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Protein

Probable cation-transporting P-type ATPase

Gene

pacL

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Could mediate calcium influx.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3314-aspartylphosphate intermediateBy similarity1
Metal bindingi587MagnesiumBy similarity1
Metal bindingi591MagnesiumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting P-type ATPase (EC:3.6.3.-)
Gene namesi
Name:pacL
Ordered Locus Names:MPN_209
ORF Names:MP622
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000808 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 79ExtracellularSequence analysisAdd BLAST17
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 237CytoplasmicSequence analysisAdd BLAST137
Transmembranei238 – 257HelicalSequence analysisAdd BLAST20
Topological domaini258 – 275ExtracellularSequence analysisAdd BLAST18
Transmembranei276 – 293HelicalSequence analysisAdd BLAST18
Topological domaini294 – 642CytoplasmicSequence analysisAdd BLAST349
Transmembranei643 – 662HelicalSequence analysisAdd BLAST20
Topological domaini663 – 685ExtracellularSequence analysisAdd BLAST23
Transmembranei686 – 706HelicalSequence analysisAdd BLAST21
Topological domaini707 – 724CytoplasmicSequence analysisAdd BLAST18
Transmembranei725 – 747HelicalSequence analysisAdd BLAST23
Topological domaini748 – 768ExtracellularSequence analysisAdd BLAST21
Transmembranei769 – 788HelicalSequence analysisAdd BLAST20
Topological domaini789 – 801CytoplasmicSequence analysisAdd BLAST13
Transmembranei802 – 824HelicalSequence analysisAdd BLAST23
Topological domaini825 – 842ExtracellularSequence analysisAdd BLAST18
Transmembranei843 – 863HelicalSequence analysisAdd BLAST21
Topological domaini864 – 872CytoplasmicSequence analysis9

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461631 – 872Probable cation-transporting P-type ATPaseAdd BLAST872

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

IntActiP78036. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP78036.
SMRiP78036.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OMAiCRSESKS.

Family and domain databases

Gene3Di3.40.1110.10. 2 hits.
InterProiView protein in InterPro
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PRINTSiPR00120. HATPASE.
SMARTiView protein in SMART
SM00831. Cation_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

P78036-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKWTGLSAA AVLESRAQHG ANLIPTKKLT PFWLLFLEQF KSLVVILLLV
60 70 80 90 100
ATILSLVVAI ISGVNANWLF DHNLVIEWTQ PFVILITVLA NSLIGSIQEF
110 120 130 140 150
KAQKSAHTLK SLTQPFTRVF REEGLVSLPV GEVVVGDIIF LEAGDIIPAD
160 170 180 190 200
GKVLQANHLR CMESFLTGES VPVDKSVVNT GGKGLLEQTN LLFSGAQVVF
210 220 230 240 250
GSGVFEVTAV GLNTQVGQIV KTVDSSATKL SPLQQKLEKV GKWFSWFGLG
260 270 280 290 300
LFVVVFLVQL GLLGFHNFSA NWSIALIGAI ALVVAIIPEG LVTFINVIFA
310 320 330 340 350
LSVQKLTKQK AIIKYLAAIE TLGGVQIICT DKTGTLTQNK MKVVDYFCFS
360 370 380 390 400
NTTQTDLARA LCLCNNATVN TNGDSTGDPT EIALLQWLDR DGLELNHYTR
410 420 430 440 450
VYEKAFDSNR KLMSVVVQKD NRFIVIVKGA HDVLLPLCKG LDSNQIKPLI
460 470 480 490 500
DERASNGLRN LAVGLKVLYC FDPENTQTVN ELESELDFLG SVSLQDPPRI
510 520 530 540 550
ESKAAIMACH QANITPIMIT GDHLKTATAI AKELGILTDE RQAILGVDLD
560 570 580 590 600
PAKIMEYRVF ARVTPQQKLE IVNAWKQAGY TVAVTGDGVN DAPALVTSDV
610 620 630 640 650
GCCMGQTGVD IAKDAADVII SDDNFATIVN GIEQGRKTFL TCKRVLFNLF
660 670 680 690 700
LTSIAGTIVV LLGLFVLGEV FREQLSKANH NFQVFTPTQL LIINLFVHGF
710 720 730 740 750
PAVALAIQPV QEKLMLKPFS TKNLFYNRGG FDLIWQSLLL SFLTLLFYSL
760 770 780 790 800
GMVYAINDPE LGKSGDLINR AGATCGFMVL GGSAALNSLN LMVDRPLVAT
810 820 830 840 850
NPKHYGIVWL GALSSIFVFL LIIFINPLGL VFSTLKDLTA HPVLIGYSFG
860 870
GVLLYMTINE VVKLIRLSYG SV
Length:872
Mass (Da):94,968
Last modified:February 1, 1997 - v1
Checksum:i42F8001C4798CAFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96270.1.
PIRiS73948.
RefSeqiNP_109897.1. NC_000912.1.
WP_010874566.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96270; AAB96270; MPN_209.
GeneIDi876769.
KEGGimpn:MPN209.
PATRICifig|272634.6.peg.228.

Similar proteinsi

Entry informationi

Entry nameiATCL_MYCPN
AccessioniPrimary (citable) accession number: P78036
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 7, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families