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Protein

RNA-binding protein 6

Gene

RBM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Specifically binds poly(G) RNA homopolymers in vitro.

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc

GO - Biological processi

  • RNA processing Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000004534-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 6
Alternative name(s):
Lung cancer antigen NY-LU-12
Protein G16
RNA-binding motif protein 6
RNA-binding protein DEF-3
Gene namesi
Name:RBM6
Synonyms:DEF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:9903. RBM6.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10180.
OpenTargetsiENSG00000004534.
PharmGKBiPA34268.

Polymorphism and mutation databases

BioMutaiRBM6.
DMDMi116242749.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817601 – 1123RNA-binding protein 6Add BLAST1123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei344PhosphothreonineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1
Cross-linki386Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki453Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki569Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei891PhosphoserineCombined sources1
Modified residuei1022PhosphoserineCombined sources1
Modified residuei1025PhosphoserineCombined sources1
Cross-linki1046Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP78332.
MaxQBiP78332.
PaxDbiP78332.
PeptideAtlasiP78332.
PRIDEiP78332.

PTM databases

iPTMnetiP78332.
PhosphoSitePlusiP78332.

Expressioni

Tissue specificityi

Ubiquitous in adults.

Gene expression databases

BgeeiENSG00000004534.
CleanExiHS_RBM6.
ExpressionAtlasiP78332. baseline and differential.
GenevisibleiP78332. HS.

Organism-specific databases

HPAiHPA026272.
HPA027164.

Interactioni

Subunit structurei

May interact with FAM168B.

Binary interactionsi

WithEntry#Exp.IntActNotes
EEF1GP26641-23EBI-2692323,EBI-10177695

Protein-protein interaction databases

BioGridi115479. 27 interactors.
IntActiP78332. 18 interactors.
STRINGi9606.ENSP00000266022.

Structurei

3D structure databases

ProteinModelPortaliP78332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini456 – 536RRMPROSITE-ProRule annotationAdd BLAST81
Domaini1051 – 1097G-patchPROSITE-ProRule annotationAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi826 – 829Poly-Glu4
Compositional biasi892 – 895Poly-Pro4
Compositional biasi915 – 921Poly-Glu7

