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Protein

RNA-binding protein 6

Gene

RBM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Specifically binds poly(G) RNA homopolymers in vitro.

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc

GO - Biological processi

  • RNA processing Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 6
Alternative name(s):
Lung cancer antigen NY-LU-12
Protein G16
RNA-binding motif protein 6
RNA-binding protein DEF-3
Gene namesi
Name:RBM6
Synonyms:DEF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:9903. RBM6.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34268.

Polymorphism and mutation databases

BioMutaiRBM6.
DMDMi116242749.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11231123RNA-binding protein 6PRO_0000081760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171PhosphoserineCombined sources
Modified residuei240 – 2401PhosphoserineCombined sources
Modified residuei344 – 3441PhosphothreonineCombined sources
Modified residuei360 – 3601PhosphoserineCombined sources
Modified residuei362 – 3621PhosphoserineCombined sources
Cross-linki386 – 386Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki453 – 453Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki569 – 569Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei891 – 8911PhosphoserineCombined sources
Modified residuei1022 – 10221PhosphoserineCombined sources
Modified residuei1025 – 10251PhosphoserineCombined sources
Cross-linki1046 – 1046Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP78332.
MaxQBiP78332.
PaxDbiP78332.
PeptideAtlasiP78332.
PRIDEiP78332.

PTM databases

iPTMnetiP78332.
PhosphoSiteiP78332.

Expressioni

Tissue specificityi

Ubiquitous in adults.

Gene expression databases

BgeeiP78332.
CleanExiHS_RBM6.
ExpressionAtlasiP78332. baseline and differential.
GenevisibleiP78332. HS.

Organism-specific databases

HPAiHPA026272.
HPA027164.

Interactioni

Subunit structurei

May interact with FAM168B.

Binary interactionsi

WithEntry#Exp.IntActNotes
EEF1GP26641-23EBI-2692323,EBI-10177695

Protein-protein interaction databases

BioGridi115479. 27 interactions.
IntActiP78332. 18 interactions.
STRINGi9606.ENSP00000266022.

Structurei

3D structure databases

ProteinModelPortaliP78332.
SMRiP78332. Positions 657-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini456 – 53681RRMPROSITE-ProRule annotationAdd
BLAST
Domaini1051 – 109747G-patchPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi826 – 8294Poly-Glu
Compositional biasi892 – 8954Poly-Pro
Compositional biasi915 – 9217Poly-Glu

Sequence similaritiesi

Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQDR. Eukaryota.
ENOG4111TS3. LUCA.
GeneTreeiENSGT00510000046476.
HOGENOMiHOG000133022.
HOVERGENiHBG007537.
InParanoidiP78332.
OMAiYDLDFRG.
OrthoDBiEOG7JT6VF.
PhylomeDBiP78332.
TreeFamiTF315789.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR028806. RBM6.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR13948:SF22. PTHR13948:SF22. 3 hits.
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P78332-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWGDSRPANR TGPFRGSQEE RFAPGWNRDY PPPPLKSHAQ ERHSGNFPGR
60 70 80 90 100
DSLPFDFQGH SGPPFANVEE HSFSYGARDG PHGDYRGGEG PGHDFRGGDF
110 120 130 140 150
SSSDFQSRDS SQLDFRGRDI HSGDFRDREG PPMDYRGGDG TSMDYRGREA
160 170 180 190 200
PHMNYRDRDA HAVDFRGRDA PPSDFRGRGT YDLDFRGRDG SHADFRGRDL
210 220 230 240 250
SDLDFRAREQ SRSDFRNRDV SDLDFRDKDG TQVDFRGRGS GTTDLDFRDR
260 270 280 290 300
DTPHSDFRGR HRSRTDQDFR GREMGSCMEF KDREMPPVDP NILDYIQPST
310 320 330 340 350
QDREHSGMNV NRREESTHDH TIERPAFGIQ KGEFEHSETR EGETQGVAFE
360 370 380 390 400
HESPADFQNS QSPVQDQDKS QLSGREEQSS DAGLFKEEGG LDFLGRQDTD
410 420 430 440 450
YRSMEYRDVD HRLPGSQMFG YGQSKSFPEG KTARDAQRDL QDQDYRTGPS
460 470 480 490 500
EEKPSRLIRL SGVPEDATKE EILNAFRTPD GMPVKNLQLK EYNTGYDYGY
510 520 530 540 550
VCVEFSLLED AIGCMEANQG TLMIQDKEVT LEYVSSLDFW YCKRCKANIG
560 570 580 590 600
GHRSSCSFCK NPREVTEAKQ ELITYPQPQK TSIPAPLEKQ PNQPLRPADK
610 620 630 640 650
EPEPRKREEG QESRLGHQKR EAERYLPPSR REGPTFRRDR ERESWSGETR
660 670 680 690 700
QDGESKTIML KRIYRSTPPE VIVEVLEPYV RLTTANVRII KNRTGPMGHT
710 720 730 740 750
YGFIDLDSHA EALRVVKILQ NLDPPFSIDG KMVAVNLATG KRRNDSGDHS
760 770 780 790 800
DHMHYYQGKK YFRDRRGGGR NSDWSSDTNR QGQQSSSDCY IYDSATGYYY
810 820 830 840 850
DPLAGTYYDP NTQQEVYVPQ DPGLPEEEEI KEKKPTSQGK SSSKKEMSKR
860 870 880 890 900
DGKEKKDRGV TRFQENASEG KAPAEDVFKK PLPPTVKKEE SPPPPKVVNP
910 920 930 940 950
LIGLLGEYGG DSDYEEEEEE EQTPPPQPRT AQPQKREEQT KKENEEDKLT
960 970 980 990 1000
DWNKLACLLC RRQFPNKEVL IKHQQLSDLH KQNLEIHRKI KQSEQELAYL
1010 1020 1030 1040 1050
ERREREGKFK GRGNDRREKL QSFDSPERKR IKYSRETDSD RKLVDKEDID
1060 1070 1080 1090 1100
TSSKGGCVQQ ATGWRKGTGL GYGHPGLASS EEAEGRMRGP SVGASGRTSK
1110 1120
RQSNETYRDA VRRVMFARYK ELD
Length:1,123
Mass (Da):128,644
Last modified:October 17, 2006 - v5
Checksum:i2952ED1BAA839DE4
GO
Isoform 2 (identifier: P78332-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-522: Missing.

