P78325 (ADAM8_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 116.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Disintegrin and metalloproteinase domain-containing protein 8 Short name=ADAM 8 EC=3.4.24.- Alternative name(s): Cell surface antigen MS2 CD_antigen=CD156a | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 824 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Possible involvement in extravasation of leukocytes. |
| Cofactor | Binds 1 zinc ion per subunit Probable. |
| Subunit structure | Interacts with FST3. Ref.2 |
| Subcellular location | |
| Tissue specificity | Expressed on neutrophils and monocytes. |
| Sequence similarities | Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 16 | 16 | Potential | ||||||||
| Chain | 17 – 824 | 808 | Disintegrin and metalloproteinase domain-containing protein 8 | PRO_0000029060 | |||||||
Regions | |||||||||||
| Topological domain | 17 – 655 | 639 | Extracellular Potential | ||||||||
| Transmembrane | 656 – 676 | 21 | Helical; Potential | ||||||||
| Topological domain | 677 – 824 | 148 | Cytoplasmic Potential | ||||||||
| Domain | 200 – 400 | 201 | Peptidase M12B | ||||||||
| Domain | 408 – 494 | 87 | Disintegrin | ||||||||
Sites | |||||||||||
| Active site | 335 | 1 | By similarity | ||||||||
| Metal binding | 334 | 1 | Zinc; catalytic Probable | ||||||||
| Metal binding | 338 | 1 | Zinc; catalytic Probable | ||||||||
| Metal binding | 344 | 1 | Zinc; catalytic Probable | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 67 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 91 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 436 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 612 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 310 ↔ 395 | By similarity | |||||||||
| Disulfide bond | 351 ↔ 379 | By similarity | |||||||||
| Disulfide bond | 353 ↔ 362 | By similarity | |||||||||
| Disulfide bond | 466 ↔ 486 | By similarity | |||||||||
| Disulfide bond | 613 ↔ 623 | By similarity | |||||||||
| Disulfide bond | 617 ↔ 629 | By similarity | |||||||||
| Disulfide bond | 631 ↔ 640 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 101 | 1 | G → R. Corresponds to variant rs11101675 [ dbSNP | Ensembl ]. | VAR_059760 | |||||||
| Natural variant | 189 | 1 | R → W. Corresponds to variant rs45451297 [ dbSNP | Ensembl ]. | VAR_061735 | |||||||
| Natural variant | 433 | 1 | R → C. Corresponds to variant rs12257830 [ dbSNP | Ensembl ]. | VAR_061736 | |||||||
| Natural variant | 775 | 1 | I → T. Corresponds to variant rs3008319 [ dbSNP | Ensembl ]. | VAR_061737 | |||||||
Sequences
| ||||||||||||||||||
References
| [1] | "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location." Yoshiyama K., Higuchi Y., Kataoka M., Matsuura K., Yamamoto S. Genomics 41:56-62(1997) [PubMed: 9126482] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood. |
| [2] | "FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation." Bartholin L., Destaing O., Forissier S., Martel S., Maguer-Satta V., Jurdic P., Rimokh R. Biol. Cell 97:577-588(2005) [PubMed: 15574124] [Abstract] Cited for: INTERACTION WITH FST3. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D26579 mRNA. Translation: BAA05626.1. |
| IPI | IPI00019158. |
| UniGene | Hs.501574. |
3D structure databases | |
| ProteinModelPortal | P78325. |
| SMR | P78325. Positions 195-646. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P78325. 2 interactions. |
| STRING | P78325. |
Protein family/group databases | |
| MEROPS | M12.208. |
PTM databases | |
| PhosphoSite | P78325. |
Polymorphism databases | |
| DMDM | 2499914. |
Proteomic databases | |
| PRIDE | P78325. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Organism-specific databases | |
| GeneCards | GC10M135075. |
| H-InvDB | HIX0035404. |
| HGNC | HGNC:215. ADAM8. |
| MIM | 602267. gene. |
| neXtProt | NX_P78325. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG15149. |
| HOVERGEN | HBG006978. |
| InParanoid | P78325. |
Gene expression databases | |
| ArrayExpress | P78325. |
| CleanEx | HS_ADAM8. |
| Genevestigator | P78325. |
| GermOnline | ENSG00000151651. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006586. ADAM_Cys-rich. IPR001762. Blood-coag_inhib_Disintegrin. IPR018358. Disintegrin_CS. IPR006210. EGF-like. IPR013032. EGF-like_reg_CS. IPR000742. EGF_3. IPR024079. MetalloPept_cat_dom. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. [Graphical view] |
| Gene3D | G3DSA:4.10.70.10. Blood-coag_inhib_Disintegrin. 1 hit. G3DSA:3.40.390.10. G3DSA:3.40.390.10. 1 hit. |
| Pfam | PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. [Graphical view] |
| PRINTS | PR00289. DISINTEGRIN. |
| SMART | SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit. SM00181. EGF. 1 hit. [Graphical view] |
| SUPFAM | SSF57552. Disintegrin. 1 hit. |
| PROSITE | PS50215. ADAM_MEPRO. 1 hit. PS00427. DISINTEGRIN_1. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. PS00022. EGF_1. False negative. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 1 hit. PS00142. ZINC_PROTEASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 381. |
| SOURCE | Search... |
Entry information
| Entry name | ADAM8_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P78325 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Peptidase families Classification of peptidase families and list of entries |
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with