P78314 (3BP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SH3 domain-binding protein 2
Short name=3BP-2

Gene names

Name:	SH3BP2
Synonyms:	3BP2
ORF Names:	RES4-23

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	561 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
Tissue specificity	Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas. Ref.3
Post-translational modification	Phosphorylated. Phosphorylation at Tyr-448 may stimulate the activity of the LYN kinase By similarity.
Involvement in disease	Cherubism (CRBM) [MIM:118400]: An autosomal dominant syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.11 Ref.12 Ref.13
Sequence similarities	Contains 1 PH domain. Contains 1 SH2 domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Disease	Disease mutation
Domain	SH2 domain SH3-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Traceable author statement Ref.2. Source: ProtInc
Molecular_function	SH3/SH2 adaptor activity Traceable author statement Ref.2. Source: ProtInc phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TNKS2	Q9H2K2	5	EBI-727062,EBI-4398527

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform Long (identifier: P78314-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Short (identifier: P78314-2)

The sequence of this isoform differs from the canonical sequence as follows:
     81-97: VMRAAEETTSNNVFPFK → QPRPQPAQALSQTEAGP
     98-561: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 3 (identifier: P78314-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MASLGPRTPAPSRSRGRRAMCWVSTISFM

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 561

561

SH3 domain-binding protein 2

PRO_0000064365

Regions

Domain

26 – 130

105

PH

Domain

457 – 555

99

SH2

Motif

201 – 210

10

SH3-binding

Compositional bias

205 – 212

8

Poly-Pro

Compositional bias

236 – 240

5

Poly-Pro

Amino acid modifications

Modified residue

174

1

Phosphotyrosine; by SYK By similarity

Modified residue

183

1

Phosphotyrosine; by SYK By similarity

Modified residue

278

1

Phosphoserine Ref.9

Modified residue

444

1

Phosphoserine By similarity

Modified residue

448

1

Phosphotyrosine; by SYK By similarity

Natural variations

Alternative sequence

1

1

M → MASLGPRTPAPSRSRGRRAM CWVSTISFM in isoform 3.

VSP_043636

Alternative sequence

81 – 97

17

VMRAA…VFPFK → QPRPQPAQALSQTEAGP in isoform Short.

VSP_004085

Alternative sequence

98 – 561

464

Missing in isoform Short.

VSP_004086

Natural variant

415

1

R → P in CRBM. Ref.11

VAR_013257

Natural variant

415

1

R → Q in CRBM. Ref.11

VAR_013258

Natural variant

418

1

P → H in CRBM. Ref.11

VAR_013259

Natural variant

418

1

P → L in CRBM. Ref.11

VAR_013260

Natural variant

418

1

P → R in CRBM. Ref.11 Ref.13

VAR_013261

Natural variant

420

1

G → E in CRBM. Ref.11
Corresponds to variant rs28938171 [ dbSNP | Ensembl ].

VAR_013262

Natural variant

420

1

G → R in CRBM. Ref.11 Ref.12
Corresponds to variant rs28938170 [ dbSNP | Ensembl ].

VAR_013263

Experimental info

Sequence conflict

27

1

V → L in AAB59973. Ref.3

Sequence conflict

224

1

H → N in AAB59973. Ref.3

Sequence conflict

249

1

L → R in AAB59973. Ref.3

Sequence conflict

251

1

A → P in AAB59973. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

561

Helix Strand Turn

Details...