Note: No experimental confirmation available.
Show »
Length:601
Mass (Da):69,179
Checksum:i0A367656D7AB22A3
GO
Isoform 3 (identifier: P78332-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     496-520: YDYGYVCVEFSLLEDAIGCMEANQG → NSNDPGQRSYPGVCIKPGFLVLQTM
     521-1123: Missing.

Note: No experimental confirmation available.
Show »
Length:520
Mass (Da):59,201
Checksum:iDD45F095380D72D4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti642 – 6421R → K in AAC21578 (PubMed:10352938).Curated
Sequence conflicti710 – 7101A → V in AAC05826 (PubMed:9500467).Curated
Sequence conflicti796 – 7961T → S in AAC05826 (PubMed:9500467).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti353 – 3531S → F in a non-small cell lung cancer cell line. 1 Publication
Corresponds to variant rs61731329 [ dbSNP | Ensembl ].
VAR_014226
Natural varianti721 – 7211N → T.
Corresponds to variant rs34707170 [ dbSNP | Ensembl ].
VAR_052216

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 522522Missing in isoform 2. 1 PublicationVSP_045202Add
BLAST
Alternative sequencei496 – 52025YDYGY…EANQG → NSNDPGQRSYPGVCIKPGFL VLQTM in isoform 3. 1 PublicationVSP_057401Add
BLAST
Alternative sequencei521 – 1123603Missing in isoform 3. 1 PublicationVSP_057402Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042857 mRNA. Translation: AAC05826.1.
AF069517 mRNA. Translation: AAC21578.1.
AF091264 mRNA. Translation: AAD04160.1.
U50839 mRNA. Translation: AAC35207.1.
AK303371 mRNA. Translation: BAG64428.1.
AC104450 Genomic DNA. No translation available.
AC105935 Genomic DNA. No translation available.
BC046643 mRNA. Translation: AAH46643.1.
CCDSiCCDS2809.1. [P78332-1]
CCDS54586.1. [P78332-2]
RefSeqiNP_001161054.1. NM_001167582.1. [P78332-2]
NP_005768.1. NM_005777.2. [P78332-1]
XP_005264843.1. XM_005264786.1. [P78332-2]
XP_005264844.1. XM_005264787.1. [P78332-2]
XP_005264845.1. XM_005264788.1. [P78332-2]
UniGeneiHs.696735.

Genome annotation databases

EnsembliENST00000266022; ENSP00000266022; ENSG00000004534. [P78332-1]
ENST00000422955; ENSP00000392939; ENSG00000004534. [P78332-2]
ENST00000425608; ENSP00000408665; ENSG00000004534. [P78332-3]
ENST00000442092; ENSP00000393530; ENSG00000004534. [P78332-2]
GeneIDi10180.
KEGGihsa:10180.
UCSCiuc003cyc.4. human. [P78332-1]
uc062jzu.1. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042857 mRNA. Translation: AAC05826.1.
AF069517 mRNA. Translation: AAC21578.1.
AF091264 mRNA. Translation: AAD04160.1.
U50839 mRNA. Translation: AAC35207.1.
AK303371 mRNA. Translation: BAG64428.1.
AC104450 Genomic DNA. No translation available.
AC105935 Genomic DNA. No translation available.
BC046643 mRNA. Translation: AAH46643.1.
CCDSiCCDS2809.1. [P78332-1]
CCDS54586.1. [P78332-2]
RefSeqiNP_001161054.1. NM_001167582.1. [P78332-2]
NP_005768.1. NM_005777.2. [P78332-1]
XP_005264843.1. XM_005264786.1. [P78332-2]
XP_005264844.1. XM_005264787.1. [P78332-2]
XP_005264845.1. XM_005264788.1. [P78332-2]
UniGeneiHs.696735.

