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Protein

Immunoglobulin-binding protein 1

Gene

IGBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.2 Publications

GO - Molecular functioni

GO - Biological processi

  • B cell activation Source: UniProtKB-KW
  • negative regulation of apoptotic signaling pathway Source: Ensembl
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • negative regulation of protein dephosphorylation Source: Ensembl
  • negative regulation of stress-activated MAPK cascade Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of dephosphorylation Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • regulation of microtubule-based movement Source: UniProtKB
  • response to interleukin-1 Source: UniProtKB
  • response to tumor necrosis factor Source: UniProtKB
  • signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

B-cell activation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089289-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin-binding protein 1
Alternative name(s):
B-cell signal transduction molecule alpha 4
Short name:
Protein alpha-4
CD79a-binding protein 1
Protein phosphatase 2/4/6 regulatory subunit
Renal carcinoma antigen NY-REN-16
Gene namesi
Name:IGBP1
Synonyms:IBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:5461. IGBP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: GO_Central
  • microtubule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Mental retardation, X-linked, syndromic, 28 (MRXS28)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA mental retardation syndrome characterized by agenesis of the corpus callosum, coloboma of the iris and optic nerve, severe retrognathia, and intellectual deficit. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
See also OMIM:300472

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi155R → E: Abolishes interaction with PPP2CA. 1 Publication1
Mutagenesisi158K → D: Abolishes interaction with PPP2CA. 1 Publication1
Mutagenesisi162Y → D: Abolishes interaction with PPP2CA. 1 Publication1
Mutagenesisi214E → R: Abolishes interaction with PPP2CA. 1 Publication1

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNETi3476.
MalaCardsiIGBP1.
MIMi300472. phenotype.
OpenTargetsiENSG00000089289.
Orphaneti52055. Agenesis of the corpus callosum - intellectual disability - coloboma - micrognathia.
PharmGKBiPA29694.

Polymorphism and mutation databases

BioMutaiIGBP1.
DMDMi14285501.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002186182 – 339Immunoglobulin-binding protein 1Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei241N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylated.By similarity
Monoubiquitination by MID1 triggers calpain-mediated cleavage and switches IGBP1 activity from protective to destructive.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei255 – 256Cleavage; by calpain2

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP78318.
MaxQBiP78318.
PaxDbiP78318.
PeptideAtlasiP78318.
PRIDEiP78318.

PTM databases

iPTMnetiP78318.
PhosphoSitePlusiP78318.

Expressioni

Tissue specificityi

Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas.

Gene expression databases

BgeeiENSG00000089289.
CleanExiHS_IGBP1.
GenevisibleiP78318. HS.

Organism-specific databases

HPAiCAB034139.
HPA000634.
HPA001004.

Interactioni

Subunit structurei

Interacts with partially folded PPP2CA, but not with the fully active protein. Interacts with PPP2CB, and with PP4 and PP6. Interacts with MID1 and MID2. Interacts with ubiquitin.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HSPB1P047923EBI-1055954,EBI-352682
PPP2CAP6777512EBI-1055954,EBI-712311
PPP2CBP627145EBI-1055954,EBI-1044367
PPP4CP605109EBI-1055954,EBI-1046072
PPP6CO0074311EBI-1055954,EBI-359751
TIPRLO756632EBI-1055954,EBI-1054735

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109698. 130 interactors.
IntActiP78318. 36 interactors.
MINTiMINT-3022988.
STRINGi9606.ENSP00000348784.

Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 5Combined sources4
Helixi12 – 27Combined sources16
Helixi36 – 59Combined sources24
Helixi68 – 70Combined sources3
Turni73 – 75Combined sources3
Helixi76 – 80Combined sources5
Helixi81 – 90Combined sources10
Helixi95 – 97Combined sources3
Helixi98 – 118Combined sources21
Beta strandi143 – 145Combined sources3
Helixi156 – 180Combined sources25
Helixi186 – 219Combined sources34

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IYPX-ray2.80A2-234[»]
ProteinModelPortaliP78318.
SMRiP78318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 60UIMCuratedAdd BLAST15

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 202Interaction with PPP2CAAdd BLAST105
Regioni225 – 290Interaction with MID11 PublicationAdd BLAST66

Domaini

The UIM domain is required for protective effect on PP2A.By similarity

Sequence similaritiesi

Belongs to the IGBP1/TAP42 family.Curated

Phylogenomic databases

eggNOGiKOG2830. Eukaryota.
ENOG41110HD. LUCA.
GeneTreeiENSGT00390000002414.
HOGENOMiHOG000038526.
HOVERGENiHBG052090.
InParanoidiP78318.
KOiK17606.
OMAiGSRIIQD.
OrthoDBiEOG091G0ELO.
PhylomeDBiP78318.
TreeFamiTF313433.

