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Protein

Tyrosine-protein phosphatase non-receptor type substrate 1

Gene

SIRPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.By similarity2 Publications

GO - Biological processi

  • cell adhesion Source: ProtInc
  • leukocyte migration Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33364-MONOMER.
ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-391160. Signal regulatory protein (SIRP) family interactions.
R-HSA-6798695. Neutrophil degranulation.
SignaLinkiP78324.
SIGNORiP78324.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type substrate 1
Short name:
SHP substrate 1
Short name:
SHPS-1
Alternative name(s):
Brain Ig-like molecule with tyrosine-based activation motifs
Short name:
Bit
CD172 antigen-like family member A
Inhibitory receptor SHPS-1
Macrophage fusion receptor
MyD-1 antigen
Signal-regulatory protein alpha-1
Short name:
Sirp-alpha-1
Signal-regulatory protein alpha-2
Short name:
Sirp-alpha-2
Signal-regulatory protein alpha-3
Short name:
Sirp-alpha-3
p84
CD_antigen: CD172a
Gene namesi
Name:SIRPA
Synonyms:BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:9662. SIRPA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 373ExtracellularSequence analysisAdd BLAST343
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 504CytoplasmicSequence analysisAdd BLAST110

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi140885.
OpenTargetsiENSG00000198053.
PharmGKBiPA34006.

Polymorphism and mutation databases

BioMutaiSIRPA.
DMDMi327478534.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001494131 – 504Tyrosine-protein phosphatase non-receptor type substrate 1Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 121PROSITE-ProRule annotation2 Publications
Disulfide bondi170 ↔ 228PROSITE-ProRule annotation
Glycosylationi245N-linked (GlcNAc...)1 Publication1
Glycosylationi270N-linked (GlcNAc...)1 Publication1
Disulfide bondi273 ↔ 331PROSITE-ProRule annotation
Glycosylationi292N-linked (GlcNAc...)1 Publication1
Glycosylationi319N-linked (GlcNAc...)Sequence analysis1
Modified residuei429Phosphotyrosine; by Tyr-kinasesSequence analysis1
Modified residuei453Phosphotyrosine; by Tyr-kinasesSequence analysis1
Modified residuei470Phosphotyrosine; by Tyr-kinasesBy similarity1
Modified residuei496PhosphotyrosineCombined sources1

Post-translational modificationi

N-glycosylated.3 Publications
Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP78324.
MaxQBiP78324.
PaxDbiP78324.
PeptideAtlasiP78324.
PRIDEiP78324.

PTM databases

iPTMnetiP78324.
PhosphoSitePlusiP78324.
UniCarbKBiP78324.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.

Gene expression databases

BgeeiENSG00000198053.
GenevisibleiP78324. HS.

Organism-specific databases

HPAiCAB002776.
CAB015122.

Interactioni

Subunit structurei

Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.By similarity1 Publication

Protein-protein interaction databases

BioGridi126752. 12 interactors.
IntActiP78324. 6 interactors.
MINTiMINT-5004422.
STRINGi9606.ENSP00000348307.

Structurei

Secondary structure

1504
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi41 – 46Combined sources6
Beta strandi51 – 53Combined sources3
Beta strandi56 – 58Combined sources3
Beta strandi66 – 70Combined sources5
Beta strandi77 – 85Combined sources9
Beta strandi90 – 94Combined sources5
Beta strandi106 – 110Combined sources5
Helixi113 – 115Combined sources3
Beta strandi117 – 125Combined sources9
Beta strandi127 – 129Combined sources3
Beta strandi132 – 136Combined sources5
Beta strandi140 – 145Combined sources6
Beta strandi152 – 154Combined sources3
Beta strandi165 – 178Combined sources14
Beta strandi181 – 186Combined sources6
Beta strandi194 – 199Combined sources6
Beta strandi207 – 216Combined sources10
Helixi221 – 223Combined sources3
Beta strandi225 – 231Combined sources7
Beta strandi240 – 245Combined sources6
Helixi246 – 248Combined sources3
Beta strandi255 – 261Combined sources7
Beta strandi269 – 281Combined sources13
Beta strandi283 – 289Combined sources7
Beta strandi292 – 298Combined sources7
Beta strandi310 – 318Combined sources9
Beta strandi328 – 335Combined sources8
Beta strandi341 – 346Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JJSX-ray1.85A/B31-149[»]
2JJTX-ray2.30A/B31-149[»]
2UV3X-ray1.80A/B31-149[»]
2WNGX-ray2.49A31-350[»]
4CMMX-ray1.92A31-149[»]
ProteinModelPortaliP78324.
SMRiP78324.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78324.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 137Ig-like V-typeAdd BLAST106
Domaini148 – 247Ig-like C1-type 1Add BLAST100
Domaini254 – 348Ig-like C1-type 2Add BLAST95