Sequence similaritiesi

Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQDR. Eukaryota.
ENOG4111TS3. LUCA.
GeneTreeiENSGT00510000046476.
HOGENOMiHOG000133022.
HOVERGENiHBG007537.
InParanoidiP78332.
OMAiYDLDFRG.
OrthoDBiEOG091G00Y8.
PhylomeDBiP78332.
TreeFamiTF315789.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR028806. RBM6.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR13948:SF22. PTHR13948:SF22. 3 hits.
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P78332-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWGDSRPANR TGPFRGSQEE RFAPGWNRDY PPPPLKSHAQ ERHSGNFPGR
60 70 80 90 100
DSLPFDFQGH SGPPFANVEE HSFSYGARDG PHGDYRGGEG PGHDFRGGDF
110 120 130 140 150
SSSDFQSRDS SQLDFRGRDI HSGDFRDREG PPMDYRGGDG TSMDYRGREA
160 170 180 190 200
PHMNYRDRDA HAVDFRGRDA PPSDFRGRGT YDLDFRGRDG SHADFRGRDL
210 220 230 240 250
SDLDFRAREQ SRSDFRNRDV SDLDFRDKDG TQVDFRGRGS GTTDLDFRDR
260 270 280 290 300
DTPHSDFRGR HRSRTDQDFR GREMGSCMEF KDREMPPVDP NILDYIQPST
310 320 330 340 350
QDREHSGMNV NRREESTHDH TIERPAFGIQ KGEFEHSETR EGETQGVAFE
360 370 380 390 400
HESPADFQNS QSPVQDQDKS QLSGREEQSS DAGLFKEEGG LDFLGRQDTD
410 420 430 440 450
YRSMEYRDVD HRLPGSQMFG YGQSKSFPEG KTARDAQRDL QDQDYRTGPS
460 470 480 490 500
EEKPSRLIRL SGVPEDATKE EILNAFRTPD GMPVKNLQLK EYNTGYDYGY
510 520 530 540 550
VCVEFSLLED AIGCMEANQG TLMIQDKEVT LEYVSSLDFW YCKRCKANIG
560 570 580 590 600
GHRSSCSFCK NPREVTEAKQ ELITYPQPQK TSIPAPLEKQ PNQPLRPADK
610 620 630 640 650
EPEPRKREEG QESRLGHQKR EAERYLPPSR REGPTFRRDR ERESWSGETR
660 670 680 690 700
QDGESKTIML KRIYRSTPPE VIVEVLEPYV RLTTANVRII KNRTGPMGHT
710 720 730 740 750
YGFIDLDSHA EALRVVKILQ NLDPPFSIDG KMVAVNLATG KRRNDSGDHS
760 770 780 790 800
DHMHYYQGKK YFRDRRGGGR NSDWSSDTNR QGQQSSSDCY IYDSATGYYY
810 820 830 840 850
DPLAGTYYDP NTQQEVYVPQ DPGLPEEEEI KEKKPTSQGK SSSKKEMSKR
860 870 880 890 900
DGKEKKDRGV TRFQENASEG KAPAEDVFKK PLPPTVKKEE SPPPPKVVNP
910 920 930 940 950
LIGLLGEYGG DSDYEEEEEE EQTPPPQPRT AQPQKREEQT KKENEEDKLT
960 970 980 990 1000
DWNKLACLLC RRQFPNKEVL IKHQQLSDLH KQNLEIHRKI KQSEQELAYL
1010 1020 1030 1040 1050
ERREREGKFK GRGNDRREKL QSFDSPERKR IKYSRETDSD RKLVDKEDID
1060 1070 1080 1090 1100
TSSKGGCVQQ ATGWRKGTGL GYGHPGLASS EEAEGRMRGP SVGASGRTSK
1110 1120
RQSNETYRDA VRRVMFARYK ELD
Length:1,123
Mass (Da):128,644
Last modified:October 17, 2006 - v5
Checksum:i2952ED1BAA839DE4
GO
Isoform 2 (identifier: P78332-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-522: Missing.

Note: No experimental confirmation available.
Show »
Length:601
Mass (Da):69,179
Checksum:i0A367656D7AB22A3
GO
Isoform 3 (identifier: P78332-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     496-520: YDYGYVCVEFSLLEDAIGCMEANQG → NSNDPGQRSYPGVCIKPGFLVLQTM
     521-1123: Missing.

Note: No experimental confirmation available.
Show »
Length:520
Mass (Da):59,201
Checksum:iDD45F095380D72D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti642R → K in AAC21578 (PubMed:10352938).Curated1
Sequence conflicti710A → V in AAC05826 (PubMed:9500467).Curated1
Sequence conflicti796T → S in AAC05826 (PubMed:9500467).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014226353S → F in a non-small cell lung cancer cell line. 1 PublicationCorresponds to variant rs61731329dbSNPEnsembl.1
Natural variantiVAR_052216721N → T.Corresponds to variant rs34707170dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0452021 – 522Missing in isoform 2. 1 PublicationAdd BLAST522
Alternative sequenceiVSP_057401496 – 520YDYGY…EANQG → NSNDPGQRSYPGVCIKPGFL VLQTM in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_057402521 – 1123Missing in isoform 3. 1 PublicationAdd BLAST603

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042857 mRNA. Translation: AAC05826.1.
AF069517 mRNA. Translation: AAC21578.1.
AF091264 mRNA. Translation: AAD04160.1.
U50839 mRNA. Translation: AAC35207.1.
AK303371 mRNA. Translation: BAG64428.1.
AC104450 Genomic DNA. No translation available.
AC105935 Genomic DNA. No translation available.
BC046643 mRNA. Translation: AAH46643.1.
CCDSiCCDS2809.1. [P78332-1]
CCDS54586.1. [P78332-2]
RefSeqiNP_001161054.1. NM_001167582.1. [P78332-2]
NP_005768.1. NM_005777.2. [P78332-1]
XP_005264843.1. XM_005264786.1. [P78332-2]
XP_005264844.1. XM_005264787.2. [P78332-2]
XP_016860988.1. XM_017005499.1. [P78332-2]
XP_016860989.1. XM_017005500.1. [P78332-2]
XP_016860990.1. XM_017005501.1. [P78332-2]
XP_016860991.1. XM_017005502.1. [P78332-2]
UniGeneiHs.696735.