3D structure databases

ProteinModelPortaliP78332.
SMRiP78332. Positions 657-738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115479. 27 interactions.
IntActiP78332. 18 interactions.
STRINGi9606.ENSP00000266022.

PTM databases

iPTMnetiP78332.
PhosphoSiteiP78332.

Polymorphism and mutation databases

BioMutaiRBM6.
DMDMi116242749.

Proteomic databases

EPDiP78332.
MaxQBiP78332.
PaxDbiP78332.
PeptideAtlasiP78332.
PRIDEiP78332.

Protocols and materials databases

DNASUi10180.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266022; ENSP00000266022; ENSG00000004534. [P78332-1]
ENST00000422955; ENSP00000392939; ENSG00000004534. [P78332-2]
ENST00000425608; ENSP00000408665; ENSG00000004534. [P78332-3]
ENST00000442092; ENSP00000393530; ENSG00000004534. [P78332-2]
GeneIDi10180.
KEGGihsa:10180.
UCSCiuc003cyc.4. human. [P78332-1]
uc062jzu.1. human.

Organism-specific databases

CTDi10180.
GeneCardsiRBM6.
HGNCiHGNC:9903. RBM6.
HPAiHPA026272.
HPA027164.
MIMi606886. gene.
neXtProtiNX_P78332.
PharmGKBiPA34268.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQDR. Eukaryota.
ENOG4111TS3. LUCA.
GeneTreeiENSGT00510000046476.
HOGENOMiHOG000133022.
HOVERGENiHBG007537.
InParanoidiP78332.
OMAiYDLDFRG.
OrthoDBiEOG7JT6VF.
PhylomeDBiP78332.
TreeFamiTF315789.

Miscellaneous databases

ChiTaRSiRBM6. human.
GeneWikiiRBM6.
GenomeRNAii10180.
PROiP78332.
SOURCEiSearch...

Gene expression databases

BgeeiP78332.
CleanExiHS_RBM6.
ExpressionAtlasiP78332. baseline and differential.
GenevisibleiP78332. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR028806. RBM6.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR13948:SF22. PTHR13948:SF22. 3 hits.
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3."
    Gure A.O., Altorki N.K., Stockert E., Scanlan M.J., Old L.J., Chen Y.-T.
    Cancer Res. 58:1034-1041(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lung.
  2. "A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3."
    Timmer T., Terpstra P., van den Berg A., Veldhuis P.M., Ter Elst A., Voutsinas G., Hulsbeek M.M.F., Draaijers T.G., Looman M.W.G., Kok K., Naylor S.L., Buys C.H.C.M.
    Eur. J. Hum. Genet. 7:478-486(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC."
    Drabkin H.A., West J.D., Hotfilder M., Heng Y.M., Erickson P., Calvo R., Dalmau J., Gemmill R.M., Sablitzky F.
    Oncogene 18:2589-2597(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "A highly conserved and universally expressed gene is interrupted by a homozygous deletion in a small cell lung cancer cell line NCI-H740."
    Latif F., Duh F.-M., Wei M.H., Sekido Y., Forgacs E., Minna J.D., Lerman M.I.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Thymus.
  6. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  8. "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes."
    The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium
    Lerman M.I., Minna J.D.
    Cancer Res. 60:6116-6133(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE, VARIANT PHE-353.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1025, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360 AND SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1025, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360; SER-362 AND SER-1025, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360 AND SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-891 AND SER-1025, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "The novel protein MANI modulates neurogenesis and neurite-cone growth."
    Mishra M., Akatsu H., Heese K.
    J. Cell. Mol. Med. 15:1713-1725(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FAM168B.
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; SER-240; THR-344; SER-360; SER-362; SER-1022 AND SER-1025, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360; SER-362; SER-891 AND SER-1025, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  20. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-386; LYS-453; LYS-569 AND LYS-1046, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "SUMO-2 orchestrates chromatin modifiers in response to DNA damage."
    Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V., Vertegaal A.C.
    Cell Rep. 10:1778-1791(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-453 AND LYS-569, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  22. "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability."
    Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., Vertegaal A.C.
    Mol. Cell. Proteomics 14:1419-1434(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-453 AND LYS-569, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRBM6_HUMAN
AccessioniPrimary (citable) accession number: P78332
Secondary accession number(s): B4E0G6
, O60549, O75524, Q86SS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 17, 2006
Last modified: July 6, 2016
This is version 154 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.