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi429 – 432SH2-bindingSequence analysis4
Motifi439 – 444SH3-bindingSequence analysis6
Motifi453 – 456SH2-bindingSequence analysis4
Motifi470 – 473SH2-bindingSequence analysis4
Motifi496 – 499SH2-bindingSequence analysis4

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3-binding, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKYM. Eukaryota.
ENOG410YKK2. LUCA.
GeneTreeiENSGT00440000033339.
HOVERGENiHBG056632.
InParanoidiP78324.
KOiK06551.
OMAiHEPEKNT.
OrthoDBiEOG091G05RP.
PhylomeDBiP78324.
TreeFamiTF341862.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00407. IGc1. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P78324-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPAGPAPGR LGPLLCLLLA ASCAWSGVAG EEELQVIQPD KSVLVAAGET
60 70 80 90 100
ATLRCTATSL IPVGPIQWFR GAGPGRELIY NQKEGHFPRV TTVSDLTKRN
110 120 130 140 150
NMDFSIRIGN ITPADAGTYY CVKFRKGSPD DVEFKSGAGT ELSVRAKPSA
160 170 180 190 200
PVVSGPAARA TPQHTVSFTC ESHGFSPRDI TLKWFKNGNE LSDFQTNVDP
210 220 230 240 250
VGESVSYSIH STAKVVLTRE DVHSQVICEV AHVTLQGDPL RGTANLSETI
260 270 280 290 300
RVPPTLEVTQ QPVRAENQVN VTCQVRKFYP QRLQLTWLEN GNVSRTETAS
310 320 330 340 350
TVTENKDGTY NWMSWLLVNV SAHRDDVKLT CQVEHDGQPA VSKSHDLKVS
360 370 380 390 400
AHPKEQGSNT AAENTGSNER NIYIVVGVVC TLLVALLMAA LYLVRIRQKK
410 420 430 440 450
AQGSTSSTRL HEPEKNAREI TQDTNDITYA DLNLPKGKKP APQAAEPNNH
460 470 480 490 500
TEYASIQTSP QPASEDTLTY ADLDMVHLNR TPKQPAPKPE PSFSEYASVQ

VPRK
Length:504
Mass (Da):54,967
Last modified:April 5, 2011 - v2
Checksum:i18D2FD04F6182AD0
GO
Isoform 2 (identifier: P78324-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     422-422: Q → QVQSL

Note: No experimental confirmation available.
Show »
Length:508
Mass (Da):55,394
Checksum:i098D9B24276FA4E1
GO
Isoform 4 (identifier: P78324-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-130: Missing.