Turn

455 – 457

3

Helix

464 – 474

11

Beta strand

485 – 489

5

Beta strand

496 – 501

6

Turn

503 – 505

3

Beta strand

506 – 508

3

Beta strand

514 – 516

3

Beta strand

519 – 525

7

Beta strand

527 – 530

4

Helix

531 – 538

8

Beta strand

544 – 548

5

Beta strand

553 – 556

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform Long [UniParc]. Last modified July 15, 1998. Version 2. Checksum: 69E6846A4F6D8F15	FASTA	561	62,244
	10 20 30 40 50 60 MAAEEMHWPV PMKAIGAQNL LTMPGGVAKA GYLHKKGGTQ LQLLKWPLRF VIIHKRCVYY 70 80 90 100 110 120 FKSSTSASPQ GAFSLSGYNR VMRAAEETTS NNVFPFKIIH ISKKHRTWFF SASSEEERKS 130 140 150 160 170 180 WMALLRREIG HFHEKKDLPL DTSDSSSDTD SFYGAVERPV DISLSPYPTD NEDYEHDDED 190 200 210 220 230 240 DSYLEPDSPE PGRLEDALMH PPAYPPPPVP TPRKPAFSDM PRAHSFTSKG PGPLLPPPPP 250 260 270 280 290 300 KHGLPDVGLA AEDSKRDPLC PRRAEPCPRV PATPRRMSDP PLSTMPTAPG LRKPPCFRES 310 320 330 340 350 360 ASPSPEPWTP GHGACSTSSA AIMATATSRN CDKLKSFHLS PRGPPTSEPP PVPANKPKFL 370 380 390 400 410 420 KIAEEDPPRE AAMPGLFVPP VAPRPPALKL PVPEAMARPA VLPRPEKPQL PHLQRSPPDG 430 440 450 460 470 480 QSFRSFSFEK PRQPSQADTG GDDSDEDYEK VPLPNSVFVN TTESCEVERL FKATSPRGEP 490 500 510 520 530 540 QDGLYCIRNS STKSGKVLVV WDETSNKVRN YRIFEKDSKF YLEGEVLFVS VGSMVEHYHT 550 560 HVLPSHQSLL LRHPYGYTGP R
	Isoform Short [UniParc]. Checksum: 58CB0FBE9EB3A7FF	FASTA	97	10,624
	10 20 30 40 50 60 MAAEEMHWPV PMKAIGAQNL LTMPGGVAKA GYLHKKGGTQ LQLLKWPLRF VIIHKRCVYY 70 80 90 FKSSTSASPQ GAFSLSGYNR QPRPQPAQAL SQTEAGP
	Isoform 3 [UniParc]. Checksum: B41A1B1688245A77	FASTA	589	65,305
	10 20 30 40 50 60 MASLGPRTPA PSRSRGRRAM CWVSTISFMA AEEMHWPVPM KAIGAQNLLT MPGGVAKAGY 70 80 90 100 110 120 LHKKGGTQLQ LLKWPLRFVI IHKRCVYYFK SSTSASPQGA FSLSGYNRVM RAAEETTSNN 130 140 150 160 170 180 VFPFKIIHIS KKHRTWFFSA SSEEERKSWM ALLRREIGHF HEKKDLPLDT SDSSSDTDSF 190 200 210 220 230 240 YGAVERPVDI SLSPYPTDNE DYEHDDEDDS YLEPDSPEPG RLEDALMHPP AYPPPPVPTP 250 260 270 280 290 300 RKPAFSDMPR AHSFTSKGPG PLLPPPPPKH GLPDVGLAAE DSKRDPLCPR RAEPCPRVPA 310 320 330 340 350 360 TPRRMSDPPL STMPTAPGLR KPPCFRESAS PSPEPWTPGH GACSTSSAAI MATATSRNCD 370 380 390 400 410 420 KLKSFHLSPR GPPTSEPPPV PANKPKFLKI AEEDPPREAA MPGLFVPPVA PRPPALKLPV 430 440 450 460 470 480 PEAMARPAVL PRPEKPQLPH LQRSPPDGQS FRSFSFEKPR QPSQADTGGD DSDEDYEKVP 490 500 510 520 530 540 LPNSVFVNTT ESCEVERLFK ATSPRGEPQD GLYCIRNSST KSGKVLVVWD ETSNKVRNYR 550 560 570 580 IFEKDSKFYL EGEVLFVSVG SMVEHYHTHV LPSHQSLLLR HPYGYTGPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"3BP2 binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase c-FES to the cytoplasmic membrane in a phosphorylation dependent mechanism." Gokemeijer J., Deligiannidis K.E., Ligris K., Ernst T.J. Blood 88:473A-473A(1996) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG). Tissue: Tonsil.
[2]	"Identification and characterization of the human homologue of SH3BP2, an SH3 binding domain protein within a common region of deletion at 4p16.3 involved in bladder cancer." Bell S.M., Shaw M., Jou Y.-S., Myers R.M., Knowles M.A. Genomics 44:163-170(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
[3]	"The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3." Hadano S., Ishida Y., Ikeda J.-E. DNA Res. 5:177-186(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), TISSUE SPECIFICITY. Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LONG AND 3). Tissue: Cerebellum.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG). Tissue: Cervix.
[8]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Solution structure of the SH2 domain of human SH3BP2 protein." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 444-558.
[11]	"Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism." Ueki Y., Tiziani V., Santanna C., Fukai N., Maulik C., Garfinkle J., Ninomiya C., doAmaral C., Peters H., Habal M., Rhee-Morris L., Doss J.B., Kreiborg S., Olsen B.R., Reichenberger E. Nat. Genet. 28:125-126(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS CRBM GLN-415; PRO-415; ARG-418; HIS-418; LEU-418; ARG-420 AND GLU-420.
[12]	"Novel mutation in the gene encoding c-Abl-binding protein SH3BP2 causes cherubism." Lo B., Faiyaz-Ul-Haque M., Kennedy S., Aviv R., Tsui L.-C., Teebi A.S. Am. J. Med. Genet. A 121:37-40(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT CRBM ARG-420.
[13]	"A missense mutation in the SH3BP2 gene on chromosome 4p16.3 found in a case of nonfamilial cherubism." Imai Y., Kanno K., Moriya T., Kayano S., Seino H., Matsubara Y., Yamada A. Cleft Palate Craniofac. J. 40:632-638(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT CRBM ARG-418.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF000936 mRNA. Translation: AAB59973.1.
U56386 mRNA. Translation: AAB72034.1.
AB000462 mRNA. Translation: BAA19119.1.
AB000463 mRNA. Translation: BAA19120.1.
AK299996 mRNA. Translation: BAG61816.1.
AK312286 mRNA. Translation: BAG35213.1.
AL121750 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82509.1.
CH471131 Genomic DNA. Translation: EAW82510.1.
CH471131 Genomic DNA. Translation: EAW82511.1.
CH471131 Genomic DNA. Translation: EAW82512.1.
BC022996 mRNA. Translation: AAH22996.1.