Genome annotation databases

EnsembliENST00000266022; ENSP00000266022; ENSG00000004534. [P78332-1]
ENST00000422955; ENSP00000392939; ENSG00000004534. [P78332-2]
ENST00000425608; ENSP00000408665; ENSG00000004534. [P78332-3]
ENST00000442092; ENSP00000393530; ENSG00000004534. [P78332-2]
GeneIDi10180.
KEGGihsa:10180.
UCSCiuc003cyc.4. human. [P78332-1]
uc062jzu.1. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042857 mRNA. Translation: AAC05826.1.
AF069517 mRNA. Translation: AAC21578.1.
AF091264 mRNA. Translation: AAD04160.1.
U50839 mRNA. Translation: AAC35207.1.
AK303371 mRNA. Translation: BAG64428.1.
AC104450 Genomic DNA. No translation available.
AC105935 Genomic DNA. No translation available.
BC046643 mRNA. Translation: AAH46643.1.
CCDSiCCDS2809.1. [P78332-1]
CCDS54586.1. [P78332-2]
RefSeqiNP_001161054.1. NM_001167582.1. [P78332-2]
NP_005768.1. NM_005777.2. [P78332-1]
XP_005264843.1. XM_005264786.1. [P78332-2]
XP_005264844.1. XM_005264787.2. [P78332-2]
XP_016860988.1. XM_017005499.1. [P78332-2]
XP_016860989.1. XM_017005500.1. [P78332-2]
XP_016860990.1. XM_017005501.1. [P78332-2]
XP_016860991.1. XM_017005502.1. [P78332-2]
UniGeneiHs.696735.

3D structure databases

ProteinModelPortaliP78332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115479. 27 interactors.
IntActiP78332. 18 interactors.
STRINGi9606.ENSP00000266022.

PTM databases

iPTMnetiP78332.
PhosphoSitePlusiP78332.

Polymorphism and mutation databases

BioMutaiRBM6.
DMDMi116242749.

Proteomic databases

EPDiP78332.
MaxQBiP78332.
PaxDbiP78332.
PeptideAtlasiP78332.
PRIDEiP78332.

Protocols and materials databases

DNASUi10180.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266022; ENSP00000266022; ENSG00000004534. [P78332-1]
ENST00000422955; ENSP00000392939; ENSG00000004534. [P78332-2]
ENST00000425608; ENSP00000408665; ENSG00000004534. [P78332-3]
ENST00000442092; ENSP00000393530; ENSG00000004534. [P78332-2]
GeneIDi10180.
KEGGihsa:10180.
UCSCiuc003cyc.4. human. [P78332-1]
uc062jzu.1. human.

Organism-specific databases

CTDi10180.
DisGeNETi10180.
GeneCardsiRBM6.
HGNCiHGNC:9903. RBM6.
HPAiHPA026272.
HPA027164.
MIMi606886. gene.
neXtProtiNX_P78332.
OpenTargetsiENSG00000004534.
PharmGKBiPA34268.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQDR. Eukaryota.
ENOG4111TS3. LUCA.
GeneTreeiENSGT00510000046476.
HOGENOMiHOG000133022.
HOVERGENiHBG007537.
InParanoidiP78332.
OMAiYDLDFRG.
OrthoDBiEOG091G00Y8.
PhylomeDBiP78332.
TreeFamiTF315789.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000004534-MONOMER.

Miscellaneous databases

ChiTaRSiRBM6. human.
GeneWikiiRBM6.
GenomeRNAii10180.
PROiP78332.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000004534.
CleanExiHS_RBM6.
ExpressionAtlasiP78332. baseline and differential.
GenevisibleiP78332. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR028806. RBM6.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR13948:SF22. PTHR13948:SF22. 3 hits.
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM6_HUMAN
AccessioniPrimary (citable) accession number: P78332
Secondary accession number(s): B4E0G6
, O60549, O75524, Q86SS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 157 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.