Show »
Length:503
Mass (Da):54,852
Checksum:iAB4F162B7FF8D97A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti259T → I in CAA71944 (PubMed:9485180).Curated1
Sequence conflicti503R → K in CAA71944 (PubMed:9485180).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0154626 – 7PA → RS.2
Natural variantiVAR_01546320A → P.1
Natural variantiVAR_01546440D → E.1
Natural variantiVAR_01546544L → S.4 PublicationsCorresponds to variant rs1135193dbSNPEnsembl.1
Natural variantiVAR_01546650T → S.4 PublicationsCorresponds to variant rs17855609dbSNPEnsembl.1
Natural variantiVAR_01546852T → I.4 PublicationsCorresponds to variant rs17855610dbSNPEnsembl.1
Natural variantiVAR_01547054R → H.4 PublicationsCorresponds to variant rs17855611dbSNPEnsembl.1
Natural variantiVAR_01547157A → V.4 PublicationsCorresponds to variant rs17855612dbSNPEnsembl.1
Natural variantiVAR_01547261I → N.1
Natural variantiVAR_01547368W → R.1
Natural variantiVAR_01547475G → A.4 PublicationsCorresponds to variant rs1057114dbSNPEnsembl.1
Natural variantiVAR_01547577E → K.1
Natural variantiVAR_01547781N → H.1
Natural variantiVAR_01547895D → E.4 PublicationsCorresponds to variant rs138283486dbSNPEnsembl.1
Natural variantiVAR_01547996L → S.4 Publications1
Natural variantiVAR_015480100N → E Requires 2 nucleotide substitutions. 4 PublicationsCorresponds to variant rs386811662dbSNPEnsembl.1
Natural variantiVAR_015483107R → S.4 PublicationsCorresponds to variant rs17855615dbSNPEnsembl.1
Natural variantiVAR_015484109G → S.4 PublicationsCorresponds to variant rs17855616dbSNPEnsembl.1
Natural variantiVAR_015485125R → Q.Corresponds to variant rs767136065dbSNPEnsembl.1
Natural variantiVAR_015486132V → T Requires 2 nucleotide substitutions. 4 PublicationsCorresponds to variant rs386811663dbSNPEnsembl.1
Natural variantiVAR_015487134F → L.1
Natural variantiVAR_015488163Q → D Requires 2 nucleotide substitutions. 1
Natural variantiVAR_015489181T → S.1
Natural variantiVAR_015490190E → Q.1
Natural variantiVAR_015491201 – 202VG → AR.2
Natural variantiVAR_015492214K → N.1
Natural variantiVAR_015493220E → G.1
Natural variantiVAR_015494222V → I.Corresponds to variant rs143385810dbSNPEnsembl.1
Natural variantiVAR_015495236Q → R.1
Natural variantiVAR_015496239 – 240PL → SF.2
Natural variantiVAR_015497251R → Q.Corresponds to variant rs377448893dbSNPEnsembl.1
Natural variantiVAR_015498261Q → L.1
Natural variantiVAR_015499263V → M.Corresponds to variant rs754806675dbSNPEnsembl.1
Natural variantiVAR_015500271V → I.1
Natural variantiVAR_015501276R → T.1
Natural variantiVAR_015502302V → L.Corresponds to variant rs2422666dbSNPEnsembl.1
Natural variantiVAR_015503339P → S.1
Natural variantiVAR_015504353P → L.Corresponds to variant rs138876160dbSNPEnsembl.1
Natural variantiVAR_015505357G → S.1
Natural variantiVAR_015506367S → P.1
Natural variantiVAR_015507370R → Q.Corresponds to variant rs778218860dbSNPEnsembl.1
Natural variantiVAR_015508389A → E.1
Natural variantiVAR_015509443Q → R.1
Natural variantiVAR_015510460P → L.1
Natural variantiVAR_015511486A → L Requires 2 nucleotide substitutions. 1
Natural variantiVAR_015512491P → L.Corresponds to variant rs367629199dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040799130Missing in isoform 4. Curated1
Alternative sequenceiVSP_007030422Q → QVQSL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86043 mRNA. Translation: BAA12974.1.
Y10375 mRNA. Translation: CAA71403.1.
AB023430 mRNA. Translation: BAA87929.1.
AK290776 mRNA. Translation: BAF83465.1.
AK312521 mRNA. Translation: BAG35420.1.
AL034562 Genomic DNA. Translation: CAB38874.2.
AL034562, AL117335 Genomic DNA. Translation: CAM28287.1.
AL117335 Genomic DNA. Translation: CAC12723.2.
AL117335, AL034562 Genomic DNA. Translation: CAM28335.1.
BC026692 mRNA. Translation: AAH26692.1.
BC033092 mRNA. Translation: AAH33092.1.
BC038510 mRNA. Translation: AAH38510.1.
BC075849 mRNA. Translation: AAH75849.1.
Y11047 mRNA. Translation: CAA71944.1.
CCDSiCCDS13022.1. [P78324-1]
CCDS82593.1. [P78324-2]
PIRiJC5287.
RefSeqiNP_001035111.1. NM_001040022.1. [P78324-1]
NP_001035112.1. NM_001040023.1. [P78324-1]
NP_001317657.1. NM_001330728.1.
NP_542970.1. NM_080792.2. [P78324-1]
XP_005260727.1. XM_005260670.3. [P78324-2]
UniGeneiHs.581021.