IPI

IPI00218997.
IPI00219071.
IPI00926189.

RefSeq

NP_001116153.1. NM_001122681.1.
NP_001139327.1. NM_001145855.1.
NP_001139328.1. NM_001145856.1.
NP_003014.3. NM_003023.4.

UniGene

Hs.167679.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CR4	NMR	-	A	446-558	[»]
3TWR	X-ray	1.55	E/F/G/H	410-425	[»]

ProteinModelPortal

P78314.

ModBase

Search...

Protein-protein interaction databases

IntAct

P78314. 3 interactions.

MINT

MINT-254189.

STRING

9606.ENSP00000348685.

PTM databases

PhosphoSite

P78314.

Polymorphism databases

DMDM

3023207.

Proteomic databases

PaxDb

P78314.

PRIDE

P78314.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000356331; ENSP00000348685; ENSG00000087266.
ENST00000389838; ENSP00000374488; ENSG00000087266.
ENST00000435136; ENSP00000403231; ENSG00000087266.
ENST00000442312; ENSP00000388152; ENSG00000087266.
ENST00000452765; ENSP00000409746; ENSG00000087266.
ENST00000511747; ENSP00000424846; ENSG00000087266.
ENST00000513020; ENSP00000424072; ENSG00000087266.
ENST00000515737; ENSP00000422605; ENSG00000087266.

GeneID

6452.

KEGG

hsa:6452.

UCSC

uc003gfi.4. human.
uc011bvp.2. human.

Organism-specific databases

CTD

6452.

GeneCards

GC04P002831.

HGNC

HGNC:10825. SH3BP2.

HPA

HPA036790.

MIM

118400. phenotype.
602104. gene.

neXtProt

NX_P78314.

Orphanet

184. Cherubism.

PharmGKB

PA35733.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG42035.

HOVERGEN

HBG000016.

InParanoid

P78314.

KO

K07984.

OrthoDB

EOG4SN1P6.

Enzyme and pathway databases

Pathway_Interaction_DB

tcrpathway. TCR signaling in naive CD4+ T cells.

SignaLink

P78314.

Gene expression databases

ArrayExpress

P78314.

Bgee

P78314.

CleanEx

HS_SH3BP2.

Genevestigator

P78314.

GermOnline

ENSG00000087266. Homo sapiens.

Family and domain databases

Gene3D

2.30.29.30. 1 hit.
3.30.505.10. 1 hit.

InterPro

IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR000980. SH2.
[Graphical view]

Pfam

PF00169. PH. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]

SMART

SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]

PROSITE

PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

SH3BP2. human.

EvolutionaryTrace

P78314.

GenomeRNAi

6452.

NextBio

25079.

SOURCE

Search...

Entry information

Entry name

3BP2_HUMAN

Accession

Primary (citable) accession number: P78314
Secondary accession number(s): A6NNC2 , B2R5R6, B4DT04, D3DVR0, O00500, O15373, P78315

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	May 29, 2013
This is version 120 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.