOnline	ENSG00000179399. Homo sapiens.
Family and domain databases
InterPro	IPR001863. Glypican. IPR019803. Glypican_CS. [Graphical view]
PANTHER	PTHR10822. PTHR10822. 1 hit.
Pfam	PF01153. Glypican. 1 hit. [Graphical view]
PROSITE	PS01207. GLYPICAN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2262.
NextBio	9185.
SOURCE	Search...

Entry information

Entry name

GPC5_HUMAN

Accession

Primary (citable) accession number: P78333
Secondary accession number(s): B2R726, O60436, Q9BX27

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	May 29, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.