Genome annotation databases

EnsembliENST00000356025; ENSP00000348307; ENSG00000198053. [P78324-1]
ENST00000358771; ENSP00000351621; ENSG00000198053. [P78324-1]
ENST00000400068; ENSP00000382941; ENSG00000198053. [P78324-1]
ENST00000622179; ENSP00000478763; ENSG00000198053. [P78324-2]
GeneIDi140885.
KEGGihsa:140885.
UCSCiuc002wfq.3. human. [P78324-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86043 mRNA. Translation: BAA12974.1.
Y10375 mRNA. Translation: CAA71403.1.
AB023430 mRNA. Translation: BAA87929.1.
AK290776 mRNA. Translation: BAF83465.1.
AK312521 mRNA. Translation: BAG35420.1.
AL034562 Genomic DNA. Translation: CAB38874.2.
AL034562, AL117335 Genomic DNA. Translation: CAM28287.1.
AL117335 Genomic DNA. Translation: CAC12723.2.
AL117335, AL034562 Genomic DNA. Translation: CAM28335.1.
BC026692 mRNA. Translation: AAH26692.1.
BC033092 mRNA. Translation: AAH33092.1.
BC038510 mRNA. Translation: AAH38510.1.
BC075849 mRNA. Translation: AAH75849.1.
Y11047 mRNA. Translation: CAA71944.1.
CCDSiCCDS13022.1. [P78324-1]
CCDS82593.1. [P78324-2]
PIRiJC5287.
RefSeqiNP_001035111.1. NM_001040022.1. [P78324-1]
NP_001035112.1. NM_001040023.1. [P78324-1]
NP_001317657.1. NM_001330728.1.
NP_542970.1. NM_080792.2. [P78324-1]
XP_005260727.1. XM_005260670.3. [P78324-2]
UniGeneiHs.581021.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JJSX-ray1.85A/B31-149[»]
2JJTX-ray2.30A/B31-149[»]
2UV3X-ray1.80A/B31-149[»]
2WNGX-ray2.49A31-350[»]
4CMMX-ray1.92A31-149[»]
ProteinModelPortaliP78324.
SMRiP78324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126752. 12 interactors.
IntActiP78324. 6 interactors.
MINTiMINT-5004422.
STRINGi9606.ENSP00000348307.

PTM databases

iPTMnetiP78324.
PhosphoSitePlusiP78324.
UniCarbKBiP78324.

Polymorphism and mutation databases

BioMutaiSIRPA.
DMDMi327478534.

Proteomic databases

EPDiP78324.
MaxQBiP78324.
PaxDbiP78324.
PeptideAtlasiP78324.
PRIDEiP78324.

Protocols and materials databases

DNASUi140885.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356025; ENSP00000348307; ENSG00000198053. [P78324-1]
ENST00000358771; ENSP00000351621; ENSG00000198053. [P78324-1]
ENST00000400068; ENSP00000382941; ENSG00000198053. [P78324-1]
ENST00000622179; ENSP00000478763; ENSG00000198053. [P78324-2]
GeneIDi140885.
KEGGihsa:140885.
UCSCiuc002wfq.3. human. [P78324-1]

Organism-specific databases

CTDi140885.
DisGeNETi140885.
GeneCardsiSIRPA.
HGNCiHGNC:9662. SIRPA.
HPAiCAB002776.
CAB015122.
MIMi602461. gene.
neXtProtiNX_P78324.
OpenTargetsiENSG00000198053.
PharmGKBiPA34006.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKYM. Eukaryota.
ENOG410YKK2. LUCA.
GeneTreeiENSGT00440000033339.
HOVERGENiHBG056632.
InParanoidiP78324.
KOiK06551.
OMAiHEPEKNT.
OrthoDBiEOG091G05RP.
PhylomeDBiP78324.
TreeFamiTF341862.

Enzyme and pathway databases

BioCyciZFISH:G66-33364-MONOMER.
ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-391160. Signal regulatory protein (SIRP) family interactions.
R-HSA-6798695. Neutrophil degranulation.
SignaLinkiP78324.
SIGNORiP78324.

Miscellaneous databases

ChiTaRSiSIRPA. human.
EvolutionaryTraceiP78324.
GeneWikiiSignal-regulatory_protein_alpha.
GenomeRNAii140885.
PROiP78324.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198053.
GenevisibleiP78324. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00407. IGc1. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHPS1_HUMAN
AccessioniPrimary (citable) accession number: P78324
Secondary accession number(s): A2A2E1
, A8K411, B2R6C3, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 174 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.