Family and domain databases

InterProiIPR007304. TAP42-like.
[Graphical view]
PANTHERiPTHR10933. PTHR10933. 1 hit.
PfamiPF04177. TAP42. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P78318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEDELQLP RLPELFETGR QLLDEVEVAT EPAGSRIVQE KVFKGLDLLE
60 70 80 90 100
KAAEMLSQLD LFSRNEDLEE IASTDLKYLL VPAFQGALTM KQVNPSKRLD
110 120 130 140 150
HLQRAREHFI NYLTQCHCYH VAEFELPKTM NNSAENHTAN SSMAYPSLVA
160 170 180 190 200
MASQRQAKIQ RYKQKKELEH RLSAMKSAVE SGQADDERVR EYYLLHLQRW
210 220 230 240 250
IDISLEEIES IDQEIKILRE RDSSREASTS NSSRQERPPV KPFILTRNMA
260 270 280 290 300
QAKVFGAGYP SLPTMTVSDW YEQHRKYGAL PDQGIAKAAP EEFRKAAQQQ
310 320 330
EEQEEKEEED DEQTLHRARE WDDWKDTHPR GYGNRQNMG
Length:339
Mass (Da):39,222
Last modified:May 1, 1997 - v1
Checksum:iBB00A116EB45273A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04957020R → K.Corresponds to variant rs6625580dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08915 mRNA. Translation: CAA70119.1.
BT006736 mRNA. Translation: AAP35382.1.
AL158141, AL139111 Genomic DNA. Translation: CAD13488.2.
BC004137 mRNA. Translation: AAH04137.1.
CCDSiCCDS14396.1.
RefSeqiNP_001542.1. NM_001551.2.
XP_016884978.1. XM_017029489.1.
UniGeneiHs.496267.

Genome annotation databases

EnsembliENST00000342206; ENSP00000363661; ENSG00000089289.
ENST00000356413; ENSP00000348784; ENSG00000089289.
GeneIDi3476.
KEGGihsa:3476.
UCSCiuc004dxv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08915 mRNA. Translation: CAA70119.1.
BT006736 mRNA. Translation: AAP35382.1.
AL158141, AL139111 Genomic DNA. Translation: CAD13488.2.
BC004137 mRNA. Translation: AAH04137.1.
CCDSiCCDS14396.1.
RefSeqiNP_001542.1. NM_001551.2.
XP_016884978.1. XM_017029489.1.
UniGeneiHs.496267.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IYPX-ray2.80A2-234[»]
ProteinModelPortaliP78318.
SMRiP78318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109698. 130 interactors.
IntActiP78318. 36 interactors.
MINTiMINT-3022988.
STRINGi9606.ENSP00000348784.

PTM databases

iPTMnetiP78318.
PhosphoSitePlusiP78318.

Polymorphism and mutation databases

BioMutaiIGBP1.
DMDMi14285501.

Proteomic databases

EPDiP78318.
MaxQBiP78318.
PaxDbiP78318.
PeptideAtlasiP78318.
PRIDEiP78318.

Protocols and materials databases

DNASUi3476.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342206; ENSP00000363661; ENSG00000089289.
ENST00000356413; ENSP00000348784; ENSG00000089289.
GeneIDi3476.
KEGGihsa:3476.
UCSCiuc004dxv.4. human.

Organism-specific databases

CTDi3476.
DisGeNETi3476.
GeneCardsiIGBP1.
HGNCiHGNC:5461. IGBP1.
HPAiCAB034139.
HPA000634.
HPA001004.
MalaCardsiIGBP1.
MIMi300139. gene.
300472. phenotype.
neXtProtiNX_P78318.
OpenTargetsiENSG00000089289.
Orphaneti52055. Agenesis of the corpus callosum - intellectual disability - coloboma - micrognathia.
PharmGKBiPA29694.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2830. Eukaryota.
ENOG41110HD. LUCA.
GeneTreeiENSGT00390000002414.
HOGENOMiHOG000038526.
HOVERGENiHBG052090.
InParanoidiP78318.
KOiK17606.
OMAiGSRIIQD.
OrthoDBiEOG091G0ELO.
PhylomeDBiP78318.
TreeFamiTF313433.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089289-MONOMER.

Miscellaneous databases

ChiTaRSiIGBP1. human.
GeneWikiiIGBP1.
GenomeRNAii3476.
PROiP78318.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000089289.
CleanExiHS_IGBP1.
GenevisibleiP78318. HS.

Family and domain databases

InterProiIPR007304. TAP42-like.
[Graphical view]
PANTHERiPTHR10933. PTHR10933. 1 hit.
PfamiPF04177. TAP42. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGBP1_HUMAN
AccessioniPrimary (citable) accession number: P78318
Secondary accession number(s): Q8TAB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.